Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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mTOR Signaling in Growth Control and Disease

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

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Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

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Autophagy and Viruses: Adversaries or Allies?

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Resveratrol improves health and survival of mice on a high-calorie diet

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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Antimicrobial Autophagy: A Conserved Innate Immune Response in Drosophila

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Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

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Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

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Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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Impairment of starvation-induced and constitutive autophagy in Atg7 -deficient mice

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Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

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Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages

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Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

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Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

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The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

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Autophagy in infection, inflammation and immunity

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Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis

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Induction of autophagy by spermidine promotes longevity

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

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The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

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Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion: Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy

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Systemic lupus erythematosus

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Autophagy modulation as a potential therapeutic target for diverse diseases

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Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

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Autophagy-deficient mice develop multiple liver tumors

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Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry

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Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

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Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in C. elegans

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Mitochondria and the Autophagy–Inflammation–Cell Death Axis in Organismal Aging

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

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Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

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Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

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Autophagy in malignant transformation and cancer progression

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Cardioprotection and lifespan extension by the natural polyamine spermidine

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Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

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Protection against Fatal Sindbis Virus Encephalitis by Beclin, a Novel Bcl-2-Interacting Protein

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Adult-Onset Primary Open-Angle Glaucoma Caused by Mutations in Optineurin

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Autophagy Defends Cells Against Invading Group A Streptococcus

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Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

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Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

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Discovery of Atg5/Atg7-independent alternative macroautophagy

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Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

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Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)

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Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome

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Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

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The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

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Chaperone-mediated autophagy: roles in disease and aging

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Microautophagy: lesser-known self-eating

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Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

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HSV-1 ICP34.5 Confers Neurovirulence by Targeting the Beclin 1 Autophagy Protein

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Metabolic control of autophagy

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Compromised autophagy and neurodegenerative diseases

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Pathogenic Lysosomal Depletion in Parkinson's Disease

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Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

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The cell biology of lysosomal storage disorders

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Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

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Cardiac autophagy is a maladaptive response to hemodynamic stress

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Identification of a candidate therapeutic autophagy-inducing peptide

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TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity

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Metabolic Control of Longevity

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Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

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Autophagy influences glomerular disease susceptibility and maintains podocyte homeostasis in aging mice

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Overexpression of Atg5 in mice activates autophagy and extends lifespan

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Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

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p53 status determines the role of autophagy in pancreatic tumour development

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Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

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To Be or Not to Be? How Selective Autophagy and Cell Death Govern Cell Fate

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Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

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AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

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<emph type="ital">SQSTM1</emph> Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

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Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

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Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex.

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Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

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What is the role of protein aggregation in neurodegeneration?

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A critical role for the autophagy gene Atg5 in T cell survival and proliferation

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Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes

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Host Cell Autophagy Activated by Antibiotics Is Required for Their Effective Antimycobacterial Drug Action

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Autophagy is an adaptive response in desmin-related cardiomyopathy

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Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses

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Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

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Autophagy in acute brain injury

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Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of Tuberous Sclerosis Complex

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Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

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Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model

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Cystatin C-Cathepsin B Axis Regulates Amyloid Beta Levels and Associated Neuronal Deficits in an Animal Model of Alzheimer's Disease

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Macroautophagy is dispensable for growth of KRAS mutant tumors and chloroquine efficacy

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Aspergillus Cell Wall Melanin Blocks LC3-Associated Phagocytosis to Promote Pathogenicity

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Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.

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Neuroprotection of rapamycin in lactacystin-induced neurodegeneration via autophagy enhancement

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Defects in autophagy favour adherent-invasive Escherichia coli persistence within macrophages leading to increased pro-inflammatory response

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Lack of Neuronal IFN-β-IFNAR Causes Lewy Body- and Parkinson’s Disease-like Dementia

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FGF signalling regulates bone growth through autophagy

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Liver autophagy: much more than just taking out the trash

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Genetic and Chemical Correction of Cholesterol Accumulation and Impaired Autophagy in Hepatic and Neural Cells Derived from Niemann-Pick Type C Patient-Specific iPS Cells

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Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice

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Laforin, the most common protein mutated in Lafora disease, regulates autophagy

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The Parasitophorous Vacuole Membrane of Toxoplasma gondii Is Targeted for Disruption by Ubiquitin-like Conjugation Systems of Autophagy

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Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

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Biological Functions of Autophagy Genes: A Disease Perspective

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Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion

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Macrophages and metabolism in the tumor microenvironment

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Modulation of autophagy in human diseases strategies to foster strengths and circumvent weaknesses

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Targeting Autophagy as a Strategy for Drug Discovery and Therapeutic Modulation

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Targeting autophagy with pharmacological small molecules to treat human diseases

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Chemical modulators of autophagy as biological probes and potential therapeutics

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Autophagy-targeted therapy to modulate age-related diseases: Success, pitfalls, and new directions

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