Cited by 4,233Nanoparticle-Based Drug DeliveryNanoplatforms for cancer theranosticsRadiation Therapy and Dosimetry

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Nanoparticle therapeutics: an emerging treatment modality for cancer

Davis, Mark E., Chen, Zhuo, Shin, Dong M.·2008·Nature Reviews Drug Discovery

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Abstract

Nanoparticles--particles in the size range 1-100 nm--are emerging as a class of therapeutics for cancer. Early clinical results suggest that nanoparticle therapeutics can show enhanced efficacy, while simultaneously reducing side effects, owing to properties such as more targeted localization in tumours and active cellular uptake. Here, we highlight the features of nanoparticle therapeutics that distinguish them from previous anticancer therapies, and describe how these features provide the potential for therapeutic effects that are not achievable with other modalities. While large numbers of preclinical studies have been published, the emphasis here is placed on preclinical and clinical studies that are likely to affect clinical investigations and their implications for advancing the treatment of patients with cancer.

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Authors: Davis, M. E., Chen, Z., & Shin, D. M.
Affiliations: California Institute of Technology (US)
Emory University (US)
Corresponding author: Davis, Mark E.
ORCID: Davis, Mark E.
Chen, Zhuo
Shin, Dong M.
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2008-09
Volume: 7
Issue: 9
Pages: 771-782
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd2614
OpenAlex: W2082511916
Cited by: 4,233
References: 108
Citations by year: 2026: 68 · 2025: 134 · 2024: 165 · 2023: 143 · 2022: 171 · 2021: 217 · 2020: 224 · 2019: 260 · 2018: 316 · 2017: 340 · 2016: 364 · 2015: 383 · 2014: 385 · 2013: 332 · 2012: 268
FWCI: 7.10
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed (publishedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Funders: National Cancer Institute (U54CA119338)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Physical Sciences › Physics and Astronomy › Radiation › Radiation Therapy and Dosimetry
Keywords: nanotherapeutics, cancer therapy, nanomedicine, targeted drug delivery, tumor localization, cellular uptake, clinical translation, clinical trials, anticancer agents, adverse drug reactions
MeSH terms: Animals, Antineoplastic Agents, Clinical Trials as Topic, Drug Evaluation, Preclinical, Humans, Neoplasms, Drug Delivery Systems, Nanoparticles

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