The FGF family: biology, pathophysiology and therapy

Beenken, Andrew, Mohammadi, Moosa·2009·Nature Reviews Drug Discovery

Cited by (1,001)

Items 401–500 of 1,001

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    Molly R. Ryan, Christal Dyane Sohl, BeiBei Luo, Karen S. Anderson · 2018 · Molecular Cancer Research
  2. Inhibition of vascular neointima hyperplasia by FGF21 associated with FGFR1/Syk/NLRP3 inflammasome pathway in diabetic mice
    Wei Wei, Xiao-Xue Li, Ming Xu · 2019 · Atherosclerosis
  3. The application of click chemistry in the synthesis of agents with anticancer activity
    Jiang Sheng, Nan Ma, Ying Wang, Wen‐Cai Ye, Bing‐Xin Zhao · 2015 · Drug Design Development and Therapy
  4. Caveolin‐1 orchestrates fibroblast growth factor 2 signaling control of angiogenesis in placental artery endothelial cell caveolae
    Lin Feng, Wu-xiang Liao, Quan Luo, Hong‐Hai Zhang, Wen Wang, Jing Juan Zheng, Dong‐Bao Chen · 2011 · Journal of Cellular Physiology
  5. A new material for tissue engineered vagina reconstruction: Acellular porcine vagina matrix
    Jingkun Zhang, Runxuan Du, Lin Zhang, Yanan Li, Ming‐Le Zhang, Shuo Zhao, Xianghua Huang, Yanfang Xu · 2017 · Journal of Biomedical Materials Research Part A
  6. FGF18, a prominent player in FGF signaling, promotes gastric tumorigenesis through autocrine manner and is negatively regulated by miR-590-5p
    Jinglin Zhang, Yuhang Zhou, Tingting Huang, Feng Wu, Yi Pan, Yujuan Dong, Yan Wang, Aden Ka‐Yin Chan, Liping Liu, Johnny S. H. Kwan et al. · 2018 · Oncogene
  7. Targeting the Fibroblast Growth Factor Receptor (FGFR) Family in Lung Cancer
    Laura Pacini, Andrew D. Jenks, Nadia Carvalho Lima, Paul H. Huang · 2021 · Cells
  8. Rationale for targeting VEGF, FGF, and PDGF for the treatment of NSCLC
    Ballas, Chachoua · 2011 · OncoTargets and Therapy
  9. Fibroblast Growth Factor-10 Promotes Cardiomyocyte Differentiation from Embryonic and Induced Pluripotent Stem Cells
    Sunny Sun-Kin Chan, Hui-Jing Li, Ying-Chang Hsueh, Desy S. Lee, Jyh-Hong Chen, Shiaw‐Min Hwang, Chen-Yun Chen, Emily Shih, Patrick C.H. Hsieh · 2010 · PLoS ONE
  10. Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways
    Kyong Joo Lee, Yoon Ok Jang, Seung‐Kuy Cha, Moon Young Kim, Kyu‐Sang Park, Young Woo Eom, Soon Koo Baik · 2018 · Gut and Liver
  11. Progress in Research on the Role of FGF in the Formation and Treatment of Corneal Neovascularization
    Mengji Chen, Licheng Bao, Mengying Zhao, Jiarong Cao, Haihua Zheng · 2020 · Frontiers in Pharmacology
  12. Controlled growth factor delivery system with osteogenic-angiogenic coupling effect for bone regeneration
    Fei Kang, Qiying Yi, Pengcheng Gu, Yuhan Dong, Ziyang Zhang, Lijuan Zhang, Yan Bai · 2021 · Journal of Orthopaedic Translation
  13. Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy
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  14. Fibroblast Growth Factor Signaling Pathway in Endothelial Cells Is Activated by BMPER to Promote Angiogenesis
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  15. Advanced silk material spun by a transgenic silkworm promotes cell proliferation for biomedical application
    Feng Wang, Hanfu Xu, Yuancheng Wang, Riyuan Wang, Lin Yuan, Huan Ding, Chunnuan Song, Sanyuan Ma, Zhixin Peng, Zhangchuan Peng et al. · 2014 · Acta Biomaterialia
  16. Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126–5p in control of endothelial cell function in angiogenesis
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  17. Zirconium oxide and niobium oxide used as radiopacifiers in a calcium silicate‐based material stimulate fibroblast proliferation and collagen formation
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  18. Rush to the fire: FGF21 extinguishes metabolic stress, metaflammation and tissue damage
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  19. FGF2 Attenuates Neural Cell Death via Suppressing Autophagy after Rat Mild Traumatic Brain Injury
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  20. The role of fibroblast growth factor 8 in cartilage development and disease
    Hao-Ran Chen, Yujia Cui, Demao Zhang, Jing Xie, Xue-Dong Zhou · 2022 · Journal of Cellular and Molecular Medicine
  21. Fibroblast growth factor signaling in macrophage polarization: impact on health and diseases
    Luyao Shen, Yongsheng Li, Huakan Zhao · 2024 · Frontiers in Immunology
  22. Fgf10 is required for specification of non-sensory regions of the cochlear epithelium
    Lisa D. Urness, Xiaofen Wang, Shumei Shibata, Takahiro Ohyama, Suzanne L. Mansour · 2015 · Developmental Biology
  23. DFG-out Mode of Inhibition by an Irreversible Type-1 Inhibitor Capable of Overcoming Gate-Keeper Mutations in FGF Receptors
    Zhifeng Huang, Li Tan, Huiyan Wang, Yang Liu, Steven P. Blais, Jingjing Deng, Thomas A. Neubert, Nathanael S. Gray, Xiaokun Li, Moosa Mohammadi · 2014 · ACS Chemical Biology
  24. Roles of Fibroblast Growth Factors and Their Therapeutic Potential in Treatment of Ischemic Stroke
    Confidence Dordoe, Keyang Chen, Wenting Huang, Jun Chen, JIAN LI HU, Xue Bing Wang, Li Lin · 2021 · Frontiers in Pharmacology
  25. Organoid Vascularization: Strategies and Applications
    Qianmin Gao, Jian Wang, Hao Zhang, Jianhua Wang, Yingying Jing, Jiacan Su · 2025 · Advanced Healthcare Materials
  26. Detection of FGF15 in Plasma by Stable Isotope Standards and Capture by Anti-peptide Antibodies and Targeted Mass Spectrometry
    Takeshi Katafuchi, Daria Esterházy, Andrew S. Lemoff, Xunshan Ding, Varun Sondhi, Steven A. Kliewer, Hamid Mirzaei, David J. Mangelsdorf · 2015 · Cell Metabolism
  27. Early Stages of Bone Fracture Healing: Formation of a Fibrin–Collagen Scaffold in the Fracture Hematoma
    Luis Fernando Echeverri López, Miguel A. Herrero, José Manuel López, Gerardo E. Oleaga · 2014 · Bulletin of Mathematical Biology
  28. Role of FGFRL1 and other FGF signaling proteins in early kidney development
    Beat Trüeb, Ruth Amann, Simon D. Gerber · 2012 · Cellular and Molecular Life Sciences
  29. Fibroblast Growth Factor-9 Enhances M2 Macrophage Differentiation and Attenuates Adverse Cardiac Remodeling in the Infarcted Diabetic Heart
    Dinender Kumar Singla, Reetu D. Singla, Latifa S. Abdelli, Carley E. Glass · 2015 · PLoS ONE
  30. Protein Engineering for Cardiovascular Therapeutics
    Steven M. Jay, Richard Theodore Lee · 2013 · Circulation Research
  31. The neuroprotective activity of the amyloid precursor protein against traumatic brain injury is mediated via the heparin binding site in residues 96‐110
    Frances Corrigan, Emma Thornton, Laila C. Roisman, Anna V. Leonard, Robert Vink, Peter Charles Blumbergs, Corinna van den Heuvel, Roberto Cappai · 2013 · Journal of Neurochemistry
  32. Characterization of FGFR signaling pathway as therapeutic targets for sarcoma patients
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  33. A direct gateway into the extracellular space: Unconventional secretion of FGF2 through self-sustained plasma membrane pores
    Julia P. Steringer, Walter Nickel · 2018 · Seminars in Cell and Developmental Biology
  34. FGF23 regulates atrial fibrosis in atrial fibrillation by mediating the STAT3 and SMAD3 pathways
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  35. Inflammatory markers in children and adolescents with type 2 diabetes mellitus
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  36. Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study
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  38. Enhanced FGFR signalling predisposes pancreatic cancer to the effect of a potent FGFR inhibitor in preclinical models
    H Zhang, Bonnie Lee Hylander, Charles LeVea, Elizabeth A. Repasky, Robert M. Straubinger, Alex A. Adjei, W W Ma · 2013 · British Journal of Cancer
  39. Prognostic significance of angiogenesis and angiogenic growth factors in nonsmall cell lung cancer
    Ravi Salgia · 2011 · Cancer
  40. Two recessive mutations in FGF5 are associated with the long-hair phenotype in donkeys
    Romain Legrand, Laurent Tiret, Marie Abitbol · 2014 · Genetics Selection Evolution
  41. Altered FGF signalling in congenital craniofacial and skeletal disorders
    Shahida Moosa, Bernd Wollnik · 2015 · Seminars in Cell and Developmental Biology
  42. Association Between Serum Fibroblast Growth Factor 21 and Mortality Among Patients With Coronary Artery Disease
    Qing Li, Yuan Zhang, Ding Ding, Yunou Yang, Qian Chen, Dongfang Su, Xuechen Chen, Wenqi Yang, Jian Qiu, Wenhua Ling · 2016 · The Journal of Clinical Endocrinology & Metabolism
  43. Deciphering role of FGFR signalling pathway in pancreatic cancer
    Xiaodiao Kang, Lin Zeng, Minhui Xu, Jun Pan, Zhiwei Peter Wang · 2019 · Cell Proliferation
  44. Targeting the Oncogenic FGF-FGFR Axis in Gastric Carcinogenesis
    Jinglin Zhang, Patrick Ming‐Kuen Tang, Yuhang Zhou, Alfred S.L. Cheng, Jun Qing Yu, Wei Kang, Ka Fai To · 2019 · Cells
  45. FGF2 and IL-1β – explorers of unconventional secretory pathways at a glance
    Maria Teresa Pallotta, Walter Nickel · 2020 · Journal of Cell Science
  46. FGFR signaling and endocrine resistance in breast cancer: Challenges for the clinical development of FGFR inhibitors
    Alberto Servetto, Luigi Formisano, Carlos L. Arteaga · 2021 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  47. The Role of Chronic Inflammation in Cutaneous Fibrosis: Fibroblast Growth Factor Receptor Deficiency in Keratinocytes as an Example
    Michael Meyer, Anna‐Katharina Müller, Jingxuan Yang, Jitka Šulcová, Sabine Werner · 2011 · Journal of Investigative Dermatology Symposium Proceedings
  48. FGF receptors 1 and 2 control chemically-induced injury and compound detoxification in regenerating livers of mice
    Friederike Böhm, T. Speicher, C. Hellerbrand, C. Dickson, J. Partanen, D. Ornitz, S. Werner · 2010 · Gastroenterology
  49. A Better Anti-Diabetic Recombinant Human Fibroblast Growth Factor 21 (rhFGF21) Modified with Polyethylene Glycol
    Zhifeng Huang, Huiyan Wang, Meifei Lu, Chuanchuan Sun, Xiaoping Wu, Yi Tan, Chaohui Ye, Guanghui Zhu, Xiaojie Wang, Lu Cai et al. · 2011 · PLoS ONE
  50. Identification of a Mutation in FGF23 Involved in Mandibular Prognathism
    Fengshan Chen, Qin Li, Mingliang Gu, Xin Li, Jun Myoung Yu, Yong‐Biao Zhang · 2015 · Scientific Reports
  51. Fibroblast Growth Factor Type 1 (FGF1)-Overexpressed Adipose-Derived Mesenchaymal Stem Cells (AD-MSCFGF1) Induce Neuroprotection and Functional Recovery in a Rat Stroke Model
    Hamed Ghazavi, Seyed Javad Hoseini, Alireza Ebrahimzadeh‐Bideskan, Baratali Mashkani, Soghra Mehri, Ahmad Ghorbani, Kayvan Sadri, Elahe Mahdipour, Faezeh Ghasemi, Fatemeh Forouzanfar et al. · 2017 · Stem Cell Reviews and Reports
  52. Repurposing suramin for the treatment of breast cancer lung metastasis with glycol chitosan-based nanoparticles
    Bei Cheng, Feng Gao, Erica S. Maissy, Peisheng Xu · 2018 · Acta Biomaterialia
  53. Cardiac progenitors and paracrine mediators in cardiogenesis and heart regeneration
    Nevin Witman, Chikai Zhou, Niels Grote Beverborg, Makoto Sahara, Kenneth R. Chien · 2019 · Seminars in Cell and Developmental Biology
  54. Novel EPR-enhanced strategies for targeted drug delivery in pancreatic cancer: An update
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  55. Type VIII Collagen Modulates TGF-β1-induced Proliferation of Mesangial Cells
    Ivonne Loeffler, Ulrike Hopfer, Dirk Koczan, Günter Wolf · 2011 · Journal of the American Society of Nephrology
  56. Molecular signaling in bone cells: Regulation of cell differentiation and survival
    Lilian Irene Plotkin, Angela Bruzzaniti · 2019 · Advances in protein chemistry and structural biology
  57. FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes
    Ekaterina Savchenko, Gabriel Teku, Antonio Boza‐Serrano, Kaspar Russ, Manon Berns, Tomas Deierborg, Nuno Jorge Lamas, Hynek Wichterle, Jeffrey D. Rothstein, Christopher E. Henderson et al. · 2019 · Scientific Reports
  58. N-cadherin-regulated FGFR ubiquitination and degradation control mammalian neocortical projection neuron migration
    Elif Kon, Elisa Calvo-Jiménez, Alexia Cossard, Youn Na, Jonathan A. Cooper, Yves Jossin · 2019 · eLife
  59. Mapping of the Fibroblast Growth Factors in Human White Adipose Tissue
    Niklas Mejhert, Jean Galitzky, Amanda Pettersson, Clara Bambace, Lennart Blomqvist, Anne Bouloumié, Keith N. Frayn, Ingrid A. Dahlman, Peter Arner, Mikael Rydén · 2010 · The Journal of Clinical Endocrinology & Metabolism
  60. An emerging case for membrane pore formation as a common mechanism for the unconventional secretion of FGF2 and IL-1β
    David Brough, Pablo Pelegrı́n, Walter Nickel · 2017 · Journal of Cell Science
  61. Current Advances of Nanomedicines Delivering Arsenic Trioxide for Enhanced Tumor Therapy
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  62. Multi-organ FGF21-FGFR1 signaling in metabolic health and disease
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  63. Functions of exogenous FGF signals in regulation of fibroblast to myofibroblast differentiation and extracellular matrix protein expression
    Changye Sun, Xiangqin Tian, Yangyang Jia, Mingming Yang, Yong Li, David Garth Fernig · 2022 · Open Biology
  64. Fibroblast growth factor 7 alleviates myocardial infarction by improving oxidative stress via PI3Kα/AKT-mediated regulation of Nrf2 and HXK2
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  65. Clinical advances and challenges in targeting FGF/FGFR signaling in lung cancer
    Mei Peng, Jun Deng, Xiangping Li · 2024 · Molecular Cancer
  66. Levels of circulating selenoprotein P, fibroblast growth factor (FGF) 21 and FGF23 in relation to the metabolic syndrome in young children
    Ko Bj, Seon Mee Kim, Park Kh, Park Hs, Christos Socrates Mantzoros · 2014 · International Journal of Obesity
  67. Repair of spinal cord injury by implantation of bFGF-incorporated HEMA-MOETACL hydrogel in rats
    Bo Chen, Jianyu He, Hao Yang, Qian Zhang, Lingling Zhang, Xian Zhang, En Xie, Cuicui Liu, Rui Zhang, Yi Wang et al. · 2015 · Scientific Reports
  68. Differential Phosphoproteomics of Fibroblast Growth Factor Signaling: Identification of Src Family Kinase-Mediated Phosphorylation Events
    Debbie L. Cunningham, Steve M. M. Sweet, Helen J. Cooper, John K. Heath · 2010 · Journal of Proteome Research
  69. Fibroblast growth factor receptors in breast cancer: expression, downstream effects, and possible drug targets
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  70. Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination
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  71. Prognostic Value of Basic Fibroblast Growth Factor (bFGF) in Lung Cancer: A Systematic Review with Meta-Analysis
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  72. The therapeutic landscape of non‐alcoholic steatohepatitis
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  73. FGF Trapping Inhibits Multiple Myeloma Growth through c-Myc Degradation–Induced Mitochondrial Oxidative Stress
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  74. Inflammatory biomarkers in dentinal fluid as an approach to molecular diagnostics in pulpitis.
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  76. Roles of the fibroblast growth factor signal transduction system in tissue injury repair
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  78. Role of fibroblast growth factor 19 in the control of glucose homeostasis
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  79. Fibroblast Growth Factor Signaling in Non–Small-Cell Lung Cancer
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  80. Expression of fibroblast growth factor 9 is associated with poor prognosis in patients with resected non-small cell lung cancer.
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  81. Biologic adjuvants for fracture healing
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  89. RhoD activated by fibroblast growth factor induces cytoneme-like cellular protrusions through mDia3C
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  92. Carbohydrate Feeding Dissociates the Postprandial FGF19 Response From Circulating Bile Acid Levels in Humans
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  93. Dynamics and Distribution of Klothoβ (KLB) and Fibroblast Growth Factor Receptor-1 (FGFR1) in Living Cells Reveal the Fibroblast Growth Factor-21 (FGF21)-induced Receptor Complex
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  94. Plasticity in Interactions of Fibroblast Growth Factor 1 (FGF1) N Terminus with FGF Receptors Underlies Promiscuity of FGF1*
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  95. Clathrin- and Dynamin-Independent Endocytosis of FGFR3 – Implications for Signalling
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  98. FGF19 Signaling Cascade Suppresses APOA Gene Expression
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  99. Structural Mimicry of A-Loop Tyrosine Phosphorylation by a Pathogenic FGF Receptor 3 Mutation
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