Cited by 1,945Fibroblast Growth Factor ResearchConnective Tissue Growth Factor ResearchAngiogenesis and VEGF in Cancer

The DOI matches its Crossref record; 280 of the 281 references it cites were found in a registry or an index.

The FGF family: biology, pathophysiology and therapy

Open access

Beenken, Andrew, Mohammadi, Moosa·2009·Nature Reviews Drug Discovery

Open this paper in CoChat — free account

Abstract

The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development. Several mitogenic, cytoprotective and angiogenic therapeutic applications of FGFs are already being explored, and the recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in bile acid, glucose and phosphate homeostasis has sparked renewed interest in the pharmacological potential of this family. This Review discusses traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer and cardiovascular disease and their emerging potential in the treatment of metabolic syndrome and hypophosphataemic diseases.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nrd2792

Cites

280 of 280 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Mutation of the mouse klotho gene leads to a syndrome resembling ageing
Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837
Thalidomide is an inhibitor of angiogenesis.
D'Amato, R. J., Loughnan, M. S., Flynn, E., & Folkman, J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4082 · Cited by 2,454
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440
FGF-21 as a novel metabolic regulator
Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125
Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.
Kirkwood, J. M., Strawderman, M. H., Ernstoff, M. S., Smith, T. J., Borden, E. C., & Blum, R. H. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.1.7 · Cited by 2,089
Suppression of Aging in Mice by the Hormone Klotho
Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865
Klotho converts canonical FGF receptor into a specific receptor for FGF23
Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865
Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis
Gutiérrez, O. M., Mannstadt, M., Isakova, T., Rauh‐Hain, J. A., Tamez, H. E., Shah, A., Smith, K. T., Lee, H., Thadhani, R., Jüppner, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706130 · Cited by 1,729
Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21
Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504
Self-citation

Flagged first, then by citations

Show all 281 references

1 of the 281 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

Aono Y, et al. The neutralization of FGF-23 ameliorates hypophosphatemia and rickets in Hyp mice. J. Bone Miner. Res. 18, S16 (2003).

Sorted by citations

Items 501–600 of 1,001

Sustained-release of FGF-2 from a hybrid hydrogel of heparin-poloxamer and decellular matrix promotes the neuroprotective effects of proteins after spinal injury
Xu, H., Tian, F., Xiao, J., Chen, P.-P., Xu, J., Fan, Z.-L., Yang, J., Lu, C., & Zhao, Y. (2018) · International Journal of Nanomedicine · doi:10.2147/ijn.s152246 · Cited by 46
Single event visualization of unconventional secretion of FGF2
Dimou, E., Cosentino, K., Platonova, E., Ros, U., Sadeghi, M., Kashyap, P., Katsinelos, P., Wegehingel, S., Noé, F., García‐Sáez, A. J., et al. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201802008 · Cited by 46
Fibroblast growth factor-2 alleviates the capillary leakage and inflammation in sepsis
Pan, X., Xu, S., Zhou, Z., Wang, F., Mao, L., Li, H., Wu, C., Wang, J., Huang, Y., Li, D., et al. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00221-y · Cited by 46
FGF, Mechanism of Action, Role in Parkinson’s Disease, and Therapeutics
Liu, Y., Deng, J., Liu, Y., Li, W., & Nie, X. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.675725 · Cited by 46
Hepatic hormone FGF21 and its analogues in clinical trials
Shao, W., & Jin, T. (2021) · Chronic Diseases and Translational Medicine · doi:10.1016/j.cdtm.2021.08.005 · Cited by 49
Tumor Vessel Normalization: A Window to Enhancing Cancer Immunotherapy
Li, S., Zhang, Q., & Hong, Y. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820980116 · Cited by 52
Role of signaling pathways in age-related orthopedic diseases: focus on the fibroblast growth factor family
Li, H.-Z., Zhang, J.-L., Yuan, D.-L., Xie, W., Ladel, C. H., Mobasheri, A., & Li, Y. (2024) · Military Medical Research · doi:10.1186/s40779-024-00544-5 · Cited by 49
HaloTag is an effective expression and solubilisation fusion partner for a range of fibroblast growth factors
Sun, C., Li, Y., Taylor, S. E., Mao, X., Wilkinson, M. C., & Fernig, D. G. (2015) · PeerJ · doi:10.7717/peerj.1060 · Cited by 45
Antiangiogenic agents and targets: A perspective
Teicher, B. A. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.09.023 · Cited by 46
FGFR1, 2 and 3 protein overexpression and molecular aberrations of FGFR3 in early stage non‐small cell lung cancer
Theelen, W. S. M. E., Mittempergher, L., Willems, S. M., Bosma, A. J., Peters, D. D. G. C., van der Noort, V., Japenga, E. J., Peeters, T., Koole, K., Šuštić, T., et al. (2016) · The Journal of Pathology Clinical Research · doi:10.1002/cjp2.51 · Cited by 45
Role of fibroblast growth factor receptor 4 in cancer
Tang, S., Hao, Y., Yao Zong, Y. U. A. N., Liu, R. R., & Chen, Q. (2018) · Cancer Science · doi:10.1111/cas.13759 · Cited by 43
Synthesis, Regulatory Factors, and Signaling Pathways of Estrogen in the Ovary
Xiao, C., Wang, J., & Zhang, C. (2022) · Reproductive Sciences · doi:10.1007/s43032-022-00932-z · Cited by 44
Fibroblast growth factor 21 in heart failure
Tucker, W., Tucker, B., Rye, K., & Ong, K. L. (2022) · Heart Failure Reviews · doi:10.1007/s10741-022-10268-0 · Cited by 44
Pathogenesis and therapy of radiation enteritis with gut microbiota
Yang, Q., Qin, B., Hou, W., Qin, H., & Yin, F.-F. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1116558 · Cited by 44
Discovery of a Selective and Orally Bioavailable FGFR2 Degrader for Treating Gastric Cancer
Ma, L., Li, Y., Luo, R., Wang, Y., Cao, J., Fu, W., Qian, B., Zheng, L., Tang, L., Lv, X., et al. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.3c00150 · Cited by 44
Tumor angiogenesis and anti-angiogenic therapy
Guo, Z., Xu, J., Sun, X., Sun, S., Yang, Y., & Cao, Y. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003231 · Cited by 48
Acidic Fibroblast Growth Factor (FGF) Potentiates Glial-mediated Neurotoxicity by Activating FGFR2 IIIb Protein
Lee, M., Kang, Y., Suk, K., Schwab, C., Yu, S. Y., & McGeer, P. L. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.270470 · Cited by 44
Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis
Liu, F., Pogoda, H., Pearson, C. A., Ohyama, K., Löhr, H., Hammerschmidt, M., & Placzek, M. (2013) · Development · doi:10.1242/dev.080226 · Cited by 42
Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes
Kähkönen, T. E., Ivaska, K. K., Jiang, M.-T., Büki, K. G., Väänänen, H. K., & Härkönen, P. L. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.09.015 · Cited by 44
FGF23C-tail improves diabetic nephropathy by attenuating renal fibrosis and inflammation
Zhang, X., Guo, K., Xia, F., Zhao, X., Huang, Z., & Niu, J. (2018) · BMC Biotechnology · doi:10.1186/s12896-018-0449-7 · Cited by 44
EGFL7 regulates sprouting angiogenesis and endothelial integrity in a human blood vessel model
Usuba, R., Pauty, J., Soncin, F., & Matsunaga, Y. T. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.01.022 · Cited by 44
Sulfated polysaccharides interact with fibroblast growth factors and protect from denaturation
Sun, C., Liu, M., Sun, P., Yang, M., Yates, E. A., Guo, Z., & Fernig, D. G. (2019) · FEBS Open Bio · doi:10.1002/2211-5463.12696 · Cited by 45
Association between Circulating Fibroblast Growth Factor 21 and Aggressiveness in Thyroid Cancer
Kang, Y. E., Kim, J. T., Lim, M. A., Oh, C., Liu, L., Jung, S., Won, H.-R., Lee, K.-M., Chang, J. W., Yi, H., et al. (2019) · Cancers · doi:10.3390/cancers11081154 · Cited by 44
Phase-field model of vascular tumor growth: Three-dimensional geometry of the vascular network and integration with imaging data
Xu, J., Vilanova, G., & Gómez, H. (2019) · Computer Methods in Applied Mechanics and Engineering · doi:10.1016/j.cma.2019.112648 · Cited by 44
Angiokinase inhibition of VEGFR-2, PDGFR and FGFR and cell growth inhibition in lung cancer: Design, synthesis, biological evaluation and molecular docking of novel azaheterocyclic coumarin derivatives
Ahmed, E. Y., Elserwy, W. S. G., El‐Mansy, M. F., Serry, A. M., Salem, A. M., Abdou, A. M., Abdelrahman, B. A., Elsayed, K. H., & Elaziz, M. R. A. (2021) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2021.128258 · Cited by 44
Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice
Chen, G., An, N., Shen, J., Chen, H., Chen, Y., Sun, J. M., Hu, Z., Qiu, J., Jin, C., He, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36895-1 · Cited by 43
FGFs: neurodevelopment’s Jack-of-all-trades – how do they do it?
Hébert, J. M. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00133 · Cited by 43
Targeting angiogenesis with compounds from the extracellular matrix
Belotti, D., Foglieni, C., Resovi, A., Giavazzi, R., & Taraboletti, G. (2011) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.08.012 · Cited by 44
Correlation of Perfusion Parameters with Genes Related to Angiogenesis Regulation in Glioblastoma: A Feasibility Study
Jain, R., Poisson, L., Narang, J., Scarpace, L. M., Rosenblum, M. L., Rempel, S. A., & Mikkelsen, T. (2012) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2956 · Cited by 43
Dual pH- and temperature-responsive microparticles for protein delivery to ischemic tissues
Joshi, R. V., Nelson, C. E., O’Grady, K. P., Skala, M. C., & Duvall, C. L. (2013) · Acta Biomaterialia · doi:10.1016/j.actbio.2013.01.041 · Cited by 43
FGF9-induced changes in cellular redox status and HO-1 upregulation are FGFR-dependent and proceed through both ERK and AKT to induce CREB and Nrf2 activation
Chuang, J., Huang, J.-Y., Tsai, S., Sun, H. S., Yang, S., Chuang, P., Huang, B., & Ching, C. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.011 · Cited by 44
Fibroblast growth factor 21: effects on carbohydrate and lipid metabolism in health and disease
Kralisch, S., & Faßhauer, M. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328346a326 · Cited by 44
Vaccarin hastens wound healing by promoting angiogenesis via activation of MAPK/ERK and PI3K/AKT signaling pathways in vivo
Hou, B., Cai, W., Chen, T., Zhang, Z., Gong, H., Yang, W., & Qiu, L. (2019) · Acta Cirúrgica Brasileira · doi:10.1590/s0102-865020190120000002 · Cited by 43
The Role of Fibroblast Growth Factor 19 in Hepatocellular Carcinoma
Chen, Z., Jiang, L., Liang, L., Koral, K., Zhang, Q., Zhao, L., Lu, S., & Tao, J. (2021) · American Journal Of Pathology · doi:10.1016/j.ajpath.2021.04.014 · Cited by 43
FGF Signalling in Vertebrate Development
Pownall, M. E., & Isaacs, H. V. (2010) · Colloquium Series on Developmental Biology · doi:10.4199/c00011ed1v01y201004deb002 · Cited by 45
Emerging Roles for Mammalian Target of Rapamycin (mTOR) Complexes in Bladder Cancer Progression and Therapy
Huan, J., Grivas, P. D., Birch, J., & Hansel, D. E. (2022) · Cancers · doi:10.3390/cancers14061555 · Cited by 45
Changing Landscape of Systemic Therapy in Biliary Tract Cancer
Woods, E., Le, D. T., Jakka, B. K., & Manne, A. (2022) · Cancers · doi:10.3390/cancers14092137 · Cited by 44
Neurite outgrowth from PC12 cells by basic fibroblast growth factor (bFGF) is mediated by RhoA inactivation through p190RhoGAP and ARAP3
Jeon, C., Kim, H., Morii, H., Mori, N., Settleman, J. E., Lee, J., Kim, J., Kim, S., & Park, J. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22184 · Cited by 43
Direct and Allosteric Inhibition of the FGF2/HSPGs/FGFR1 Ternary Complex Formation by an Antiangiogenic, Thrombospondin-1-Mimic Small Molecule
Pagano, K., Torella, R., Foglieni, C., Bugatti, A., Tomaselli, S., Zetta, L., Presta, M., Rusnati, M., Taraboletti, G., Colombo, G., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036990 · Cited by 43
The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors
Dordoe, C., Huang, W., Bwalya, C., Wang, X., Shen, B., Wang, H., Wang, J., Ye, S., Wang, P., Xiaoyan, B., et al. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.07.005 · Cited by 44
Fibroblast Growth Factor 21 and Fetuin-A in Obese Adolescents With and Without Type 2 Diabetes
Reinehr, T., Karges, B., Meißner, T., Wiegand, S., Fritsch, M., Holl, R. W., & Woelfle, J. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2192 · Cited by 42
Fibroblast growth factor (Fgf) 21 is a novel target gene of the aryl hydrocarbon receptor (AhR)
Cheng, X., Vispute, S. G., Liu, J., Cheng, C., Kharitonenkov, A., & Klaassen, C. D. (2014) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2014.04.013 · Cited by 42
Acellular implantable and injectable hydrogels for vascular regeneration
Blatchley, M. R., & Gerecht, S. (2015) · Biomedical Materials · doi:10.1088/1748-6041/10/3/034001 · Cited by 42
Therapeutic uses of FGFs
Zhang, J., & Li, Y. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.09.007 · Cited by 44
Implications of Fibroblast growth factor/Klotho system in glucose metabolism and diabetes
Donate‐Correa, J., Martín‐Núñez, E., Pérez‐Delgado, N., de Fuentes, M. M., Ortíz, A., Fernández, C. M., & Navarro‐González, J. F. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.12.003 · Cited by 44
Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity
Agrawal, A., Parlee, S. D., Pérez–Tilve, D., Li, P., Pan, J. H., Mroz, P. A., Hansen, A. M. K., Andersen, B., Finan, B., Kharitonenkov, A., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.05.003 · Cited by 42
Efficient treatment of Parkinson’s disease using ultrasonography-guided rhFGF20 proteoliposomes
Niu, J., Xie, J.-J., Guo, K., Zhang, X., Xia, F., Zhao, X., Song, L., Zhuge, D., Li, X., Zhao, Y., et al. (2018) · Drug Delivery · doi:10.1080/10717544.2018.1482972 · Cited by 42
FGFR2 Promotes Gastric Cancer Progression by Inhibiting the Expression of Thrombospondin4 via PI3K-Akt-Mtor Pathway
Huang, T., Liu, D., Wang, Y., Li, P., Sun, L., Xiong, H., Dai, Y., Zou, M., Yuan, X., & Qiu, H. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000494590 · Cited by 42
Long noncoding RNA Linc00460 promotes breast cancer progression by regulating the miR-489-5p/FGF7/AKT axis
Zhu, Y., Yang, L., Chong, Q.-Y., Yan, H., Zhang, W., Qian, W., Tan, S. H., Wu, Z., Lobie, P. E., & Zhu, T. (2019) · Cancer Management and Research · doi:10.2147/cmar.s207084 · Cited by 42
Genetic Variants in the Fibroblast Growth Factor Pathway as Potential Markers of Ovarian Cancer Risk, Therapeutic Response, and Clinical Outcome
Meng, Q. H., Xu, E., Hildebrandt, M. A. T., Liang, D., Lu, K. H., Ye, Y., Wagar, E. A., & Wu, X. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2013.211490 · Cited by 41
Large-scale production of bioactive recombinant human acidic fibroblast growth factor in transgenic silkworm cocoons
Wang, F., Wang, R., Wang, Y., Zhao, P., & Xia, Q. (2015) · Scientific Reports · doi:10.1038/srep16323 · Cited by 42
A Phosphoinositide 3-Kinase/Phospholipase Cgamma1 Pathway Regulates Fibroblast Growth Factor-Induced Capillary Tube Formation
Maffucci, T., Raimondi, C., Abu‐Hayyeh, S., Dominguez, V., Sala, G., Zachary, I. C., & Falasca, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008285 · Cited by 42
Concomitant Retrograde Coronary Venous Infusion of Basic Fibroblast Growth Factor Enhances Engraftment and Differentiation of Bone Marrow Mesenchymal Stem Cells for Cardiac Repair after Myocardial Infarction
Wang, X., Lei, Z., Miao, H., Sun, Q., Yang, Y., Que, B., Lao, E. P. L., Wu, X.-X., Ren, H., Shi, S., et al. (2015) · Theranostics · doi:10.7150/thno.11607 · Cited by 41
ASP5878, a Novel Inhibitor of FGFR1, 2, 3, and 4, Inhibits the Growth of FGF19-Expressing Hepatocellular Carcinoma
Futami, T., Okada, H., Kihara, R., Kawase, T., Nakayama, A., Suzuki, T., Kameda, M., Shindoh, N., Terasaka, T., Hirano, M., et al. (2016) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-16-0188 · Cited by 41
FGF9‐induced ovarian cancer cell invasion involves VEGF‐A/VEGFR2 augmentation by virtue of ETS1 upregulation and metabolic reprogramming
Bhattacharya, R., Chaudhuri, S. R., & Roy, S. S. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26820 · Cited by 42
Unveiling Mesenchymal Stromal Cells’ Organizing Function in Regeneration
Nimiritsky, P., Eremichev, R. Y., Alexandrushkina, N. A., Efimenko, A. Y., Va, T., & Макаревич, П. И. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040823 · Cited by 41
Molecular dynamics insights into protein‐glycosaminoglycan systems from microsecond‐scale simulations
Bojarski, K. K., Sieradzan, A. K., & Samsonov, S. A. (2019) · Biopolymers · doi:10.1002/bip.23252 · Cited by 41
Fibroblast Growth Factor 2 Attenuates Renal Ischemia-Reperfusion Injury via Inhibition of Endoplasmic Reticulum Stress
Tan, X., Tao, Q., Li, G., Xiang, L., Zheng, X., Zhang, T., Wu, C., & Li, D. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00147 · Cited by 41
Role of the fibroblast growth factor 19 in the skeletal system
Chen, H., Li, J., Zhang, D., Zhou, X., & Xie, J. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118804 · Cited by 41
FGF10 promotes cardiac repair through a dual cellular mechanism increasing cardiomyocyte renewal and inhibiting fibrosis
Hubert, F., Payan, S. M., Pelcé, E., Bouchard, L., Sturny, R., Lenfant, N., Mottola, G., Collart, F., Kelly, R. G., & Rochais, F. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab340 · Cited by 42
A validated LC-MS/MS analytical method for the quantification of pemigatinib: metabolic stability evaluation in human liver microsomes
Attwa, M. W., Abdelhameed, A. S., Alsaif, N. A., Kadi, A. A., & Alrabiah, H. K. (2022) · RSC Advances · doi:10.1039/d2ra02885a · Cited by 40
Intranasal administration of TAT-haFGF14–154 attenuates disease progression in a mouse model of Alzheimer’s disease
Lou, G., ZHANG, Q.-H., Xiao, F., Xiang, Q., Su, Z., Zhang, L., Yang, P., Yang, Y. F., Zheng, Q., & Huang, Y. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.003 · Cited by 40
Challenges and opportunities in the targeting of fibroblast growth factor receptors in breast cancer
Jain, V. K. S., & Turner, N. C. (2012) · Breast Cancer Research · doi:10.1186/bcr3139 · Cited by 42
Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis
Azuma, A., Inomata, M., & Nishioka, Y. (2015) · Core evidence · doi:10.2147/ce.s82905 · Cited by 43
The Effect of SHH-Gli Signaling Pathway on the Synovial Fibroblast Proliferation in Rheumatoid Arthritis
Qin, S., Sun, D., Li, H., Li, X., Pan, W. X., Yan, C., Tang, R., & Liu, X. (2015) · Inflammation · doi:10.1007/s10753-015-0273-3 · Cited by 40
Muscle-invasive urothelial bladder cancer: an update on systemic therapy
Knollman, H. M., Godwin, J. L., Jain, R., Wong, Y., Plimack, E. R., & Geynisman, D. M. (2015) · Therapeutic Advances in Urology · doi:10.1177/1756287215607418 · Cited by 40
Local delivery of recombinant human FGF7 enhances bone formation in rat mandible defects
Poudel, S. B., Bhattarai, G., Kim, J.-H., Kook, S., Seo, Y., Jeon, Y., & Lee, J. (2016) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-016-0784-5 · Cited by 40
Paternal exercise protects mouse offspring from high-fat-diet-induced type 2 diabetes risk by increasing skeletal muscle insulin signaling
Krout, D., Roemmich, J. N., Bundy, A. N., Garcia, R. A. G., Yan, L., & Larson, K. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.03.013 · Cited by 42
Fibroblast growth factor 21 in lipid metabolism and non-alcoholic fatty liver disease
Su, X., Kong, Y., & Peng, D. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.08.005 · Cited by 40
Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants
Lin, Q., Chen, X., Qu, L., Guo, M., Wei, H., Dai, S., Jiang, L., & Chen, Y. (2022) · Communications Chemistry · doi:10.1038/s42004-022-00718-z · Cited by 40
Advances in the Use of Growth Factors for Treatment of Disorders of Soft Tissues
Halper, J. T. (2013) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-7893-1_5 · Cited by 40
Bile Acid Metabolome after an Oral Lipid Tolerance Test by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)
Schmid, A., Neumann, H., Karrasch, T., Liebisch, G., & Schäffler, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0148869 · Cited by 40
FGF19 increases mitochondrial biogenesis and fusion in chondrocytes via the AMPKα-p38/MAPK pathway
Kan, S., Pi, C., Zhang, L., Guo, D., Niu, Z., Liu, Y., Duan, M., Pu, X., Bai, M., Zhou, C., et al. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01069-5 · Cited by 41
Ponatinib: An update on its drug targets, therapeutic potential and safety
Gao, Y., Ding, Y., Tai, X., Zhang, C., & Wang, D. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188949 · Cited by 39
MYCN-mediated transcriptional repression in neuroblastoma: the other side of the coin
Gherardi, S., Valli, E., Erriquez, D., & Perini, G. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00042 · Cited by 39
Small Molecule Inhibitors Targeting Tec Kinase Block Unconventional Secretion of Fibroblast Growth Factor 2
Venuta, G. L., Wegehingel, S., Sehr, P. A., Müller, H., Dimou, E., Steringer, J. P., Grotwinkel, M., Hentze, N., Mayer, M. P., Will, D. W., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.729384 · Cited by 37
Combined delivery of FGF‐2, TGF‐β1, and adipose‐derived stem cells from an engineered periosteum to a critical‐sized mouse femur defect
Romero, R., Travers, J. K., Asbury, E., Pennybaker, A., Chubb, L. S., Rose, R. J., Ehrhart, N. P., & Kipper, M. J. (2016) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35965 · Cited by 39
Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation
Massafra, V., Milona, A., Vos, H. R., Burgering, B. M. T., & van Mil, S. W. C. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171185 · Cited by 40
FGF-FGFR Mediates the Activity-Dependent Dendritogenesis of Layer IV Neurons during Barrel Formation
Huang, J.-Y., Miskus, M. L., & Lu, H. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1174-17.2017 · Cited by 38
Changes in Gene Expression and Hearing Thresholds After Cochlear Implantation
Zhang, H., Stark, G. N., & Reiss, L. A. J. (2015) · Otology & Neurotology · doi:10.1097/mao.0000000000000787 · Cited by 39
Recent Developments and Advances of FGFR as a Potential Target in Cancer
Xue, W.-J., Li, M., Chen, L., Sun, L., & Li, Y. (2018) · Future Medicinal Chemistry · doi:10.4155/fmc-2018-0103 · Cited by 39
Agonistic β-Klotho antibody mimics fibroblast growth factor 21 (FGF21) functions
Min, X., Weiszmann, J., Johnstone, S., Wang, W., Yu, X., Romanow, W. G., Thibault, S. A., Li, Y., & Wang, Z. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004343 · Cited by 37
Signaling Mechanisms Underlying Genetic Pathophysiology of Craniosynostosis
Wu, X., & Gu, Y. F. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.29183 · Cited by 39
Nuclear FGFR2 negatively regulates hypoxia-induced cell invasion in prostate cancer by interacting with HIF-1 and HIF-2
Lee, J. E., Shin, S.-H., Shin, H., Chun, Y., & Park, J. (2019) · Scientific Reports · doi:10.1038/s41598-019-39843-6 · Cited by 39
miR-378a influences vascularization in skeletal muscles
Krist, B., Podkalicka, P., Mucha, O., Mendel, M., Sępioł, A., Rusiecka, O. M., Józefczuk, E., Bukowska-Straková, K., Grochot‐Przeczek, A., Tomczyk, M., et al. (2019) · Cardiovascular Research · doi:10.1093/cvr/cvz236 · Cited by 39
FGF2: a novel druggable target for glioblastoma?
Jimenez‐Pascual, A., Mitchell, K., Siebzehnrübl, F. A., & Lathia, J. D. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1736558 · Cited by 39
Intracellular partners of fibroblast growth factors 1 and 2 - implications for functions
Służalska, K. D., Sławski, J., Sochacka, M., Lampart, A., Otlewski, J., & Zakrzewska, M. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.05.004 · Cited by 40
VEGF-Independent Activation of Müller Cells by the Vitreous from Proliferative Diabetic Retinopathy Patients
Rezzola, S., Guerra, J., Chandran, A. M. K., Loda, A., Cancarini, A., Sacristani, P., Semeraro, F., & Presta, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042179 · Cited by 42
A hybrid mathematical model for self-organizing cell migration in the zebrafish lateral line
Costanzo, E. D., Roberto Natalini, D., & Preziosi, L. (2014) · Journal of Mathematical Biology · doi:10.1007/s00285-014-0812-9 · Cited by 38
Friends Turned Foes: Angiogenic Growth Factors beyond Angiogenesis
Matkar, P. N., Ariyagunarajah, R., Leong-Poi, H. M., & Singh, K. K. (2017) · Biomolecules · doi:10.3390/biom7040074 · Cited by 39
FGF19-mediated ELF4 overexpression promotes colorectal cancer metastasis through transactivating FGFR4 and SRC
Chen, X., Chen, J., Feng, W., Huang, W., Wang, G., Sun, M., Luo, X., Wang, Y., Nie, Y., Fan, D., et al. (2023) · Theranostics · doi:10.7150/thno.82269 · Cited by 38
Microneedle Patch for Transdermal Sequential Delivery of KGF‐2 and aFGF to Enhance Burn Wound Therapy
He, H., Huang, W., Zhang, S., Li, J., Zhang, J., Li, B., Xu, J., Luo, Y., Shi, H., Li, Y., et al. (2024) · Small · doi:10.1002/smll.202307485 · Cited by 38
Fucoidan Inhibits the Growth of Hepatocellular Carcinoma Independent of Angiogenesis
Zhu, C., Cao, R., Zhang, S.-X., Man, Y.-N., & Wu, X.-Z. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/692549 · Cited by 38
Involvement of multiple elements in FXR-mediated transcriptional activation of FGF19
Miyata, M., Hata, T., Yamakawa, H., Kagawa, T., Yoshinari, K., & Yamazoe, Y. (2012) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2012.04.008 · Cited by 38
Novel targets for VEGF-independent anti-angiogenic drugs
Petrillo, M., Scambia, G., & Ferrandina, G. (2012) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2012.661715 · Cited by 39
Gut-brain mechanisms controlling glucose homeostasis
Scarlett, J. M., & Schwartz, M. W. (2015) · F1000Prime Reports · doi:10.12703/p7-12 · Cited by 41
The best-laid plans go oft awry: synaptogenic growth factor signaling in neuropsychiatric disease
Williams, A. J., & Umemori, H. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00004 · Cited by 38
Identification of a novel peptide that blocks basic fibroblast growth factor-mediated cell proliferation
Wu, X., Huang, H., Wang, C., Lin, S., Huang, Y., Wang, Y., Liang, G., Yan, Q., Xiao, J., Wu, J., et al. (2013) · Oncotarget · doi:10.18632/oncotarget.1312 · Cited by 38
Regulation of FGF signaling: Recent insights from studying positive and negative modulators
Korsensky, L., & Ron, D. (2016) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2016.01.023 · Cited by 39
RAPID COMMUNICATION: Generation of FGF5 knockout sheep via the CRISPR/Cas9 system12
Hu, R., Fan, Z., Wang, B. Y., Deng, S., Zhang, X., Zhang, J. L., Han, H., & Lian, Z. (2017) · Journal of Animal Science · doi:10.2527/jas.2017.1503 · Cited by 41

Authors: Beenken, A., & Mohammadi, M.
Affiliations: New York University (US)
ORCID: Beenken, Andrew
Mohammadi, Moosa
Venue: Nature Reviews Drug Discovery
Publisher: Springer Science and Business Media LLC
Published: 2009-03
Volume: 8
Issue: 3
Pages: 235-253
ISSN: 1474-1776 (ISSN-L)
1474-1784
DOI: 10.1038/nrd2792
PMC: PMC3684054
OpenAlex: W2027239974
Cited by: 1,945
References: 281
Citations by year: 2026: 71 · 2025: 112 · 2024: 114 · 2023: 132 · 2022: 127 · 2021: 125 · 2020: 141 · 2019: 123 · 2018: 114 · 2017: 121 · 2016: 119 · 2015: 126 · 2014: 129 · 2013: 97 · 2012: 111
FWCI: 7.52
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Drug Discovery (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of General Medical Sciences (T32-GM066704-05, T32GM066704)
National Institute of Dental and Craniofacial Research (R01DE13686, R01DE013686)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: fibroblast growth factor, cancer therapy, cardiovascular disease, metabolic syndrome, FGF19, bile acid homeostasis, glucose homeostasis, phosphate homeostasis, angiogenesis, brain patterning, limb development, branching morphogenesis
MeSH terms: Animals, Cardiovascular Diseases, Fibroblast Growth Factors, Homeostasis, Humans, Neoplasms, Receptors, Fibroblast Growth Factor, Hypophosphatemia, Metabolic Syndrome

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The FGF family: biology, pathophysiology and therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks