The FGF family: biology, pathophysiology and therapy

Beenken, Andrew, Mohammadi, Moosa·2009·Nature Reviews Drug Discovery

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Items 701–800 of 1,001

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  7. New insights into the role of fibroblast growth factors in Alzheimer’s disease
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  8. The role of FGF2 in migration and tubulogenesis of endothelial progenitor cells in relation to pro-angiogenic growth factor production
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  9. Role of fibroblast growth factors in organ regeneration and repair
    Elie El Agha, Djuro Kosanovic, RALPH THEO SCHERMULY, Savério Bellusci · 2015 · Seminars in Cell and Developmental Biology
  10. A functional polymorphism at the FGF10 gene is associated with extreme myopia.
    E. Hsi, Ku-Chung Chen, Wansu Chang, Ming-Lung Yu, Chung-Ling Liang, S. Juo · 2013 · Investigative Ophthalmology and Visual Science
  11. Matrix metalloproteinases (MMPs) are required for wound closure and healing during larval leg regeneration in the flour beetle, Tribolium castaneum
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  12. BIBF 1120/nintedanib: a new triple angiokinase inhibitor-directed therapy in patients with non-small cell lung cancer
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  13. miR‐149 controls non‐alcoholic fatty liver by targeting FGF ‐21
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  14. Unique patterns of organization and migration of FGF-expressing cells during Drosophila morphogenesis
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  15. Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expression
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  16. Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease.
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  17. Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4
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  18. Molecular Targeting of the Fibroblast Growth Factor Receptor Pathway across Various Cancers
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  19. Understanding Neovascularization in Glioblastoma: Insights from the Current Literature
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  20. Signal transduction in podocytes—spotlight on receptor tyrosine kinases
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  21. Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer
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  22. The association of serum FGF 23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patients
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  23. Fibroblast Growth Factor-1 Improves Insulin Resistance via Repression of JNK-Mediated Inflammation
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  24. MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3)
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  25. Integrating Single-Step GWAS and Bipartite Networks Reconstruction Provides Novel Insights into Yearling Weight and Carcass Traits in Hanwoo Beef Cattle
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  26. Stromal Activation Associated with Development of Prostate Cancer in Prostate-Targeted Fibroblast Growth Factor 8b Transgenic Mice
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  27. Twist1 correlates with poor differentiation and progression in gastric adenocarcinoma via elevation of FGFR2 expression
    Dongyuan Zhu · 2014 · World Journal of Gastroenterology
  28. Casein kinase 1 regulates Sprouty2 in FGF–ERK signaling
    Daniel Yim, Sujoy Ghosh, Graeme R. Guy, David M. Virshup · 2014 · Oncogene
  29. In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancer
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  30. DSF Guided Refolding As A Novel Method Of Protein Production
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  31. Elevated FGF 21 in myotonic dystrophy type 1 and mitochondrial diseases
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  32. Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigation
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  33. Analysis of the fibroblast growth factor receptor ( FGFR ) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling network
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  34. N-Phenyl-N′-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinases
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  36. FGFR3 mRNA overexpression defines a subset of oligometastatic colorectal cancers with worse prognosis
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  42. PLAP-1/Asporin Positively Regulates FGF-2 Activity
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  45. The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition
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  46. AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decay
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  47. Differential splicing generates new transmembrane receptor and extracellular matrix-related targets for antibody-based therapy of cancer.
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  49. 2-Oxo-3, 4-dihydropyrimido[4, 5- d ]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors
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  50. A novel fibroblast growth factor-1 ligand with reduced heparin binding protects the heart against ischemia-reperfusion injury in the presence of heparin co-administration
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  52. Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic Targets
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  53. A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancers
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  54. Embryonic coronary vasculogenesis and angiogenesis are regulated by interactions between multiple FGFs and VEGF and are influenced by mesenchymal stem cells
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  55. Role of fibroblast growth factor (FGF) signaling in the neuroendocrine control of human reproduction
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  56. Cancer Selectivity of Tetrabranched Neurotensin Peptides Is Generated by Simultaneous Binding to Sulfated Glycosaminoglycans and Protein Receptors
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  57. Interactions between FGF21 and BMP-2 in osteogenesis
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  58. Novel Adipokine Fibroblast Growth Factor 21 Is Increased in Rheumatoid Arthritis
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  59. Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cells
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  60. SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo
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  61. Molecular Pathology of Lung Cancer
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  63. Antagonism of interferon signaling by fibroblast growth factors promotes viral replication
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  66. FGFR2 upregulates PAI-1 via JAK2/STAT3 signaling to induce M2 polarization of macrophages in colorectal cancer
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  67. FGFs in endochondral skeletal development
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  68. Gene therapy in peripheral artery disease
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  69. Cardiomyocyte FGF signaling is required for Cx43 phosphorylation and cardiac gap junction maintenance
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  70. Tissue-engineered pro-angiogenic fibroblast scaffold improves myocardial perfusion and function and limits ventricular remodeling after infarction
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  71. Nociceptor Sensitization by Proinflammatory Cytokines And Chemokines
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  72. Unliganded Fibroblast Growth Factor Receptor 1 Forms Density-independent Dimers
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  73. FGF signaling controls caudal hindbrain specification through Ras-ERK1/2 pathway
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  74. Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors
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  86. MMP-1 and Pro-MMP-10 as Potential Urinary Pharmacodynamic Biomarkers of FGFR3-Targeted Therapy in Patients with Bladder Cancer
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  87. Association between insulin resistance and impairment of FGF21 signal transduction in skeletal muscles
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  88. Alterations in Enterohepatic Fgf15 Signaling and Changes in Bile Acid Composition Depend on Localization of Murine Intestinal Inflammation
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  89. Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO mice
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  90. The ileal FGF15/19 to hepatic FGFR4 axis regulates liver regeneration after partial hepatectomy in mice
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  91. Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment of Wilms tumor
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  92. Killing two birds with one stone: dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacification
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  93. Protective Mechanism and Treatment of Neurogenesis in Cerebral Ischemia
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  94. Role of FGF10/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium Proliferation
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  95. Facilely preparing carboxymethyl chitosan/hydroxyethyl cellulose hydrogel films for protective and sustained release of fibroblast growth factor 2 to accelerate dermal tissue repair
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  98. Fibroblast growth factor receptors as therapeutic targets in clear-cell renal cell carcinoma
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  100. Extending the family table: Insights from beyond vertebrates into the regulation of embryonic development by FGFs
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