The FGF family: biology, pathophysiology and therapy
DOI 10.1038/nrd2792
Cited by (1,001)
Items 701–800 of 1,001
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- The role of FGF2 in migration and tubulogenesis of endothelial progenitor cells in relation to pro-angiogenic growth factor productionMonika Litwin, Agata Radwańska, Maria Paprocka, Claudine Kiéda, Tadeusz Dobosz, Wojciech Witkiewicz, Dagmara Baczyńska · 2015 · Molecular and Cellular Biochemistry
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- A functional polymorphism at the FGF10 gene is associated with extreme myopia.E. Hsi, Ku-Chung Chen, Wansu Chang, Ming-Lung Yu, Chung-Ling Liang, S. Juo · 2013 · Investigative Ophthalmology and Visual Science
- Matrix metalloproteinases (MMPs) are required for wound closure and healing during larval leg regeneration in the flour beetle, Tribolium castaneumEmilie K. Mitten, Diana Jing, Yuichiro Suzuki · 2012 · Insect Biochemistry and Molecular Biology
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- miR‐149 controls non‐alcoholic fatty liver by targeting FGF ‐21Junjie Xiao, Dongchao Lv, Yingying Zhao, Xiaoyu Chen, Meiyi Song, Jingqi Liu, Yihua Bei, Fei Wang, Wenzhuo Yang, Changqing Yang · 2016 · Journal of Cellular and Molecular Medicine
- Unique patterns of organization and migration of FGF-expressing cells during Drosophila morphogenesisLijuan Du, Amy Zhou, Akshay Patel, Mishal Rao, Kelsey C. Anderson, Sougata Roy · 2017 · Developmental Biology
- Pregnane X receptor (PXR) deficiency improves high fat diet-induced obesity via induction of fibroblast growth factor 15 (FGF15) expressionLiyang Zhao, Jiayi Xu, Zhe Shi, Neal A. Englert, Shuyun Zhang · 2017 · Biochemical Pharmacology
- Fibroblast growth factor 1attenuates 6-hydroxydopamine-induced neurotoxicity: an in vitro and in vivo investigation in experimental models of parkinson's disease.Xiaojie Wei, Songbin He, Zhouguang Wang, Jiamin Wu, Jinjing Zhang, Yi Hsuan Cheng, Jie Yang, Xinlong Xu, Zaifeng Chen, Junmin Ye et al. · 2014 · Europe PMC (PubMed Central)
- Sustained remission of type 2 diabetes in rodents by centrally administered fibroblast growth factor 4Hongbin Sun, Wei Lin, Yu Tang, Hongqing Tu, Ting Chen, Jie Zhou, Dezhong Wang, Qingqing Xu, Jianlou Niu, Wenliya Dong et al. · 2023 · Cell Metabolism
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- Understanding Neovascularization in Glioblastoma: Insights from the Current LiteratureMariagiovanna Ballato, Emanuela Germanà, Gabriele Ricciardi, Walter Giuseppe Giordano, Pietro Tralongo, Mariachiara Buccarelli, Giorgia Castellani, Lucia Ricci‐Vitiani, Quintino Giorgio D’Alessandris, Giuseppe Giuffrè et al. · 2025 · International Journal of Molecular Sciences
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- Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung CancerWei Zhu, Hui Chen, Yulan Wang, Jiang Wang, Peng Xia, Xianjie Chen, Yinglei Gao, Chunpu Li, Yulong He, Jing Ai et al. · 2017 · Journal of Medicinal Chemistry
- The association of serum FGF 23 and non‐alcoholic fatty liver disease is independent of vitamin D in type 2 diabetes patientsXingxing He, Yun Shen, Xiaojing Ma, Lingwen Ying, Jiahui Peng, Xiaoping Pan, Yuqian Bao, Jian Zhou · 2018 · Clinical and Experimental Pharmacology and Physiology
- Fibroblast Growth Factor-1 Improves Insulin Resistance via Repression of JNK-Mediated InflammationLei Fan, Linchao Ding, Junjie Lan, Jianlou Niu, Yiling He, Lintao Song · 2019 · Frontiers in Pharmacology
- MicroRNA-574-5p in gastric cancer cells promotes angiogenesis by targeting protein tyrosine phosphatase non-receptor type 3 (PTPN3)Shu Zhang, Renwen Zhang, Rui Xu, Jiaqi Shang, Haitao He, Qing Yang · 2020 · Gene
- Integrating Single-Step GWAS and Bipartite Networks Reconstruction Provides Novel Insights into Yearling Weight and Carcass Traits in Hanwoo Beef CattleMasoumeh Naserkheil, Abolfazl Bahrami, Deukhwan Lee, Hossein Mehrban · 2020 · Animals
- Stromal Activation Associated with Development of Prostate Cancer in Prostate-Targeted Fibroblast Growth Factor 8b Transgenic MiceTeresa Elo, Eeva M. Valve, Jani Seppänen, Heikki Vuorikoski, Sari Mäkelä, Matti H. POUTANEN, Paula M. Kujala, Pirkko L. Härkönen · 2010 · Neoplasia
- Twist1 correlates with poor differentiation and progression in gastric adenocarcinoma via elevation of FGFR2 expressionDongyuan Zhu · 2014 · World Journal of Gastroenterology
- Casein kinase 1 regulates Sprouty2 in FGF–ERK signalingDaniel Yim, Sujoy Ghosh, Graeme R. Guy, David M. Virshup · 2014 · Oncogene
- In vitro and in vivo evaluation of the radiosensitizing effect of a selective FGFR inhibitor (JNJ-42756493) for rectal cancerM. Verstraete, Annelies Debucquoy, Annelies Gonnissen, Rüveyda Dok, Sofie F. Isebaert, Ellen Devos, William H. McBride, Karin M. Haustermans · 2015 · BMC Cancer
- DSF Guided Refolding As A Novel Method Of Protein ProductionAmadeo B. Biter, Andres H. de la Peña, Roopa Thapar, Jean Z. Lin, Kevin J. Phillips · 2016 · Scientific Reports
- Elevated FGF 21 in myotonic dystrophy type 1 and mitochondrial diseasesEmese Lovadi, Márta Csereklyei, Hajnalka Merkli, Krisztina Fülöp, Ágnes Sebök, Veronika Karcagi, Sámuel Komoly, Endre Pál · 2016 · Muscle & Nerve
- Metabolic effects of basic fibroblast growth factor in streptozotocin-induced diabetic rats: A 1H NMR-based metabolomics investigationXiaodong Lin, Liangcai Zhao, Shengli Tang, Qi Zhou, Qiuting Lin, Xiaokun Li, Hong Xing Zheng, Hongchang Gao · 2016 · Scientific Reports
- Analysis of the fibroblast growth factor receptor ( FGFR ) signalling network with heparin as coreceptor: evidence for the expansion of the core FGFR signalling networkRuoyan Xu, Timothy Robert Rudd, Ashley J. Hughes, Giuliano Siligardi, David Garth Fernig, Edwin Alexander Yates · 2013 · FEBS Journal
- N-Phenyl-N′-[4-(5H-pyrrolo[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as novel inhibitors of VEGFR and FGFR kinasesYuya Oguro, Naoki Miyamoto, Terufumi Takagi, Kengo Okada, Yoshiko Awazu, Hiroshi Miki, Akira Hori, Keiji Kamiyama, Shinichi Imamura · 2010 · Bioorganic & Medicinal Chemistry
- Biochemical Stimulus-Based Strategies for Meniscus Tissue Engineering and RegenerationMingxue Chen, Weimin Guo, Shunag Gao, Chunxiang Hao, Shi Hong Shen, Zengzeng Zhang, Zhenyong Wang, Zehao Wang, Xu Li, Xiaoguang Jing et al. · 2018 · BioMed Research International
- FGFR3 mRNA overexpression defines a subset of oligometastatic colorectal cancers with worse prognosisJulia Elisabeth Fromme, Katja Schmitz, Astrid Wachter, Marius Grzelinski, Dirk Zielinski, Christina Koppel, Lena‐Christin Conradi, Kia Homayounfar, Tabea Hugo, Sara Hugo et al. · 2018 · Oncotarget
- A phase II trial of single oral FGF inhibitor, AZD4547, as second or third line therapy in malignant pleural mesotheliomaWei‐Sen Lam, Jenette Creaney, Fred Kuanfu Chen, Wee Loong Chin, Sanjeevan Muruganandan, Sukanya Arunachalam, Mary S. Attia, Catherine Read, Kevin Murray, Michael Millward et al. · 2019 · Lung Cancer
- Stable Fibroblast Growth Factor 2 Dimers with High Pro-Survival and Mitogenic PotentialDaria Nawrocka, Mateusz Adam Krzyścik, Łukasz Opaliński, Małgorzata Zakrzewska, Jacek Otlewski · 2020 · International Journal of Molecular Sciences
- Curtailing FGF19’s mitogenicity by suppressing its receptor dimerization abilityJianlou Niu, Jing Zhao, Jiamin Wu, Guanting Qiao, Junlian Gu, Chuanren Zhou, Qi Li, Ying Lei, Dezhong Wang, Huan Lin et al. · 2020 · Proceedings of the National Academy of Sciences
- The Multiple Roles of Fibroblast Growth Factor in Diabetic NephropathyJunyu Deng, Ye Liu, Yiqiu Liu, Wei Li, Xuqiang Nie · 2021 · Journal of Inflammation Research
- Integrated regulation of chondrogenic differentiation in mesenchymal stem cells and differentiation of cancer cellsXiaohui Yang, S. Tian, Lin-Lin Fan, Rui Niu, Man Yan, Shuo Chen, Minying Zheng, Shi-Wu Zhang · 2022 · Cancer Cell International
- PLAP-1/Asporin Positively Regulates FGF-2 ActivityToshihito Awata, Satoru Yamada, K. Tsushima, H. Sakashita, Satoko Yamaba, Tetsuhiro Kajikawa, M. Yamashita, Masahide Takedachi, Manabu Yanagita, Masahiro Kitamura et al. · 2015 · Journal of Dental Research
- Mechanisms of skeletal muscle-tendon development and regeneration/healing as potential therapeutic targetsYuki Yoshimoto, Yumiko Oishi · 2023 · Pharmacology & Therapeutics
- Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoterSongwei Feng, Bo Ding, Zhu Dai, Han Yin, Yue Ding, Sicong Liu, Ke Zhang, Hao Ran Lin, Zhongdang Xiao, Yang Shen · 2024 · Journal of Translational Medicine
- The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognitionY. Yosaatmadja, Adam Vorn Patterson, Jeff Bruce Smaill, Christopher John Squire · 2015 · Acta Crystallographica Section D Biological Crystallography
- AUF1 p42 isoform selectively controls both steady-state and PGE2-induced FGF9 mRNA decayTsung-Ming Chen, Chien-Hui Hsu, Shaw‐Jenq Tsai, H. Sunny Sun · 2010 · Nucleic Acids Research
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- The Zinc-Schiff Base-Novicidin Complex as a Potential Prostate Cancer TherapyVedran Milosavljević, Yazan Haddad, Miguel Ángel Merlos Rodrigo, Amitava Moulick, Hana Holcova Polanska, David Hynek, Zbyněk Heger, Pavel Kopel, Vojtěch Adam · 2016 · PLoS ONE
- 2-Oxo-3, 4-dihydropyrimido[4, 5- d ]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitorsXueqiang Li, Christopher P. Guise, Rana Taghipouran, Y. Yosaatmadja, Amir Ashoorzadeh, W.-K. Paik, Christopher John Squire, Shuang Jiang, Jinfeng Luo, Yong Xu et al. · 2017 · European Journal of Medicinal Chemistry
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- Advances of Fibroblast Growth Factor/Receptor Signaling Pathway in Hepatocellular Carcinoma and its Pharmacotherapeutic TargetsHaijun Wang, Jie Yang, Ke Zhang, Jia Liu, Yushan Li, Wei Su, Na Song · 2021 · Frontiers in Pharmacology
- A long pentraxin-3-derived pentapeptide for the therapy of FGF8b-driven steroid hormone-regulated cancersArianna Giacomini, Sara Matarazzo, Katiuscia Pagano, Laura Ragona, Sara Rezzola, Michela Corsini, Emanuela Di Salle, Marco Presta, Roberto Ronca · 2015 · Oncotarget
- Embryonic coronary vasculogenesis and angiogenesis are regulated by interactions between multiple FGFs and VEGF and are influenced by mesenchymal stem cellsRobert J. Tomanek, Lance P. Christensen, Michael Simons, Masahiro Murakami, Wei Zheng, Gina C. Schatteman · 2010 · Developmental Dynamics
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- Interactions between FGF21 and BMP-2 in osteogenesisKazunari Ishida, Dominik R. Haudenschild · 2013 · Biochemical and Biophysical Research Communications
- Novel Adipokine Fibroblast Growth Factor 21 Is Increased in Rheumatoid ArthritisHana Hulejová, Lucie Andrés Cerezo, Markéta Kuklová, Ondřej Pecha, T. VONDRÁČEK, Karel Pavelká, Jiří Vencovský, Martin Haluzı́k, Ladislav Šenolt · 2012 · Physiological Research
- Activation of Aurora A kinase through the FGF1/FGFR signaling axis sustains the stem cell characteristics of glioblastoma cellsYi‐Chao Hsu, Chien‐Yu Kao, Yu‐Fen Chung, Don-Ching Lee, Jen-Wei Liu, Ing‐Ming Chiu · 2016 · Experimental Cell Research
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- FGF4 Promotes Skin Wound Repair through p38 MAPK and GSK3β-Mediated Stabilization of SlugJian Sun, Jie Zhou, Jianhui Zhou, Wenxin Xu, Yali Du, Zhenyu Jia, Yingjie Shen, Xiaohua Lin, Xulan Wang, Yuxuan Bao et al. · 2022 · Journal of Investigative Dermatology
- FGFR2 upregulates PAI-1 via JAK2/STAT3 signaling to induce M2 polarization of macrophages in colorectal cancerYiming Li, Yongkang Shi, Xiuyuan Zhang, Piao Li, Li Ma, Pengbo Hu, Liang Xu, Yuhong Dai, Shu Xia, Hong Qiu · 2023 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- FGFs in endochondral skeletal developmentCatherine Degnin, Melanie B. Laederich, William A. Horton · 2010 · Journal of Cellular Biochemistry
- Gene therapy in peripheral artery diseaseFumihiro Sanada, Yoshiaki Taniyama, Yasuhiro Kanbara, Rei Otsu, Yuka Ikeda-Iwabu, Miguel Carracedo, Hiromi Rakugi, Ryuichi Morishita · 2015 · Expert Opinion on Biological Therapy
- Cardiomyocyte FGF signaling is required for Cx43 phosphorylation and cardiac gap junction maintenanceTakashi Sakurai, Mariko Tsuchida, Paul D. Lampe, Masahiro Murakami · 2013 · Experimental Cell Research
- Tissue-engineered pro-angiogenic fibroblast scaffold improves myocardial perfusion and function and limits ventricular remodeling after infarctionJ. Raymond Fitzpatrick, John R. Frederick, Ryan C. McCormick, David A. Harris, Ah-Young Kim, Jeffrey R. Muenzer, Alex J. Gambogi, Jing Ping Liu, Emily Carter Paulson, Yi-Ping Joseph Woo · 2010 · Journal of Thoracic and Cardiovascular Surgery
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- Unliganded Fibroblast Growth Factor Receptor 1 Forms Density-independent DimersLaëtitia Comps‐Agrar, Diana Ronai Dunshee, Dan Eaton, Junichiro Sonoda · 2015 · Journal of Biological Chemistry
- FGF signaling controls caudal hindbrain specification through Ras-ERK1/2 pathwayFerran Aragon, Cristina Pujades · 2009 · BMC Developmental Biology
- Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II InhibitorsSergei Boichuk, Павел Дмитриевич Дунаев, Aigul R. Galembikova, Firuza Bikinieva, Nurgatina Ilmira, Мустафин Ильшат Ганиевич, Aida Aukhadieva, Refat Kurtasanov, Natalia S. Andriutsa, Shagimardanova Elena et al. · 2020 · International Journal of Molecular Sciences
- Fibroblast Growth Factor 10 Attenuates Renal Damage by Regulating Endoplasmic Reticulum Stress After Ischemia–Reperfusion InjuryXiaohua Tan, Lixia Yu, Ruo Yang, Qianyu Tao, Lijun Xiang, Jian Xiao, Jin‐San Zhang · 2020 · Frontiers in Pharmacology
- The role of fibroblast growth factor 21 in the pathogenesis of liver disease: a novel predictor and therapeutic targetWen‐Yue Liu, Sha Huang, Keqing Shi, Chenchen Zhao, Li-Li Chen, Martin Braddock, Yongping Chen, Wenke Feng, Ming‐Hua Zheng · 2014 · Expert Opinion on Therapeutic Targets
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- Roles of FGF8 subfamily in embryogenesis and oral‑maxillofacial diseases (Review)Yilong Hao, Shuya Tang, Yao Zong YUAN, Rui R Liu, Qianming Chen · 2019 · International Journal of Oncology
- Bioinformatics analysis of evolutionary characteristics and biochemical structure of FGF5 Gene in sheepRui Zhang, Hongping Wu, Zhengxing Lian · 2019 · Gene
- The Canonical Wnt Signaling (Wnt/β-Catenin Pathway): A Potential Target for Cancer Prevention and TherapyS. Mahmoud A. Najafi · 2020 · Iranian Biomedical Journal
- FGF5 Regulates Schwann Cell Migration and AdhesionBing Chen, Rong Hu, Qing Min, Yankun Li, David B. Parkinson, Xin‐Peng Dun · 2020 · Frontiers in Cellular Neuroscience
- Endocrine Therapy for the Functional Recovery of Spinal Cord InjuryHui Wang, Wen-xian Zhou, Jin-feng Huang, Xuan-Qi Zheng, Haijun Tian, Bin Wang, Weili Fu, Aimin Wu · 2020 · Frontiers in Neuroscience
- Fibroblast growth factor 21 (FGF21) promotes porcine granulosa cell estradiol production and proliferation via PI3K/AKT/mTOR signalingYamei Hu, Junjie Xu, Sheng jie Shi, Xiaoge Zhou, Liguang Wang, Liang Huang, Lei Gao, Weijun Pang, Gongshe Yang, Guiyan Chu · 2022 · Theriogenology
- FGF/FGFR system in the central nervous system demyelinating disease: Recent progress and implications for multiple sclerosisQingxiang Zhang, Zhiguo Chen, Kaili Zhang, Jie Zhu, Tao Jin · 2023 · CNS Neuroscience & Therapeutics
- Mechanism of antitumor effect of a novel bFGF binding peptide on human colon cancer cellsCong Wang, Shaoqiang Lin, Yanfang Nie, Xinglong Jia, Jing Wang, Jian Xiao, Jianzhang Wu, Xiaokun Li, Xiaoping Wu · 2010 · Cancer Science
- MMP-1 and Pro-MMP-10 as Potential Urinary Pharmacodynamic Biomarkers of FGFR3-Targeted Therapy in Patients with Bladder CancerXiangnan Du, Benjamin C. Lin, Qian-Rena Wang, Hao Li, Ellen Ingalla, Janet Tien, Isabelle Anne Rooney, Avi Ashkenazi, Elicia M. Penuel, Jing Qing · 2014 · Clinical Cancer Research
- Association between insulin resistance and impairment of FGF21 signal transduction in skeletal musclesJa Young Jeon, Sung‐E Choi, Eun Suk Ha, Tae Ho Kim, Jong Gab Jung, Seung Jin Han, Hae Jin Kim, Dae Jung Kim, YUP Y. KANG, Kwan Woo Lee · 2016 · Endocrine
- Alterations in Enterohepatic Fgf15 Signaling and Changes in Bile Acid Composition Depend on Localization of Murine Intestinal InflammationMonika Rau, Bruno Stieger, María Jesús Monte, Johannes Schmitt, Daniel Jahn, Isabelle M. Frey-Wagner, Tina Raselli, José J.G. Marı́n, Beat Müllhaupt, Gerhard Rogler et al. · 2016 · Inflammatory Bowel Diseases
- Potent long-acting rhFGF21 analog for treatment of diabetic nephropathy in db/db and DIO miceLongwei Zhao, Huiyan Wang, Jun-Jun Xie, Zilu Chen, Xiaokun Li, Jianlou Niu · 2017 · BMC Biotechnology
- The ileal FGF15/19 to hepatic FGFR4 axis regulates liver regeneration after partial hepatectomy in miceQiang Li, Qiang Zhao, Chuanzhao Zhang, Peng Zhang, Anbin Hu, Longjuan Zhang, Paul Michael Schroder, Yi Ma, Zhiyong Guo, Xiao‐Feng Zhu et al. · 2018 · Journal of Physiology and Biochemistry
- Calcinosis cutis dermatologic toxicity associated with fibroblast growth factor receptor inhibitor for the treatment of Wilms tumorKrishna Arudra, Ravi Patel, Michael T. Tetzlaff, Sharon R. Hymes, Vivek Subbiah, Funda Meric‐Bernstam, Carlos Antonio Torres-Cabala, Phyu P. Aung, Priyadharsini Nagarajan, Adi K. Diab et al. · 2018 · Journal of Cutaneous Pathology
- Killing two birds with one stone: dual blockade of integrin and FGF signaling through targeting syndecan-4 in postoperative capsular opacificationYingyan Qin, Yi Zhu, Furong Luo, Chuan Chen, Xiaoyun Chen, Mingxing Wu · 2017 · Cell Death and Disease
- Protective Mechanism and Treatment of Neurogenesis in Cerebral IschemiaWanting Li, Anqi Ye, Luyao Ao, Lin Zhou, Yunyi Yan, Ya‐Hui Hu, Weirong Fang, Yunman Li · 2020 · Neurochemical Research
- Role of FGF10/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium ProliferationEmma N Finburgh, Olivier Mauduit, Takako Noguchi, Jennifer J. Bu, Anser A. Abbas, Dominic F. Hakim, Savério Bellusci, Robyn Meech, Helen P. Makarenkova, Natalie A. Afshari · 2023 · Investigative Ophthalmology & Visual Science
- Facilely preparing carboxymethyl chitosan/hydroxyethyl cellulose hydrogel films for protective and sustained release of fibroblast growth factor 2 to accelerate dermal tissue repairKhanh-Thien Le, Cong-Thuan Nguyen, Thuy-Dung Lac, Le-Giang Thi Nguyen, Thuoc Linh Tran, Hieu Tran‐Van · 2023 · Journal of Drug Delivery Science and Technology
- Fibroblast Growth Factor 23 and Muscle Wasting: A Metabolic Point of ViewRengin Elsürer Afşar, Barış Afşar, Talat Alp Ikizler · 2023 · Kidney International Reports
- The fibroblast growth factor system in cognitive disorders and dementiaWujianwen Zhai, Tong Zhang, Yujing Jin, Shijing Huang, Manman Xu, Juhua Pan · 2023 · Frontiers in Neuroscience
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