The FGF family: biology, pathophysiology and therapy

Beenken, Andrew, Mohammadi, Moosa·2009·Nature Reviews Drug Discovery

DOI 10.1038/nrd2792

Cited by (1,001)

Items 301–400 of 1,001

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Sen Wang, Yudong Qiu, Bing Bai · 2019 · Frontiers in Oncology
Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate
Song Xue, Fan Zhou, Tian Zhao, Huimin Zhao, Xuewei Wang, Long Chen, Jin‐Ping Li, Shizhong Luo, Shizhong Luo · 2022 · Nature Communications
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Zhiwei Chen, Lili Yang, Yang Liu, Ping Huang, Haiyan Song, Peiyong Zheng · 2022 · Frontiers in Pharmacology
Roles of FGFs as Adipokines in Adipose Tissue Development, Remodeling, and Metabolism
Hiroya Ohta, Nobuyuki Itoh · 2014 · Frontiers in Endocrinology
CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene
Shusaku Uchida, Brett J.W. Teubner, Charles Hevi, Kumiko Hara, Ayumi Kobayashi, Rutu M. Dave, Tatsushi Shintaku, Pattaporn Poonsawas, Hirotaka Yamagata, Takayoshi Suzuki et al. · 2017 · Cell Reports
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Effects of fibroblast growth factor 21 on the heart
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Long pentraxin‐3 as an epithelial–stromal fibroblast growth factor‐targeting inhibitor in prostate cancer
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Fibroblast growth factor-based pharmacotherapies for the treatment of obesity-related metabolic complications
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Ari J. Firestone, James Chen · 2009 · ACS Chemical Biology
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Glycosaminoglycan Neutralization in Coagulation Control
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Guoqi Li, Yihui Shao, Hong Chang Guo, Ying Zhi, Bokang Qiao, Ke Ma, Jie Du, Yong Qiang Lai, Yulin Li · 2021 · Cardiovascular Research
Role of Basic Fibroblast Growth Factor in Cancer: Biological Activity, Targeted Therapies, and Prognostic Value
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Classical and non-classical proangiogenic factors as a target of antiangiogenic therapy in tumor microenvironment
Ilaria Marech, Christian Leporini, Michele Ammendola, Mariangela Porcelli, Cosmo Damiano Gadaleta, Emilio Russo, Giovambattista De Sarro, Girolamo Ranieri · 2015 · Cancer Letters
Targeting tumor angiogenesis with TSP-1-based compounds: rational design of antiangiogenic mimetics of endogenous inhibitors
Giulia Taraboletti, Marco Rusnati, Laura Ragona, Giorgio Colombo · 2010 · Oncotarget
The FGFRL1 Receptor Is Shed from Cell Membranes, Binds Fibroblast Growth Factors (FGFs), and Antagonizes FGF Signaling in Xenopus Embryos*
Florian Steinberg, L. Zhuang, Michael Beyeler, R. Kälin, P. Mullis, A. Brändli, B. Trueb · 2009 · Journal of Biological Chemistry
Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep
Rui Zhang, Yan Li, Kun Jia, Xueling Xu, Yao Li, Yue Zhao, Xiaosheng Zhang, Jinlong Zhang, Guoshi Liu, Shoulong Deng et al. · 2020 · Cell Death and Disease
Drug resistance mechanisms and progress in the treatment of EGFR‑mutated lung adenocarcinoma (Review)
Ruizhu Sun, Zhansheng Hou, Yankui Zhang, Bo Jiang · 2022 · Oncology Letters
Recent Advances in the Digestive, Metabolic and Therapeutic Effects of Farnesoid X Receptor and Fibroblast Growth Factor 19: From Cholesterol to Bile Acid Signaling
Agostino Di Ciaula, Leonilde Bonfrate, Jacek Baj, Mohamad Khalil, Gabriella Garruti, Frans Stellaard, Helen H. Wang, David Q.‐H. Wang, Piero Portincasa · 2022 · Nutrients
Fabrication of the FGF1-functionalized sericin hydrogels with cell proliferation activity for biomedical application using genetically engineered Bombyx mori (B. mori) silk
Feng Wang, Yuancheng Wang, Chi Tian, Sheng Xu, Riyuan Wang, Kai Hou, Wenjing Chen, Ping Zhao, Ling Yu, Zhisong Lu et al. · 2018 · Acta Biomaterialia
Tumor-induced osteomalacia
Zinan Yin, Juan Du, Fan Yu, Weibo Xia · 2018 · Osteoporosis and Sarcopenia
Fgfr1 regulates development through the combinatorial use of signaling proteins
J. Richard Brewer, Andrei Molotkov, Pierre Mazot, Renée V. Hoch, Philippe M. Soriano · 2015 · Genes & Development
Fibroblast Growth Factors in Depression
Zheng Hao Deng, Sheng Deng, Mu-Rong Zhang, Mimi Tang · 2019 · Frontiers in Pharmacology
The role of FGF21 in the pathogenesis of cardiovascular disease
Ying Zhang, Dan Liu, Xiao-Xue Long, Qi-Chen Fang, Wei-Ping Jia, Hua-Ting Li · 2021 · Chinese Medical Journal
Binding affinity estimation from restrained umbrella sampling simulations
Vivek Govind Kumar, Adithya Polasa, Shilpi Agrawal, Thallapuranam Krishnaswamy Suresh Kumar, Mahmoud Moradi · 2022 · Nature Computational Science
Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis
Fei Pei, Li Ma, Junjun Jing, Jifan Feng, Yuan Yuan, Tingwei Guo, Xia Han, Thach‐Vu Ho, Jie Lei, Jinzhi He et al. · 2023 · Nature Communications
Profile of nintedanib in the treatment of solid tumors: the evidence to date
Niranjan Awasthi, Roderich Egbert Schwarz · 2015 · OncoTargets and Therapy
Thermo-sensitive hydrogels combined with decellularised matrix deliver bFGF for the functional recovery of rats after a spinal cord injury
Helin Xu, Fu-Rong Tian, Cui‐Tao Lu, Jie Xu, Zi-Liang Fan, Jingjing Yang, Pian-Pian Chen, Yadong Huang, Jian Xiao, Ying‐Zheng Zhao · 2016 · Scientific Reports
Physiology of FGF15/19
Stacey A. Jones · 2012 · Advances in experimental medicine and biology
Antiangiogenesis therapy: an update after the first decade
Sandro De Falco · 2014 · The Korean Journal of Internal Medicine
Pathogenetic Features and Current Management of Glioblastoma
Hong-My Nguyen, Kirsten Guz-Montgomery, Devin B. Lowe, Dipongkor Saha · 2021 · Cancers
Role of bFGF in Acquired Resistance upon Anti-VEGF Therapy in Cancer
F. T. Zahra, M. S. Sajib, Constantinos M Mikelis · 2021 · Cancers
FGF21 facilitates autophagy in prostate cancer cells by inhibiting the PI3K–Akt–mTOR signaling pathway
Han Dai, Wenjing Hu, Lianying Zhang, Feiyu Jiang, Xiongmin Mao, Gangyi Yang, Ling Li · 2021 · Cell Death and Disease
Radiation countermeasure agents: an update
Francis J. Dumont, Antoine Le Roux, Pierre L. Bischoff · 2009 · Expert Opinion on Therapeutic Patents
The roles of receptor tyrosine kinases and their ligands in the wound repair process.
Anna-Katharina Müller, M. Meyer, S. Werner · 2012 · Seminars in Cell and Developmental Biology
The fibroblast growth factor family: involvement in the regulation of folliculogenesis
Roberta Nogueira Chaves, M.H.T. Matos, José Buratini Junior, J.R. Figueiredo · 2012 · Reproduction Fertility and Development
Antibody-Mediated Activation of FGFR1 Induces FGF23 Production and Hypophosphatemia
Ai-Luen Wu, Bo Feng, Mark Z. Chen, Ganesh A. Kolumam, Jose Zavala‐Solorio, Shelby K. Wyatt, Vineela D. Gandham, Richard A.D. Carano, Junichiro Sonoda · 2013 · PLoS ONE
The FGF21 Receptor Signaling Complex
Dawn M. Kilkenny, Jonathan V. Rocheleau · 2016 · Vitamins and hormones
FGF10 Protects Against Renal Ischemia/Reperfusion Injury by Regulating Autophagy and Inflammatory Signaling
Xiaohua Tan, Hongmei Zhu, Qianyu Tao, Lisha Guo, Tian‐Fang Jiang, Le Xu, Ruo Yang, Xiayu Wei, Jin Wu, Xiaokun Li et al. · 2018 · Frontiers in Genetics
γ-PGA hydrogel loaded with cell-free fat extract promotes the healing of diabetic wounds
Mengting Yin, Xiangsheng Wang, Ziyou Yu, Yun Wang, Xiansong Wang, Mingwu Deng, Danyang Zhao, Shaowei Ji, Nengqing Jia, Wenjie Zhang · 2020 · Journal of Materials Chemistry B
Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2
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The Saga of Endocrine FGFs
Phuc Phan, Bibhuti Ballav Saikia, Shivakumar Sonnaila, Shilpi Agrawal, Zeina Alraawi, Thallapuranam Krishnaswamy Suresh Kumar, Shilpa Iyer · 2021 · Cells
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DJ-1 promotes angiogenesis and osteogenesis by activating FGF receptor-1 signaling
Jung‐Min Kim, Hong-In Shin, Sun‐Shin Cha, Chang Sup Lee, Bok Sil Hong, Seyoung Lim, Hyun‐Jun Jang, Jaeyoon John Kim, Yong Ryoul Yang, Yun‐Hee Kim et al. · 2012 · Nature Communications
High Molecular Weight Fibroblast Growth Factor-2 in the Human Heart Is a Potential Target for Prevention of Cardiac Remodeling
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miR‐381‐3p restrains cervical cancer progression by downregulating FGF7
Anquan Shang, Cheng Zhou, Ganxia Bian, Wei Chen, Wenying Lu, Weiwei Wang, Dong Li · 2018 · Journal of Cellular Biochemistry
The central fibroblast growth factor receptor/beta klotho system: Comprehensive mapping in Mus musculus and comparisons to nonhuman primate and human samples using an automated in situ hybridization platform
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FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP‐activated protein kinase–Caspase 6 signal axis
Lintao Song, Luyao Wang, Yushu Hou, Jie Zhou, Chen Chuchu, Xianxi Ye, Wenliya Dong, Huan Fang Gao, Yi Liu, Guanting Qiao et al. · 2022 · Hepatology
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Marcello Tiseo, Francesco Gelsomino, Roberta R Alfieri, Andrea Cavazzoni, Cecilia Bozzetti, Annamaria De Giorgi, Pier Giorgio Petronini, Andrea Ardizzoni · 2015 · Cancer Treatment Reviews
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Scott A. Rankin, Alyssa L. Gallas, Ana Neto, José Luis Gómez-Skármeta, Aaron M. Zorn · 2012 · Development
Calorie restriction and Roux‐en‐Y gastric bypass have opposing effects on circulating FGF 21 in morbidly obese subjects
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Fibroblast growth factor-21 serum concentrations are associated with metabolic and hepatic markers in humans
Susan Kralisch, Anke Tönjes, Kerstin Krause, Judit Richter, Ulrike Lössner, Peter Louis Kovacs, Thomas Ebert, Matthias Blüher, Michael Stümvoll, Mathias Faßhauer · 2012 · Journal of Endocrinology
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Penghong Chen, Shijie Tang, Ming Li, Dezhi Wang, Caixiang Chen, Yiqun Qiu, Zhuoqun Fang, Haoruo Zhang, Hangqi Gao, Haiyan Weng et al. · 2022 · Advanced Science
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Sophia Harlid, Robin Myte, Bethany R. Van Guelpen · 2017 · Mediators of Inflammation
CHIR99021 and fibroblast growth factor 1 enhance the regenerative potency of human cardiac muscle patch after myocardial infarction in mice
Chengming Fan, Yawen Tang, Meng Zhao, Xi Lou, Daniëlle Pretorius, Philippe Menasché, Wuqiang Zhu, Jianyi Jay Zhang · 2020 · Journal of Molecular and Cellular Cardiology
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Daniel Jahn, Monika Rau, Heike M. Hermanns, Andreas Geier · 2015 · Cytokine & Growth Factor Reviews
FGF21 Protects Dopaminergic Neurons in Parkinson’s Disease Models Via Repression of Neuroinflammation
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FGF8 promotes colorectal cancer growth and metastasis by activating YAP1
Rui R Liu, Shan Huang, Yunlong Lei, Tao Zhang, Kui Wang, Bo Liu, Edouard Collins Nice, Rong Xiang, Ke Xie, Jingyi Li et al. · 2014 · Oncotarget
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Tomohiro Miyachi, Munenori Nagao, Chikashi Shibata, Yoshiro Kitahara, Naoki Tanaka, Kazuhiro Watanabe, Takahiro Tsuchiya, Fuyuhiko Motoi, Takeshi Naitoh, Michiaki Unno · 2016 · Surgery
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Varsha Gupta, Manjistha Sengupta, Jaya Prakash, Baishnab Charan Tripathy · 2016 · Springer eBooks
Radiation-induced YAP activation confers glioma radioresistance via promoting FGF2 transcription and DNA damage repair
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Haiyang Zhao, Jiang Wu, Jing-jing Zhu, Zecong Xiao, Chaochao He, Hongxue Shi, Xiaokun Li, Shulin Yang, Jian Xiao · 2015 · BioMed Research International
Age-related Changes in Rat Myocardium Involve Altered Capacities of Glycosaminoglycans to Potentiate Growth Factor Functions and Heparan Sulfate-altered Sulfation
Minh Bao Huynh, Christophe Morin, Gilles Carpentier, Stéphanie Garcia-Filipe, Sofia Talhas-Perret, Véronique Barbier-Chassefière, Toin H. van Kuppevelt, Isabelle Martelly, Patricia Albanese, Dulce Papy-García · 2012 · Journal of Biological Chemistry
Fibroblast Growth Factors in Neurodevelopment and Psychopathology
Afke F. Terwisscha van Scheltinga, S C Bakker, René S. Kahn, Martien J. Kas · 2013 · The Neuroscientist
Basic fibroblast growth factor promotes the development of human ovarian early follicles during growth in vitro
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Bin Yang, Song Zhang, Xueen Fang, Jilie Kong · 2019 · Biosensors and Bioelectronics
FGF Receptor Inhibitors: Role in Cancer Therapy
Gennaro Daniele, Jesus Corral, Lulama Rhoda Molife, Johann Sebastian De Bono · 2012 · Current Oncology Reports
Mutations in fibroblast growth factor (FGF8) and FGF10 identified in patients with conotruncal defects
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Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance
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Potential for Targeting the Fibroblast Growth Factor Receptors in Breast Cancer
Nancy E. Hynes, Julien H. Dey · 2010 · Cancer Research
FGF19 and FGFR4 promotes the progression of gallbladder carcinoma in an autocrine pathway dependent on GPBAR1-cAMP-EGR1 axis
Tianli Chen, Hongda Liu, Zengli Liu, Kangshuai Li, Ruixi Qin, Yue Wang, Jialiang Liu, Zhipeng Li, Qinglun Gao, Chang Pan et al. · 2021 · Oncogene
Enhanced Expression of Integrin αvβ3 Induced by TGF-β Is Required for the Enhancing Effect of Fibroblast Growth Factor 1 (FGF1) in TGF-β-Induced Epithelial-Mesenchymal Transition (EMT) in Mammary Epithelial Cells
Seiji Mori, Moe Kodaira, Ayano Ito, Mika Okazaki, Naomasa Kawaguchi, Yoshinosuke Hamada, Yoshikazu Takada, Nariaki Matsuura∥ · 2015 · PLoS ONE
Peroxisomes in Human Health and Disease: Metabolic Pathways, Metabolite Transport, Interplay with Other Organelles and Signal Transduction
Ronald J. A. Wanders · 2013 · Sub-cellular biochemistry/Subcellular biochemistry
Pten Loss Induces Autocrine FGF Signaling to Promote Skin Tumorigenesis
Kristina Hertzler-Schaefer, Grinu Mathew, Ally-Khan B. Somani, Sunil S. Tholpady, Madhavi Kadakia, Yiping Chen, Dan F. Spandau, Xin Zhang · 2014 · Cell Reports
Is Fibroblast Growth Factor Receptor 4 a Suitable Target of Cancer Therapy?
Christine F. Heinzle, Zeynep Erdem, Jakob Paur, Bettina Grasl‐Kraupp, Klaus Holzmann, Michael Grusch, Walter Berger, Brigitte Marian · 2014 · Current Pharmaceutical Design
The integrin-binding defective FGF2 mutants potently suppress FGF2 signalling and angiogenesis
Seiji Mori, Nobuaki Hatori, Naomasa Kawaguchi, Yoshinosuke Hamada, Tsung‐Chieh Shih, Chun‐Yi Wu, Kit S. Lam, Nariaki Matsuura∥, Hirofumi Yamamoto, Yoko K. Takada et al. · 2017 · Bioscience Reports