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The FGF family: biology, pathophysiology and therapy
Open accessAbstract
The family of fibroblast growth factors (FGFs) regulates a plethora of developmental processes, including brain patterning, branching morphogenesis and limb development. Several mitogenic, cytoprotective and angiogenic therapeutic applications of FGFs are already being explored, and the recent discovery of the crucial roles of the endocrine-acting FGF19 subfamily in bile acid, glucose and phosphate homeostasis has sparked renewed interest in the pharmacological potential of this family. This Review discusses traditional applications of recombinant FGFs and small-molecule FGF receptor kinase inhibitors in the treatment of cancer and cardiovascular disease and their emerging potential in the treatment of metabolic syndrome and hypophosphataemic diseases.
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“As a non-canonical fibroblast growth factor, fibroblast growth factor 21 (FGF21) functions as an endocrine hormone that signals to distinct targets throughout the body.”
From Metabolic messengers: FGF21 (2021) · cites this paper as [1]
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FGFR3 Stimulates Stearoyl CoA Desaturase 1 Activity to Promote Bladder Tumor Growth
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Morris, Q., Liu, P., Woloszynska‐Read, A., Zhang, J., Luo, W. F., Qin, M., Bshara, W., Conroy, J. M., Sabatini, L. M., Vedell, P. T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1313580111 · Cited by 107
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Metadata
- Authors
- Beenken, A., & Mohammadi, M.
- Affiliations
- New York University (US)
- Venue
- Nature Reviews Drug Discovery
- Published
- 2009-03
- Volume
- 8
- Issue
- 3
- Pages
- 235-253
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- PMC
- PMC3684054
- OpenAlex
- W2027239974
- Cited by
- 1,945
- References
- 281
- Citations by year
- 2026: 71 · 2025: 112 · 2024: 114 · 2023: 132 · 2022: 127 · 2021: 125 · 2020: 141 · 2019: 123 · 2018: 114 · 2017: 121 · 2016: 119 · 2015: 126 · 2014: 129 · 2013: 97 · 2012: 111
- FWCI
- 7.52
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature Reviews Drug Discovery (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32-GM066704-05, T32GM066704)
- National Institute of Dental and Craniofacial Research (R01DE13686, R01DE013686)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- fibroblast growth factor, cancer therapy, cardiovascular disease, metabolic syndrome, FGF19, bile acid homeostasis, glucose homeostasis, phosphate homeostasis, angiogenesis, brain patterning, limb development, branching morphogenesis
- MeSH terms
- Animals, Cardiovascular Diseases, Fibroblast Growth Factors, Homeostasis, Humans, Neoplasms, Receptors, Fibroblast Growth Factor, Hypophosphatemia, Metabolic Syndrome
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