The FGF family: biology, pathophysiology and therapy

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Kuro-o, M., Matsumura, Y., Aizawa, H., Kawaguchi, H., Suga, T., Utsugi, T., Ohyama, Y., Kurabayashi, M., Kaname, T., Kume, E., et al. (1997) · Nature · doi:10.1038/36285 · Cited by 3,837

Thalidomide is an inhibitor of angiogenesis.

D'Amato, R. J., Loughnan, M. S., Flynn, E., & Folkman, J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.9.4082 · Cited by 2,454

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

Yayon, A., Klagsbrun, M., Esko, J. D., Leder, P., & Ornitz, D. M. (1991) · Cell · doi:10.1016/0092-8674(91)90512-w · Cited by 2,440

FGF-21 as a novel metabolic regulator

Kharitonenkov, A., Shiyanova, T. L., Koester, A., Ford, A. M., Micanovic, R., Galbreath, E. J., Sandusky, G. E., Hammond, L. J., Moyers, J. S., Owens, R. A., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23606 · Cited by 2,125

Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684.

Kirkwood, J. M., Strawderman, M. H., Ernstoff, M. S., Smith, T. J., Borden, E. C., & Blum, R. H. (1996) · Journal of Clinical Oncology · doi:10.1200/jco.1996.14.1.7 · Cited by 2,089

Suppression of Aging in Mice by the Hormone Klotho

Kurosu, H., Yamamoto, M., Clark, J. D., Pastor, J. V., Nandi, A., Gurnani, P., McGuinness, O. P., Chikuda, H., Yamaguchi, M., Kawaguchi, H., et al. (2005) · Science · doi:10.1126/science.1112766 · Cited by 1,935

Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis

Inagaki, T., Choi, M., Moschetta, A., Peng, L., Cummins, C. L., McDonald, J. G., Luo, G., Jones, S. A., Goodwin, B., Richardson, J. A., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.09.001 · Cited by 1,865

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Urakawa, I., Yamazaki, Y., Shimada, T., Iijima, K., Hasegawa, H., Okawa, K., Fujita, T., Fukumoto, S., & Yamashita, T. (2006) · Nature · doi:10.1038/nature05315 · Cited by 1,865

Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

Gutiérrez, O. M., Mannstadt, M., Isakova, T., Rauh‐Hain, J. A., Tamez, H. E., Shah, A., Smith, K. T., Lee, H., Thadhani, R., Jüppner, H., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706130 · Cited by 1,729

Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Inagaki, T., Dutchak, P., Zhao, G., Ding, X., Gautron, L., Parameswara, V., Li, Y., Goetz, R., Mohammadi, M., Esser, V., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.05.003 · Cited by 1,504

Extracellular modulation of Fibroblast Growth Factor signaling through heparan sulfate proteoglycans in mammalian development

Matsuo, I., & Kimura-Yoshida, C. (2013) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2013.02.004 · Cited by 106

FGFR4 promotes stroma-induced epithelial-to-mesenchymal transition in colorectal cancer.

Liu, R., Li, J., Xie, K., Zhang, T., Lei, Y., Chen, Y., Zhang, L., Huang, K., Wang, K., Wu, H., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4718 · Cited by 104

Uncoupling the Mitogenic and Metabolic Functions of FGF1 by Tuning FGF1-FGF Receptor Dimer Stability

Huang, Z., Tan, Y., Gu, J., Liu, Y., Song, L., Niu, J., Zhao, L., Srinivasan, L., Lin, Q., Deng, J., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.06.063 · Cited by 103

Hypoxia Induces Resistance to EGFR Inhibitors in Lung Cancer Cells via Upregulation of FGFR1 and the MAPK Pathway

Lü, Y., Liu, Y., Oeck, S., Zhang, G. J., Schramm, A. R., & Glazer, P. M. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-1192 · Cited by 104

Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

Hu, C., Qiao, W., Li, X. O., Ning, Z., Liu, J., Dalangood, S., Li, H., Yu, X., Zong, Z., Wen, Z., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.01.005 · Cited by 116

Discovery of the Irreversible Covalent FGFR Inhibitor 8-(3-(4-Acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-(methylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (PRN1371) for the Treatment of Solid Tumors

Brameld, K. A., Owens, T. D., Verner, E. J., Venetsanakos, E., Bradshaw, J. M., Phan, V. T., Tam, D., Leung, K., Shu, J., LaStant, J., et al. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.7b00360 · Cited by 103

Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis

Markan, K. R., & Potthoff, M. J. (2016) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2015.09.021 · Cited by 103

FGF21 promotes thermogenic gene expression as an autocrine factor in adipocytes

Abu-Odeh, M., Zhang, Y., Reilly, S. M., Ebadat, N., Keinan, O., Valentine, J. M., Hafezi-Bakhtiari, M., Ashayer, H., Mamoun, L., Zhou, X., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109331 · Cited by 106

FGFR Signaling as a Target for Lung Cancer Therapy

Desai, A., & Adjei, A. A. (2016) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2015.08.003 · Cited by 107

Mouse species-specific control of hepatocarcinogenesis and metabolism by FGF19/FGF15

Zhou, M., Luo, J., Chen, M., Yang, H., Learned, R. M., DePaoli, A. M., Tian, H., & Ling, L. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.01.027 · Cited by 102

AAOS Research Symposium Updates and Consensus: Biologic Treatment of Orthopaedic Injuries

LaPrade, R. F., Dragoo, J. L., Koh, J. L., Murray, I. R., Geeslin, A. G., & Chu, C. R. (2016) · Journal of the American Academy of Orthopaedic Surgeons · doi:10.5435/jaaos-d-16-00086 · Cited by 103

Peripherally derived FGF21 promotes remyelination in the central nervous system

Kuroda, M., Muramatsu, R., Maedera, N., Koyama, Y., Hamaguchi, M., Fujimura, H., Yoshida, M., Konishi, M., Itoh, N., Mochizuki, H., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94337 · Cited by 101

Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor-1 Interaction

Hu, Y., Zhong, Y., Chen, Z., Chen, C., Shi, Z., Zulueta, M. M. L., Ku, C., Lee, P.-Y., Wang, C., & Hung, S. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3090065 · Cited by 102

Angiogenesis in cancer: Anti-VEGF escape mechanisms.

Prager, G. W., Poettler, M., Unseld, M., & Zielinski, C. C. (2012) · Europe PMC (PubMed Central) · doi:10.3978/j.issn.2218-6751.2011.11.02 · Cited by 101

Human GnRH Deficiency: A Unique Disease Model to Unravel the Ontogeny of GnRH Neurons

Balasubramanian, R., Dwyer, A. A., Seminara, S. B., Pitteloud, N., Kaiser, U. B., & Crowley, W. F. (2010) · Neuroendocrinology · doi:10.1159/000314193 · Cited by 104

Regulation of serum 1,25(OH) 2 Vitamin D 3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4

Gattineni, J., Twombley, K. E., Goetz, R. M., Mohammadi, M., & Baum, M. G. (2011) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00740.2010 · Cited by 102

Perspectives on cancer stem cells in osteosarcoma

Basu-Roy, U., Basilico, C., & Mansukhani, A. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.05.028 · Cited by 105

Fibroblast growth factor 21 night watch: advances and uncertainties in the field

Kharitonenkov, A., & DiMarchi, R. D. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12580 · Cited by 97

Transcriptomic profile of leg muscle during early growth in chicken

Xue, Q., Zhang, G., Li, T., Ling, J., Zhang, X., & Wang, J. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173824 · Cited by 101

Rogaratinib: A potent and selective pan‐FGFR inhibitor with broad antitumor activity in FGFR‐overexpressing preclinical cancer models

Grünewald, S., Politz, O., Bender, S., Héroult, M., Lustig, K., Thuß, U., Kneip, C., Kopitz, C., Zopf, D., Collin, M.-P. L., et al. (2019) · International Journal of Cancer · doi:10.1002/ijc.32224 · Cited by 100

Platelet-Derived Factors Involved in Tissue Repair—From Signal to Function

Mazzucco, L., Borzini, P., & Gope, R. (2010) · Transfusion Medicine Reviews · doi:10.1016/j.tmrv.2010.03.004 · Cited by 101

Targeting Fibroblast Growth Factor Pathways in Prostate Cancer

Corn, P. G., Wang, F., McKeehan, W. L., & Navone, N. M. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-1550 · Cited by 99

Conversion of a Paracrine Fibroblast Growth Factor into an Endocrine Fibroblast Growth Factor

Goetz, R. M., Ohnishi, M., Kır, S., Kurosu, H., Wang, L., Pastor, J. V., Ma, J., Gai, W., Kuro‐o, M., Razzaque, M. S., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.342980 · Cited by 100

Expression of hepatic Fibroblast Growth Factor 19 is enhanced in Primary Biliary Cirrhosis and correlates with severity of the disease

Wunsch, E., Milkiewicz, M., Wasik, U., Trottier, J., Kempińska‐Podhorodecka, A., Elias, E., Barbier, O., & Milkiewicz, P. (2015) · Scientific Reports · doi:10.1038/srep13462 · Cited by 97

Interleukin-22 promotes tumor angiogenesis

Protopsaltis, N. J., Liang, W. P., Nudleman, E., & Ferrara, N. (2018) · Angiogenesis · doi:10.1007/s10456-018-9658-x · Cited by 99

FGFR4: A promising therapeutic target for breast cancer and other solid tumors

Levine, K. M., Ding, K., Chen, L., & Oesterreich, S. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107590 · Cited by 100

Targeted therapies for advanced bladder cancer: new strategies with FGFR inhibitors

Casadei, C., Dizman, N., Schepisi, G., Cursano, M. C., Basso, U., Santini, D., Pal, S. K., & Giorgi, U. D. (2019) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835919890285 · Cited by 97

Alternative Splicing of Fibroblast Growth Factor Receptor IgIII Loops in Cancer

Holzmann, K., Grunt, T. W., Heinzle, C. F., Sampl, S., Steinhoff, H., Reichmann, N., KLEITER, M. M., Hauck, M., & Marian, B. (2011) · Journal of Nucleic Acids · doi:10.1155/2012/950508 · Cited by 102

Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice

Padrissa‐Altés, S., Bachofner, M., Bogorad, R. L., Pohlmeier, L. M., Rossolini, T., Böhm, F., Liebisch, G., Hellerbrand, C., Koteliansky, V., Speicher, T., et al. (2014) · Gut · doi:10.1136/gutjnl-2014-307874 · Cited by 98

Neuroendocrine tumors and fibrosis: An unsolved mystery?

Laskaratos, F., Rombouts, K., Caplin, M. E., Toumpanakis, C., Thirlwell, C., & Mandair, D. (2017) · Cancer · doi:10.1002/cncr.31079 · Cited by 97

Fibroblast growth factor receptor 2 gene amplification status and its clinicopathologic significance in gastric carcinoma

Jung, E.-J., Jung, E., Min, S. Y., Kim, M. A., & Kim, W. H. (2012) · Human Pathology · doi:10.1016/j.humpath.2011.12.002 · Cited by 98

Msx Homeobox Genes Critically Regulate Embryo Implantation by Controlling Paracrine Signaling between Uterine Stroma and Epithelium

Nallasamy, S., Li, Q., Bagchi, M. K., & Bagchi, I. C. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002500 · Cited by 93

Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver

Cicione, C., Degirolamo, C., & Moschetta, A. (2012) · Hepatology · doi:10.1002/hep.25929 · Cited by 95

bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusion via activation of PI 3K/Akt/ ERK 1/2 pathway

Wang, Z., Wang, Y., Ye, J., Lu, X., Cheng, Y. H., Xiang, L., Chen, L., Feng, W., Shi, H., Yu, X., et al. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12346 · Cited by 94

Cell-Autonomous and Non–Cell-Autonomous Mechanisms of Transformation by Amplified FGFR1 in Lung Cancer

Malchers, F., Dietlein, F., Schöttle, J., Lu, X. L., Nogová, L., Albus, K., Fernandez‐Cuesta, L., Heuckmann, J. M., Gautschi, O. P., Diebold, J., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-13-0323 · Cited by 95

A phase I, first in human study of FP-1039 (GSK3052230), a novel FGF ligand trap, in patients with advanced solid tumors

Tolcher, A. W., Papadopoulos, K. P., Patnaik, A., Wilson, K. M. O., Thayer, S., Zanghi, J. A., Gemo, A. T., Kavanaugh, W. M., Keer, H. N., & LoRusso, P. M. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv591 · Cited by 94

The Role of PPARγ in Cardiovascular Diseases

Kvandová, M., Majzúnová, M., & Dovinová, I. (2016) · Physiological Research · doi:10.33549/physiolres.933439 · Cited by 95

Resistance to Anti-angiogenic Therapies: A Mechanism Depending on the Time of Exposure to the Drugs

Montemagno, C., & Pagès, G. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00584 · Cited by 100

The Alternatively Spliced Acid Box Region Plays a Key Role in FGF Receptor Autoinhibition

Kalinina, J., Dutta, K., Ilghari, D., Beenken, A., Goetz, R., Eliseenkova, A. V., Cowburn, D., & Mohammadi, M. (2012) · Structure · doi:10.1016/j.str.2011.10.022 · Cited by 94

Exercise-stimulated FGF23 promotes exercise performance via controlling the excess reactive oxygen species production and enhancing mitochondrial function in skeletal muscle

Li, D.-J., Fu, H., Zhao, T., Ni, M., & Shen, F.-M. (2016) · Metabolism · doi:10.1016/j.metabol.2016.02.009 · Cited by 92

Fibroblast growth factor receptor fusions in cancer: opportunities and challenges

Chen, L., Zhang, Y., Yin, L., Cai, B., Huang, P. C., Li, X., & Liang, G. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02156-6 · Cited by 94

Copper influx transporter 1 is required for FGF, PDGF and EGF-induced MAPK signaling

Tsai, C., Finley, J. C., Ali, S. S., Patel, H. H., & Howell, S. B. (2012) · Biochemical Pharmacology · doi:10.1016/j.bcp.2012.07.014 · Cited by 92

Erdafitinib for the treatment of metastatic bladder cancer

Montazeri, K., & Joaquim Bellmunt, B. (2019) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2020.1702025 · Cited by 92

The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration

Augustyniak, E., Trzeciak, T., Richter, M., Kaczmarczyk, J., & Suchorska, W. M. (2014) · International Orthopaedics · doi:10.1007/s00264-014-2619-0 · Cited by 92

Anti-vascular therapies in ovarian cancer: moving beyond anti-VEGF approaches

Choi, H. J., Armaiz-Peña, G. N., Pradeep, S., Cho, M. S., Coleman, R. L., & Sood, A. K. (2014) · Cancer and Metastasis Reviews · doi:10.1007/s10555-014-9538-9 · Cited by 92

Preclinical Activity of ARQ 087, a Novel Inhibitor Targeting FGFR Dysregulation

Hall, T. G., Yu, Y., Eathiraj, S., Wang, Y., Savage, R. E., Lapierre, J., Schwartz, B. E., & Abbadessa, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162594 · Cited by 90

Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis

Li, S., Hsu, D. D., Li, B., Luo, X., Alderson, N. B., Qiao, L., Ma, L., Zhu, H. H., He, Z., Suino-Powell, K. M., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.020 · Cited by 91

The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis

Ronca, R., Giacomini, A., Rusnati, M., & Presta, M. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2015.1062475 · Cited by 90

Modeling human pancreatic beta cell dedifferentiation

Diedisheim, M., Oshima, M., Albagli, O., Huldt, C. W., Ahlstedt, I., Clausen, M., Menon, S., Aivazidis, A., Andréasson, A., Haynes, W. G., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.02.002 · Cited by 91

Receptor Tyrosine Kinases in Osteosarcoma Treatment: Which Is the Key Target?

Tian, Z., Niu, X., & Yao, W. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.01642 · Cited by 87

Hepatic FXR-FGF4 is required for bile acid homeostasis via an FGFR4-LRH-1 signal node under cholestatic stress

Song, L., Hou, Y., Xu, D., Dai, X., Luo, J., Liu, Y., Huang, Z., Yang, M., Chen, J., Hu, Y., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.09.008 · Cited by 91

The angiogenic process as a therapeutic target in cancer

Bridges, E., & Harris, A. L. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.02.016 · Cited by 87

Hydrogel vehicles for sequential delivery of protein drugs to promote vascular regeneration

Zhao, W., Volkova, E., Blatchley, M. R., & Gerecht, S. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.08.005 · Cited by 90

Signaling pathways and intervention for therapy of type 2 diabetes mellitus

Cao, R. Y., Tian, H., Zhang, Y., Liu, G., Xu, H., Rao, G., Tian, Y., & Fu, X. (2023) · MedComm · doi:10.1002/mco2.283 · Cited by 98

Blocking the FGF/FGFR system as a two-compartment antiangiogenic/antitumor approach in cancer therapy

Giacomini, A., Chiodelli, P., Matarazzo, S., Rusnati, M., Presta, M., & Ronca, R. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.03.024 · Cited by 89

Isoforms of Receptors of Fibroblast Growth Factors

Gong, S. (2014) · Journal of Cellular Physiology · doi:10.1002/jcp.24649 · Cited by 90

A Matter of Balance: Role of Neurexin and Neuroligin at the Synapse

Bang, M., & Owczarek, S. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1029-9 · Cited by 92

Action and function of Wnt/β-catenin signaling in the progression from chronic hepatitis C to hepatocellular carcinoma

Wang, W., Pan, Q., Fuhler, G. M., Smits, R., & Peppelenbosch, M. P. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1299-5 · Cited by 89

Sustained release of a GLP-1 and FGF21 dual agonist from an injectable depot protects mice from obesity and hyperglycemia

Gilroy, C. A., Capozzi, M. E., Varanko, A. K., Tong, J., D’Alessio, D. A., Campbell, J. E., & Chilkoti, A. (2020) · Science Advances · doi:10.1126/sciadv.aaz9890 · Cited by 85

Receptor tyrosine kinase mutations in developmental syndromes and cancer: two sides of the same coin

McDonell, L. M., Kernohan, K. D., Boycott, K. M., & Sawyer, S. L. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv254 · Cited by 86

Chemical Tumor Biology of Heparan Sulfate Proteoglycans

Raman, K., & Kuberan, B. (2010) · Current Chemical Biology · doi:10.2174/187231310790226206 · Cited by 88

FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology

Murata, Y., Konishi, M., & Itoh, N. (2011) · Journal of Nutrition and Metabolism · doi:10.1155/2011/981315 · Cited by 87

The adhesion molecule NCAM promotes ovarian cancer progression via FGFR signalling

Zecchini, S., Bombardelli, L., Decio, A., Bianchi, M., Mazzarol, G., Sanguineti, F., Aletti, G. D., Maddaluno, L., Berezin, V., Bock, E., et al. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100152 · Cited by 85

Klotho Coreceptors Inhibit Signaling by Paracrine Fibroblast Growth Factor 8 Subfamily Ligands

Goetz, R. M., Ohnishi, M., Ding, X., Kurosu, H., Wang, L., Akiyoshi, J., Ma, J., Gai, W., Sidis, Y., Pitteloud, N., et al. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06603-11 · Cited by 86

YAP induces high-grade serous carcinoma in fallopian tube secretory epithelial cells

Hua, G., Lv, X., He, C., Remmenga, S. W., Rodabough, K. J., Dong, J., Yang, L., Lele, S. M., Yang, P., Zhou, J., et al. (2015) · Oncogene · doi:10.1038/onc.2015.288 · Cited by 83

Cytokine-release kinetics of platelet-rich plasma according to various activation protocols

Roh, Y. H., Kim, W., Park, K. U., & Oh, J. H. (2016) · Bone and Joint Research · doi:10.1302/2046-3758.52.2000540 · Cited by 86

Medicinal chemistry perspective of pyrido[2,3- d ]pyrimidines as anticancer agents

Kumar, A., Bhagat, K. K., Singh, A. K., Singh, H., Angre, T. D., Verma, A., Khalilullah, H., Jaremko, M., Emwas, A.-H. M., & Kumar, P. (2023) · RSC Advances · doi:10.1039/d3ra00056g · Cited by 85

Regulation of fibroblast growth factor receptor signalling and trafficking by Src and Eps8

Auciello, G., Cunningham, D. L., Tatar, T., Heath, J. K., & Rappoport, J. Z. (2012) · Journal of Cell Science · doi:10.1242/jcs.116228 · Cited by 82

Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements

Inoue, T., Kohro, T., Tanaka, T., Kanki, Y., Li, G., Poh, H.-M., Mimura, I., Kobayashi, M., Taguchi, A., Maejima, T., et al. (2014) · Genome biology · doi:10.1186/gb-2014-15-4-r63 · Cited by 86

A review of radiation countermeasure work ongoing at the Armed Forces Radiobiology Research Institute

Singh, V. K., Ducey, E. J., Brown, D. S., & Whitnall, M. H. (2011) · International Journal of Radiation Biology · doi:10.3109/09553002.2012.652726 · Cited by 84

Activating Adenosine Monophosphate–Activated Protein Kinase Mediates Fibroblast Growth Factor 1 Protection From Nonalcoholic Fatty Liver Disease in Mice

Lin, Q., Huang, Z., Cai, G., Fan, X., Yan, X., Liu, Z., Zhao, Z., Li, J., Li, J. X., Shi, H., et al. (2020) · Hepatology · doi:10.1002/hep.31568 · Cited by 81

Identification of Fibroblast Growth Factor Receptor 3 (FGFR3) as a Protein Receptor for Botulinum Neurotoxin Serotype A (BoNT/A)

Jacky, B., Garay, P. E., Dupuy, J., Nelson, J. B., Cai, B. B., Molina, Y., Wang, J., Steward, L. E., Broide, R. S., Francis, J., et al. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003369 · Cited by 84

A Phase 1 Study of LY2874455, an Oral Selective pan-FGFR Inhibitor, in Patients with Advanced Cancer

Michael, M., Bang, Y., Park, Y. S., Kang, Y., Kim, T. M., Hamid, O., Thornton, D., Tate, S. C., Raddad, E., & Tie, J. (2017) · Targeted Oncology · doi:10.1007/s11523-017-0502-9 · Cited by 81

Safety, pharmacokinetic, and pharmacodynamics of erdafitinib, a pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor, in patients with advanced or refractory solid tumors

Nishina, T., Takahashi, S., Iwasawa, R., Noguchi, H., Aoki, M., & Doi, T. (2017) · Investigational New Drugs · doi:10.1007/s10637-017-0514-4 · Cited by 81

The FGF/FGFR system in the physiopathology of the prostate gland

Giacomini, A., Grillo, E., Rezzola, S., Ribatti, D., Rusnati, M., Ronca, R., & Presta, M. (2020) · Physiological Reviews · doi:10.1152/physrev.00005.2020 · Cited by 81

Discovery of Pemigatinib: A Potent and Selective Fibroblast Growth Factor Receptor (FGFR) Inhibitor

Wu, L., Zhang, C., He, C., Qian, D., Lü, L., Sun, Y., Xu, M., Zhuo, J., Liu, P. C. C., Klabe, R. M., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00713 · Cited by 82

Fibroblast Growth Factor Receptors as Therapeutic Targets in Human Melanoma: Synergism with BRAF Inhibition

Metzner, T., Bedeir, A., Held, G., Peter‐Vörösmarty, B., Ghassemi, S., Heinzle, C. F., Spiegl‐Kreinecker, S., Marian, B., Holzmann, K., Grasl‐Kraupp, B., et al. (2011) · Journal of Investigative Dermatology · doi:10.1038/jid.2011.177 · Cited by 82

Fibroblast growth factor signaling controlling bone formation: An update

Marie, P. J. (2012) · Gene · doi:10.1016/j.gene.2012.01.086 · Cited by 80

Mechanisms of fibroblast growth factor signaling in the ovarian follicle

Price, C. A. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0414 · Cited by 83

Impact of Fibroblast Growth Factor-Binding Protein–1 Expression on Angiogenesis and Wound Healing

Tassi, E., McDonnell, K., Gibby, K. A., Tilan, J. U., Kim, S. E., Kodack, D. P., Schmidt, M. O., Sharif, G. M., Wilcox, C. S., Welch, W. J., et al. (2011) · American Journal Of Pathology · doi:10.1016/j.ajpath.2011.07.043 · Cited by 81

Loss of ileum decreases serum fibroblast growth factor 19 in relation to liver inflammation and fibrosis in pediatric onset intestinal failure

Mutanen, A., Lohi, J., Heikkilä, P., Jalanko, H., & Pakarinen, M. P. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.01.004 · Cited by 79

The Unconventional Secretory Machinery of Fibroblast Growth Factor 2

Nickel, W. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01187.x · Cited by 76

Computer‐assisted engineering of hyperstable fibroblast growth factor 2

Dvořák, P., Bednář, D., Vaňáček, P., Bálek, L., Eiselleová, L., Štěpánková, V., Šebestová, E., Bosakova, M. K., Konečná, Ž., Mazurenko, S., et al. (2017) · Biotechnology and Bioengineering · doi:10.1002/bit.26531 · Cited by 77

A single nanowire sensor for intracellular glucose detection

Liao, Q., Jiang, H., Zhang, X., Qiu, Q., Tang, Y., Yang, X., Liu, Y., & Huang, W. (2019) · Nanoscale · doi:10.1039/c9nr01997a · Cited by 79

Targeting FGF19/FGFR4 Pathway: A Novel Therapeutic Strategy for Hepatocellular Carcinoma

Repana, D., & Ross, P. J. (2015) · Diseases · doi:10.3390/diseases3040294 · Cited by 78

Tumor-Specific Isoform Switch of the Fibroblast Growth Factor Receptor 2 Underlies the Mesenchymal and Malignant Phenotypes of Clear Cell Renal Cell Carcinomas

Zhao, Q., Caballero, O. L., Davis, I. D., Jonasch, E., Tamboli, P., Yung, W. K. A., Weinstein, J. N., Strausberg, R. L., & Yao, J. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3708 · Cited by 82

Fibroblast Growth Factor 19 Treatment Ameliorates Disruption of Hepatic Lipid Metabolism in Farnesoid X Receptor (Fxr)-Null Mice

Miyata, M., Sakaida, Y., Matsuzawa, H., Yoshinari, K., & Yamazoe, Y. (2011) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.34.1885 · Cited by 77

FGFR families: biological functions and therapeutic interventions in tumors

Liu, Q., Huang, J., Yan, W., Liu, Z., Liu, S., & Fang, W. (2023) · MedComm · doi:10.1002/mco2.367 · Cited by 77

Non-peptidic Thrombospondin-1 Mimics as Fibroblast Growth Factor-2 Inhibitors

Colombo, G., Margosio, B., Ragona, L., Neves, M. A. C., Bonifacio, S., Annis, D. S., Stravalaci, M., Tomaselli, S., Giavazzi, R., Rusnati, M., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.085605 · Cited by 77

Inflammation Markers in Type 2 Diabetes and the Metabolic Syndrome in the Pediatric Population

Reinehr, T., & Roth, C. L. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1110-5 · Cited by 78

Of mice and men: converging on a common molecular understanding of osteoarthritis

Vincent, T. L. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30279-4 · Cited by 76

Single‐cell transcriptomes reveal heterogeneity of high‐grade serous ovarian carcinoma

Hao, Q., Li, J., Zhang, Q., Xu, F., Xie, B., Lu, H., Wu, X., & Zhou, X. Y. (2021) · Clinical and Translational Medicine · doi:10.1002/ctm2.500 · Cited by 76

Glucose, Insulin, and Oxygen Interplay in Placental Hypervascularisation in Diabetes Mellitus

Cvitic, S., Desoyé, G., & Hiden, U. (2014) · BioMed Research International · doi:10.1155/2014/145846 · Cited by 80

A mathematical model of tumour angiogenesis: growth, regression and regrowth

Vilanova, G., Colominas, I., & Gómez, H. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2016.0918 · Cited by 79

Signaling Required for Blood Vessel Maintenance: Molecular Basis and Pathological Manifestations

Murakami, M. (2011) · International Journal of Vascular Medicine · doi:10.1155/2012/293641 · Cited by 77

Stressed Liver and Muscle Call on Adipocytes with FGF21

Luo, Y., & McKeehan, W. L. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00194 · Cited by 75

Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia

Liu, S. Q., Tefft, B. J., Roberts, D., Zhang, L., Ren, Y., Li, Y. C., Huang, Y., Zhang, D., Phillips, H. R., & Wu, Y. H. (2012) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00362.2012 · Cited by 78

Pan-FGFR Inhibition Leads to Blockade of FGF23 Signaling, Soft Tissue Mineralization, and Cardiovascular Dysfunction

Yanochko, G. M., Vitsky, A., Heyen, J. R. R., Hirakawa, B. P., Lam, J. L., May, J. R., Nichols, T., Sace, F., Trajkovic, D., & Blasi, E. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft161 · Cited by 76

Glycosaminoglycan and Chemokine/Growth Factor Interactions

Shute, J. K. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-23056-1_13 · Cited by 76

FGF10 promotes regional foetal cardiomyocyte proliferation and adult cardiomyocyte cell-cycle re-entry

Rochais, F., Sturny, R., Chao, C., Mesbah, K., Bennett, M., Mohun, T. J., Bellusci, S., & Kelly, R. G. (2014) · Cardiovascular Research · doi:10.1093/cvr/cvu232 · Cited by 74

FGF Family: From Drug Development to Clinical Application

Hui, Q., Jin, Z., Li, X., Liu, C., & Wang, X. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19071875 · Cited by 182

Therapeutic uses of FGFs

Zhang, J., & Li, Y. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.09.007 · Cited by 44

FGF-based drug discovery: advances and challenges

Chen, G., Chen, L., Li, X., & Mohammadi, M. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01125-w · Cited by 51

成纤维细胞生长因子家族：生物学特性，病理生理学作用及相关治疗方法

时小燕, & 郭靓 (2009)

Pathology and Therapeutic Significance of Fibroblast Growth Factors

Edirisinghe, O., Ternier, G., & Kumar, T. K. S. (2025) · Targets · doi:10.3390/targets3010005 · Cited by 8