The DOI matches its Crossref record; 295 of the 295 references it cites were found in a registry or an index.
Can we safely target the WNT pathway?
Open accessAbstract
WNT–β-catenin signalling is involved in a multitude of developmental processes and the maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation, migration, genetic stability and apoptosis, as well as by maintaining adult stem cells in a pluripotent state. Not surprisingly, aberrant regulation of this pathway is therefore associated with a variety of diseases, including cancer, fibrosis and neurodegeneration. Despite this knowledge, therapeutic agents specifically targeting the WNT pathway have only recently entered clinical trials and none has yet been approved. This Review examines the problems and potential solutions to this vexing situation and attempts to bring them into perspective.
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1 retracted
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Cited by
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
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Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities
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Metadata
- Authors
- Kahn, M.
- Venue
- Nature Reviews Drug Discovery
- Published
- 2014-07
- Volume
- 13
- Issue
- 7
- Pages
- 513-532
- ISSN
- 1474-1776 (ISSN-L)
- 1474-1784
- OpenAlex
- W1994928797
- Cited by
- 1,034
- References
- 295
- FWCI
- 6.53
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
