Adipose tissue browning and metabolic health

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664

Identification and Importance of Brown Adipose Tissue in Adult Humans

Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864

Cold-Activated Brown Adipose Tissue in Healthy Men

van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

The P2X7 ion channel is dispensable for energy and metabolic homeostasis of white and brown adipose tissues

Tian, T., Heine, M., Evangelakos, I., Jaeckstein, M. Y., Schaltenberg, N., Stähler, T., Koch‐Nolte, F., Kumari, M., & Heeren, J. (2020) · Purinergic Signalling · doi:10.1007/s11302-020-09738-7 · Cited by 14

Wt1 haploinsufficiency induces browning of epididymal fat and alleviates metabolic dysfunction in mice on high-fat diet

Kirschner, K. M., Foryst‐Ludwig, A., Gohlke, S., Li, C., Flores, R. E., Kintscher, U., Schupp, M., Schulz, T. J., & Scholz, H. (2021) · Diabetologia · doi:10.1007/s00125-021-05621-1 · Cited by 16

Metformin and vitamin D modulate adipose-derived stem cell differentiation towards the beige phenotype

Cruciani, S., Garroni, G., Pala, R., Coradduzza, D., Cossu, M. L., Ginesu, G. C., Capobianco, G., Dessole, S., Ventura, C., & Maioli, M. (2022) · Adipocyte · doi:10.1080/21623945.2022.2085417 · Cited by 19

The TRPM2 ion channel regulates metabolic and thermogenic adaptations in adipose tissue of cold-exposed mice

Benzi, A., Heine, M., Spinelli, S., Salis, A., Worthmann, A., Diercks, B., Astigiano, C., Mato, R. P., Memushaj, A., Sturla, L., et al. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1251351 · Cited by 14

Bazi Bushen ameliorates age-related energy metabolism dysregulation by targeting the IL-17/TNF inflammatory pathway associated with SASP

Shen, X., Li, M., Li, Y., Jiang, Y., Niu, K., Zhang, S., Lu, X., Zhang, R., Zhao, Z., Zhou, L., et al. (2024) · Chinese Medicine · doi:10.1186/s13020-024-00927-9 · Cited by 15

Macrophage-derived chemokine CCL22 establishes local LN-mediated adaptive thermogenesis and energy expenditure

Yuan, Y., Hu, R., Park, J., Xiong, S., Wang, Z., Qian, Y., Shi, Z., Wu, R., Han, Z., Ong, S., et al. (2024) · Science Advances · doi:10.1126/sciadv.adn5229 · Cited by 14

Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion

Li, Z., Shi, B., Li, N., Sun, J., Zeng, X., Huang, R., Bok, S., Chen, X., Han, J., Yallowitz, A. R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-51155-6 · Cited by 16

Iron-Mediated Regulation in Adipose Tissue: A Comprehensive Review of Metabolism and Physiological Effects

Yang, X., Wang, X., Yang, Z., & Lu, H. (2025) · Current Obesity Reports · doi:10.1007/s13679-024-00600-0 · Cited by 16

Preliminary evaluation of β3-adrenoceptor agonist-induced 18F-FDG metabolic activity of brown adipose tissue in obese Zucker rat

Schade, K. N., Baranwal, A., Liang, C., Mirbolooki, M., & Mukherjee, J. (2015) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2015.04.003 · Cited by 14

Autologous subcutaneous adipose tissue transplants improve adipose tissue metabolism and reduce insulin resistance and fatty liver in diet-induced obesity rats

Torres‐Villalobos, G., Hamdan‐Pérez, N., Díaz‐Villaseñor, A., Tovar, A. R., Torre-Villalvazo, I., Ordáz‐Nava, G., Morán‐Ramos, S., Noriega, L. G., Martínez‐Benítez, B., Lopez-Garibay, A., et al. (2016) · Physiological Reports · doi:10.14814/phy2.12909 · Cited by 14

Differential effects of Calca-derived peptides in male mice with diet-induced obesity

Bartelt, A., Jeschke, A., Müller, B., Gaziano, I., Morales, M., Yorgan, T. A., Heckt, T., Heine, M., Gagel, R. F., Emeson, R. B., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180547 · Cited by 15

Physiological regulation and metabolic role of browning in white adipose tissue

Janković, A., Otašević, V., Stančić, A., Buzadžić, B., Korać, A., & Korać, B. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0034 · Cited by 14

Prenylated flavonoid‐standardized extract from seeds of Psoralea corylifolia L. activated fat browning in high‐fat diet–induced obese mice

Liu, J., Zhao, Y., Huang, C., Li, Y., & Guo, F. (2019) · Phytotherapy Research · doi:10.1002/ptr.6374 · Cited by 15

The Turkish version of the Neck Bournemouth Questionnaire in patients with chronic neck pain: a cultural adaptation, reliability, and validity study

Telci, E. A., Aslan, Ü. B., Yağcı, N., Cavlak, U., Kabul, E. G., Kara, G., Kose, T., Yarar, F., Karahan, S., & Atalay, O. T. (2019) · Archives of Medical Science · doi:10.5114/aoms.2019.89322 · Cited by 14

Green tea aqueous extract (GTAE) prevents high‐fat diet‐induced obesity by activating fat browning

Li, J., Chen, Q., Zhai, X., Wang, D., Hou, Y., & Tang, M. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2580 · Cited by 14

Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues through Sympathetic Nerve Activation

Ishii, Y., Muta, O., Teshima, T., Hirasima, N., Odaka, M., Fushimi, T., Fujii, Y., & Osakabe, N. (2021) · Nutrients · doi:10.3390/nu13124214 · Cited by 14

Crosstalk between adipose tissue and the microbiota-gut-brain axis in metabolic diseases

Yu, Z.-W., Wang, Y., Yu, Z. H., Lu, M., & Xu, B. (2022) · International Journal of Biological Sciences · doi:10.7150/ijbs.68786 · Cited by 15

RIIβ‐PKA in GABAergic Neurons of Dorsal Median Hypothalamus Governs White Adipose Browning

Wang, B., Zhao, M., Su, Z., Jin, B., Yang, X., Zhang, C., Guo, B., Li, J., Hong, W., Liu, J., et al. (2022) · Advanced Science · doi:10.1002/advs.202205173 · Cited by 14

Inhibition of AXL receptor tyrosine kinase enhances brown adipose tissue functionality in mice

Efthymiou, V., Ding, L., Baláž, M., Sun, W., Balážová, L., Straub, L. G., Dong, H., Simon, E., Ghosh, A., Perdikari, A., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39715-8 · Cited by 13

Anti-Obesity Effects of Soybean Embryo Extract and Enzymatically-Modified Isoquercitrin

Kim, M., Im, S., Cho, Y. K., Choi, C., Son, Y., Kwon, D.-Y., Jung, Y.-S., & Lee, Y. (2020) · Biomolecules · doi:10.3390/biom10101394 · Cited by 14

When fat becomes an ally of the enemy: adipose tissue as collaborator in human breast cancer

Lapeire, L., Denys, H. G., Cocquyt, V., & Wever, O. D. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2015-0018 · Cited by 16

Follistatin and follistatin-like 3 in metabolic disorders

Bielka, W., Przezak, A., & Pawlik, A. (2023) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2023.106785 · Cited by 15

Butyrate Prevents Obesity Accompanied by HDAC9-Mediated Browning of White Adipose Tissue

Yang, J., Li, G., Wang, S., He, M., Dong, S., Wang, T., Shi, B., Rensen, P. C. N., & Wang, Y. (2025) · Biomedicines · doi:10.3390/biomedicines13020260 · Cited by 13

Predicted secreted protein analysis reveals synaptogenic function of Clstn3 during WAT browning and BAT activation in mice

Chen, S., Niu, Q., Ju, L., Alimujiang, M., Han, Y. Y., Bai, N.-N., Xu, J. Y., Fang, Q., Han, J., Yang, Y., et al. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0211-2 · Cited by 13

Tanshinone IIA and its derivative activate thermogenesis in adipocytes and induce “beiging” of white adipose tissue

Ma, L., Zhao, Z., Guo, X., Li, J., Xu, L., Mei, W., Dong, G., Zhong, Z., & Yang, Z. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111557 · Cited by 13

Angiotensin II Promotes White Adipose Tissue Browning and Lipolysis in Mice

Cai, Z., Fang, L., Jiang, Y., Liang, M., Wang, J., Shen, Y., Wang, Z., Liang, F., Huo, H., Pan, C., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/6022601 · Cited by 13

Metabolic improvement and liver regeneration by inhibiting CXXC5 function for non-alcoholic steatohepatitis treatment

Seo, S. H., Kim, E., Yoon, M., Lee, S., Park, B., & Choi, K. (2022) · Experimental & Molecular Medicine · doi:10.1038/s12276-022-00851-8 · Cited by 13

Role of Epicardial Adipose Tissue Secretome on Cardiovascular Diseases

Leo, S., Tremoli, E., Ferroni, L., & Zavan, B. (2023) · Biomedicines · doi:10.3390/biomedicines11061653 · Cited by 15

Brown adipocyte and browning thermogenesis: metabolic crosstalk beyond mitochondrial limits and physiological impacts

Nguyen, V. T.-T., Vu, V. V., & Pham, P. V. (2023) · Adipocyte · doi:10.1080/21623945.2023.2237164 · Cited by 15

Adipocyte-Derived Extracellular Vesicles: Small Vesicles with Big Impact

Li, Y., Xue Ming, T. A. N. G., Gu, Y., & Zhou, G. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2807149 · Cited by 13

The obesity‐linked human lncRNA AATBC stimulates mitochondrial function in adipocytes

Giroud, M., Kotschi, S., Kwon, Y., Thuc, O. L., Hoffmann, A., Gil‐Lozano, M., Karbiener, M., Higareda‐Almaraz, J. C., Khani, S., Tews, D., et al. (2023) · EMBO Reports · doi:10.15252/embr.202357600 · Cited by 16

Cold‐inducible lncRNA266 promotes browning and the thermogenic program in white adipose tissue

Ma, J., Wu, Y., Cen, L., Wang, Z., Jiang, K., Lian, B., & Sun, C. (2023) · EMBO Reports · doi:10.15252/embr.202255467 · Cited by 13

The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis

Zhang, Y., Zhang, B., & Sun, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1378202 · Cited by 17

Estrogen-Related Receptor α: A Key Transcription Factor in the Regulation of Energy Metabolism at an Organismic Level and a Target of the ABA/LANCL Hormone Receptor System

Spinelli, S., Bruschi, M., Passalacqua, M., Guida, L., Magnone, M., Sturla, L., & Zocchi, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094796 · Cited by 13

Thermogenic Fat as a New Obesity Management Tool: From Pharmaceutical Reagents to Cell Therapies

Cheng, Y., Liang, S., Zhang, S., & Hui, X. H. (2024) · Biomedicines · doi:10.3390/biomedicines12071474 · Cited by 13

Effects of Resveratrol on Adipocytes: Evidence from In Vitro and In Vivo Studies

Terzo, M., Iantomasi, M., & Tsiani, E. (2024) · Molecules · doi:10.3390/molecules29225359 · Cited by 15

Alterations to adipose tissue morphology during inflammatory arthritis is indicative of vasculopathology in DBA/1 mice

Sime, K., Choy, E., & Williams, A. S. (2017) · Adipocyte · doi:10.1080/21623945.2017.1295174 · Cited by 13

Modulation of transforming growth factor-β/follistatin signaling and white adipose browning: therapeutic implications for obesity related disorders

Pervin, S., Singh, V., Tucker, A., Collazo, J., & Singh, R. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0036 · Cited by 13

Hypothalamic CDK4 regulates thermogenesis by modulating sympathetic innervation of adipose tissues

Castillo‐Armengol, J., Barquissau, V., Geller, S., Ji, H., Severi, I., Venema, W., Fernandez, E. A., Moret, C., Huber, K., Leal-Esteban, L. C., et al. (2020) · EMBO Reports · doi:10.15252/embr.201949807 · Cited by 13

Strategies for Browning Agent Delivery

Zhang, W., Sheng, T., Gu, Z., & Zhang, Y. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03081-1 · Cited by 14

Sex‐Specific Effects of Maternal and Post‐Weaning High‐Fat Diet on Adipose Tissue Remodeling and Asprosin Expression in Mice Offspring

Yang, Z., Jiang, J., Chen, M., Huang, J., Liu, J., Wei, X., Jia, R., Song, L., Sun, B., Luo, X. M., et al. (2021) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100470 · Cited by 14

Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation

Kihara‐Negishi, F., Ohkura, N., Takahashi, Y., Fujita, T., Nakamura, Y., Maruyama, K., Oshitari, T., & Yamaguchi, S. (2022) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00988 · Cited by 13

The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms

Lu, B., Diz-Chaves, Y., Markovic, D., Contarino, A., Pénicaud, L., Fanelli, F., Clark, S., Lehnert, H., Cota, D., Grammatopoulos, D. K., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.164 · Cited by 13

SYK kinase mediates brown fat differentiation and activation

Knoll, M., Winther, S., Natarajan, A., Yang, H., Jiang, M., Thiru, P., Shahsafaei, A., Chavarria, T. E., Lamming, D. W., Sun, L., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-02162-3 · Cited by 14

Lessons from Cre-Mice and Indicator Mice

Wolfrum, C., & Straub, L. G. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2018_146 · Cited by 12

Circulating factors present in the sera of naturally skinny people may influence cell commitment and adipocyte differentiation of mesenchymal stromal cells

Alessio, N., Squillaro, T., Monda, V., Peluso, G., Monda, M., Melone, M. A. B., Galderisi, U., & Bernardo, G. D. (2019) · World Journal of Stem Cells · doi:10.4252/wjsc.v11.i3.180 · Cited by 13

Fast Noninvasive Measurement of Brown Adipose Tissue in Living Mice by Near-Infrared Fluorescence and Photoacoustic Imaging

Li, W., Ma, J., Jiang, Q., Zhang, T., Qi, Q., & Cheng, Y. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b05162 · Cited by 13

Omija fruit ethanol extract improves adiposity and related metabolic disturbances in mice fed a high-fat diet

Park, H., Kim, H.-J., Kim, S. R., Choi, M., & Jung, U. J. (2017) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.12.016 · Cited by 13

Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation

Park, E., Kim, H. S., Lee, D.-H., Kim, S., Yoon, J.-S., Lee, J.-M., Im, S. J., Lee, H., Lee, M.-W., & Lee, C. (2023) · Nature Communications · doi:10.1038/s41467-023-36836-y · Cited by 12

Linking Adiposity to Interstitial Lung Disease: The Role of the Dysfunctional Adipocyte and Inflammation

Macklin, M., Thompson, C., Kawano-Dourado, L. B., Ventura, I. B., Weschenfelder, C., Trostchansky, A., Marcadenti, A., & Tighe, R. M. (2023) · Cells · doi:10.3390/cells12182206 · Cited by 13

Yerba Maté (Ilex paraguariensis) Supplement Exerts Beneficial, Tissue-Specific Effects on Mitochondrial Efficiency and Redox Status in Healthy Adult Mice

Walton, C. M., Saito, E. R., Warren, C. E., Larsen, J. G., Remund, N. P., Reynolds, P. R., Hansen, J. M., & Bikman, B. T. (2023) · Nutrients · doi:10.3390/nu15204454 · Cited by 16

Intestinal dual-specificity phosphatase 6 regulates the cold-induced gut microbiota remodeling to promote white adipose browning

Chen, P.-C., Tsai, T.-P., Liao, Y.-C., Liao, Y.-C., Cheng, H.-W., Weng, Y.-H., Lin, C.-M., Kao, C., Tai, C.-C., & Ruan, J. (2024) · npj Biofilms and Microbiomes · doi:10.1038/s41522-024-00495-8 · Cited by 14

SRSF1 Is Required for Mitochondrial Homeostasis and Thermogenic Function in Brown Adipocytes Through its Control of Ndufs3 Splicing

Yuan, N., Shen, L., Peng, Q., Sha, R., Wang, Z., Xie, Z., You, X., & Feng, Y. (2024) · Advanced Science · doi:10.1002/advs.202306871 · Cited by 12

Cross-talk between adipose tissue and microbiota-gut-brain-axis in brain development and neurological disorder

Thakur, P., Baraskar, K., Shrivastava, V. K., & Medhi, B. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149176 · Cited by 12

Resveratrol stimulates brown of white adipose via regulating ERK/DRP1-mediated mitochondrial fission and improves systemic glucose homeostasis

Yan, H., Shao, M., Lin, X., Peng, T., Chen, C., Yang, M., Zhong, J., Yang, J., & Hui, S. (2024) · Endocrine · doi:10.1007/s12020-024-04008-7 · Cited by 13

Lycium barbarum polysaccharide increases thermogenesis and energy metabolism through modulation of the gut microbiota to confer resistance to cold temperatures

Sun, C., Su, J., Wang, J., Ding, K., & Chen, C. (2024) · The FASEB Journal · doi:10.1096/fj.202400870r · Cited by 12

Ucp1 Ablation Improves Skeletal Muscle Glycolytic Function in Aging Mice

Qiu, J., Guo, Y., Guo, X., Liu, Z., Li, Z., Zhang, J., Cao, Y., Li, J., Yu, S., Xu, S., et al. (2024) · Advanced Science · doi:10.1002/advs.202411015 · Cited by 12

Agonist Antibody Converts Stem Cells into Migrating Brown Adipocyte-Like Cells in Heart

Han, K. H., Arlian, B. M., Lin, C.-W., Jin, H. Y., Kang, G.-H., Lee, S., Lee, P. C.-W., & Lerner, R. A. (2020) · Cells · doi:10.3390/cells9010256 · Cited by 13

Role of Dietary Polyphenols in Adipose Tissue Browning: A Narrative Review

Salazar, J. J., Cano, C., Pérez, J. L., Castro, A., Diaz, M. P., Garrido, B., Carrasquero, R., Chacín, M., Velasco, M., D’Marco, L., et al. (2020) · Current Pharmaceutical Design · doi:10.2174/1381612826666200701211422 · Cited by 12

Endothelial Lipase Is Involved in Cold-Induced High-Density Lipoprotein Turnover and Reverse Cholesterol Transport in Mice

Schaltenberg, N., John, C., Heine, M., Haumann, F., Rinninger, F., Scheja, L., Heeren, J., & Worthmann, A. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.628235 · Cited by 12

Src family kinases involved in the differentiation of human preadipocytes

Feng, J., Zhang, X., Shan, C., Xia, J., Zhang, Z., Shi, H., Leng, K., Wu, Y., Ji, C., & Zhong, T. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111323 · Cited by 14

Long Noncoding RNAs: Novel Important Players in Adipocyte Lipid Metabolism and Derivative Diseases

Zhang, B., Xu, S., Liu, J., Xie, Y. C., & Xiaobo, S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.691824 · Cited by 12

The capacity of differentiation of stromal vascular fraction cells into beige adipocytes is markedly reduced in subjects with overweight/obesity and insulin resistance: effect of genistein

Rodríguez-López, L. A., Torre-Villalvazo, I., Alemán, G., Flores‐López, A., Guevara‐Cruz, M., Sánchez‐Tapia, M., Torre-Anaya, E. A., Martínez-López, V., Vásquez‐Reyes, S., Torres‐Villalobos, G., et al. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00921-3 · Cited by 12

A Correlation Study on In Vitro Physiological Activities of Soybean Cultivars, 19 Individual Isoflavone Derivatives, and Genetic Characteristics

Chu, H.-N., Lee, S., Wang, X., Lee, S.-H., Yoon, H., Hwang, Y.-J., Jung, E.-S., Kwon, Y., Wee, C.-D., Jang, K.-A., et al. (2021) · Antioxidants · doi:10.3390/antiox10122027 · Cited by 12

Integrated proteome and phosphoproteome analysis of interscapular brown adipose and subcutaneous white adipose tissues upon high fat diet feeding in mouse

Wang, Y., Li, J., Lu, D., Meng, Q., Song, N., Zhou, H., Xiao, X., Sun, L., & Zhu, H. (2022) · Journal of Proteomics · doi:10.1016/j.jprot.2022.104500 · Cited by 12

Brown Adipose Tissue: A Short Historical Perspective

Trayhurn, P. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2087-8_1 · Cited by 15

Tanshinone 1 prevents high fat diet-induced obesity through activation of brown adipocytes and induction of browning in white adipocytes

Jung, D. Y., Suh, N., & Jung, M. H. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120488 · Cited by 12

Formation of carotenoid supramolecular aggregates in nanocarriers monitored via aggregation-sensitive chiroptical output of enantiopure (3 S ,3′ S )-astaxanthin

Orlef, A., Stanek, E., Czamara, K., Wajda, A., & Kaczor, A. (2022) · Chemical Communications · doi:10.1039/d2cc02649j · Cited by 12

RAGE displays sex-specific differences in obesity-induced adipose tissue insulin resistance

Du, Z., Wu, J., Feng, Z., Ma, X., Zhang, T., Shu, X., Xu, J., Wang, L., Luo, M., & Wu, J. (2022) · Biology of Sex Differences · doi:10.1186/s13293-022-00476-6 · Cited by 12

Pharmacologic Management of Nonalcoholic Steatohepatitis.

Neuschwander‐Tetri, B. A. (2018) · Europe PMC (PubMed Central) · Cited by 13

Artemisinin derivatives inhibit adipogenic differentiation of 3T3-L1 preadipocytes through upregulation of CHOP

Zhang, G., Li, N., Tong, Y., Li, P., Han, H., Song, Q., Yang, B., & Cui, L. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.04.013 · Cited by 12

Ethanol extract from Moringa oleifera leaves modulates brown adipose tissue and bone morphogenetic protein 7 in high-fat diet mice

Syamsunarno, M. R. A. A., Alia, F., Anggraeni, N., Sumirat, V. A., Praptama, S., & Atik, N. (2021) · Veterinary World · doi:10.14202/vetworld.2021.1234-1240 · Cited by 12

Discovery and functional assessment of a novel adipocyte population driven by intracellular Wnt/β-catenin signaling in mammals

Zhi, L., Tian, C., Zhang, S., Yang, T., Gong, Y., Deng, H., Bai, D., Tian, W., & Chen, Y. (2022) · eLife · doi:10.7554/elife.77740 · Cited by 13

Brain-to-BAT - and Back?: Crosstalk between the Central Nervous System and Thermogenic Adipose Tissue in Development and Therapy of Obesity

Till, A., Fries, C., & Fenske, W. K. (2022) · Brain Sciences · doi:10.3390/brainsci12121646 · Cited by 12

βAR-mTOR-lipin1 pathway mediates PKA-RIIβ deficiency-induced adipose browning

Wang, B., Hu, Z., Cui, L., Zhao, M., Su, Z., Jiang, Y., Liu, J., Zhao, Y., Hou, Y., Yang, X., et al. (2024) · Theranostics · doi:10.7150/thno.97046 · Cited by 11

Molecular cloning, expression pattern analysis of porcine Rb1 gene and its regulatory roles during primary dedifferentiated fat cells adipogenic differentiation

Hu, X., Luo, P., Peng, X., Song, T., Zhou, Y., Wei, H., Peng, J., & Jiang, S. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2015.01.016 · Cited by 11

Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity

Voigt, A., Katterle, Y., Kahle, M., Kluge, R., Schürmann, A., Joost, H., & Klaus, S. (2015) · Genes & Nutrition · doi:10.1007/s12263-015-0507-x · Cited by 11

The administration of an extract from Berberis microphylla stimulates energy expenditure, thermogenesis and mitochondrial dynamics in mice brown adipose tissue

Ramirez, L., Quezada, J. U. C., Duarte-Silva, L., Concha, F., Escobillana, L., Rincón‐Cervera, M. Á., Pérez‐Bravo, F., Elorza, Á. A., Bravo, R., & García‐Díaz, D. F. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.100988 · Cited by 11

3-N-butylphthalide protects against high-fat-diet-induced obesity in C57BL/6 mice and increases metabolism in lipid-accumulating cells

Lu, K.-Y., Lin, S., Dass, K. T. P., Lin, W.-J., Liu, S., & Harn, H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111687 · Cited by 12

SNAP25 mutation disrupts metabolic homeostasis, steroid hormone production and central neurobehavior

Xiao, H., Zhu, B. D., Yang, P., Dong, D., Sahbaie, P., Oliver, P. L., Shen, W., Azhar, S., & Kraemer, F. B. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2021.166304 · Cited by 10

Possible Role of GnIH as a Novel Link between Hyperphagia-Induced Obesity-Related Metabolic Derangements and Hypogonadism in Male Mice

Luo, R., Chen, L., Song, X., Zhang, X., Xu, W., Han, D., Zuo, J., Hu, W., Shi, Y., Cao, Y., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158066 · Cited by 11

Identification of thermogenesis-related lncRNAs in small extracellular vesicles derived from adipose tissue

Hong, P., Wu, Y., Zhang, Q., Liu, P., Zhang, S., Yu, M., & Tian, W. (2022) · BMC Genomics · doi:10.1186/s12864-022-08883-0 · Cited by 12

The Different Shades of Thermogenic Adipose Tissue

Hu, Y., Huang, Y., Jiang, Y., Weng, L., Cai, Z., & He, B. (2024) · Current Obesity Reports · doi:10.1007/s13679-024-00559-y · Cited by 11

Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice

Kataoka, N., Takeuchi, T., Kusudo, T., Li, Y., Endo, Y., & Yamashita, H. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165762 · Cited by 12

Anti-obesity effect and mechanism of mesenchymal stem cells influence on obese mice

Xie, Z., Cheng, Y., Zhang, Q., Hao, H., Yin, Y., Zang, L., Wang, X., & Mu, Y. (2021) · Open Life Sciences · doi:10.1515/biol-2021-0061 · Cited by 12

The potential of brown adipogenesis and browning in porcine bone marrow-derived mesenchymal stem cells1

Chen, Y.-C., & Yu, Y. (2018) · Journal of Animal Science · doi:10.1093/jas/sky230 · Cited by 11

The biological actions of prostanoids in adipose tissue in physiological and pathophysiological conditions

Civelek, E., & Özen, G. (2022) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2022.102508 · Cited by 13

Guanidinoacetic acid ameliorates hepatic steatosis and inflammation and promotes white adipose tissue browning in middle-aged mice with high-fat-diet-induced obesity

Su, Y., Li, X., Jiamin, Z., Ji, B., Zhao, X., Feng, J., & Zhao, J. (2024) · Food & Function · doi:10.1039/d3fo05201j · Cited by 10

Evidence of Browning and Inflammation Features in Visceral Adipose Tissue of Women with Endometriosis

Abobeleira, J. P., Neto, A. C., Mauersberger, J., Salazar, M., Botelho, M. F., Fernandes, A. S., Martinho, M. S. L., Serrão, P., Rodrigues, A. R., Almeida, H., et al. (2024) · Archives of Medical Research · doi:10.1016/j.arcmed.2024.103064 · Cited by 10

Thermogenic adipose tissues: Promising therapeutic targets for metabolic diseases

Pahlavani, M., Pham, K., Kalupahana, N. S., Morovati, A., Ramalingam, L., Abidi, H., Kiridana, V., & Moustaïd‐Moussa, N. (2024) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2024.109832 · Cited by 12

NAD+/sirtuin metabolism is enhanced in response to cold‐induced changes in lipid metabolism in mouse liver

Wei, X., Jia, R., Yang, Z., Jiang, J., Huang, J., Yan, J., & Luo, X. M. (2020) · FEBS Letters · doi:10.1002/1873-3468.13779 · Cited by 10

Nutritional assessment among adult patients with suspected or confirmed active tuberculosis disease in rural India

Yu, E. A., Finkelstein, J. L., Brannon, P. M., Bonam, W., Russell, D. G., Glesby, M. J., & Mehta, S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0233306 · Cited by 12

Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling

van Krieken, P. P., Odermatt, T. S., Borsigova, M., Blüher, M., Wueest, S., & Konrad, D. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101341 · Cited by 10

Role of CD38 in Adipose Tissue: Tuning Coenzyme Availability?

Benzi, A., Grozio, A., Spinelli, S., Sturla, L., Guse, A. H., FLORA, A. D., Zocchi, E., Heeren, J., & Bruzzone, S. (2021) · Nutrients · doi:10.3390/nu13113734 · Cited by 10

Genistein Stimulation of White Adipose Tissue Thermogenesis Is Partially Dependent on GPR30 in Mice

Vásquez‐Reyes, S., Vargas‐Castillo, A., Noriega, L. G., Velázquez‐Villegas, L. A., Pérez, B., Sánchez‐Tapia, M., Ordáz, G., Suárez‐Monroy, R., Ulloa‐Aguirre, A., Offner, H., et al. (2022) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202100838 · Cited by 10

Brown adipocytes promote epithelial mesenchymal transition of neuroblastoma cells by inducing PPAR-γ/UCP2 expression

Ge, Z., Shang, Y., Wang, W., Yang, J., & Chen, S. (2022) · Adipocyte · doi:10.1080/21623945.2022.2073804 · Cited by 10

Regulation of beige adipocyte thermogenesis by the cold-repressed ER protein NNAT

Choi, K.-M., Ko, C. Y., An, S.-M., Cho, S., Rowland, D. J., Kim, J. H., Fasoli, A., Chaudhari, A. J., Bers, D. M., & Yoon, J. C. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101679 · Cited by 10

In vitro studies of the renin-angiotensin system in human adipose tissue/adipocytes and possible relationship to SARS-CoV-2: a scoping review

Ting, R., Dutton, H., & Sorisky, A. (2023) · Adipocyte · doi:10.1080/21623945.2023.2194034 · Cited by 10

Mulberry leaf flavonoids activate BAT and induce browning of WAT to improve type 2 diabetes via regulating the AMPK/SIRT1/PGC-1α signaling pathway

CHENG, L., Shi, L., He, C., Chen, W. A. N. G., Lv, Y., Li, H., An, Y., Duan, Y., Dai, H., Zhang, H., et al. (2023) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(23)60481-9 · Cited by 13

Brown and beige adipose tissue: New therapeutic targets for metabolic disorders

Magro, B. S., & Dias, D. P. M. (2024) · Health Sciences Review · doi:10.1016/j.hsr.2024.100148 · Cited by 34

Physiological regulation and metabolic role of browning in white adipose tissue

Janković, A., Otašević, V., Stančić, A., Buzadžić, B., Korać, A., & Korać, B. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0034 · Cited by 14

Metabolic regulation of brown adipose : a possible new therapeutic approach for metabolic diseases

Xiao, Z.-H. (2014) · Zhonghua neifenmi daixie zazhi · doi:10.3760/cma.j.issn.1000-6699.2014.10.001

Recent advance in brown adipose physiology and its therapeutic potential

Lee, Y., Jung, Y.-S., & Choi, D. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.163 · Cited by 56

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328