Adipose tissue browning and metabolic health

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., Rasbach, K. A., Boström, E. A., Choi, J. H., Long, J. Z., et al. (2012) · Nature · doi:10.1038/nature10777 · Cited by 4,810

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664

Identification and Importance of Brown Adipose Tissue in Adult Humans

Cypess, A. M., Lehman, S., Williams, G., Tal, I., Rodman, D., Goldfine, A. B., Kuo, F. C., Palmer, E. L., Tseng, Y.-H., Doria, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810780 · Cited by 4,399

Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α

Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975

A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

Puigserver, P., Wu, Z., Park, C. W., Graves, R., Wright, M., & Spiegelman, B. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81410-5 · Cited by 3,864

Cold-Activated Brown Adipose Tissue in Healthy Men

van Marken Lichtenbelt, W. D., Vanhommerig, J. W., Smulders, N. M., Drossaerts, J. M. A. F. L., Kemerink, G. J., Bouvy, N. D., Schrauwen, P., & Teule, G. J. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808718 · Cited by 3,452

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

Wu, J., Boström, P., Sparks, L. M., Li, Y., Choi, J. H., Giang, A.-H., Khandekar, M. J., Virtanen, K. A., Nuutila, P., Schaart, G., et al. (2012) · Cell · doi:10.1016/j.cell.2012.05.016 · Cited by 3,406

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

Cantó, C., Gerhart-Hines, Z., Feige, J. N., Lagouge, M., Noriega, L., Milne, J. C., Elliott, P. J., Puigserver, P., & Auwerx, J. (2009) · Nature · doi:10.1038/nature07813 · Cited by 3,300

Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue

Hoffmann, L. S., Etzrodt, J., Willkomm, L., Sanyal, A., Scheja, L., Fischer, A. W., Stasch, J., Bloch, W., Friebe, A., Heeren, J., et al. (2015) · Nature Communications · doi:10.1038/ncomms8235 · Cited by 103

Dual-Energy CT of the Heart

Vliegenthart, R., Pelgrim, G. J., Ebersberger, U., Rowe, G. W., Oudkerk, M., & Schoepf, U. J. (2012) · American Journal of Roentgenology · doi:10.2214/ajr.12.9208 · Cited by 104

Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation

Song, N.-J., Kim, S., Jang, B.-H., Chang, S., Yun, U. J., Park, K.-M., Waki, H., Li, D. Y., Tontonoz, P., & Park, K. W. (2016) · PLoS ONE · doi:10.1371/journal.pone.0162228 · Cited by 103

An update on brown adipose tissue and obesity intervention: Function, regulation and therapeutic implications

Liu, X., Zhang, Z., Song, Y., Xie, H., & Dong, M. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1065263 · Cited by 102

Eicosapentaenoic acid regulates brown adipose tissue metabolism in high-fat-fed mice and in clonal brown adipocytes

Pahlavani, M., Razafimanjato, F., Ramalingam, L., Kalupahana, N. S., Moussa, H. M., Scoggin, S. O., & Moustaïd‐Moussa, N. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.08.012 · Cited by 102

Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals

Zhu, Y., Gao, Y., Tao, C., Shao, M., Zhao, S., Huang, W., Yao, T., Johnson, J. A., Liu, T., Cypess, A. M., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.005 · Cited by 100

Activation of mTORC1 in skeletal muscle regulates whole-body metabolism through FGF21

Guridi, M., Tintignac, L. A. J., Lin, S., Kupr, B., Castets, P., & Rüegg, M. A. (2015) · Science Signaling · doi:10.1126/scisignal.aab3715 · Cited by 98

Taurine-mediated browning of white adipose tissue is involved in its anti-obesity effect in mice

Guo, Y., Li, B., Peng, W.-Q., Guo, L., & Tang, Q. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009936 · Cited by 103

Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis

Zhang, L., Li, F., Guo, Q., Duan, Y., Wang, W., Zhong, Y., Yang, Y., & Yin, Y. (2020) · Nutrients · doi:10.3390/nu12051299 · Cited by 100

MCT1 and MCT4 Expression and Lactate Flux Activity Increase During White and Brown Adipogenesis and Impact Adipocyte Metabolism

Petersen, C., Nielsen, M. D., Andersen, E. S., Basse, A. L., Isidor, M. S., Markussen, L. K., Viuff, B. M., Lambert, I. H., Hansen, J. B., & Pedersen, S. F. (2017) · Scientific Reports · doi:10.1038/s41598-017-13298-z · Cited by 102

Actomyosin-Mediated Tension Orchestrates Uncoupled Respiration in Adipose Tissues

Tharp, K. M., Kang, M. S., Timblin, G. A., Dempersmier, J. M., Dempsey, G., Zushin, P. H., Benavides, J., Choi, C., Li, C. X., Jha, A. K., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.005 · Cited by 104

Adipose morphology and metabolic disease

Tandon, P., Wafer, R., & Minchin, J. E. N. (2018) · Journal of Experimental Biology · doi:10.1242/jeb.164970 · Cited by 106

Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function

Oliverio, M., Schmidt, E., Mauer, J., Baitzel, C., Hansmeier, N., Khani, S., Konieczka, S., Pradas-Juni, M., Brodesser, S., Van, T.-M., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3316 · Cited by 94

Integrated stress response stimulates FGF21 expression: Systemic enhancer of longevity

Salminen, A., Kaarniranta, K., & Kauppinen, A. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.08.009 · Cited by 100

Role of Cannabinoids in Obesity

Rossi, F., Punzo, F., Umano, G. R., Argenziano, M., & del Giudice, E. M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092690 · Cited by 98

Fucoxanthin and lipid metabolism: A minireview

Muradian, K. K., Vaiserman, A. M., Min, K., & Fraifeld, V. E. (2015) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2015.05.010 · Cited by 96

Cold and Exercise: Therapeutic Tools to Activate Brown Adipose Tissue and Combat Obesity

da Silva, C. P. V., Hernández‐Saavedra, D., White, J. D., & Stanford, K. (2019) · Biology · doi:10.3390/biology8010009 · Cited by 102

Resveratrol enhances brown adipose tissue activity and white adipose tissue browning in part by regulating bile acid metabolism via gut microbiota remodeling

Hui, S., Liu, Y., Huang, L., Zheng, L., Zhou, M., Lang, H., Wang, X., Yi, L., & Mi, M. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0566-y · Cited by 97

Deletion of Nampt in Projection Neurons of Adult Mice Leads to Motor Dysfunction, Neurodegeneration, and Death

Wang, X., Zhang, Q., Bao, R., Zhang, N., Wang, Y., Polo‐Parada, L., Tarim, A. O., Alemifar, A., Han, X., Wilkins, H., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.022 · Cited by 93

Role of adipose tissue in methionine–choline-deficient model of non-alcoholic steatohepatitis (NASH)

Jha, P., Knopf, A., Köfeler, H. C., Mueller, M., Lackner, C., Höefler, G., Claudel, T., & Trauner, M. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.02.012 · Cited by 99

Regulatory microRNAs in Brown, Brite and White Adipose Tissue

Gharanei, S., Shabir, K., Brown, J. E. P., Weickert, M. O., Barber, T. M., Kyrou, I., & Randeva, H. S. (2020) · Cells · doi:10.3390/cells9112489 · Cited by 100

Interactions between central nervous system and peripheral metabolic organs

Zeng, W., Yang, F., Shen, W. L., Zhan, C., Zheng, P., & Hu, J. (2022) · Science China Life Sciences · doi:10.1007/s11427-021-2103-5 · Cited by 103

Leucine in Obesity: Therapeutic Prospects

Yao, K., Duan, Y., Li, F., Tan, B., Hou, Y., Wu, G., & Yin, Y. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.004 · Cited by 90

Obesity: pathophysiology and therapeutic interventions

Kong, Y., Yang, H., Nie, R., Zhang, X., Zuo, F., Zhang, H., & Nian, X. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00264-9 · Cited by 89

Monoacylglycerol signalling and ABHD6 in health and disease

Poursharifi, P., Madiraju, S. R. M., & Prentki, M. (2017) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13008 · Cited by 96

The Impact of the Adipose Organ Plasticity on Inflammation and Cancer Progression

Corrêa, L. H., Cardoso, G. S. H. R., & Magalhães, K. G. (2019) · Cells · doi:10.3390/cells8070662 · Cited by 98

The role of stress kinases in metabolic disease

Nikolić, I., Leiva, M., & Sabio, G. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00418-5 · Cited by 92

Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue

Wankhade, U. D., Shen, M., Yadav, H., & Thakali, K. M. (2016) · BioMed Research International · doi:10.1155/2016/2365609 · Cited by 91

Adipose tissue lipolysis and energy metabolism in early cancer cachexia in mice

Kliewer, K., Ke, J., Tian, M., Cole, R. M., Andridge, R., & Belury, M. A. (2014) · Cancer Biology & Therapy · doi:10.4161/15384047.2014.987075 · Cited by 87

Ageing is associated with brown adipose tissue remodelling and loss of white fat browning in female C57 BL /6 mice

Gonçalves, L. F., Machado, T. Q., Castro‐Pinheiro, C., de Souza, N. G., Oliveira, K. J., & Fernandes‐Santos, C. (2017) · International Journal of Experimental Pathology · doi:10.1111/iep.12228 · Cited by 88

Maize extract rich in ferulic acid and anthocyanins prevents high-fat-induced obesity in mice by modulating SIRT1, AMPK and IL-6 associated metabolic and inflammatory pathways

Luna‐Vital, D. A., Luzardo‐Ocampo, I., Cuéllar-Núñez, M. L., Loarca-Piña, G. F., & de Mejía, E. G. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108343 · Cited by 90

Leucine and isoleucine have similar effects on reducing lipid accumulation, improving insulin sensitivity and increasing the browning of WAT in high-fat diet-induced obese mice

Ma, Q., Zhou, X., Hu, L., Chen, J., Zhu, J., & Shan, A. (2020) · Food & Function · doi:10.1039/c9fo03084k · Cited by 86

Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content

Zhao, Y., Pilvar, A., Tank, A., Peterson, H. M., Jiang, J., Aster, J. C., Dumas, J. P., Pierce, M. C., & Roblyer, D. M. (2020) · Nature Communications · doi:10.1038/s41467-020-19128-7 · Cited by 86

The pesticide chlorpyrifos promotes obesity by inhibiting diet-induced thermogenesis in brown adipose tissue

Wang, B., Tsakiridis, E. E., Zhang, S., Llanos, A., Desjardins, E. M., Yabut, J. M., Green, A. E., Day, E. A., Smith, B. K., Lally, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25384-y · Cited by 86

Retinoic acid induces white adipose tissue browning by increasing adipose vascularity and inducing beige adipogenesis of PDGFRα+ adipose progenitors

Wang, B., Fu, X., Liang, X., de Avila, J. M., Wang, Z., Zhao, L., Tian, Q., Zhao, J., Gomez, N. A., Trombetta, S. C., et al. (2017) · Cell Discovery · doi:10.1038/celldisc.2017.36 · Cited by 86

Eicosapentaenoic acid promotes mitochondrial biogenesis and beige-like features in subcutaneous adipocytes from overweight subjects

Laiglesia, L. M., Lorente-Cebrián, S., Prieto-Hontoria, P. L., Fernández-Galilea, M., Ribeiro, S. M. R., Sáinz, N., Martínez, J. A., & Moreno-Aliaga, M. J. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.07.019 · Cited by 85

Supraclavicular Skin Temperature as a Measure of 18F-FDG Uptake by BAT in Human Subjects

Boon, M. R., Bakker, L. E. H., van der Linden, R. A. D., Arias‐Bouda, L. M. P., Smit, F., Verberne, H. J., Lichtenbelt, W. D. V. M., Jazet, I. M., & Rensen, P. C. N. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098822 · Cited by 89

Molecular insights of exercise therapy in disease prevention and treatment

Walzik, D., Chirino, T. Y. W., Zimmer, P., & Joisten, N. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01841-0 · Cited by 95

α/β-Hydrolase Domain 6 Deletion Induces Adipose Browning and Prevents Obesity and Type 2 Diabetes

Zhao, S., Mugabo, Y., Ballentine, G., Attané, C., Iglesias, J., Poursharifi, P., Zhang, D., Nguyen, T. A., Erb, H., Prentki, R. J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.076 · Cited by 85

Parabrachial neuron types categorically encode thermoregulation variables during heat defense

Yang, W. Z., Du, X., Zhang, W., Gao, C., Xie, H., Xiao, Y., Jia, X., Liu, J., Xu, J., Fu, X., et al. (2020) · Science Advances · doi:10.1126/sciadv.abb9414 · Cited by 87

Timing of energy intake and the therapeutic potential of intermittent fasting and time-restricted eating in NAFLD

Marjot, T., Tomlinson, J., Hodson, L., & Ray, D. W. (2023) · Gut · doi:10.1136/gutjnl-2023-329998 · Cited by 91

Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice

Pierre, J. F., Martinez, K., Ye, H., Nadimpalli, A., Morton, T. C., Yang, J., Wang, Q., Patno, N., Chang, E. B., & Yin, D. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00202.2016 · Cited by 83

m6A methylation promotes white-to-beige fat transition by facilitating Hif1a translation

Wu, R., Chen, Y., Liu, Y., Zhuang, L., Chen, W., Zeng, B., Liao, X., Guo, G., Wang, Y., & Wang, X. (2021) · EMBO Reports · doi:10.15252/embr.202052348 · Cited by 82

SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression

Villanueva-Carmona, T., Cedó, L., Madeira, A., Ceperuelo‐Mallafré, V., Rodríguez‐Peña, M., Núñez‐Roa, C., Maymó‐Masip, E., Repollés-de-Dalmau, M., Badia, J., Keiran, N., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.03.004 · Cited by 84

Mitochondrial uncoupling and longevity – A role for mitokines?

Klaus, S., & Ost, M. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110796 · Cited by 80

Regulation of Adaptive Thermogenesis and Browning by Prebiotics and Postbiotics

Reynés, B., Palou, M., Rodríguez, A. M., & Palou, A. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01908 · Cited by 83

Bone marrow adipose tissue: formation, function and regulation

Suchacki, K. J., Cawthorn, W. P., & Rosen, C. J. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.03.001 · Cited by 84

The significance of beige and brown fat in humans

Kiefer, F. W. (2017) · Endocrine Connections · doi:10.1530/ec-17-0037 · Cited by 82

Transdermal Photothermal-Pharmacotherapy to Remodel Adipose Tissue for Obesity and Metabolic Disorders

Zan, P., Than, A., Zhang, W., Cai, H. X., Zhao, W., & Chen, P. (2022) · ACS Nano · doi:10.1021/acsnano.1c06410 · Cited by 79

Increased Energy Expenditure, Ucp1 Expression, and Resistance to Diet-induced Obesity in Mice Lacking Nuclear Factor-Erythroid-2-related Transcription Factor-2 (Nrf2)

Schneider, K., Valdez, J. L., Nguyen, J. M., Vawter, M. P., Galke, B. L., Kurtz, T. W., & Chan, J. Y. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.673756 · Cited by 83

BMP4 Gene Therapy in Mature Mice Reduces BAT Activation but Protects from Obesity by Browning Subcutaneous Adipose Tissue

Hoffmann, J. M., Grünberg, J. R., CHURCH, C. D., Elias, I., Pálsdóttir, V., Jansson, J., Bosch, F., Hammarstedt, A., Hedjazifar, S., & Smith, U. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.020 · Cited by 80

Mitochondrial oxidative stress in obesity: role of the mineralocorticoid receptor

Lefranc, C., Friederich‐Persson, M., Palacios, R., & Cat, A. N. D. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0163 · Cited by 80

Stilbenes in grape berries and wine and their potential role as anti-obesity agents: A review

Benbouguerra, N., Ortega, R. H., Garcia, F., Khawand, T. E., Saucier, C., & Richard, T. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.03.060 · Cited by 90

Dissociation of Adaptive Thermogenesis from Glucose Homeostasis in Microbiome-Deficient Mice

Krisko, T. I., Nicholls, H. T., Bare, C. J., Holman, C. D., Putzel, G., Jansen, R. S., Sun, N. Z., Rhee, K. Y., Banks, A. S., & Cohen, D. E. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.012 · Cited by 78

Exercise-Induced Adaptations to Adipose Tissue Thermogenesis

Vidal, P., & Stanford, K. I. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00270 · Cited by 84

Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles

Cheng, Y., Li, J., Keipert, S., Zhang, S., Hauser, A., Graf, E., Strom, T. M., Tschöp, M. H., Jastroch, M., & Perocchi, F. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.05.021 · Cited by 73

Walnut green husk polysaccharides prevent obesity, chronic inflammatory responses, nonalcoholic fatty liver disease and colonic tissue damage in high-fat diet fed rats

Wang, G., Yang, X., Wang, J., Zhong, D., Zhang, R., Zhang, Y., Feng, L., & Zhang, Y. (2021) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2021.04.047 · Cited by 76

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

Ost, M., Coleman, V., Voigt, A., van Schothorst, E. M., Keipert, S., van der Stelt, I., Ringel, S., Graja, A., Ambrosi, T., Kipp, A. P., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2015.11.002 · Cited by 75

Role of histone acetyltransferases and histone deacetylases in adipocyte differentiation and adipogenesis

Zhou, Y., Peng, J., & Jiang, S. (2014) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2014.03.001 · Cited by 74

Adipokines influence the inflammatory balance in autoimmunity

Hutcheson, J. (2015) · Cytokine · doi:10.1016/j.cyto.2015.04.004 · Cited by 78

The intersection of nonalcoholic fatty liver disease and obesity

Baidal, J. W., & Lavine, J. E. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad8390 · Cited by 75

Target acquired: Selective autophagy in cardiometabolic disease

Evans, T. D., Sergin, I., Zhang, X., & Razani, B. (2017) · Science Signaling · doi:10.1126/scisignal.aag2298 · Cited by 74

TFEB drives PGC-1α expression in adipocytes to protect against diet-induced metabolic dysfunction

Evans, T. D., Zhang, X., Jeong, S., He, A., Song, E., Bhattacharya, S., Holloway, K. B., Lodhi, I. J., & Razani, B. (2019) · Science Signaling · doi:10.1126/scisignal.aau2281 · Cited by 76

Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool

Babu, A. F., Csader, S., Männistö, V., Tauriainen, M., Pentikäinen, H., Savonen, K. P., Klåvus, A., Koistinen, V., Hanhineva, K., & Schwab, U. (2022) · Scientific Reports · doi:10.1038/s41598-022-10481-9 · Cited by 83

Food Ingredients Involved in White-to-Brown Adipose Tissue Conversion and in Calorie Burning

Hadi, H. E., Vincenzo, A. D., Vettor, R., & Rossato, M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2018.01954 · Cited by 74

Relationship of the Phytochemicals from Coffee and Cocoa By-Products with their Potential to Modulate Biomarkers of Metabolic Syndrome In Vitro

Rebollo‐Hernanz, M., Zhang, Q., Aguilera, Y., Martin-Cabrejas, M. A., & de Mejı́a, E. G. (2019) · Antioxidants · doi:10.3390/antiox8080279 · Cited by 78

Two Faces of White Adipose Tissue with Heterogeneous Adipogenic Progenitors

Hwang, I., & Kim, J. B. (2019) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0174 · Cited by 72

Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTPβ/ζ Axis: Relevance in Therapeutic Development

Herradón, G., Ramos, P., & Gramage, E. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00377 · Cited by 73

Feeding-induced hepatokine, Manf, ameliorates diet-induced obesity by promoting adipose browning via p38 MAPK pathway

Wu, T., Liu, Q., Li, Y., Li, H., Chen, L., Yang, X., Tang, Q., Pu, S., Kuang, J., Li, R., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20201203 · Cited by 72

Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research

Renner, S., Dobenecker, B., Blutke, A., Zöls, S., Wanke, R., Ritzmann, M., & Wolf, E. (2016) · Theriogenology · doi:10.1016/j.theriogenology.2016.04.055 · Cited by 75

Vanillic acid activates thermogenesis in brown and white adipose tissue

Han, X., Guo, J., You, Y., Yin, M., Liang, J. B., Ren, C., Zhan, J., & Huang, W. (2018) · Food & Function · doi:10.1039/c8fo00978c · Cited by 70

Sesamol ameliorates diet‐induced obesity in C57BL/6J mice and suppresses adipogenesis in 3T3‐L1 cells via regulating mitochondria‐lipid metabolism

Liu, Z., Qiao, Q., Sun, Y., Chen, Y., Ren, B., & Liu, X. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600717 · Cited by 71

The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPARγ activity

Nie, T., Zhao, S., Mao, L., Yang, Y., Sun, W., Lin, X., Liu, S., Li, K., Sun, Y., Li, P., et al. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14139 · Cited by 69

The role of adipose tissue in fatty liver diseases

Parker, R. (2018) · Liver Research · doi:10.1016/j.livres.2018.02.002 · Cited by 75

IL-6 Signal From the Bone Marrow is Required for the Browning of White Adipose Tissue Post Burn Injury

Abdullahi, A., Chen, P., Stanojcic, M., Sadri, A.-R., Coburn, N. G., & Jeschke, M. G. (2016) · Shock · doi:10.1097/shk.0000000000000749 · Cited by 69

PRDM16 Regulating Adipocyte Transformation and Thermogenesis: A Promising Therapeutic Target for Obesity and Diabetes

Jiang, N., Yang, M., Han, Y., Zhao, H., & Sun, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.870250 · Cited by 68

Myostatin signals through miR-34a to regulate Fndc5 expression and browning of white adipocytes

Ge, X., Sathiakumar, D., Lua, B.-N., Kukreti, H., Lee, M., & McFarlane, C. (2016) · International Journal of Obesity · doi:10.1038/ijo.2016.110 · Cited by 67

Restricting glycolysis impairs brown adipocyte glucose and oxygen consumption

Winther, S., Isidor, M. S., Basse, A. L., Skjoldborg, N. B., Cheung, A., Quistorff, B., & Hansen, J. B. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00218.2017 · Cited by 68

A Lipophilic Fucoxanthin-Rich Phaeodactylum tricornutum Extract Ameliorates Effects of Diet-Induced Obesity in C57BL/6J Mice

Gille, A., Stojnic, B., Derwenskus, F., Trautmann, A., Schmid‐Staiger, U., Posten, C. H., Briviba, K., Palou, A., Bonet, M. L., & Ribot, J. (2019) · Nutrients · doi:10.3390/nu11040796 · Cited by 70

Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

Fischer, A. W., Jaeckstein, M. Y., Gottschling, K., Heine, M., Sass, F., Mangels, N., Schlein, C., Worthmann, A., Bruns†, O. T., Yuan, Y., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.001 · Cited by 70

Unlocking the Full Potential of SGLT2 Inhibitors: Expanding Applications beyond Glycemic Control

Youssef, M. E., Yahya, G., Popoviciu, M. S., Cavalu, S. D., Abdel-Dayem, M. A., & Saber, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076039 · Cited by 72

Angiotensin type 2 receptor activation promotes browning of white adipose tissue and brown adipogenesis

Than, A., Xu, S., Li, R., Leow, M. K., Sun, L., & Chen, P. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.22 · Cited by 69

Taming the Flames: Targeting White Adipose Tissue Browning in Hypermetabolic Conditions

Abdullahi, A., & Jeschke, M. G. (2017) · Endocrine Reviews · doi:10.1210/er.2017-00163 · Cited by 68

Irisin Exerts Inhibitory Effect on Adipogenesis Through Regulation of Wnt Signaling

Ma, E. B., Sahar, N.-E., Jeong, M., & Huh, J. Y. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.01085 · Cited by 69

Modulation of immunity by the secreted phospholipase A2 family

Murakami, M., Sato, H., & Taketomi, Y. (2023) · Immunological Reviews · doi:10.1111/imr.13205 · Cited by 66

Coordination Among Lipid Droplets, Peroxisomes, and Mitochondria Regulates Energy Expenditure Through the CIDE-ATGL-PPARα Pathway in Adipocytes

Zhou, L., Yu, M., Arshad, M., Wang, W., Lu, Y., Gong, J., Gu, Y., Li, P., & Xu, L. M. (2018) · Diabetes · doi:10.2337/db17-1452 · Cited by 65

Lactobacillus amylovorus KU4 ameliorates diet-induced obesity in mice by promoting adipose browning through PPARγ signaling

Park, S. S., Lee, Y., Kang, H., Yang, G., Hong, E. J., Lim, J. Y., Oh, S., & Kim, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-56817-w · Cited by 65

Proteomics analysis of adipose depots after intermittent fasting reveals visceral fat preservation mechanisms

Harney, D., Cielesh, M., Chu, R., Cooke, K. C., James, D. E., Stöckli, J., & Larance, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108804 · Cited by 68

Adipocyte IRE1α promotes PGC1α mRNA decay and restrains adaptive thermogenesis

Chen, Y., Wu, Z., Huang, S., Wang, X., He, S., Liu, L., Hu, Y., Chen, L., Chen, P., Liu, S., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00631-8 · Cited by 67

Endocannabinoid regulation in white and brown adipose tissue following thermogenic activation

Krott, L. M., Piscitelli, F., Heine, M., Borrino, S., Scheja, L., Silvestri, C., Heeren, J., & Marzo, V. D. (2016) · Journal of Lipid Research · doi:10.1194/jlr.m065227 · Cited by 71

Brown adipose tissue during puberty and with aging

Rogers, N. H. (2014) · Annals of Medicine · doi:10.3109/07853890.2014.914807 · Cited by 63

The multifaceted factor peroxisome proliferator-activated receptor γ (PPARγ) in metabolism, immunity, and cancer

Kim, J.-H., Song, J., & Park, K. W. (2015) · Archives of Pharmacal Research · doi:10.1007/s12272-015-0559-x · Cited by 63

Fisiopatología de la obesidad: Perspectiva actual

Carmona, W. S., Sánchez-Oliver, A. J., & González-Jurado, J. A. (2017) · Revista chilena de nutrición · doi:10.4067/s0717-75182017000300226 · Cited by 97

α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects

Fernández‐Galilea, M., Pérez‐Matute, P., Prieto-Hontoria, P. L., Houssier, M., Burrell, M. A., Langin, D., Martínez, J. A., & Moreno-Aliaga, M. J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.013 · Cited by 62

STAT3: The art of multi-tasking of metabolic and immune functions in obesity

Hu, W., Lv, J., Han, M., Yang, Z. P., Li, T. X., Jiang, S., & Yang, Y. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.04.002 · Cited by 64

Tumor Cell “Slimming” Regulates Tumor Progression through PLCL1/UCP1‐Mediated Lipid Browning

Xiong, Z., Xiao, W., Bao, L., Xiong, W., Xiao, H., Qü, Y., Yuan, C., Ruan, H., Cao, Q., Wang, K., et al. (2019) · Advanced Science · doi:10.1002/advs.201801862 · Cited by 62

Anthocyanin Bioactivity in Obesity and Diabetes: The Essential Role of Glucose Transporters in the Gut and Periphery

Solverson, P. M. (2020) · Cells · doi:10.3390/cells9112515 · Cited by 64

The evolving view of thermogenic fat and its implications in cancer and metabolic diseases

Yin, X., Chen, Y., Ruze, R., Xu, R., Song, J., Wang, C., & Xu, Q. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01178-6 · Cited by 72

The phospholipase A2 superfamily as a central hub of bioactive lipids and beyond

Murakami, M. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108382 · Cited by 66

Cardiotrophin-1: A multifaceted cytokine

Lópeź‐Yoldi, M., Moreno-Aliaga, M. J., & Bustos, M. (2015) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2015.07.009 · Cited by 63

Brown and beige adipose tissue: New therapeutic targets for metabolic disorders

Magro, B. S., & Dias, D. P. M. (2024) · Health Sciences Review · doi:10.1016/j.hsr.2024.100148 · Cited by 34

Physiological regulation and metabolic role of browning in white adipose tissue

Janković, A., Otašević, V., Stančić, A., Buzadžić, B., Korać, A., & Korać, B. (2017) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2017-0034 · Cited by 14

Metabolic regulation of brown adipose : a possible new therapeutic approach for metabolic diseases

Xiao, Z.-H. (2014) · Zhonghua neifenmi daixie zazhi · doi:10.3760/cma.j.issn.1000-6699.2014.10.001

Recent advance in brown adipose physiology and its therapeutic potential

Lee, Y., Jung, Y.-S., & Choi, D. (2014) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.163 · Cited by 56

Brown and beige fat: Development, function and therapeutic potential

Harms, M., & Seale, P. (2013) · Nature Medicine · doi:10.1038/nm.3361 · Cited by 2,328