Role of microRNAs in diabetes and its cardiovascular complications
Open accessAbstract
Diabetes is the most common metabolic disorder and is recognized as one of the most important health threats of our time. MicroRNAs (miRNAs) are a novel group of non-coding small RNAs that have been implicated in a variety of physiological processes, including glucose homeostasis. Recent research has suggested that miRNAs play a critical role in the pathogenesis of diabetes and its related cardiovascular complications. This review focuses on the aberrant expression of miRNAs in diabetes and examines their role in the pathogenesis of endothelial dysfunction, cardiovascular disease, and diabetic retinopathy. Furthermore, we discuss the potential role of miRNAs as blood biomarkers and examine the potential of therapeutic interventions targeting miRNAs in diabetes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
microRNAs may link the metabolic dysregulation seen in prediabetes with vascular dysfunction.
“microRNAs may also link the metabolic dysregulation seen in prediabetes with vascular dysfunction.”
From The Vasculature in Prediabetes (2018) · cites this paper as [135]
microRNAs can alter the expression of genes in insulin-producing and insulin-sensitive tissues, including the pancreas, liver, and vasculature.
“microRNAs can alter the expression of genes in insulin-producing and insulin-sensitive tissues, including the pancreas, liver, and vasculature.”
From The Vasculature in Prediabetes (2018) · cites this paper as [135]
Hyperglycemia increases the expression of several microRNAs found in the endothelium, including miR-320, miR-221, miR-503, and miR-125b.
“Hyperglycemia increases the expression of several microRNAs found in the endothelium, including miR-320, miR-221, miR-503, and miR-125b.”
From The Vasculature in Prediabetes (2018) · cites this paper as [135]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
3 retracted
RETRACTED: A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis
Valastyan, S., Reinhardt, F., Benaich, N., Calogrias, D., Szász, A. M., Wang, Z. C., Brock, J. E., Richardson, A. L., & Weinberg, R. A. (2009) · Cell · doi:10.1016/j.cell.2009.03.047 · Cited by 821 · see citing works
RetractedXiao, J., Luo, X., Lin, H., Zhang, Y., Lu, Y., Wang, N., Zhang, Y., Yang, B., & Wang, Z. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.c700015200 · Cited by 234 · see citing works
RetractedTogliatto, G., Trombetta, A., Dentelli, P., Rosso, A., & Brizzi, M. F. (2011) · Diabetologia · doi:10.1007/s00125-011-2125-5 · Cited by 64 · see citing works
RetractedThe C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481 · see citing works
Global estimates of the prevalence of diabetes for 2010 and 2030
Shaw, J. E., Sicree, R. A., & Zimmet, P. Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2009.10.007 · Cited by 7,216 · see citing works
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 5,910 · see citing works
The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets
Gerold, G., & Pietschmann, T. (2014) · Digestive Diseases · doi:10.1159/000360830 · Cited by 4,854 · see citing works
Prediction of Mammalian MicroRNA Targets
Lewis, B. P., Shih, I.-H., Jones-Rhoades, M. W., Bartel, D. P., & Burge, C. B. (2003) · Cell · doi:10.1016/s0092-8674(03)01018-3 · Cited by 4,333 · see citing works
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317 · see citing works
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949 · see citing works
John, B., Enright, A. J., Aravin, A., Tuschl, T., Sander, C., & Marks, D. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020363 · Cited by 3,796 · see citing works
Arroyo, J. D., Chevillet, J. R., Kroh, E. M., Ruf, I. K., Pritchard, C. C., Gibson, D. F., Mitchell, P. S., Bennett, C. F., Pogosova-Agadjanyan, E. L., Stirewalt, D. L., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1019055108 · Cited by 3,294 · see citing works
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation
Chen, J., Mandel, E. M., Thomson, J. M., Wu, Q., Callis, T. E., Hammond, S. M., Conlon, F. L., & Wang, D.-Z. (2005) · Nature Genetics · doi:10.1038/ng1725 · Cited by 2,763 · see citing works
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., & Remaley, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2210 · Cited by 2,741 · see citing works
Elective induction versus spontaneous labor after sonographic diagnosis of fetal macrosomia.
Combs, C. A., Singh, N. B., & Khoury, J. C. (1993) · PubMed · Cited by 2,462 · see citing works
Overweight, Obesity, and Mortality in a Large Prospective Cohort of Persons 50 to 71 Years Old
Adams, K. F., Schatzkin, A. G., Harris, T. B., Kipnis, V., Mouw, T., Ballard-Barbash, R. R., Hollenbeck, A. R., & Leitzmann, M. F. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa055643 · Cited by 2,115 · see citing works
A pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102 · see citing works
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082 · see citing works
MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
Ebert, M. S., Neilson, J. R., & Sharp, P. A. (2007) · Nature Methods · doi:10.1038/nmeth1079 · Cited by 1,845 · see citing works
The Endothelial-Specific MicroRNA miR-126 Governs Vascular Integrity and Angiogenesis
Wang, S., Aurora, A. B., Johnson, B. A., Qi, X., McAnally, J., Hill, J. A., Richardson, J. A., Bassel‐Duby, R., & Olson, E. N. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.002 · Cited by 1,825 · see citing works
MicroRNA-133 controls cardiac hypertrophy
Carè, A., Catalucci, D., Felicetti, F., Bonci, D., Addario, A., Gallo, P., Bang, M., Segnalini, P., Gu, Y., Dalton, N. D., et al. (2007) · Nature Medicine · doi:10.1038/nm1582 · Cited by 1,775 · see citing works
miR-126 Regulates Angiogenic Signaling and Vascular Integrity
Fish, J. E., Santoro, M. M., Morton, S. U., Yu, S., Yeh, R.-F., Wythe, J. D., Ivey, K. N., Bruneau, B. G., Stainier, D. Y. R., & Srivastava, D. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.07.008 · Cited by 1,728 · see citing works
Therapeutic microRNA Delivery Suppresses Tumorigenesis in a Murine Liver Cancer Model
Kota, J., Chivukula, R. R., O’Donnell, K. A., Wentzel, E. A., Montgomery, C. L., Hwang, H., Chang, T.-C., Vivekanandan, P., Torbenson, M. S., Clark, K. R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.04.021 · Cited by 1,711 · see citing works
Jia, Q.-W., Chen, Z.-H., Ding, X.-Q., Liu, J.-Y., Ge, P.-C., An, F.-H., Li, L.-H., Wang, L.-S., Ma, W.-Z., Yang, Z.-J., et al. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000478071 · Cited by 1,693 · see citing works
Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection
Lanford, R. E., Hildebrandt-Eriksen, E. S., Petri, A., Persson, R., Lindow, M., Munk, M. E., Kauppinen, S., & Ørum, H. (2009) · Science · doi:10.1126/science.1178178 · Cited by 1,654 · see citing works
The Wisconsin Epidemiologic Study of Diabetic Retinopathy
Klein, R. (1984) · Archives of Ophthalmology · doi:10.1001/archopht.1984.01040030405011 · Cited by 1,482 · see citing works
Plasma MicroRNA Profiling Reveals Loss of Endothelial MiR-126 and Other MicroRNAs in Type 2 Diabetes
Zampetaki, A., Kiechl, S. J., Drozdov, I. A., Willeit, P., Mayr, U., Prokopi, M., Mayr, A., Weger, S., Oberhollenzer, F., Bonora, E., et al. (2010) · Circulation Research · doi:10.1161/circresaha.110.226357 · Cited by 1,457 · see citing works
Detection of microRNA Expression in Human Peripheral Blood Microvesicles
Hunter, M. P., Ismail, N., Zhang, X., Aguda, B. D., Lee, E. J., Yu, L., Xiao, T., Schafer, J., Lee, M. T., Schmittgen, T. D., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003694 · Cited by 1,453 · see citing works
Serum MicroRNAs Are Promising Novel Biomarkers
Gilad, S., Meiri, E., Yogev, Y., Benjamin, S., Lebanony, D., Yerushalmi, N., Benjamin, H., Kushnir, M., Cholakh, H., Melamed, N., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003148 · Cited by 1,349 · see citing works
Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection
Zernecke, A., Bidzhekov, K., Noels, H., Shagdarsuren, E., Gan, L., Denecke, B., Hristov, M., Koeppel, T. A., Nazari-Jahantigh, M., Lutgens, E., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000610 · Cited by 1,335 · see citing works
The Wisconsin Epidemiologic Study of Diabetic Retinopathy
Klein, R., Klein, R., Moss, S. E., Davis, M. D., & DeMets, D. L. (1987) · Ophthalmology · doi:10.1016/s0161-6420(87)33525-0 · Cited by 1,247 · see citing works
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,206 · see citing works
Susztak, K., Raff, A. C., Schiffer, M., & Böttinger, E. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-0894 · Cited by 1,125 · see citing works
Role of Mitochondrial Dysfunction in Insulin Resistance
Kim, J.-A., Wei, Y., & Sowers, J. R. (2008) · Circulation Research · doi:10.1161/circresaha.107.165472 · Cited by 1,103 · see citing works
MicroRNA-143 Regulates Adipocyte Differentiation
Esau, C., Kang, X., Peralta, E. R., Hanson, E. M., Marcusson, E. G., Ravichandran, L. V., Sun, Y., Koo, S., Perera, R. J., Jain, R., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.c400438200 · Cited by 1,017 · see citing works
The Drosophila MicroRNA Mir-14 Suppresses Cell Death and Is Required for Normal Fat Metabolism
Xu, P., Vernooy, S. Y., Guo, M., & Hay, B. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00250-1 · Cited by 1,006 · see citing works
Sheedy, F. J., Palsson-McDermott, E., Hennessy, E. J., Martin, C., O'Leary, J. J., Ruan, Q., Johnson, D. S., Chen, Y., & O'Neill, L. A. J. (2010) · Nature Immunology · doi:10.1038/ni.1828 · Cited by 1,005 · see citing works
MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
Najafi-Shoushtari, S. H., Kristo, F., Li, Y., Shioda, T., Cohen, D. E., Gerszten, R. E., & Näär, A. M. (2010) · Science · doi:10.1126/science.1189123 · Cited by 957 · cited 1× · see citing works
“miR-33a and miR-33b have been shown to regulate cholesterol homeostasis through interaction with sterol regulatory elementbinding proteins.(48) Davalos et al.”
BackgroundChang, J., Nicolas, É., Marks, D. S., Sander, C., Lerro, A., Buendia, M. A., Xu, C., Mason, W. S., Moloshok, T. D., Bort, R., et al. (2004) · RNA Biology · doi:10.4161/rna.1.2.1066 · Cited by 809 · see citing works
Blüher, M., Michael, M. D., Peroni, O. D., Ueki, K., Carter, N., Kahn, B. B., & Kahn, C. R. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00199-5 · Cited by 806 · see citing works
MicroRNAs modulate the angiogenic properties of HUVECs
Poliseno, L., Tuccoli, A., Mariani, L., Evangelista, M., Citti, L., Woods, K., Mercatanti, A., Hammond, S. M., & Rainaldi, G. (2006) · Blood · doi:10.1182/blood-2006-01-012369 · Cited by 754 · see citing works
<i>miR-375</i> maintains normal pancreatic α- and β-cell mass
Poy, M. N., Hausser, J., Trajkovski, M., Braun, M., Collins, S., Rorsman, P., Zavolan, M., & Stoffel, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810550106 · Cited by 740 · see citing works
The Importance of -Cell Failure in the Development and Progression of Type 2 Diabetes
Kahn, S. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7713 · Cited by 694 · see citing works
miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling
Dávalos, A., Goedeke, L., Smibert, P., Ramírez, C. M., Warrier, N. P., Andreo, U., Cirera-Salinas, D., Rayner, K., Suresh, U., Pastor-Pareja, J. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102281108 · Cited by 670 · cited 3× · see citing works
“In any case, targeting miR-122 therapeutically may correct the imbalances seen in liver insulin resistance. miR-33a and miR-33b have been shown to regulate cholesterol homeostasis through interaction with sterol regulatory elementbinding proteins.48 Davalos et al.49 have recently reported the role of these two miRNAs…”
BackgroundInfluentialDifferential Roles of Vascular Endothelial Growth Factor Receptor-1 and Receptor-2 in Angiogenesis
Shibuya, M. (2006) · BMB Reports · doi:10.5483/bmbrep.2006.39.5.469 · Cited by 623 · see citing works
The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance
Goossens, G. H. (2008) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.10.010 · Cited by 591 · see citing works
Xie, H., Lim, B., & Lodish, H. F. (2009) · Diabetes · doi:10.2337/db08-1299 · Cited by 577 · see citing works
van Rooij, E. (2011) · Circulation Research · doi:10.1161/circresaha.110.227496 · Cited by 534 · see citing works
Kong, L., Zhu, J., Han, W., Jiang, X., Xu, M., Zhao, Y., Dong, Q., Pang, Z., Guan, Q., Gao, L., et al. (2010) · Acta Diabetologica · doi:10.1007/s00592-010-0226-0 · Cited by 529 · see citing works
Rescue of Diabetes-Related Impairment of Angiogenesis by Intramuscular Gene Therapy with Adeno-VEGF
Rivard, A., Silver, M., Chen, D., Kearney, M., Magner, M., Annex, B. H., Peters, K. G., & Isner, J. M. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65282-0 · Cited by 471 · see citing works
Endothelial Dysfunction in Diabetes
Avogaro, A., Albiero, M., Menegazzo, L., de Kreutzenberg, S., & Fadini, G. P. (2011) · Diabetes Care · doi:10.2337/dc11-s239 · Cited by 465 · see citing works
Ouaamari, A. E., Baroukh, N., Martens, G. A., Lebrun, P., PIPELEERS, D. G., & OBBERGHEN, E. V. (2008) · Diabetes · doi:10.2337/db07-1614 · Cited by 430 · see citing works
Villeneuve, L. M., Reddy, M. A., Lanting, L. L., Wang, M., Li, M., & Natarajan, R. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803623105 · Cited by 412 · see citing works
microRNA miR-27b impairs human adipocyte differentiation and targets PPARγ
Karbiener, M., Fischer, C., Nowitsch, S., Opriessnig, P., Papak, C., Ailhaud, G., Dani, C., Amri, E.-Z., & Scheideler, M. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.09.098 · Cited by 409 · see citing works
He, A., Zhu, L., Gupta, N., Chang, Y., & Fang, F. (2007) · Molecular Endocrinology · doi:10.1210/me.2007-0167 · Cited by 407 · see citing works
Caporali, A., Meloni, M., Völlenkle, C., Bonci, D., Sala-Newby, G. B., Addis, R., Spinetti, G., Losa, S., Masson, R., Baker, A. H., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.952325 · Cited by 397 · see citing works
Self-citationGlucose or diabetes activates p38 mitogen-activated protein kinase via different pathways
Igarashi, M., Wakasaki, H., Takahara, N., Ishii, H., Jiang, Z.-Y., Yamauchi, T., Kuboki, K., Meier, M., Rhodes, C. J., & King, G. L. (1999) · Journal of Clinical Investigation · doi:10.1172/jci3326 · Cited by 386 · see citing works
Lee, E. K., Lee, M., Abdelmohsen, K., Kim, W., Kim, M. M., Srikantan, S., Martindale, J. L., Hutchison, E. R., Kim, H. H., Marasa, B. S., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00894-10 · Cited by 360 · see citing works
Plaisance, V., Abderrahmani, A., Perret-Menoud, V., Jacquemin, P., Lemaigre, F., & Regazzi, R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601225200 · Cited by 350 · see citing works
Micro RNA 145 Targets the Insulin Receptor Substrate-1 and Inhibits the Growth of Colon Cancer Cells
Shi, B., Sepp‐Lorenzino, L., di Prisco, M., Linsley, P. S., DeAngelis, T., & Baserga, R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702806200 · Cited by 349 · see citing works
Alterations in MicroRNA Expression Contribute to Fatty Acid–Induced Pancreatic β-Cell Dysfunction
Lovis, P., Roggli, E., Laybutt, D. R., Gattesco, S., Yang, J.-Y., Widmann, C., Abderrahmani, A., & Regazzi, R. (2008) · Diabetes · doi:10.2337/db07-1252 · Cited by 346 · see citing works
Chan, C. B., De Leo, D., Joseph, J. W., McQuaid, T. S., Ha, X. F., Xu, F., Tsushima, R. G., Pennefather, P. S., Salapatek, A. M. F., & Wheeler, M. B. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1302 · Cited by 341 · see citing works
MicroRNA Expression in Human Omental and Subcutaneous Adipose Tissue
Klöting, N., Berthold, S., Kovacs, P. L., Schön, M. R., Faßhauer, M., Ruschke, K., Stümvoll, M., & Blüher, M. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004699 · Cited by 337 · see citing works
MicroRNA-223 regulates Glut4 expression and cardiomyocyte glucose metabolism
Han, L., Buchan, R. J., & Cook, S. A. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq010 · Cited by 332 · see citing works
Mcarthur, K., Feng, B., Wu, Y., Chen, S., & Chakrabarti, S. (2011) · Diabetes · doi:10.2337/db10-1557 · Cited by 329 · see citing works
MicroRNA-124a Regulates Foxa2 Expression and Intracellular Signaling in Pancreatic β-Cell Lines*
Baroukh, N., Ravier, M. A., Loder, M. K., Hill, E. V., Bounacer, A., Scharfmann, R., Rutter, G. A., & Van Obberghen, E. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611841200 · Cited by 326 · see citing works
Roggli, E., Britan, A., Gattesco, S., Lin-Marq, N., Abderrahmani, A., Meda, P., & Regazzi, R. (2010) · Diabetes · doi:10.2337/db09-0881 · Cited by 320 · see citing works
Diabetes mellitus, a microRNA-related disease?
Guay, C., Roggli, E., Nesca, V., Jacovetti, C., & Regazzi, R. (2011) · Translational Research: The Journal of Laboratory and Clinical Medicine · doi:10.1016/j.trsl.2011.01.009 · Cited by 313 · see citing works
Waltenberger, J. L. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00228-5 · Cited by 310 · see citing works
microRNAs in Early Diabetic Retinopathy in Streptozotocin-Induced Diabetic Rats
Kovacs, B., Lumayag, S., Cowan, C. E., & Xu, S. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-6879 · Cited by 293 · see citing works
Gallagher, I. J., Schéele, C., Keller, P., Nielsen, A. R., Reményi, J., Fischer, C. P., Roder, K., Babraj, J., Wahlestedt, C., Hutvágner, G., et al. (2010) · Genome Medicine · doi:10.1186/gm130 · Cited by 291 · see citing works
Kowluru, R. A., Koppolu, P., Chakrabarti, S., & Chen, S. (2003) · Free Radical Research · doi:10.1080/10715760310001604189 · Cited by 289 · see citing works
Herrera, B. M., Lockstone, H. E., Taylor, J. M., Ria, M., Barrett, A., Collins, S. C., Kaisaki, P. J., Argoud, K., Fernández, C., Travers, M. E., et al. (2010) · Diabetologia · doi:10.1007/s00125-010-1667-2 · Cited by 287 · see citing works
Yoon, Y., Uchida, S., Masuo, O., Cejna, M., Park, J., Gwon, H., Kirchmair, R., Bahlman, F., Walter, D. H., Curry, C., et al. (2005) · Circulation · doi:10.1161/01.cir.0000162472.52990.36 · Cited by 287 · see citing works
Tang, X., Muniappan, L., Tang, G., & Özcan, S. (2008) · RNA · doi:10.1261/rna.1211209 · Cited by 277 · see citing works
Wilfred, B. R., Wang, W.-X., & Nelson, P. T. (2007) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2007.03.011 · Cited by 276 · see citing works
Wang, X., Qian, R., Zhang, W., Chen, S., Jin, H., & Hu, R. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.05057.x · Cited by 271 · see citing works
Lovis, P., Gattesco, S., & Regazzi, R. (2008) · bchm · doi:10.1515/bc.2008.026 · Cited by 257 · see citing works
Gatto, G., Rossi, A., Rossi, D. P., Kroening, S., Bonatti, S., & Mallardo, M. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn666 · Cited by 254 · see citing works
Waltenberger, J. L., Lange, J., & Kranz, A. (2000) · Circulation · doi:10.1161/01.cir.102.2.185 · Cited by 253 · see citing works
Drosophila lacking microRNA miR-278 are defective in energy homeostasisPreprint
Teleman, A. A., & Cohen, S. M. (2006) · Genes & Development · doi:10.1101/gad.374406 · Cited by 238 · see citing works
Shan, Y. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/s0022-2828(03)00229-3 · Cited by 235 · see citing works
Responses of GLUT4-Deficient Hearts to Ischemia Underscore the Importance of Glycolysis
Tian, R., & Abel, E. D. (2001) · Circulation · doi:10.1161/01.cir.103.24.2961 · Cited by 233 · see citing works
Winer, N., & Sowers, J. R. (2004) · The Journal of Clinical Pharmacology · doi:10.1177/0091270004263017 · Cited by 224 · see citing works
CHANGES IN microRNA (miR) PROFILE AND EFFECTS OF miR‐320 IN INSULIN‐RESISTANT 3T3‐L1 ADIPOCYTES
Ling, H., Ou, H., Feng, S., Zhang, X., Tuo, Q., Chen, L., Zhu, B., Gao, Z., Tang, C., Yin, W., et al. (2009) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2009.05207.x · Cited by 217 · see citing works
miR133a regulates cardiomyocyte hypertrophy in diabetes
Feng, B., Chen, S., George, B., Feng, Q., & Chakrabarti, S. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.1054 · Cited by 210 · see citing works
MicroRNAs as mediators and therapeutic targets in chronic kidney disease
Lorenzen, J. M., Haller, H. G., & Thum, T. (2011) · Nature Reviews Nephrology · doi:10.1038/nrneph.2011.26 · Cited by 198 · see citing works
Esguerra, J. L. S., Bolmeson, C., Cilio, C., & Eliasson, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018613 · Cited by 186 · see citing works
Horie, T., Ono, K., Nishi, H., Iwanaga, Y., Nagao, K., Kinoshita, M., Kuwabara, Y., Takanabe, R., Hasegawa, K., Kita, T., et al. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.08.136 · Cited by 186 · see citing works
Villeneuve, L. M., Kato, M., Reddy, M. A., Wang, M., Lanting, L., & Natarajan, R. (2010) · Diabetes · doi:10.2337/db10-0208 · Cited by 186 · see citing works
Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1
Yu, X.-Y., Song, Y.-H., Geng, Y., Lin, Q.-X., Shan, Z., Shu-guang, L., & Li, Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.09.025 · Cited by 177 · see citing works
Prolonged QTc interval predicts mortality in patients with Type 1 diabetes mellitus
Rossing, P. R., Breum, L., Major‐Pedersen, A., et al. (2001) · Diabetic Medicine · doi:10.1046/j.1464-5491.2001.00446.x · Cited by 172 · see citing works
MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression
Sun, L., Jiang, B., Li, W., Zou, J., Shi, Y., & Liu, Z. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.11.006 · Cited by 164 · see citing works
White, M. F. (2006) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y06-008 · Cited by 163 · see citing works
microRNA-221 regulates high glucose-induced endothelial dysfunction
Li, Y., Song, Y.-H., Li, F., Yang, T., Lu, Y. W., & Geng, Y.-J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.02.013 · Cited by 158 · see citing works
Ryu, H. S., Park, S., Ma, D., Zhang, J., & Lee, W. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017343 · Cited by 146 · see citing works
Katare, R., Caporali, A., Zentilin, L., Avolio, E., Sala‐Newby, G. B., Oikawa, A., Cesselli, D., Beltrami, A. P., Giacca, M., Emanueli, C., et al. (2011) · Circulation Research · doi:10.1161/circresaha.110.239111 · Cited by 130 · see citing works
Self-citationNuclear Factor-κB Activity in β-Cells Is Required for Glucose-Stimulated Insulin Secretion
Norlin, S., Ahlgren, U., & Edlund, H. (2005) · Diabetes · doi:10.2337/diabetes.54.1.125 · Cited by 130 · see citing works
Aoyama, T., Matsui, T., Novikov, M., Park, J., Hemmings, B. A., & Rosenzweig, A. (2005) · Circulation · doi:10.1161/01.cir.0000160352.58142.06 · Cited by 128 · see citing works
Herrera, B. M., Lockstone, H. E., Taylor, J. M., Wills, Q. F., Kaisaki, P. J., Barrett, A., Camps, C., Fernández, C., Ragoussis, J., Gauguier, D., et al. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-54 · Cited by 122 · see citing works
microRNA miR-27b impairs human adipocyte differentiation and targets PPARg
Karbiener, M., Fischer, C., Nowitsch, S., et al. (2010) · Cited by 117 · see citing works
Zhao, H., Guan, J. Z., Lee, H.-M., et al. (2010) · Pancreas · doi:10.1097/mpa.0b013e3181d12613 · Cited by 100 · see citing works
Insulin-like Growth Factor I Plasmid Therapy Promotes in Vivo Angiogenesis
Rabinovsky, E. D., & Draghia, R. (2003) · Molecular Therapy · doi:10.1016/j.ymthe.2003.10.003 · Cited by 96 · see citing works
Li, Y., Higashi, Y., Itabe, H., Song, Y., Du, J., & Delafontaine, P. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000099788.31333.db · Cited by 90 · see citing works
Potential of AAV vectors in the treatment of metabolic disease
Alexander, I. E., Cunningham, S. C., Logan, G. J., & Christodoulou, J. (2008) · Gene Therapy · doi:10.1038/gt.2008.64 · Cited by 88 · see citing works
Li, Y., Xu, X., Liang, Y., Liu, S., Xiao, H., Li, F., Cheng, H., & Zu-zhi, F. (2010) · PubMed Central · Cited by 83 · see citing works
Zhang, Y., Xiao, J., Lin, H., et al. (2007) · Cellular Physiology and Biochemistry · doi:10.1159/000100642 · Cited by 77 · see citing works
Role and therapeutic potential of microRNAs in diabetes
Kolfschoten, I., Roggli, E., Nesca, V., & Regazzi, R. (2009) · Diabetes, obesity and metabolism · doi:10.1111/j.1463-1326.2009.01118.x · Cited by 77 · see citing works
Prevention of Diabetes-Induced Microangiopathy by Human Tissue Kallikrein Gene Transfer
Emanueli, C., Salis, M. B., Pinna, A., Stacca, T., Milia, A. F., Spano, A., Chao, J., Chao, L., Sciola, L., & Madeddu, P. R. (2002) · Circulation · doi:10.1161/01.cir.0000027104.33206.c8 · Cited by 76 · see citing works
Self-citationExpressing short hairpin RNAs in vivo
Snøve, O., & Rossi, J. (2006) · Nature Methods · doi:10.1038/nmeth927 · Cited by 76 · see citing works
MicroRNAs in atherosclerosis and lipoprotein metabolism
Vickers, K. C., & Remaley, A. T. (2010) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0b013e32833727a1 · Cited by 72 · see citing works
The roles of microRNAs in tumorigenesis and angiogenesis.
Yang, W., Lee, D. Y., & Ben‐David, Y. (2011) · PubMed Central · Cited by 66 · see citing works
Muraski, J. A., Fischer, K. M., Wu, W., Cottage, C. T., Quijada, P. J., Mason, M., Din, S., Gude, N. A., Alvarez, R., Rota, M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709135105 · Cited by 63 · see citing works
Growth Factors in Proliferative Diabetic Retinopathy
Khan, Z. A., & Chakrabarti, S. (2003) · Journal of Diabetes Research · doi:10.1155/edr.2003.287 · Cited by 59 · see citing works
Foxa2, a novel transcriptional regulator of insulin sensitivity
Puigserver, P., & Rodgers, J. T. (2006) · Nature Medicine · doi:10.1038/nm0106-38 · Cited by 57 · see citing works
MicroRNA expression profiling in diabetic GK rat model
Huang, B. S., Qin, W., Zhao, B., Shi, Y., Yao, C., Li, J., Xiao, H., & Jin, Y. (2009) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmp035 · Cited by 57 · see citing works
Thiazolidinediones: A 2010 Perspective
Krishnaswami, A., Ravi-Kumar, S., & Lewis, J. M. (2010) · The Permanente Journal · doi:10.7812/tpp/09-052 · Cited by 53 · see citing works
Emanueli, C., Graiani, G., Salis, M. B., Gadau, S. D., Desortes, E., & Madeddu, P. R. (2004) · Diabetes · doi:10.2337/diabetes.53.4.1096 · Cited by 51 · see citing works
Self-citationRecognition and Cleavage of Primary MicroRNA Transcripts
Zeng, Y., & Cullen, B. R. (2006) · Humana Press eBooks · doi:10.1385/1-59745-123-1:49 · Cited by 47 · see citing works
MicroRNAs in Cardiometabolic Disease
Najafi-Shoushtari, S. H. (2011) · Current Atherosclerosis Reports · doi:10.1007/s11883-011-0179-y · Cited by 41 · see citing works
A Case-Control Analysis of Intra-Arterial Urokinase Thrombolysis in Acute Cardioembolic Stroke
Inoue, T., Kimura, K., Minematsu, K., et al. (2005) · Cerebrovascular Diseases · doi:10.1159/000083887 · Cited by 33 · see citing works
Nicolás, F. E., & Lopez-Martinez, A. F. (2010) · Recent Patents on DNA & Gene Sequences · doi:10.2174/187221510794751659 · Cited by 31 · see citing works
Imai, G., Satoh, T., Kumai, T., et al. (2003) · Hypertension Research · doi:10.1291/hypres.26.339 · Cited by 23 · see citing works
Myotrophin–κB DNA interaction in the initiation process of cardiac hypertrophy
Gupta, S., & Sen, S. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00178-7 · Cited by 23 · see citing works
Davidson, M., Hu, T., Sain, G., Hoar, B. M., Stevenson, C., & Hoogwerf, B. J. (2008) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2008.00912.x · Cited by 10 · see citing works
Evidence-Based Medicine and the Physician-Patient Dyad
Kushner, H. I. (2010) · The Permanente Journal · doi:10.7812/tpp/10.992 · Cited by 7 · see citing works
New Technologies and Genetics of Type 1 Diabetes
Ilonen, J., & Åkerblom, H. K. (1999) · Diabetes Technology & Therapeutics · doi:10.1089/152091599317440 · Cited by 4 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- [50]White MF Regulating insulin signaling and beta-cell function through IRS proteins Can J Physiol Pharmacol 2006 84 725 737 16998536
Cited by
Sorted by citations
Circulating microRNAs as novel biomarkers for diabetes mellitus
Guay, C., & Regazzi, R. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.86 · Cited by 563 · see citing works
The Vasculature in Prediabetes
Wasserman, D. H., Wang, T. J., & Brown, N. J. (2018) · Circulation Research · doi:10.1161/circresaha.118.311912 · Cited by 137 · see citing works
Suresh Babu, S., Thandavarayan, R. A., Joladarashi, D., Jeyabal, P., Krishnamurthy, S., Bhimaraj, A., Youker, K. A., & Krishnamurthy, P. (2016) · Scientific Reports · doi:10.1038/srep36207 · Cited by 119 · see citing works
- Authors
- Shantikumar, S., Caporali, A., & Emanueli, C.
- Affiliations
- Bristol Royal Infirmary (GB)
- Corresponding author
- Emanueli, C.
- Venue
- Cardiovascular Research
- Publisher
- Oxford University Press (OUP)
- Published
- 2011-11-07
- Volume
- 93
- Issue
- 4
- Pages
- 583-593
- ISSN
- 0008-6363 (ISSN-L)
- PMC
- PMC3291087
- OpenAlex
- W2121271900
- Cited by
- 263
- References
- 129
- Citations by year
- 2026: 7 · 2025: 10 · 2024: 8 · 2023: 13 · 2022: 19 · 2021: 13 · 2020: 16 · 2019: 19 · 2018: 30 · 2017: 24 · 2016: 23 · 2015: 21 · 2014: 21 · 2013: 26 · 2012: 13
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- cc-by-nc
- Locations
- Cardiovascular Research (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by-nc)
- Explore Bristol Research (submittedVersion)
- Bristol Research (University of Bristol) (submittedVersion)
- Funders
- British Heart Foundation (FS/10/61/28566, FS/10/001/27959)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Keywords
- microRNA, diabetes mellitus, cardiovascular complications, endothelial dysfunction, diabetic retinopathy, glucose homeostasis, blood biomarkers, miRNA-targeted therapy, diabetic cardiomyopathy
- MeSH terms
- Animals, Diabetic Angiopathies, Diabetic Retinopathy, Disease Models, Animal, Endothelium, Vascular, Humans, Insulin Resistance, Biomarkers, MicroRNAs, Diabetes Complications, Diabetic Cardiomyopathies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
