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The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
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Human DNA methylomes at base resolution show widespread epigenomic differences
Lister, R., Pelizzola, M., Dowen, R. H., Hawkins, R. D., Hon, G., Tonti-Filippini, J., Nery, J. R., Lee, L., Ye, Z., Ngo, Q.-M., et al. (2009) · Nature · doi:10.1038/nature08514 · Cited by 4,673
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
DNA methylation: roles in mammalian development
Smith, Z. D., & Meissner, A. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3354 · Cited by 3,045
A decade of exploring the cancer epigenome—biological and translational implications
Baylin, S. B., & Jones, P. A. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3130 · Cited by 2,871
Genomic DNA methylation: the mark and its mediators.
Klose, R. J., & Bird, A. P. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.12.008 · Cited by 2,501
Function and information content of DNA methylation
Schübeler, D. (2015) · Nature · doi:10.1038/nature14192 · Cited by 2,060
DNMT3A Mutations in Acute Myeloid Leukemia
Ley, T. J., Ding, L., Walter, M. J., McLellan, M. D., Lamprecht, T., Larson, D. E., Kandoth, C., Payton, J. E., Baty, J., Welch, J., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005143 · Cited by 1,983
Stability and flexibility of epigenetic gene regulation in mammalian development
Reik, W. (2007) · Nature · doi:10.1038/nature05918 · Cited by 1,963
Cellular differentiation, cytidine analogs and DNA methylation
Jones, P. A., & Taylor, S. M. (1980) · Cell · doi:10.1016/0092-8674(80)90237-8 · Cited by 1,831
Global epigenomic reconfiguration during mammalian brain development
Lister, R., Mukamel, E. A., Nery, J. R., Urich, M., Puddifoot, C. A., Johnson, N. D., Lucero, J., Huang, Y., Dwork, A. J., Schultz, M. D., et al. (2013) · Science · doi:10.1126/science.1237905 · Cited by 1,830
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Bohnsack, K. E., Höbartner, C., & Bohnsack, M. T. (2019) · Genes · doi:10.3390/genes10020102 · Cited by 517
Induced pluripotent stem cells (iPSCs): molecular mechanisms of induction and applications
Cerneckis, J., Cai, H., & Shi, Y. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01809-0 · Cited by 452
Zhang, Y., Zhang, X., Shi, J., Tuorto, F., Li, X., Liu, Y., Liebers, R., Zhang, L., Qu, Y., Qian, J., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0087-2 · Cited by 468
“These mechanisms could be highly relevant to human health because the structure and function of DNMT2 are highly conserved, and have been harnessed to respond to environmental challenges during evolution 15, 36 .”
Self-citationMetabolic regulation of chromatin modifications and gene expression
Schvartzman, J. M., Thompson, C. B., & Finley, L. W. S. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201803061 · Cited by 233
Epigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg
Fernández-Barrena, M. G., Arechederra, M., Colyn, L., Berasain, C., & Avila, M. A. (2020) · JHEP Reports · doi:10.1016/j.jhepr.2020.100167 · Cited by 126
Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion
Ansere, V. A., Ali-Mondal, S., Sathiaseelan, R., Garcia, D. N., Isola, J. V. V., Henseb, J. D., Saccon, T. D., Ocañas, S. R., Tooley, K. B., Stout, M. B., et al. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2020.111425 · Cited by 101
Combining histone deacetylase inhibitors (HDACis) with other therapies for cancer therapy
Zhou, M., Yuan, M., Zhang, M., Lei, C., Aras, O., Zhang, X., & An, F. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113825 · Cited by 92
Schöfer, C., & Weipoltshammer, K. (2018) · Histochemistry and Cell Biology · doi:10.1007/s00418-018-1696-3 · Cited by 83
Developmental Epigenetics: Phenotype and the Flexible Epigenome
John, R. M., & Rougeulle, C. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00130 · Cited by 68
Goronzy, J. J., Hu, B., Kim, C., Jadhav, R. R., & Weyand, C. M. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ri0418-160r · Cited by 60
Fine-tuning of gene expression through the Mettl3-Mettl14-Dnmt1 axis controls ESC differentiation
Quarto, G., Li Greci, A., Bizet, M., Penning, A., Primac, I., Murisier, F., Garcia-Martinez, L., Borges, R. L., Gao, Q., Cingaram, P. K. R., et al. (2025) · Cell · doi:10.1016/j.cell.2024.12.009 · Cited by 50
DNA Methyltransferases in Depression: An Update
Duan, Z., & Lu, J. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.538683 · Cited by 32
CDCA7 is an evolutionarily conserved hemimethylated DNA sensor in eukaryotes
Wassing, I. E., Nishiyama, A., Shikimachi, R., Jia, Q., Kikuchi, A., Hiruta, M., Sugimura, K., Hong, X., Chiba, Y., Peng, J., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp5753 · Cited by 31
Wu, H., Van Der Pol, W. J., Dubois, L. G., Morrow, C. D., & Tollefsbol, T. O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24109015 · Cited by 27
Methyl Donor Nutrients in Chronic Kidney Disease: Impact on the Epigenetic Landscape
Mafra, D., Esgalhado, M., Borges, N. A., Cardozo, L. F. M. F., Stockler-Pinto, M. B., Craven, H., Buchanan, S. J., Lindholm, B., Stenvinkel, P., & Shiels, P. G. (2019) · The Journal of Nutrition · doi:10.1093/jn/nxy289 · Cited by 26
DNA methylation landscape in pregnancy-induced hypertension: progress and challenges
Deng, F., Lei, J., Qiu, J., Zhao, C., Wang, X., Li, M., Sun, M., Zhang, M., & Gao, Q. (2024) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-024-01248-0 · Cited by 25
The vibriophage-encoded inhibitor OrbA abrogates BREX-mediated defense through the ATPase BrxC
Oshiro, R. T., Dunham, D. T., & Seed, K. D. (2024) · Journal of Bacteriology · doi:10.1128/jb.00206-24 · Cited by 15
Frey, A. F., Schwan, M., Weldert, A. C., Kadenbach, V., Kopp, J., Nidoieva, Z., Zimmermann, R. A., Gleue, L., Zimmer, C., Jörg, M., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113300 · Cited by 5
Mavioglu, R. N., Ramo-Fernandez, L., Gumpp, A. M., Kolassa, I.-T., & Karabatsiakis, A. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.945343 · Cited by 5
Metadata
- Authors
- Lyko, F.
- Venue
- Nature Reviews Genetics
- Published
- 2017-10-16
- Volume
- 19
- Issue
- 2
- Pages
- 81-92
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2766704091
- Cited by
- 1,467
- References
- 28
- FWCI
- 7.15
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
