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Exploring genetic interactions and networks with yeast
Abstract
The development and application of genetic tools and resources has enabled a partial genetic-interaction network for the yeast Saccharomyces cerevisiae to be compiled. Analysis of the network, which is ongoing, has already provided a clear picture of the nature and scale of the genetic interactions that robustly sustain biological systems, and how cellular buffering is achieved at the molecular level. Recent studies in yeast have begun to define general principles of genetic networks, and also pave the way for similar studies in metazoan model systems. A comparative understanding of genetic-interaction networks promises insights into some long-standing genetic problems, such as the nature of quantitative traits and the basis of complex inherited disease.
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Metadata
- Authors
- Boone, C., Bussey, H., & Andrews, B. J.
- Affiliations
- University of Toronto (CA)
- McGill University (CA)
- Corresponding author
- Boone, Charles
- Andrews, Brenda J.
- Venue
- Nature Reviews Genetics
- Published
- 2007-06
- Volume
- 8
- Issue
- 6
- Pages
- 437-449
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2150749732
- Cited by
- 661
- References
- 90
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 20 · 2023: 17 · 2022: 25 · 2021: 25 · 2020: 21 · 2019: 37 · 2018: 28 · 2017: 57 · 2016: 27 · 2015: 29 · 2014: 43 · 2013: 41 · 2012: 44
- FWCI
- 3.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Genome Canada
- Ontario Genomics Institute
- Canada Research Chairs
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Keywords
- genetic interactions, genetic interaction networks, Saccharomyces cerevisiae, genetic screen, gene networks, quantitative traits
- MeSH terms
- Algorithms, Chromosome Mapping, Diploidy, Epistasis, Genetic, Genes, Lethal, Models, Genetic, Mutation, Phenotype, Saccharomyces cerevisiae, Genome, Fungal, Gene Deletion, Oligonucleotide Array Sequence Analysis, Genomics, Saccharomyces cerevisiae Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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