The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Cis-regulatory elements: molecular mechanisms and evolutionary processes underlying divergence
Abstract
Cis-regulatory sequences, such as enhancers and promoters, control development and physiology by regulating gene expression. Mutations that affect the function of these sequences contribute to phenotypic diversity within and between species. With many case studies implicating divergent cis-regulatory activity in phenotypic evolution, researchers have recently begun to elucidate the genetic and molecular mechanisms that are responsible for cis-regulatory divergence. Approaches include detailed functional analysis of individual cis-regulatory elements and comparing mechanisms of gene regulation among species using the latest genomic tools. Despite the limited number of mechanistic studies published to date, this work shows how cis-regulatory activity can diverge and how studies of cis-regulatory divergence can address long-standing questions about the genetic mechanisms of phenotypic evolution.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Furthermore, variation in prairie vole NAcc OXTR confers susceptibility or resilience to the effects of daily neonatal isolations, a model of neglect, in relation to the ability to form social attachments as adults (41).”
From Variation in the Oxytocin Receptor Gene Predicts Brain Region–Specific Expression and Social Attachment (2016) · cites this paper as [41]
Citations
Cites
Evolutionary divergence and convergence in proteins.
ZUCKERKANDL, E., & PAULING, L. (1965) · Evolving Genes and Proteins · doi:10.1016/b978-1-4832-2734-4.50017-6 · Cited by 3,020
King, M.-C., & Wilson, A. C. (1975) · Science · doi:10.1126/science.1090005 · Cited by 2,815
Gene Regulation for Higher Cells: A Theory
Britten, R. J., & Davidson, E. H. (1969) · Science · doi:10.1126/science.165.3891.349 · Cited by 2,078
Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution
Carroll, S. B. (2008) · Cell · doi:10.1016/j.cell.2008.06.030 · Cited by 2,067
TRANSFAC(R): transcriptional regulation, from patterns to profiles
Matys, V. (2003) · Nucleic Acids Research · doi:10.1093/nar/gkg108 · Cited by 1,985
The UCSC Genome Browser database: update 2011
Fujita, P. A., Rhead, B., Zweig, A. S., Hinrichs, A. S., Karolchik, D., Cline, M., Goldman, M. J., Barber, G. P., Clawson, H., Coelho, A., et al. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq963 · Cited by 1,843
Effective population size and patterns of molecular evolution and variation
Charlesworth, B. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2526 · Cited by 1,743
ChIP-seq accurately predicts tissue-specific activity of enhancers
Visel, A., Blow, M. J., Li, Z., Zhang, T., Akiyama, J. A., Holt, A., Plajzer-Frick, I., Shoukry, M., Wright, C., Chen, F., et al. (2009) · Nature · doi:10.1038/nature07730 · Cited by 1,639
The evolutionary significance of cis-regulatory mutations
Wray, G. A. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2063 · Cited by 1,521
Widespread parallel evolution in sticklebacks by repeated fixation of Ectodysplasin alleles.
Colosimo, P. F., Hosemann, K. E., Balabhadra, S., Villarreal, G., Dickson, M., Grimwood, J., Schmutz, J., Myers, R. M., Schluter, D., & Kingsley, D. M. (2005) · Science · doi:10.1126/science.1107239 · Cited by 1,448
Flagged first, then by citations
Cited by
Sorted by citations
Items 701–800 of 1,246
Xing, K., Yan, C., Feng, D., Wu, Z., Sun, Y., & Zhang, J. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.102248 · Cited by 6
Quantitative analysis of cis-regulatory elements in transcription with KAS-ATAC-seq
Lyu, R., Gao, Y., Wu, T., Ye, C., Wang, P., & He, C. (2024) · Nature Communications · doi:10.1038/s41467-024-50680-8 · Cited by 7
Khatun, M. S., Islam, M. S. U., Shing, P., Zohra, F. T., Rashid, S. B., Rahman, S. M., & Sarkar, M. A. R. (2024) · PLoS ONE · doi:10.1371/journal.pone.0309353 · Cited by 6
Genetic and Epigenetic Dysregulation of Transcriptional Enhancers in Cancer
Botten, G. A., & Xu, J. (2024) · Annual Review of Cancer Biology · doi:10.1146/annurev-cancerbio-060324-114306 · Cited by 7
Whole‐genome sequencing analysis of Japanese autism spectrum disorder trios
Furukawa, S., Kushima, I., Kato, H., Kimura, H., Nawa, Y., Aleksić, B., Banno, M., Yamamoto, M., Uematsu, M., Nagasaki, Y., et al. (2024) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.13767 · Cited by 7
Tripathi, A. H., Singh, D., Bhati, J., Singh, D., Taunk, J., Alkahtani, J., Al-Hashimi, A., & Singh, M. P. (2025) · BMC Plant Biology · doi:10.1186/s12870-025-06086-9 · Cited by 6
Mechanisms for DNA Interplay in Eukaryotic Transcription Factors
Muñoz, V., Goluguri, R. R., Ghosh, C., Tanielian, B., & Sadqi, M. (2025) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-071524-111008 · Cited by 8
Zhao, S., Yang, Q., Yu, Z., Chu, C., Dai, S., Li, H., Diao, M., Feng, L., Ke, J., Xue, Y., et al. (2025) · Neuron · doi:10.1016/j.neuron.2025.03.023 · Cited by 6
Guo, C., Chen, Y., Wu, L., Jin, Y., Huang, X., Gu, Q., Cao, F., Ke, P., Wang, Y., & Li, Y. (2025) · Physiologia Plantarum · doi:10.1111/ppl.70328 · Cited by 6
Uncovering the multi-layer cis-regulatory landscape of rice via integrative nascent RNA analysis
Goliasse, M., Johary, A., Platts, A. E., Ortner-Krause, F., Edger, P. P., Choi, J. Y., Purugganan, M. D., & Joly‐Lopez, Z. (2025) · Genome biology · doi:10.1186/s13059-025-03715-2 · Cited by 6
Epigenome and interactome profiling uncovers principles of distal regulation in the barley genome
Navrátilová, P., Pavlu, S., Zhu, Z., Tulpová, Z., Kopecky, O., Novák, P., Stein, N., & Šimková, H. (2025) · Cell Genomics · doi:10.1016/j.xgen.2025.101037 · Cited by 6
Transcriptome analysis of lncRNA expression patterns in human congenital lung malformations
Yang, W., Zhao, P., Liu, Y., Cao, P., Ji, X., Gao, Y., Li, P., & Cheng, J. (2021) · BMC Genomics · doi:10.1186/s12864-021-08204-x · Cited by 6
Asymmetric predictive relationships across histone modifications
Li, H., & Guan, Y. (2022) · Nature Machine Intelligence · doi:10.1038/s42256-022-00455-x · Cited by 6
Anderson, A. P., & Jones, A. G. (2022) · Evolution · doi:10.1111/evo.14483 · Cited by 6
RetractedFine mapping and candidate gene analysis of gummy stem blight resistance in cucumber stem
Han, J., Dong, S., Shi, Y., Miao, H., Liu, X., Beckles, D. M., Gu, X., & Zhang, S. (2022) · Theoretical and Applied Genetics · doi:10.1007/s00122-022-04172-2 · Cited by 6
eQTLs as causal instruments for the reconstruction of hormone linked gene networks
Bankier, S., & Michoel, T. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.949061 · Cited by 6
Zhang, J., Debernardi, J. M., Burguener, G., Choulet, F., Paux, E., O’Connor, L., Enk, J. M., & Dubcovsky, J. (2022) · The Plant Genome · doi:10.1002/tpg2.20296 · Cited by 6
Mali, S., Dutta, M., Goel, K., Raturi, V., Kundu, P., Kumar, R. S., Gahlaut, V., Acharya, V., Gupta, V. K., Sood, S., et al. (2023) · Journal of Plant Growth Regulation · doi:10.1007/s00344-023-11094-w · Cited by 6
Sarkar, M. A. R., Sarkar, S., Islam, M. S. U., Zohra, F. T., & Rahman, S. M. (2023) · Genomics & Informatics · doi:10.5808/gi.23007 · Cited by 6
Sarkar, M. A. R., Sarkar, S., Islam, M. S. U., Zohra, F. T., & Rahman, S. M. (2023) · Plant Molecular Biology Reporter · doi:10.1007/s11105-023-01416-3 · Cited by 6
Lineage‐specific genomics: Frequent birth and death in the human genome
Young, R. S. (2016) · BioEssays · doi:10.1002/bies.201500192 · Cited by 6
Computational deciphering of biotic stress associated genes in tomato ( Solanum lycopersicum )
Tandon, G., Singh, S., Kaur, S., Sarika, S., Iquebal, M. A., Rai, A. K., & Kumar, D. (2017) · Genomics Data · doi:10.1016/j.gdata.2017.09.003 · Cited by 6
Olmos, S. E., Trejo, J. M., Percibaldi, N. M., & Eyhérabide, G. H. (2018) · Molecular Breeding · doi:10.1007/s11032-018-0855-5 · Cited by 6
Wang, H. V., & Chekanova, J. A. (2019) · RNA · doi:10.1261/rna.071209.119 · Cited by 6
Non-linear Dynamics in Transcriptional Regulation: Biological Logic Gates
Frank, T. D., Cavadas, M. A. S., Nguyen, L. K., & Cheong, A. (2016) · SEMA SIMAI Springer series · doi:10.1007/978-3-319-33054-9_3 · Cited by 5
Zebrafish Zic Genes Mediate Developmental Signaling
Winata, C. L., & Korzh, V. P. (2018) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-7311-3_9 · Cited by 6
Allele-specific expression reveals the phenotypic differences between thin- and fat-tailed sheepPreprint
Shao, J., He, S., Pan, X., Yang, Z., Nanaei, H. A., Chen, L., Li, R., Wang, Y., Gao, S., Xu, H., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-56388/v1 · Cited by 6
Carlson, C. H., Choi, Y., Chan, A. P.-Y., Town, C. D., & Smart, L. B. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab436 · Cited by 6
Dong, F., Wan, S., & Zhang, W. (2024) · Tropical Plants · doi:10.48130/tp-0024-0026 · Cited by 5
A network-enabled pipeline for gene discovery and validation in non-model plant species
Ko, D. K., & Brandizzí, F. (2025) · Cell Reports Methods · doi:10.1016/j.crmeth.2024.100963 · Cited by 5
Li, F., Li, S., Yi, L., Zhao, P., Ma, C., Huang, X., Wang, J., Liu, C., Jiao, B., Mei, X., et al. (2025) · Plants · doi:10.3390/plants14172763 · Cited by 5
Bridging the variant-to-function gap in type 2 diabetes: advances and challenges
Maynard, A. G., Bhardwaj, R., Jones, T. R., & Claussnitzer, M. (2025) · Diabetologia · doi:10.1007/s00125-025-06600-6 · Cited by 7
Generative AI for synthetic biology: Designing biological parts, circuits, and genomes
Kim, N., Carluccio, G. D., Zhang, K., & Collins, J. J. (2026) · Cell Systems · doi:10.1016/j.cels.2026.101533 · Cited by 5
van Rosmalen, L., Schepers, R., Hao, W., Przybylska-Piech, A. S., Herman, J. S., Stojak, J., Wójcik, J. M., van de Zande, L., Searle, J. B., & Hut, R. A. (2023) · Genes · doi:10.3390/genes14020292 · Cited by 7
Konstantinidis, I., Sætrom, P., Brieuc, M. S. O., Jakobsen, K. S., Liedtke, H., Pohlmann, C., Tsoulia, T., & Fernandes, J. M. O. (2023) · Epigenetics · doi:10.1080/15592294.2023.2282323 · Cited by 5
Molecular Innovations Shaping Beak Morphology in Birds
Cheng, Y., Miller, M. J., & Lei, F. (2024) · Annual Review of Animal Biosciences · doi:10.1146/annurev-animal-030424-074906 · Cited by 8
ATAC‐seq in Emerging Model Organisms: Challenges and Strategies
Erdoğan, D. E., Karimifard, S., Khodadadi, M., Ling, L., Linke, L., Catalán, A., Doublet, V., Glaser‐Schmitt, A., Niehuis, O., Nowick, K., et al. (2025) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.23305 · Cited by 6
Functional Roles and Mechanistic Insights of YEATS Domain Proteins in Digestive System Tumors
Chang, F., Yang, Y., Li, X., Dong, H., & Liu, K. (2025) · Digestive Diseases and Sciences · doi:10.1007/s10620-025-09117-5 · Cited by 5
Ji, L., Zou, Q., Tang, K., & Wang, C. (2025) · Genome biology · doi:10.1186/s13059-025-03823-z · Cited by 5
Insights into nuclear dynamics using live‐cell imaging approaches
Bigley, R. B., Payumo, A. Y., Alexander, J. M., & Huang, G. N. (2017) · WIREs Systems Biology and Medicine · doi:10.1002/wsbm.1372 · Cited by 5
The role of the FHA domain-containing protein family in pollen development of Brassica rapa L
Shi, F., Liu, Z., Pang, Z., & Feng, H. (2021) · Scientia Horticulturae · doi:10.1016/j.scienta.2021.110339 · Cited by 5
Wu, F., Muvunyi, B. P., Qi, Y., Kanzana, G., Ma, T., Zhang, Z., Wang, Y., & Zhang, J. (2022) · Environmental and Experimental Botany · doi:10.1016/j.envexpbot.2022.105029 · Cited by 5
Adaptive evolution and epigenetics
Kronholm, I. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-91909-8.00014-1 · Cited by 5
Single-Cell Gene Expression Analysis Revealed Immune Cell Signatures of Delta COVID-19
Shaymardanov, A. M., Antonova, O. A., Sokol, A. D., Deinichenko, K. A., Kazakova, P. G., Milovanov, M. M., Zakubansky, A. V., Akinshina, A. I., Tsypkina, A. V., Romanova, S. V., et al. (2022) · Cells · doi:10.3390/cells11192950 · Cited by 6
Tu, G., 中山大学海洋科学学院有害生物控制与资源利用国家重点实验室(中山大学), 广. 珠. 5., Zhang, X., Jiang, R., Zhang, L., Lai, C.-J., Yan, Z., Lv, Y.-R., Weng, S., Zhang, L., et al. (2023) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2022.462 · Cited by 6
Anderson, A. P., & Renn, S. C. P. (2023) · The American Naturalist · doi:10.1086/725438 · Cited by 5
Polygenic risk score (PRS) and its potential for breast cancer risk stratification
Hovhannisyan, M., Kleiblová, P., Nehasil, P., Soukupová, J., Zemánková, P., Kleibl, Z., & Janatová, M. (2023) · Klinicka onkologie · doi:10.48095/ccko2023198 · Cited by 5
Foreign RNA spike-ins enable accurate allele-specific expression analysis at scale
Mendelevich, A., Gupta, S., Pakharev, A., Teodosiadis, A., Mironov, A. A., & Gimelbrant, A. A. (2023) · Bioinformatics · doi:10.1093/bioinformatics/btad254 · Cited by 5
Chung, H. C., Keiller, D. R., Swain, P., Chapman, S., Roberts, J., & Gordon, D. A. (2023) · PLoS ONE · doi:10.1371/journal.pone.0288996 · Cited by 6
Hasan, M. N., Mosharaf, M. P., Uddin, K. S., Das, K. R., Sultana, N., Noorunnahar, M., Naim, D., & Mollah, M. N. H. (2023) · BioMed Research International · doi:10.1155/2023/8832406 · Cited by 5
Chandrashekar, P. B., Chen, H., Lee, M., Ahmadinejad, N., & Liu, L. (2023) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2023.12.044 · Cited by 6
An InDel in the promoter of ribosomal protein S27-like gene regulates skeletal muscle growth in pigs
Liu, X., Fan, X., Yan, J., Zhang, L., Wang, L., Calnan, H. B., Yang, Y., Gardner, G. E., Zhou, R., & Tang, Z. (2024) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2024.05.005 · Cited by 6
Nomura, Y., Okada, M., Tameshige, T., Takenaka, S., Shimizu, K. K., Nasuda, S., & Nagano, A. J. (2025) · Plant and Cell Physiology · doi:10.1093/pcp/pcaf011 · Cited by 5
Morphological Mutations: Lessons from the Cockscomb
Headon, D. J. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1004979 · Cited by 5
Fang, W., Wen, Y., & Wei, X. (2019) · Methods in molecular biology · doi:10.1007/978-1-0716-0175-4_10 · Cited by 6
Repression precedes independent evolutionary gains of a highly specific gene expression pattern
Pu, J. Y., Wang, Z., Cong, H., Chin, J. S. R., Justen, J., Finet, C., Yew, J. Y., & Chung, H. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109896 · Cited by 5
Go, A. C., & Civetta, A. (2022) · BMC Genomics · doi:10.1186/s12864-021-08267-w · Cited by 5
Zeng, P., Ge, X., & Li, Z. (2023) · Plants · doi:10.3390/plants12102029 · Cited by 6
Chalivendra, S., Shi, S., Li, X., Kuang, Z., Giovinazzo, J., Zhang, L., Rossi, J., Wang, J., Saviola, A. J., Welty, R., et al. (2024) · RNA · doi:10.1261/rna.079917.123 · Cited by 5
Horiuchi, Y., Harushima, Y., Fujisawa, H., Mochizuki, T., Fujita, M., Ohyanagi, H., & Kurata, N. (2015) · BMC Genomics · doi:10.1186/s12864-015-2319-1 · Cited by 5
Tejeda, L. H. C., Viana, V. E., Maltzahn, L. E., Busanello, C., Barros, L. M., da Maia, L. C., de Oliveira, A. C., & Pegoraro, C. (2019) · Biotechnology Research and Innovation · doi:10.1016/j.biori.2019.12.001 · Cited by 5
Functional Conservation of Divergent p63-Bound cis-Regulatory Elements
Gallardo-Fuentes, L., Santos-Pereira, J. M., & Tena, J. J. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00339 · Cited by 5
He, J., Bouwmeester, H. J., Dicke, M., & Kappers, I. F. (2020) · Plants · doi:10.3390/plants9081014 · Cited by 5
Comprehensive Analyses of Nitric Oxide-Induced Plant Stem Cell-Related Genes in Arabidopsis thaliana
Shahid, M., Imran, Q. M., Hussain, A., Khan, M., Lee, S., Mun, B. G., & Yun, B. (2019) · Genes · doi:10.3390/genes10020173 · Cited by 5
Genomic signatures of the evolution of a diurnal lifestyle in Strigiformes
Espíndola‐Hernández, P., Mueller, J. C., & Kempenaers, B. (2022) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkac135 · Cited by 5
Anticipatory gene regulation driven by maternal effects in an insect–host system
Nespolo, R. F., Silva, A. X., Figueroa, C. C., & Bacigalupe, L. D. (2015) · Ecology and Evolution · doi:10.1002/ece3.1763 · Cited by 5
Noncoding DNA Evolution: Junk DNA Revisited
Ludwig, M. Z. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800049-6.00168-2 · Cited by 5
Oxytocin, Vasopressin, and Diversity in Social Behavior
King, L. B., & Young, L. J. (2016) · Wiley eBooks · doi:10.1002/9781118760369.ch19 · Cited by 5
CRUP: A comprehensive framework to predict condition-specific regulatory unitsPreprint
Ramisch, A., Heinrich, V., Glaser, L. V., Fuchs, A., Yang, X., Benner, P., Schöpflin, R., Li, N., Kinkley, S., Hillmann, A., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/501601 · Cited by 5
Dense encoding of developmental regulatory information may constrain evolvabilityPreprint
Fuqua, T., Jordan, J., van Breugel, M. V., Halavatyi, A., Tischer, C., Polidoro, P., Abe, N., Tsai, A., Mann, R., Stern, D., et al. (2020) · bioRxiv · doi:10.1101/2020.04.17.046052 · Cited by 6
A genome-wide genetic screen uncovers novel determinants of human pigmentationPreprint
Bajpai, V. K., Swigut, T., Mohammed, J., Tycko, J., Naqvi, S., Villanueva, M. A., Kim, T. C., Arora, N., Pritchard, J. K., Bassik, M. C., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.29.462413 · Cited by 5
The landscape of fitness effects of putatively functional noncoding mutations in humansPreprint
Di, C., Ramesh, S., Ernst, J., & Lohmueller, K. E. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.14.654124 · Cited by 5
Comparative analysis of IRE1s in plants: insights into heat stress adaptation in Triticum aestivum
Singh, A., Samtani, H., Gangwar, H., Sharma, A., Jaiswal, V., Djalović, I. G., Prasad, P. V. V., & Gahlaut, V. (2024) · BMC Plant Biology · doi:10.1186/s12870-024-05785-z · Cited by 4
Zeng, S., Li, Z., Li, X., Du, Q., Zhang, Y., Zhong, Z., Wang, H., Zhang, S., Li, P., Li, H., et al. (2025) · The FASEB Journal · doi:10.1096/fj.202401137r · Cited by 6
Zeng, Z., Zhu, X., Chen, J., Zhang, S., Zhou, S., Li, K., & Shen, W. (2025) · The Crop Journal · doi:10.1016/j.cj.2025.05.013 · Cited by 4
Molecular mechanism of ATP‐binding cassette transporter‐mediated insecticide resistance
Lv, Y., Wang, P., Wei, Z., & Yang, X. (2025) · New plant protection. · doi:10.1002/npp2.70018 · Cited by 4
Yun, J., Burnett, A. C., Rogers, A., & Marais, D. L. D. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf218 · Cited by 4
Controlling gene expression using AI designed Cis-regulatory elements
Xia, Y., & Huo, Y. (2026) · Biotechnology Advances · doi:10.1016/j.biotechadv.2026.108802 · Cited by 4
Genome evolution through polyploidy: Enhancing plant stress resilience in agriculture
Edger, P. P., Body, M. J. A., Donno, S. D., Platts, A. E., Wang, J., & Jiang, J. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2522064123 · Cited by 5
An Updated Functional Annotation of Protein-Coding Genes in the Cucumber Genome
Song, H., Lin, K., Hu, J., & Pang, E. (2018) · Frontiers in Plant Science · doi:10.3389/fpls.2018.00325 · Cited by 6
Wang, Y., Hua, Y., Zhou, T., Huang, J., & Yue, C. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06599-0 · Cited by 4
Ramírez–Ramírez, J. A., Madrigal, Y., Álzate, J. F., & Pabón‐Mora, N. (2021) · Cells and Development · doi:10.1016/j.cdev.2021.203755 · Cited by 4
Wang, L.-S., & Sun, Z.-L. (2022) · Interdisciplinary Sciences Computational Life Sciences · doi:10.1007/s12539-022-00538-8 · Cited by 4
Cis -regulatory landscapes in the evolution and development of the mammalian skull
Kaucká, M. (2023) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2022.0079 · Cited by 4
Everman, E. R., & Macdonald, S. J. (2024) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkae015 · Cited by 6
Xu, X., Zhang, C., Lai, C., Zhang, Z., Wu, J., Su, Q., Gan, Y., Zhang, Z., Chen, Y., Guo, R., et al. (2024) · Plants · doi:10.3390/plants13101373 · Cited by 4
Mulero-Hernández, J., Mironov, V., Miñarro-Giménez, J. A., Kuiper, M. T. R., & Fernández‐Breis, J. T. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae566 · Cited by 4
Tian, Y., Wang, J., Wang, X., Wang, D., Wang, X., Liu, J., Zhang, H., Zhang, J., & Yu, L. (2025) · Frontiers in Genetics · doi:10.3389/fgene.2025.1530910 · Cited by 5
Quantifying Transcriptome Turnover on Phylogenies by Modeling Gene Expression as a Binary Trait
Thompson, A., May, M. R., Hopkins, B. R., Riedl, N., Barmina, O., Liebeskind, B. J., Zhao, L., Begun, D., & Kopp, A. (2025) · Molecular Biology and Evolution · doi:10.1093/molbev/msaf106 · Cited by 4
Xie, C., Künzel, S., Zhang, W., Hathaway, C. A., Tworoger, S. S., & Tautz, D. (2025) · Genome biology · doi:10.1186/s13059-025-03709-0 · Cited by 4
Insights in human epigenomic dynamics through comparative primate analysis
Bell, C. G. (2016) · Genomics · doi:10.1016/j.ygeno.2016.09.003 · Cited by 4
Mao, R., Liang, C., Zhang, Y., Hao, X., & Li, J. (2017) · Frontiers in Plant Science · doi:10.3389/fpls.2017.01728 · Cited by 4
Okubo, S., Terauchi, K., Okada, S., Saito, Y. M., Yamaura, T., Misaka, T., Nakajima, K., Abe, K., & Asakura, T. (2021) · BMC Genomics · doi:10.1186/s12864-021-07674-3 · Cited by 4
Ertl, H. A., Hill, M. S., & Wittkopp, P. J. (2022) · BMC Genomics · doi:10.1186/s12864-022-09082-7 · Cited by 4
Self-citationFarfán‐Pira, K. J., Martínez-Cuevas, T. I., Evans, T. A., & Nahmad, M. (2023) · Journal of Experimental Biology · doi:10.1242/jeb.244692 · Cited by 4
Xu, Y., Bush, S. J., Yang, X., Xu, L., Wang, B., & Ye, K. (2023) · The Plant Journal · doi:10.1111/tpj.16466 · Cited by 4
Gene Therapy Using Genomic DNA
Han, Z. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809813-4.00003-x · Cited by 4
Ratcliffe, L. E., Asiedu, E. K., Pickett, C. J., Warburton, M. A., Izzi, S. A., & Meedel, T. H. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.10.010 · Cited by 4
Arabidopsis– a model to elucidate complex stress response mechanism during cryopreservation
Stock, J., Mock, H., Senula, A., & Nagel, M. (2019) · Acta Horticulturae · doi:10.17660/actahortic.2019.1234.11 · Cited by 4
Büyük, İ., Okay, A., Aksoy, T., & Aras, S. (2021) · Communications Faculty of Science University of Ankara Series C Biology Geological Engineering and Geophysical Engineering · doi:10.53447/communc.869501 · Cited by 4
Metadata
- Authors
- Wittkopp, P. J., & Kalay, G.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Wittkopp, Patricia J.
- Venue
- Nature Reviews Genetics
- Published
- 2011-12-06
- Volume
- 13
- Issue
- 1
- Pages
- 59-69
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2089806726
- Cited by
- 1,231
- References
- 103
- Citations by year
- 2026: 112 · 2025: 128 · 2024: 129 · 2023: 112 · 2022: 103 · 2021: 99 · 2020: 95 · 2019: 74 · 2018: 74 · 2017: 55 · 2016: 75 · 2015: 66 · 2014: 48 · 2013: 41 · 2012: 18
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- cis-regulatory elements, enhancers, promoter, cis-regulatory divergence, phenotypic evolution, transcription factor binding, genetic mutations, gene expression regulation, phenotypic diversity
- MeSH terms
- Animals, Base Sequence, Enhancer Elements, Genetic, Gene Expression Regulation, Humans, Regulatory Sequences, Nucleic Acid, Genome, Conserved Sequence, Evolution, Molecular, Computational Biology, Genomics, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review