Endogenous viruses: insights into viral evolution and impact on host biology

Transposable elements: targets for early nutritional effects on epigenetic gene regulation

Waterland, R. A., & Jirtle, R. L. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.15.5293-5300.2003 · Cited by 2,019

Rates of spontaneous mutation

Drake, J. W., Charlesworth, B., Charlesworth, D., & Crow, J. F. (1998) · Genetics · doi:10.1093/genetics/148.4.1667 · Cited by 1,932

KAP1 controls endogenous retroviruses in embryonic stem cells

Rowe, H. M., Jakobsson, J., Mesnard, D., Rougemont, J., Reynard, S., Aktas, T., Maillard, P. V., Layard-Liesching, H., Verp, S., Marquis, J., et al. (2010) · Nature · doi:10.1038/nature08674 · Cited by 874

LINE-1 elements in structural variation and disease

Beck, C. R., Garcia-Perez, J. L., Badge, R. M., & Moran, J. V. (2011) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-082509-141802 · Cited by 615

Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G

Sawyer, S. L., Emerman, M., & Malik, H. S. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020275 · Cited by 485

Embryonic stem cells use ZFP809 to silence retroviral DNAs

Wolf, D., & Goff, S. P. (2009) · Nature · doi:10.1038/nature07844 · Cited by 388

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

Lamprecht, B., Walter, K., Kreher, S., Kumar, R., Hummel, M., Lenze, D., Köchert, K., Bouhlel, M. A., Richter, J., Soler, E., et al. (2010) · Nature Medicine · doi:10.1038/nm.2129 · Cited by 376

Endogenous retroviral LTRs as promoters for human genes: A critical assessment

Cohen, C. J., Lock, W. M., & Mager, D. L. (2009) · Gene · doi:10.1016/j.gene.2009.06.020 · Cited by 314

Reconstitution of an Infectious Human Endogenous Retrovirus

Lee, Y. N., & Bieniasz, P. D. (2007) · PLoS Pathogens · doi:10.1371/journal.ppat.0030010 · Cited by 311

Identification of an infectious progenitor for the multiple-copy HERV-K human endogenous retroelements

Dewannieux, M., Harper, F., Richaud, A., Letzelter, C., Ribet, D., Pierron, G., & Heidmann, T. (2006) · Genome Research · doi:10.1101/gr.5565706 · Cited by 309

Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation

Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638

Loss of PTEN Promotes Resistance to T Cell–Mediated Immunotherapy

Peng, W., Chen, J. Q., Liu, C., Malu, S., Creasy, C., Tetzlaff, M. T., Xu, C., McKenzie, J. A., Zhang, C., Liang, X., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0283 · Cited by 1,539

LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

Sheng, W., LaFleur, M. W., Nguyen, T. H., Chen, S., Chakravarthy, A., Conway, J. R., Li, Y., Chen, H., Yang, H., Hsu, P.-H., et al. (2018) · Cell · doi:10.1016/j.cell.2018.05.052 · Cited by 693

Transposable Elements Are Major Contributors to the Origin, Diversification, and Regulation of Vertebrate Long Noncoding RNAs

Kapusta, A., Kronenberg, Z., Lynch, V. J., Zhuo, X., Ramsay, L., Bourque, G., Yandell, M., & Feschotte, C. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003470 · Cited by 687

A Field Guide to Eukaryotic Transposable Elements

Wells, J. N., & Feschotte, C. (2020) · Annual Review of Genetics · doi:10.1146/annurev-genet-040620-022145 · Cited by 686

Endogenous retroviruses function as species-specific enhancer elements in the placenta

Chuong, E. B., Rumi, M. A. K., Soares, M. J., & Baker, J. C. (2013) · Nature Genetics · doi:10.1038/ng.2553 · Cited by 429

Mammalian Retrovirus-like Protein PEG10 Packages Its Own MRNA and Can Be Pseudotyped for MRNA Delivery

Segel, M., Lash, B., Song, J., Ladha, A., Liu, C. C., Jin, X., Mekhedov, S. L., Macrae, R. K., Koonin, E. V., & Zhang, F. (2021) · Science · doi:10.1126/science.abg6155 · Cited by 423

Paleovirology of ‘ syncytins ’, retroviral env genes exapted for a role in placentation

Lavialle, C., Cornelis, G., Dupressoir, A., Esnault, C., Heidmann, O., Vernochet, C., & Heidmann, T. (2013) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2012.0507 · Cited by 413

Phosphatidylinositol 3-phosphates—at the interface between cell signalling and membrane traffic

Marat, A. L., & Haucke, V. (2016) · The EMBO Journal · doi:10.15252/embj.201593564 · Cited by 299

Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target

Liu, D., Wong, C. C., Fu, L., Chen, H., Zhao, L., Li, C., Zhou, Y., Zhang, Y., Xu, W., Yang, Y., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aap9840 · Cited by 257

Nucleic Acid-Sensing Toll-like Receptors Are Essential for the Control of Endogenous Retrovirus Viremia and ERV-Induced Tumors

Yu, P., Lübben, W., Slomka, H., Gebler, J., Konert, M., Cai, C., Neubrandt, L., Prazeres da Costa, O., Paul, S., Dehnert, S., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.07.018 · Cited by 192

Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

Kremer, D., Schichel, T., Förster, M., Tzekova, N., Bernard, C., van der Valk, P., van Horssen, J., Hartung, H., Perron, H., & Küry, P. (2013) · Annals of Neurology · doi:10.1002/ana.23970 · Cited by 178

Molecular Pathways: Targeting Protein Tyrosine Phosphatases in Cancer

Bollu, L. R., Mazumdar, A., Savage, M. I., & Brown, P. H. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-0934 · Cited by 168

Long-term p110α PI3K inactivation exerts a beneficial effect on metabolism

Foukas, L. C., Bilanges, B., Bettedi, L., Pearce, W., Ali, K., Sancho, S., Withers, D. J., & Vanhaesebroeck, B. (2013) · EMBO Molecular Medicine · doi:10.1002/emmm.201201953 · Cited by 91

The DNA Copy Number of Human Endogenous Retrovirus-W (MSRV-Type) Is Increased in Multiple Sclerosis Patients and Is Influenced by Gender and Disease Severity

Garcia-Montojo, M., Dominguez-Mozo, M., Arias-Leal, A., Garcia-Martinez, Á., De las Heras, V., Casanova, I., Faucard, R., Gehin, N., Madeira, A., Arroyo, R., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053623 · Cited by 90

The genetics of melanoma: recent advances

Hill, V. K., Gartner, J. J., Samuels, Y., & Goldstein, A. M. (2013) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-091212-153429 · Cited by 86

BFVD—a large repository of predicted viral protein structures

Kim, R. S., Levy Karin, E., Mirdita, M., Chikhi, R., & Steinegger, M. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkae1119 · Cited by 86

A cryo-ET survey of microtubules and intracellular compartments in mammalian axons

Foster, H. E., Ventura Santos, C., & Carter, A. P. (2022) · Journal of Cell Biology · doi:10.1083/jcb.202103154 · Cited by 69

New Insights on the Effects of Methylphenidate in Attention Deficit Hyperactivity Disorder

Pitzianti, M. B., Spiridigliozzi, S., Bartolucci, E., Esposito, S., & Pasini, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.531092 · Cited by 28

PTEN in Regulating Hematopoiesis and Leukemogenesis

Wu, Y., Zhu, H., & Wu, H. (2020) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a036244 · Cited by 22

Deep mining reveals the diversity of endogenous viral elements in vertebrate genomes

(2024) · doi:10.1038/s41564-024-01825-4 · Cited by 15

The Alzheimer’s Disease–Associated Protein BACE1 Modulates T Cell Activation and Th17 Function

Hernandez-Mir, G., Raphael, I., Revu, S., Poholek, C. H., Avery, L., Hawse, W. F., Kane, L. P., & McGeachy, M. J. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1800363 · Cited by 14