Defensins: antimicrobial peptides of innate immunity

Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides

Shai, Y. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00200-x · Cited by 1,904

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809

Defensins. Natural peptide antibiotics of human neutrophils.

Ganz, T., Selsted, M. E., Szklarek, D., Harwig, S. S. L., Daher, K. A., Bainton, D. F., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112120 · Cited by 1,416

A peptide antibiotic from human skin

Harder, J., Bartels, J., Christophers, E., & Schröder, J. ‐. (1997) · Nature · doi:10.1038/43088 · Cited by 1,365

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

Harder, J., Bartels, J., Christophers, E., & Schröder, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008557200 · Cited by 1,309

Innate antimicrobial peptide protects the skin from invasive bacterial infection

Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198

Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease

Matsui, H., Grubb, B. R., Tarran, R., Randell, S. H., Gatzy, J. T., Davis, C. W., & Boucher, R. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81724-9 · Cited by 1,168

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,076

Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

Ayabe, T., Satchell, D. P., Wilson, C. L., Parks, W. C., Selsted, M. E., & Ouellette, A. J. (2000) · Nature Immunology · doi:10.1038/77783 · Cited by 1,060

Human neutrophil peptides 1, 2 and 3 are biochemical markers for metastatic colorectal cancer

Albrethsen, J., Møller, C. H., Olsen, J., Raskov, H., & Gammeltoft, S. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.05.039 · Cited by 59

Crohn’s disease-Defect in innate defence

Gersemann, M., Wehkamp, J., Fellermann, K., & Stange, E. F. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5499 · Cited by 59

QSAR analysis of antimicrobial and haemolytic effects of cyclic cationic antimicrobial peptides derived from protegrin-1

Frecer, V. (2006) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2006.05.005 · Cited by 59

Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence

Taudien, S., Galgóczy, P., Huse, K., Reichwald, K., Schilhabel, M. B., Szafranski, K., Shimizu, A., Asakawa, S., Frankish, A., Lončarević, I., et al. (2004) · BMC Genomics · doi:10.1186/1471-2164-5-92 · Cited by 59

β-defensins and the epididymis: contrasting influences of prenatal, postnatal, and adult scenarios

Avellar, M. C. W., Ribeiro, C. M., Silva, E. J. R., & Hinton, B. (2015) · Asian Journal of Andrology · doi:10.4103/1008-682x.168791 · Cited by 60

Host-defense peptides: from biology to therapeutic strategies

Mangoni, M. L. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0709-3 · Cited by 58

Human neutrophil peptide-1 inhibits both the classical and the lectin pathway of complement activation

Groeneveld, T. W. L., Ramwadhdoebé, T. H., Trouw, L. A., van den Ham, D. L., van der Borden, V., Drijfhout, J. W., Hiemstra, P. S., Daha, M. R., & Roos, A. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.03.003 · Cited by 58

Effects of swine gut antimicrobial peptides on the intestinal mucosal immunity in specific-pathogen-free chickens

Wang, D., Ma, W., She, R., Sun, Q., Liu, Y., Hu, Y., Liu, L., Yang, Y., & Peng, K. (2009) · Poultry Science · doi:10.3382/ps.2008-00533 · Cited by 58

Factors that deregulate the protective immune response in tuberculosis

Hernández‐Pando, R., Orozco, H., & Aguilar, D. (2009) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-009-0042-9 · Cited by 58

Esculentin-1a(1-21)NH2: a frog skin-derived peptide for microbial keratitis

Kolar, S. S. N., Luca, V., Baidouri, H., Mannino, G., McDermott, A. M., & Mangoni, M. L. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1694-0 · Cited by 58

Induction of antimicrobial peptides secretion by IL-1β enhances human amniotic membrane for regenerative medicine

Tehrani, F. A., Modaresifar, K., Azizian, S., & Niknejad, H. (2017) · Scientific Reports · doi:10.1038/s41598-017-17210-7 · Cited by 58

Microbiota and Colorectal Cancer: From Gut to Bedside

Silva, M. G., Brunner, V., & Tschurtschenthaler, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.760280 · Cited by 61

Identification of Specific Protein Markers in Microdissected Hepatocellular Carcinoma

Melle, C., Ernst, G., Scheibner, O., Kaufmann, R., Schimmel, B., Bleul, A., Settmacher, U., Hommann, M., Claussen, U., & von Eggeling, F. (2006) · Journal of Proteome Research · doi:10.1021/pr060439b · Cited by 58

Existence of functional lingual antimicrobial peptide in bovine milk

Isobe, N., Nakamura, J., Nakano, H., & Yoshimura, Y. (2009) · Journal of Dairy Science · doi:10.3168/jds.2008-1940 · Cited by 58

Analyses of Five Gallinacin Genes and the Salmonella enterica Serovar Enteritidis Response in Poultry

Hasenstein, J. R., Zhang, G., & Lamont, S. J. (2006) · Infection and Immunity · doi:10.1128/iai.00027-06 · Cited by 61

High level expression of human epithelial beta-defensins (hBD-1, 2 and 3) in papillomavirus induced lesions.

Chong, K. T., Xiang, L., Wang, X., Jun, E. L., Xi, L., & Schweinfurth, J. M. (2006) · Virology Journal · doi:10.1186/1743-422x-3-75 · Cited by 58

Penicillin-Binding Protein 1a Promotes Resistance of Group B Streptococcus to Antimicrobial Peptides

Hamilton, A., Popham, D. L., Carl, D. J., Lauth, X., Nizet, V., & Jones, A. L. (2006) · Infection and Immunity · doi:10.1128/iai.00895-06 · Cited by 58

Effects of lysine and methionine in a low crude protein diet on the growth performance and gene expression of immunity genes in broilers

Lee, C. Y., Song, A. A., Loh, T. C., & Rahim, R. A. (2020) · Poultry Science · doi:10.1016/j.psj.2020.03.013 · Cited by 57

Antimicrobial Proteins in Intestine and Inflammatory Bowel Diseases

Kim, J. M. (2014) · Intestinal Research · doi:10.5217/ir.2014.12.1.20 · Cited by 57

Antimicrobial peptides in echinoderm host defense

Li, C., Blencke, H., Haug, T., & Stensvåg, K. (2014) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2014.11.002 · Cited by 57

The Conserved Salt Bridge in Human α-Defensin 5 Is Required for Its Precursor Processing and Proteolytic Stability

Rajabi, M., de Leeuw, E., Pazgier, M., Li, J., Lubkowski, J. T., & Lu, W. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801851200 · Cited by 57

Bioinformatic and molecular characterization of beta-defensins-like peptides isolated from the green lizard Anolis carolinensis

Valle, L. D., Benato, F., Maistro, S., Quinzani, S., & Alibardi, L. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.05.004 · Cited by 57

Identification of 24h Ixodes scapularis immunogenic tick saliva proteins

Lewis, L. A., Radulović, Ž. M., Kim, T. K., Porter, L., & Mulenga, A. (2015) · Ticks and Tick-borne Diseases · doi:10.1016/j.ttbdis.2015.03.012 · Cited by 59

The struggle for iron: gastrointestinal microbes modulate the host immune response during infection

Markel, T. A., Crisostomo, P. R., Wang, M., Herring, C. M., Meldrum, K. K., Lillemoe, K. D., & Meldrum, D. R. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0906579 · Cited by 57

Sometimes It Takes Two to Tango

Pazgier, M., Wei, G., Ericksen, B., Jung, G., Wu, Z., de Leeuw, E., Yuan, W., Szmacinski, H., Lu, W., Lubkowski, J., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.332205 · Cited by 58

Effects of vitamin D on immune disorders with special regard to asthma, COPD and autoimmune diseases: a short review

Székely, J. I., & Pataki, Á. (2012) · Expert Review of Respiratory Medicine · doi:10.1586/ers.12.57 · Cited by 58

Alarmins and Antitumor Immunity

Nie, Y., Yang, D., & Oppenheim, J. J. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.03.021 · Cited by 57

Effects of Prebiotic Fiber Xylooligosaccharide in Adenine‐Induced Nephropathy in Mice

Yang, J., Li, Q., Henning, S. M., Zhong, J., Hsu, M., Lee, R., Long, J., Chan, B. C., Nagami, G. T., Heber, D., et al. (2018) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201800014 · Cited by 58

Electrospun nanofibers in wound healing

Sylvester, M. A., Amini, F., & Tan, C. K. (2020) · Materials Today Proceedings · doi:10.1016/j.matpr.2020.05.686 · Cited by 57

Mechanistic and Functional Studies of the Interaction of a Proline-rich Antimicrobial Peptide with Mammalian Cells

Tomasinsig, L., Skerlavaj, B., Papo, N., Giabbai, B., Shai, Y., & Zanetti, M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510354200 · Cited by 58

Antimicrobial proteins act as “alarmins” in joint immune defense

Yang, D., & Oppenheim, J. J. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20604 · Cited by 57

Cellular Catabolism of the Iron-Regulatory Peptide Hormone Hepcidin

Preza, G. C., Pinon, R., Ganz, T., & Nemeth, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058934 · Cited by 56

Staphylococcus aureus Infection of Epidermal Keratinocytes Promotes Expression of Innate Antimicrobial Peptides

Menzies, B. E., & Kenoyer, A. L. (2005) · Infection and Immunity · doi:10.1128/iai.73.8.5241-5244.2005 · Cited by 56

Roles of short-chain fatty acids in kidney diseases

Li, L.-Z., Tao, S., Ma, L., & Fu, P. (2019) · Chinese Medical Journal · doi:10.1097/cm9.0000000000000228 · Cited by 57

Outer membrane permeabilization by the membrane attack complex sensitizes Gram-negative bacteria to antimicrobial proteins in serum and phagocytes

Heesterbeek, D. A. C., Muts, R. M., van Hensbergen, V. P., Aulaire, P. D. S., Wennekes, T., Bardoel, B. W., van Sorge, N. M., & Rooijakkers, S. H. M. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009227 · Cited by 57

Candida albicans Mucin Msb2 Is a Broad-Range Protectant against Antimicrobial Peptides

Swidergall, M., Ernst, A. M., & Ernst, J. F. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00862-13 · Cited by 56

Effects of dietary supplementation with an antimicrobial peptide-P5 on growth performance, nutrient retention, excreta and intestinal microflora and intestinal morphology of broilers

Choi, S.-G., Ingale, S. L., Kim, J., Park, Y. K., Kwon, I. K., & Chae, B. J. (2013) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2013.07.005 · Cited by 56

β-Defensin in Nile tilapia (Oreochromis niloticus): Sequence, tissue expression, and anti-bacterial activity of synthetic peptides

Dong, J., Wu, F., Ye, X., Sun, C., Tian, Y., Lu, M., Zhang, R., & Chen, Z. (2015) · Gene · doi:10.1016/j.gene.2015.04.025 · Cited by 56

Polymer multilayers loaded with antifungal β-peptides kill planktonic Candida albicans and reduce formation of fungal biofilms on the surfaces of flexible catheter tubes

Raman, N., Lee, M., Palecek, S. P., & Lynn, D. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.05.026 · Cited by 56

Antibacterial activities of synthetic peptides corresponding to the carboxy-terminal region of human β-defensins 1–3

Krishnakumari, V., Singh, S. S., & Nagaraj, R. (2006) · Peptides · doi:10.1016/j.peptides.2006.06.004 · Cited by 56

Activity, Expression and Genetic Variation of Canine β-Defensin 103: A Multifunctional Antimicrobial Peptide in the Skin of Domestic Dogs

Leonard, B. C., Marks, S. L., Outerbridge, C. A., Affolter, V. K., Kananurak, A., Young, A. E., Moore, P. F., Bannasch, D. L., & Bevins, C. L. (2012) · Journal of Innate Immunity · doi:10.1159/000334566 · Cited by 56

Expression pattern, promoter activity and bactericidal property of β-defensin from the mandarin fish Siniperca chuatsi

Wang, G., Li, J., Zou, P., Xie, H., Huang, B., Nie, P., & Chang, M. (2012) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2012.06.003 · Cited by 56

Changes in salivary antimicrobial peptides, immunoglobulin A and cortisol after prolonged strenuous exercise

Usui, T., Yoshikawa, T., Orita, K., Ueda, S.-Y., Katsura, Y., Fujimoto, S., & Yoshimura, M. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1830-6 · Cited by 56

Overlap and diversity in antimicrobial peptide databases: compiling a non-redundant set of sequences

Aguilera‐Mendoza, L., Marrero‐Ponce, Y., Ibarra, R. T., Llorente-Quesada, M. T., Salgado, J., Barigye, S. J., & Liu, J. (2015) · Bioinformatics · doi:10.1093/bioinformatics/btv180 · Cited by 58

Host defense effector molecules in mucosal secretions

Tjabringa, G. S., Vos, J. B., Rodijk‐Olthuis, D., Ninaber, D. K., Rabe, K. F., Schalkwijk, J., Hiemstra, P. S., & Zeeuwen, P. L. J. M. (2005) · FEMS Immunology & Medical Microbiology · doi:10.1016/j.femsim.2005.03.004 · Cited by 56

Intramammary challenge of lipopolysaccharide stimulates secretion of lingual antimicrobial peptide into milk of dairy cows

Isobe, N., Morimoto, K., Nakamura, J., Yamasaki, A., & Yoshimura, Y. (2009) · Journal of Dairy Science · doi:10.3168/jds.2009-2594 · Cited by 56

Human immature monocyte-derived dendritic cells produce and secrete α-defensins 1–3

Rodríguez‐García, M., Oliva, H., Climent, N., García, F., Gatell, J. M., & Gallart, T. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0507295 · Cited by 56

Human Neutrophil Peptides and Phagocytic Deficiency in Bronchiectatic Lungs

Voglis, S., Quinn, K. L., Tullis, E. D., Liu, M., Henriques, M., Zubrinich, C. M., Peñuelas, Ó., Chan, H., Silverman, F., Cherepanov, V., et al. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200808-1250oc · Cited by 56

Human β-defensin 3 contains an oncolytic motif that binds PI(4,5)P2 to mediate tumour cell permeabilisation

Phan, T. K., Lay, F. T., Poon, I. K. H., Hinds, M. G., Kvansakul, M., & Hulett, M. D. (2015) · Oncotarget · doi:10.18632/oncotarget.6520 · Cited by 60

Human Basal Tear Peptidome Characterization by CID, HCD, and ETD Followed by in Silico and in Vitro Analyses for Antimicrobial Peptide Identification

Azkargorta, M., Soria, J. M., Ojeda, C., Guzmán, F., Acera, A., Iloro, I., Suárez, T., & Elortza, F. (2015) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5b00179 · Cited by 56

β-Defensins in the Fight against Helicobacter pylori

Pero, R., Coretti, L., Nigro, E., Lembo, F., Laneri, S., Lombardo, B., Daniele, A., & Scudiero, O. (2017) · Molecules · doi:10.3390/molecules22030424 · Cited by 56

For when bacterial infections persist: Toll-like receptor-inducible direct antimicrobial pathways in macrophages

Stocks, C. J., Schembri, M. A., Sweet, M. J., & Kapétanovic, R. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.4ri0917-358r · Cited by 58

The Human Salivary Antimicrobial Peptide Profile according to the Oral Microbiota in Health, Periodontitis and Smoking

Grant, M. M., Kilsgård, O., Åkerman, S., Klinge, B., Demmer, R. T., Malmström, J. A., & Jönsson, D. (2018) · Journal of Innate Immunity · doi:10.1159/000494146 · Cited by 56

Mechanisms of toxicity mediated by neutrophil and eosinophil granule proteins

Gigon, L., Yousefi, S., Karaulov, A. V., & Simon, H. (2020) · Allergology International · doi:10.1016/j.alit.2020.11.003 · Cited by 58

Lysozyme M deficiency leads to an increased susceptibility to Streptococcus pneumoniae-induced otitis media

Shimada, J., Moon, S. K., Lee, H.-Y., Takeshita, T., Pan, H., Woo, J.-I., Gellibolian, R., Yamanaka, N., & LIM, D. J. (2008) · BMC Infectious Diseases · doi:10.1186/1471-2334-8-134 · Cited by 56

Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense

Shaw, J. L. V., Petraki, C. D., Watson, C. S., Bocking, A. D., & Diamandis, E. P. (2008) · Biological Chemistry · doi:10.1515/bc.2008.171 · Cited by 56

Susceptibility to infection in patients with neutropenia: the role of the innate immune system

Neth, O., Bajaj‐Elliott, M., TURNER, M. W., & Klein, N. J. (2005) · British Journal of Haematology · doi:10.1111/j.1365-2141.2005.05462.x · Cited by 56

Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection

Dong, X., Limjunyawong, N., Sypek, E. I., Wang, G., Ortines, R. V., Youn, C., Alphonse, M. P., Dikeman, D. A., Wang, Y., Lay, M., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.021 · Cited by 56

Harnessing the Microbiome: CRISPR-Based Gene Editing and Antimicrobial Peptides in Combating Antibiotic Resistance and Cancer

Amen, R. A., Hassan, Y. M., Essmat, R. A., Ahmed, R. H., Azab, M. M., Shehata, N. R., Elgazzar, M. M., & El-Sayed, W. M. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10573-8 · Cited by 56

Heat-killed probiotic bacteria differentially regulate colonic epithelial cell production of human β-defensin-2: dependence on inflammatory cytokines

Habil, N., Abate, W., Beal, J., & Foey, A. (2014) · Beneficial Microbes · doi:10.3920/bm2013.0061 · Cited by 55

Toll-Like Receptors in Human Papillomavirus Infection

Zhou, Q., Zhu, K., & Cheng, H. (2013) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-013-0220-7 · Cited by 55

Differential and coordinated expression of defensins and cytokines by gingival epithelial cells and dendritic cells in response to oral bacteria

Yin, L., Chino, T., Horst, O. V., Hacker, B. M., Clark, E. A., Dale, B. A., & Chung, W. O. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-37 · Cited by 55

Expression and Antimicrobial Function of Beta-Defensin 1 in the Lower Urinary Tract

Becknell, B., Spencer, J. D., Carpenter, A. R., Chen, X., Singh, A., Ploeger, S., Kline, J. M., Ellsworth, P., Li, B., Proksch, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077714 · Cited by 55

Interaction of Human β-Defensin 2 (HBD2) with Glycosaminoglycans

Seo, E. S., Blaum, B. S., Vargues, T., Cecco, M. D., Deakin, J. A., Lyon, M., Barran, P. E., Campopiano, D. J., & Uhrı́n, D. (2010) · Biochemistry · doi:10.1021/bi1011749 · Cited by 55

Why Do We have to Move Fluid to be Able to Breathe?

Fronius, M., Clauss, W. G., & Althaus, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00146 · Cited by 55

Plasticity of neutrophils reveals modulatory capacity

Perobelli, S. M., Galvani, R. G. A., Gonçalves-Silva, T., Xavier, C. R., Nóbrega, A., & Bonomo, A. C. (2015) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20154524 · Cited by 57

The gut microbiome as a virtual endocrine organ with implications for farm and domestic animal endocrinology

O’Callaghan, T. F., Ross, R. P., Stanton, C., & Clarke, G. A. (2016) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2016.05.003 · Cited by 56

Enhanced antifungal activity of bovine lactoferrin-producing probiotic Lactobacillus casei in the murine model of vulvovaginal candidiasis

Liao, H., Liu, S., Wang, H., Su, H., & Liu, Z. (2019) · BMC Microbiology · doi:10.1186/s12866-018-1370-x · Cited by 55

ADP-ribosyltransferase-specific Modification of Human Neutrophil Peptide-1

Paone, G., Stevens, L. A., Levine, R. L., Bourgeois, C., Steagall, W. K., Gochuico, B. R., & Moss, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603042200 · Cited by 55

The Potential Role of Lung Epithelial Cells and β‐defensins in Experimental Latent Tuberculosis

Rivas-Santiago, B. T., Contreras, J. C. L., Sada, E., & Hernández‐Pando, R. (2008) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2008.02088.x · Cited by 55

Mouse Paneth Cell Secretory Responses to Cell Surface Glycolipids of Virulent and Attenuated Pathogenic Bacteria

Tanabe, H., Ayabe, T., Bainbridge, B. W., Guina, T., Ernst, R. K., Darveau, R. P., Miller, S. I., & Ouellette, A. J. (2005) · Infection and Immunity · doi:10.1128/iai.73.4.2312-2320.2005 · Cited by 55

Increasing the Recruitment of Neutrophils to the Site of Infection Dramatically Attenuates Borrelia burgdorferi Infectivity

Xu, Q., Seemanapalli, S. V., Reif, K. E., Brown, C. R., & Liang, F. T. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.8.5109 · Cited by 55

Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms

Kerley, C. P., Elnazir, B., Faul, J. L., & Cormican, L. J. (2015) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2015.02.004 · Cited by 54

Structural aspects and biological properties of the cathelicidin PMAP‐36

Scocchi, M., Zelezetsky, I., Benincasa, M., Gennaro, R., Mazzoli, A., & Tossi, A. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04852.x · Cited by 54

Inactivation of the budded virus of Autographa californica M nucleopolyhedrovirus by gloverin

Moreno-Habel, D. A., Biglang-awa, I. M., Dulce, A., Luu, D. D., Garcia, P., Weers, P. M. M., & Haas-Stapleton, E. J. (2012) · Journal of Invertebrate Pathology · doi:10.1016/j.jip.2012.02.007 · Cited by 54

A Peptide Derived from Phage Display Library Exhibits Antibacterial Activity against E. coli and Pseudomonas aeruginosa

Rao, S. S., Mohan, K. V. K., & Atreya, C. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056081 · Cited by 54

Effective Control of Salmonella Infections by Employing Combinations of Recombinant Antimicrobial Human β-Defensins hBD-1 and hBD-2

Maiti, S., Patro, S., Purohit, S., Jain, S., Senapati, S., & Dey, N. (2014) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.03628-14 · Cited by 55

Proteomic discovery of diverse immunity molecules in mammalian spermatozoa

Dorus, S., Skerget, S., & Karr, T. L. (2012) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2012.700442 · Cited by 55

Immune regulatory functions of human beta‐defensin‐2 in odontoblast‐like cells

Dommisch, H., Winter, J., Willebrand, C. O. G., Eberhard, J., & Jepsen, S. V. (2007) · International Endodontic Journal · doi:10.1111/j.0143-2885.2007.01228.x · Cited by 54

Human -defensin 3 promotes NF- B-mediated CCR7 expression and anti-apoptotic signals in squamous cell carcinoma of the head and neck

Mburu, Y. K., Abe, K., Ferris, L. K., Sarkar, S. N., & Ferris, R. L. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq236 · Cited by 54

iDPF-PseRAAAC: A Web-Server for Identifying the Defensin Peptide Family and Subfamily Using Pseudo Reduced Amino Acid Alphabet Composition

Zuo, Y., Lv, Y., Wei, Z., Yang, L., Li, G., & Fan, G.-L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145541 · Cited by 54

Effective Design of Multifunctional Peptides by Combining Compatible Functions

Diener, C., Garza‐Ramos, G., Moreno-Blas, D., González, D. A. C., Corzo, G. A., Castro‐Obregón, S., & del Rio, G. (2016) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1004786 · Cited by 54

Defensins: The Case for Their Use against Mycobacterial Infections

Dong, H., Lv, Y., Zhao, D., Barrow, P., & Zhou, X. (2016) · Journal of Immunology Research · doi:10.1155/2016/7515687 · Cited by 54

Advances in lactoferrin research concerning bovine mastitis

Shimazaki, K., & Kawai, K. (2017) · Biochemistry and Cell Biology · doi:10.1139/bcb-2016-0044 · Cited by 56

Necrotizing Enterocolitis

Srinivasan, P., Brandler, M. D., & D’Souza, A. (2008) · Clinics in Perinatology · doi:10.1016/j.clp.2007.11.009 · Cited by 54

Neurogenic Inflammation: A First Line of Defense for the Ocular Surface

Beuerman, R. W., & Stern, M. E. (2005) · The Ocular Surface · doi:10.1016/s1542-0124(12)70256-2 · Cited by 54

Peptidoglycan Recognition Protein 2 (N-Acetylmuramoyl- l -Ala Amidase) Is Induced in Keratinocytes by Bacteria through the p38 Kinase Pathway

Wang, H., Gupta, D., Li, X., & Dziarski, R. (2005) · Infection and Immunity · doi:10.1128/iai.73.11.7216-7225.2005 · Cited by 56

Why Is the Arg5-Glu13 Salt Bridge Conserved in Mammalian α-Defensins?

Wu, Z., Li, X., de Leeuw, E., Ericksen, B., & Lu, W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510562200 · Cited by 54

Identification, characterization, and evolution of a primate β-defensin gene cluster

Radhakrishnan, Y., Hamil, K. G., Yenugu, S., Young, S. L., French, F. S., & Hall, S. H. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364184 · Cited by 54

The Effect of the Antimicrobial Peptide Plectasin on the Growth Performance, Intestinal Health, and Immune Function of Yellow-Feathered Chickens

Zhang, X., Zhao, Q., Wen, L., Wu, C., Yao, Z., Yan, Z., Li, R., Chen, L., Chen, F., Xie, Z., et al. (2021) · Frontiers in Veterinary Science · doi:10.3389/fvets.2021.688611 · Cited by 53

NMR Solution Structure and Condition-Dependent Oligomerization of the Antimicrobial Peptide Human Defensin 5

Wommack, A. J., Robson, S. A., Wanniarachchi, Y. A., Wan, A., Turner, C. J., Wagner, G., & Nolan, E. M. (2012) · Biochemistry · doi:10.1021/bi301255u · Cited by 54

Early Immunologic Events at the Tick-Host Interface

Heinze, D. M., Carmical, J. R., Aronson, J. F., & Thangamani, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047301 · Cited by 53

Acquisition, Evolution and Maintenance of the Normal Gut Microbiota

Macfarlane, G. T., & Macfarlane, L. E. (2009) · Digestive Diseases · doi:10.1159/000268127 · Cited by 57

Rubber elasticity for incomplete polymer networks

Nishi, K., Chijiishi, M., Katsumoto, Y., Nakao, T., Fujii, K., Chung, U., Noguchi, H., Sakai, T., & Shibayama, M. (2012) · The Journal of Chemical Physics · doi:10.1063/1.4769829 · Cited by 53

Innate Immune Functions of α-Defensins in the Small Intestine

Bevins, C. L. (2013) · Digestive Diseases · doi:10.1159/000354681 · Cited by 55

Antimicrobial activity of truncated α-defensin (human neutrophil peptide (HNP)-1) analogues without disulphide bridges

Lundy, F. T., Nelson, J., Lockhart, D., Greer, B., Harriott, P., & Marley, J. J. (2007) · Molecular Immunology · doi:10.1016/j.molimm.2007.04.018 · Cited by 53

Locus‐specific protocol for nine different innate immune genes (antimicrobial peptides: β‐defensins) across passerine bird species reveals within‐species coding variation and a case of trans‐species polymorphisms

Hellgren, O., & Sheldon, B. C. (2011) · Molecular Ecology Resources · doi:10.1111/j.1755-0998.2011.02995.x · Cited by 53

Antimicrobial peptides in saliva of children with severe early childhood caries

Colombo, N. H., Ribas, L. F. F., Pereira, J. A., Kreling, P. F., Kressirer, C. A., Tanner, A. C. R., & Duque, C. (2016) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2016.05.009 · Cited by 53

Cyclisation mechanisms in the biosynthesis of ribosomally synthesised and post-translationally modified peptides

Truman, A. W. (2016) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.12.120 · Cited by 53

Antimicrobial Properties of Amniotic and Chorionic Membranes: A Comparative Study of Two Human Fetal Sacs.

Bidaki, M. Z., Sadrinia, S., Erfani, S., Afkar, E., & Ghanbarzade, N. (2017) · PubMed Central · Cited by 53

Mammalian defensins in the antimicrobial immune response

Selsted, M. E., & Ouellette, A. J. (2005) · Nature Immunology · doi:10.1038/ni1206 · Cited by 1,231

Defensins: Natural component of human innate immunity

Jarczak, J., Kościuczuk, E. M., Lisowski, P., Strzałkowska, N., Jóźwik, A., Horbańczuk, J. O., Krzyżewski, J., Zwierzchowski, L., & Bagnicka, E. (2013) · Human Immunology · doi:10.1016/j.humimm.2013.05.008 · Cited by 200

Defensins: More than Nature�s Anti-bug Spray?

de Leeuw, E. (2013) · Journal of Bioanalysis & Biomedicine · doi:10.4172/1948-593x.s8-001 · Cited by 1

Peptides and proteins with antimicrobial activity

Coutinho, H. D. M., Lobo, K., Bezerra, D. A. C., & Lobo, I. (2008) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.40481 · Cited by 42

Defensins and Host Defense

Ganz, T. (1999) · Science · doi:10.1126/science.286.5439.420 · Cited by 321