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Signalling pathways of the TNF superfamily: a double-edged sword
Abstract
Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past two decades has shown the existence of a superfamily of TNF proteins consisting of 19 members that signal through 29 receptors. These ligands, while regulating normal functions such as immune responses, haematopoiesis and morphogenesis, have also been implicated in tumorigenesis, transplant rejection, septic shock, viral replication, bone resorption, rheumatoid arthritis and diabetes; so indicating their role as 'double-edged swords'. These cytokines either induce cellular proliferation, survival, differentiation or apoptosis. Blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases in the United States and other countries.
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“TNF-α is a pro-inflammatory cytokine and a potent activator of the transcription factor NF-κB, which induces the expression of a multitude of pro-mitogenic, pro-inflammatory, and anti-apoptotic proteins, thus promoting cell proliferation and survival [102].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [102]
In the citing paper
“However, TNF-α is also a powerful apoptotic inducer in vitro when NF-κB signaling is blocked, typically by the addition of cycloheximide.”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [102]
In the citing paper
“Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine that acts on its receptors (TNFRs) to promote either cell survival or cell death 54.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [54]
Citations
Cites
Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation.
Lacey, D. L., Timms, E., Tan, H.-L., Kelley, M. J., Dunstan, C. R., Burgess, T., Elliott, R., Colombero, A., Elliott, G., Scully, S., et al. (1998) · Cell · doi:10.1016/s0092-8674(00)81569-x · Cited by 5,439
Osteoprotegerin: a novel secreted protein involved in the regulation of bone density.
Simonet, W. S., Lacey, D. L., Dunstan, C. R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H. Q., Wooden, S., Bennett, L., Boone, T., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80209-3 · Cited by 5,130
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Nagata, S., & Golstein, P. (1995) · Science · doi:10.1126/science.7533326 · Cited by 3,979
The TNF and TNF Receptor Superfamilies
Locksley, R. M., Killeen, N., & Lenardo, M. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00237-9 · Cited by 3,650
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph node organogenesis.
Kong, Y.-Y., Yoshida, H., Sarosi, I., Tan, H.-L., Timms, E., Capparelli, C., Morony, S., Oliveira-dos-Santos, A. J., Van, G., Itie, A., et al. (1999) · Nature · doi:10.1038/16852 · Cited by 3,351
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Black, R. A., Rauch, C. T., Kozlosky, C. J., Peschon, J. J., Slack, J. L., Wolfson, M. F., Castner, B. J., Stocking, K. L., Reddy, P., Srinivasan, S., et al. (1997) · Nature · doi:10.1038/385729a0 · Cited by 3,149
Identification and characterization of a new member of the TNF family that induces apoptosis
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C.-P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., Smith, C. A., et al. (1995) · Immunity · doi:10.1016/1074-7613(95)90057-8 · Cited by 2,900
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis
Itoh, N., Yonehara, S., Ishii, A., Yonehara, M., Mizushima, S.-I., Sameshima, M., Hase, A., Seto, Y., & Nagata, S. (1991) · Cell · doi:10.1016/0092-8674(91)90614-5 · Cited by 2,736
NF-κB at the crossroads of life and death
Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification.
Bucay, N., Sarosi, I., Dunstan, C. R., Morony, S., Tarpley, J., Capparelli, C., Scully, S., Tan, H. L., Xu, W., Lacey, D. L., et al. (1998) · Genes & Development · doi:10.1101/gad.12.9.1260 · Cited by 2,483
Tumor necrosis factor signaling
Wajant, H., Pfizenmaier, K., & Scheurich, P. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401189 · Cited by 2,422
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function.
Anderson, D. M., Maraskovsky, E., Billingsley, W. L., Dougall, W. C., Tometsko, M. E., Roux, E. R., Teepe, M. C., DuBose, R. F., Cosman, D., & Galibert, L. (1997) · Nature · doi:10.1038/36593 · Cited by 2,290
Protection from obesity-induced insulin resistance in mice lacking TNF-α function
Uysal, K. T., Wiesbrock, S. M., Marino, M. W., & Hotamisligil, G. S. (1997) · Nature · doi:10.1038/39335 · Cited by 2,234
Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995) · Science · doi:10.1126/science.270.5239.1189 · Cited by 1,990
TNF-R1 Signaling: A Beautiful Pathway
Chen, G., & Goeddel, D. V. (2002) · Science · doi:10.1126/science.1071924 · Cited by 1,930
The TNF receptor superfamily of cellular and viral proteins: Activation, costimulation, and death
Smith, C. A., Farrah, T., & Goodwin, R. G. (1994) · Cell · doi:10.1016/0092-8674(94)90372-7 · Cited by 1,909
Induction of Apoptosis by Apo-2 Ligand, a New Member of the Tumor Necrosis Factor Cytokine Family
Pitti, R. M., Marsters, S. A., Ruppert, S., Donahue, C. J., Moore, A., & Ashkenazi, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.22.12687 · Cited by 1,777
The Receptor for the Cytotoxic Ligand TRAIL
Pan, G., O’Rourke, K. M., Chinnaiyan, A. M., Gentz, R., Ebner, R., Ni, J., & Dixit, V. M. (1997) · Science · doi:10.1126/science.276.5309.111 · Cited by 1,755
Signal transduction by tumor necrosis factor and its relatives.
Baud, V., & Karin, M. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02064-5 · Cited by 1,741
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
Pennica, D., Nedwin, G. E., Hayflick, J. S., Seeburg, P. H., Derynck, R., Palladino, M. A., Kohr, W. J., Aggarwal, B. B., & Goeddel, D. V. (1984) · Nature · doi:10.1038/312724a0 · Cited by 1,732
Self-citationSugarman, B. J., Aggarwal, B. B., Hass, P. E., Figari, I. S., Palladino, M. A., & Shepard, H. M. (1985) · Science · doi:10.1126/science.3933111 · Cited by 1,572
Self-citationMcDermott, M., Aksentijevich, I. A., Galon, J., McDermott, E. M., Ogunkolade, B.-W., Centola, M. B., Mansfield, E. A., Gadina, M., Karenko, L., Pettersson, T., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)80721-7 · Cited by 1,404
Yonehara, S., Ishii, A., & Yonehara, M. (1989) · The Journal of Experimental Medicine · doi:10.1084/jem.169.5.1747 · Cited by 1,398
Targeting death and decoy receptors of the tumour-necrosis factor superfamily
Ashkenazi, A. (2002) · Nature reviews. Cancer · doi:10.1038/nrc821 · Cited by 1,351
BAFF, a Novel Ligand of the Tumor Necrosis Factor Family, Stimulates B Cell Growth
Schneider, P., Mackay, F., Steiner, V., Hofmann, K., Bodmer, J.-L., Holler, N., Ambrose, C. M., Lawton, P., Bixler, S. A., Acha‐Orbea, H., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.189.11.1747 · Cited by 1,334
Grell, M., Douni, E. K., Wajant, H., Löhden, M., Clauss, M. A., Maxeiner, B., Georgopoulos, S., Lesslauer, W., Kollias, G. A., Pfizenmaier, K., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90192-2 · Cited by 1,328
A novel domain within the 55 kd TNF receptor signals cell death
Tartaglia, L. A., Ayres, T. M., Wong, G. H., & Goeddel, D. V. (1993) · Cell · doi:10.1016/0092-8674(93)90464-2 · Cited by 1,290
MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1
Malinin, N. L., Boldin, M., Kovalenko, A. V., & Wallach, D. (1997) · Nature · doi:10.1038/385540a0 · Cited by 1,279
Anti-TNFα Therapy of Rheumatoid Arthritis: What Have We Learned?
Feldmann, M., & Maini, R. N. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.163 · Cited by 1,252
Tumor necrosis factor alpha inhibits signaling from the insulin receptor.
Hotamışlıgil, G. S., Murray, D. L., Choy, L., & Spiegelman, B. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4854 · Cited by 1,220
Lpr and gld: Single Gene Models of Systemic Autoimmunity and Lymphoproliferative Disease
Cohen, P. L., & Eisenberg, R. A. (1991) · Annual Review of Immunology · doi:10.1146/annurev.iy.09.040191.001331 · Cited by 1,169
Identity of tumour necrosis factor and the macrophage-secreted factor cachectin
Beutler, B., Greenwald, D., Hulmes, J. D., Chang, M., Pan, Y.-C. E., Mathison, J. C., Ulevitch, R. J., & Cerami, A. (1985) · Nature · doi:10.1038/316552a0 · Cited by 1,132
The Death Domain Kinase RIP Mediates the TNF-Induced NF-κB Signal
Kelliher, M. A., Grimm, S., Ishida, Y., Kuo, F., Stanger, B. Z., & Leder, P. (1998) · Immunity · doi:10.1016/s1074-7613(00)80535-x · Cited by 1,102
BAFF and APRIL: A Tutorial on B Cell Survival
Mackay, F., Schneider, P., Rennert, P. D., & Browning, J. L. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141152 · Cited by 1,004
Apo2L/TRAIL-Dependent Recruitment of Endogenous FADD and Caspase-8 to Death Receptors 4 and 5
Kischkel, F. C., Lawrence, D. A., Chuntharapai, A., Schow, P., Kim, K. J., & Ashkenazi, A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80212-5 · Cited by 975
The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways
Dejardin, E., Droin, N. M., Delhase, M., Haas, E., Cao, Y., Makris, C., Li, Z., Karin, M., Ware, C. F., & Green, D. R. (2002) · Immunity · doi:10.1016/s1074-7613(02)00423-5 · Cited by 923
Human tumor necrosis factor. Production, purification, and characterization.
Aggarwal, B. B., Kohr, W. J., Hass, P. E., Moffat, B., Spencer, S. A., Henzel, W. J., Bringman, T. S., Nedwin, G. E., Goeddel, D. V., & Harkins, R. N. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89560-6 · Cited by 917
Self-citationCharacterization of receptors for human tumour necrosis factor and their regulation by γ-interferon
Aggarwal, B. B., Eessalu, T. E., & Hass, P. E. (1985) · Nature · doi:10.1038/318665a0 · Cited by 876
Self-citationA Domain in TNF Receptors That Mediates Ligand-Independent Receptor Assembly and Signaling
Chan, F. K.-M., Chun, H. J., Zheng, L., Siegel, R. M., Bui, K. L., & Lenardo, M. J. (2000) · Science · doi:10.1126/science.288.5475.2351 · Cited by 856
Wong, B. R., Josien, R., Lee, S. Y., Sauter, B., Li, H.-L., Steinman, R. M., & Choi, Y. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.12.2075 · Cited by 853
A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen
Itoh, N., & Nagata, S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)82075-0 · Cited by 845
Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis
Moore, R. J., Owens, D. M., Stamp, G., Arnott, C., Burke, F., East, N., Holdsworth, H., Turner, L., Rollins, B., Pasparakis, M., et al. (1999) · Nature Medicine · doi:10.1038/10552 · Cited by 839
Yeh, W., Shahinian, A., Speiser, D. E., Kraunus, J., Billia, F., Wakeham, A. C., de la Pompa, J. L., Ferrick, D. A., Hum, B., Iscove, N. N., et al. (1997) · Immunity · doi:10.1016/s1074-7613(00)80391-x · Cited by 798
Nagata, S. (1999) · Annual Review of Genetics · doi:10.1146/annurev.genet.33.1.29 · Cited by 777
Fata, J. E., Kong, Y.-Y., Li, J., Sasaki, T., Irie-Sasaki, J., Moorehead, R. A., Elliott, R., Scully, S., Voura, E. B., Lacey, D. L., et al. (2000) · Cell · doi:10.1016/s0092-8674(00)00103-3 · Cited by 756
Gardam, M. A., Keystone, E. C., Menzies, R., Manners, S., Skamene, E., Long, R., & Vinh, D. C. (2003) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(03)00545-0 · Cited by 742
CONTRIBUTION TO THE KNOWLEDGE OF SARCOMA
COLEY, W. B. (1891) · Annals of Surgery · doi:10.1097/00000658-189112000-00015 · Cited by 717
Chun, H. J., Zheng, L., Ahmad, M., Wang, J., Speirs, C. K., Siegel, R. M., Dale, J. K., Puck, J. M., Davis, J., Hall, C. G., et al. (2002) · Nature · doi:10.1038/nature01063 · Cited by 706
TRAIL Receptors 1 (DR4) and 2 (DR5) Signal FADD-Dependent Apoptosis and Activate NF-κB
Schneider, P., Thome, M., Burns, K., Bodmer, J.-L., Hofmann, K., Kataoka, T., Holler, N., & Tschopp, J. (1997) · Immunity · doi:10.1016/s1074-7613(00)80401-x · Cited by 697
BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells
Claudio, E., Brown, K., Park, S., Wang, H., & Siebenlist, U. K. (2002) · Nature Immunology · doi:10.1038/ni842 · Cited by 694
Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity
Gray, P. W., Aggarwal, B. B., Benton, C. V., Bringman, T. S., Henzel, W. J., Jarrett, J. A., Leung, D. W., Moffat, B., Ng, P., Svedersky, L. P., et al. (1984) · Nature · doi:10.1038/312721a0 · Cited by 641
Self-citationTL1A Is a TNF-like Ligand for DR3 and TR6/DcR3 and Functions as a T Cell Costimulator
Migone, T., Zhang, J., Luo, X., Zhuang, L., Chen, C., Hu, B., Hong, J. S., Perry, J. W., Chen, S.-F., Zhou, J. X. H., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00283-2 · Cited by 637
Cretney, E., Takeda, K., Yagita∥, H., Glaccum, M. B., Peschon, J. J., & Smyth, M. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.3.1356 · Cited by 615
Arch, R. H., Gedrich, R. W., & Thompson, C. B. (1998) · Genes & Development · doi:10.1101/gad.12.18.2821 · Cited by 611
Suda, T., Hashimoto, H., Tanaka, M., Ochi, T., & Nagata, S. (1997) · Journal of Experimental Medicine · doi:10.1084/jem.186.12.2045 · Cited by 558
Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity
Ichikawa, K., Liu, W., Zhao, L., Wang, Z., Liu, D., Ohtsuka, T., Zhang, H., Mountz, J. D., Koopman, W. J., Kimberly, R. P., et al. (2001) · Nature Medicine · doi:10.1038/91000 · Cited by 544
NF-κB blockade and oncogenic Ras trigger invasive human epidermal neoplasia
Dajee, M., Lazarov, M., Zhang, J. Y., Cai, T., Green, C. L., Russell, A. J., Marinkovich, M. P., Tao, S., Lin, Q., Kubo, Y., et al. (2003) · Nature · doi:10.1038/nature01283 · Cited by 535
Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
Hughes, A. E., Ralston, S. H., Marken, J., Bell, C., Macpherson, H. K., Wallace, R. G. H., Hul, W. V., Whyte, M. P., Nakatsuka, K., Hovy, L., et al. (2000) · Nature Genetics · doi:10.1038/71667 · Cited by 484
Cao, Y., Bonizzi, G., Seagroves, T. N., Greten, F. R., Johnson, R. S., Schmidt, E. V., & Karin, M. (2001) · Cell · doi:10.1016/s0092-8674(01)00599-2 · Cited by 479
Kayagaki, N., Yan, M., Seshasayee, D., Wang, H., Lee, W. P., French, D. M., Grewal, I. S., Cochran, A. G., Gordon, N. C., Yin, J., et al. (2002) · Immunity · doi:10.1016/s1074-7613(02)00425-9 · Cited by 476
Recruitment of TNF Receptor 1 to Lipid Rafts Is Essential for TNFα-Mediated NF-κB Activation
Legler, D. F., Micheau, O., Doucey, M., Tschopp, J., & Bron, C. (2003) · Immunity · doi:10.1016/s1074-7613(03)00092-x · Cited by 473
Straus, S. E. (2001) · Blood · doi:10.1182/blood.v98.1.194 · Cited by 464
TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2
Li, X., Yang, Y., & Ashwell, J. D. (2002) · Nature · doi:10.1038/416345a · Cited by 452
Williamson, B., Carswell, E. A., Rubin, B. Y., Prendergast, J., & Old, L. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.17.5397 · Cited by 451
Emanuelli, B., Peraldi, P., Filloux, C., Carine Chavey, A., Freidinger, K., Hilton, D. J., Hotamışlıgil, G. S., & OBBERGHEN, E. V. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104602200 · Cited by 449
Kelley, S. K., Harris, L. A., Xie, D., DeForge, L. E., Tótpál, K., Bussiere, J., & Fox, J. A. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29298-3 · Cited by 444
Powell, W. C., Fingleton, B., Wilson, C. L., Boothby, M. R., & Matrisian, L. M. (1999) · Current Biology · doi:10.1016/s0960-9822(00)80113-x · Cited by 421
Nocentini, G., Giunchi, L., Ronchetti, S., Krausz, L. T., Bartoli, A., Moraca, R., Migliorati, G., & Riccardi, C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.12.6216 · Cited by 412
Lum, L., Wong, B. R., Josien, R., Becherer, J. D., Erdjument‐Bromage, H., Schlöndorff, J. S., Tempst, P., Choi, Y., & Blobel, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13613 · Cited by 412
Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice
Li, Y., Wu, L., Wesche, H., Arthur, C. D., White, J. M., Goeddel, D. V., & Schreiber, R. D. (2001) · Science · doi:10.1126/science.1058453 · Cited by 408
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease
Suenaert, P., Bulteel, V., Lemmens, L., Noman, M., Geypens, B. J., Assche, G. V., Geboes, K. J., Ceuppens, J. L., & Rutgeerts, P. J. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05914.x · Cited by 402
Darnay, B. G., Ni, J., Moore, P. A., & Aggarwal, B. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7724 · Cited by 399
Self-citationRomas, E., Gillespie, M., & Martin, T. (2002) · Bone · doi:10.1016/s8756-3282(01)00682-2 · Cited by 390
CRINKLY4: A TNFR-Like Receptor Kinase Involved in Maize Epidermal Differentiation
Becraft, P. W., Stinard, P. S., & McCarty, D. R. (1996) · Science · doi:10.1126/science.273.5280.1406 · Cited by 386
Song, K., Chen, Y., Göke, R., Wilmen, A., Seidel, C., Göke, A., Hilliard, B. A., & Chen, Y. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.7.1095 · Cited by 361
Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL−/− mice
Lamhamedi-Cherradi, S.-E., Zheng, S. J., Maguschak, K. A., Peschon, J. J., & Chen, Y. H. (2003) · Nature Immunology · doi:10.1038/ni894 · Cited by 350
Mukhopadhyay, A., Ni, J., Zhai, Y., Yu, G.-L., & Aggarwal, B. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.15978 · Cited by 319
Self-citationRegulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-κB
Ravi, R. K., Bedi, G. C., Engstrom, L., Zeng, Q., Mookerjee, B., Gélinas, C., Fuchs, E. J., & Bedi, A. (2001) · Nature Cell Biology · doi:10.1038/35070096 · Cited by 316
Tada, K., Okazaki, T., Sakon, S., Kobarai, T., Kurosawa, K., Yamaoka, S., Hashimoto, H., Mak, T. W., Yagita, H., Okumura, K., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104837200 · Cited by 306
Identification and functional characterization of DR6, a novel death domain‐containing TNF receptor
Pan, G., Bauer, J. H., Haridas, V., Wang, S., Ding, L., Yu, G., Vincenz, C., Aggarwal, B. B., Ni, J., & Dixit, V. M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00791-1 · Cited by 292
Self-citationAggarwal, B. B., Moffat, B., & Harkins, R. N. (1984) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43716-1 · Cited by 290
Self-citationGrell, M., Zimmermann, G., Gottfried, E., Chen, C., Grünwald, U., Huang, D. C. S., Lee, Y. W., Dürkop, H., Engelmann, H., Scheurich, P., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.11.3034 · Cited by 284
Mekk3 is essential for early embryonic cardiovascular development
Yang, J., Boerm, M., McCarty, M. F., BUCANA, C. D., Fidler, I. J., Yang, Y. Z. J., & Su, B. (2000) · Nature Genetics · doi:10.1038/73550 · Cited by 244
Current uses of isolated limb perfusion in the clinic and a model system for new strategies
Eggermont, A. M. M., de Wilt, J. H., & ten Hagen, T. L. M. (2003) · The Lancet Oncology · doi:10.1016/s1470-2045(03)01141-0 · Cited by 236
Feinberg, B. A., Kurzrock, R., Talpaz, M., Blick, M. B., Saks, S. R., & Gutterman, J. U. (1988) · Journal of Clinical Oncology · doi:10.1200/jco.1988.6.8.1328 · Cited by 221
Harper, N. W., Hughes, M. A., MacFarlane, M., & Cohen, G. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303399200 · Cited by 209
Isotype-Dependent Inhibition of Tumor Growth In Vivo by Monoclonal Antibodies to Death Receptor 4
Chuntharapai, A., Dodge, K., Grimmer, K., Schroeder, K. A., Marsters, S. A., Koeppen, H., Ashkenazi, A., & Kim, K. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.4891 · Cited by 203
Identity of differentiation inducing factor and tumour necrosis factor
Takeda, K., Iwamoto, S., Sugimoto, H., Takuma, T., Kawatani, N., Noda, M., Masaki, A., Morise, H., Arimura, H., & Konno, K. (1986) · Nature · doi:10.1038/323338a0 · Cited by 182
Kwon, B. S., Wang, S., Udagawa, N., Haridas, V., Lee, Z. H., Kim, K. K., Oh, K., Greene, J., Li, Y., Su, J. Y., et al. (1998) · The FASEB Journal · doi:10.1096/fasebj.12.10.845 · Cited by 179
Self-citationPrimary structure of human lymphotoxin derived from 1788 lymphoblastoid cell line.
Aggarwal, B. B., Henzel, W. J., Moffat, B., Kohr, W. J., & Harkins, R. N. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)89559-x · Cited by 170
Self-citationWielockx, B., Lannoy, K., Shapiro, S. D., Itoh, T., Itohara, S., Vandekerckhove, J. S., & Libert, C. (2001) · Nature Medicine · doi:10.1038/nm1101-1202 · Cited by 166
Shear, M. J., Turner, F. C., Perrault, A., & Shovelton, T. (1943) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/4.1.81 · Cited by 163
A Role for Fas in Negative Selection of Thymocytes In Vivo
Kishimoto, H., Surh, C. D., & Sprent, J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1427 · Cited by 161
Zhai, Y., Ni, J., Jiang, G., Lu, J., Xing, L., Lincoln, C., Carter, K. C., Janat, F., KOZAK, D., XU, S., et al. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.1.181 · Cited by 159
Self-citationFisher, M. J., Virmani, A. K., Wu, L., Aplenc, R., Harper, J. C., Powell, S. M., Rebbeck, T. R., Sidransky, D., Gazdar, A. F., & El‐Deiry, W. S. (2001) · PubMed · Cited by 143
Weiß, T., Grell, M., Siemienski, K., Mühlenbeck, F., Dürkop, H., Pfizenmaier, K., Scheurich, P., & Wajant, H. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.6.3136 · Cited by 134
Chen, Y., Molloy, S. S., Thomas, L., Gambee, J. E., Bächinger, H. P., Ferguson, B. M., Zonana, J., Thomas, G., & Morris, N. P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.131076098 · Cited by 124
Zheng, Y., Ouaaz, F., Bruzzo, P., Singh, V., Gerondakis, S., & Beg, A. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.8.4949 · Cited by 117
Induction of TNF‐sensitive cellular phenotype by c‐Myc involves p53 and impaired NF‐κB activation
Klefström, J. T., Arighi, E., Littlewood, T., Jäättelä, M., Saksela, E., Evan, G. I., & Alitalo, K. K. (1997) · The EMBO Journal · doi:10.1093/emboj/16.24.7382 · Cited by 117
Lymphocyte in vitro Cytotoxicity: Lymphotoxins of Several Mammalian Species
Williams, T. W., & Granger, G. A. (1968) · Nature · doi:10.1038/2191076a0 · Cited by 115
Nagata, S. (1998) · Journal of Human Genetics · doi:10.1007/s100380050029 · Cited by 97
Kasof, G. M., Lu, J. J., Liu, D., Speer, B. S., Mongan, K. N., Gomes, B. C., & Lorenzi, M. V. (2001) · Oncogene · doi:10.1038/sj.onc.1204985 · Cited by 96
Inflammatory Mediators and the Failing Heart: A Translational Approach
Diwan, A., Tran, T. T., Misra, A., & Mann, D. L. (2003) · Current Molecular Medicine · doi:10.2174/1566524033361537 · Cited by 93
Tumour Necrosis Factor in Chronic Heart Failure
Bolger, A. P., & Anker, S. D. (2000) · Drugs · doi:10.2165/00003495-200060060-00002 · Cited by 86
Death Receptor Signaling Giving Life to Ectodermal Organs
Thesleff, I., & Mikkola, M. L. (2002) · Science Signaling · doi:10.1126/stke.2002.131.pe22 · Cited by 76
Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-α
Lauzurica, P., Martı́nez-Martı́nez, S., Marazuela, M., Arco, P. G., Martínez‐A, C., Sánchez‐Madrid, F., & Redondo, J. M. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199906)29:06 · Cited by 71
You, Z., Madrid, L. V., Saims, D., Sedivy, J. M., & Wang, C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203213200 · Cited by 70
O'Malley, W. E., Achinstein, B., & Shear, M. J. (1962) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/29.6.1169 · Cited by 68
Couriel, D. R., Hicks, K. L., Giralt, S. A., & Champlin, R. E. (2000) · Current Opinion in Oncology · doi:10.1097/00001622-200011000-00011 · Cited by 65
Haridas, V., Shrivastava, A., Su, J. Y., Yu, G.-L., Ni, J., Liu, D., Chen, S.-F., Ni, Y., Ruben, S. M., Gentz, R., et al. (1999) · Oncogene · doi:10.1038/sj.onc.1203059 · Cited by 60
Self-citationMukhopadhyay, A., Suttles, J., Stout, R. D., & Aggarwal, B. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105252200 · Cited by 60
Self-citationThe Role of TNF Receptor and TNF Superfamily Molecules in Organ Transplantation
Adams, A. B., Larsen, C. P., Pearson, T. C., & Newell, K. A. (2002) · American Journal of Transplantation · doi:10.1034/j.1600-6143.2002.020104.x · Cited by 53
Algire, G. H., Legallais, F. Y., & ANDERSON, B. F. (1952) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/12.6.1279 · Cited by 47
Role of Defective Apoptosis in Type 1 Diabetes and Other Autoimmune Diseases
Hayashi, T. (2003) · Recent Progress in Hormone Research · doi:10.1210/rp.58.1.131 · Cited by 45
Aganna, E., Aksentijevich, I. A., Hitman, G. A., Kastner, D. L., Hoepelman, A. I. M., Posma, F. D., Ej, Z., & McDermott, M. (2001) · European Journal of Human Genetics · doi:10.1038/sj.ejhg.5200573 · Cited by 45
Role of tumor necrosis factor on toxicity and cytokine production after isolated hepatic perfusion.
Lans, T. E., Bartlett, D. L., Libutti, S. K., Gnant, M., Liewehr, D. J., Venzon, D. J., Turner, E. M., & Alexander, H. R. (2001) · PubMed · Cited by 45
Frequent mutations of Fas gene in thyroid lymphoma.
Takakuwa, T., Dong, Z., Takayama, H., Matsuzuka, F., Nagata, S., & Aozasa, K. (2001) · PubMed · Cited by 44
Takayama, H., Takakuwa, T., Dong, Z., Nonomura, N., Okuyama, Ä., Nagata, S., & Aozasa, K. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780236 · Cited by 35
Takada, Y., & Aggarwal, B. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213237200 · Cited by 35
Self-citationO'Malley, W. E., Achinstein, B., & Shear, M. J. (1963) · PubMed · Cited by 28
Frequent Fas Gene Mutations in Testicular Germ Cell Tumors
Takayama, H., Takakuwa, T., Tsujimoto, Y., Tani, Y., Nonomura, N., Okuyama, Ä., Nagata, S., & Aozasa, K. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64219-8 · Cited by 28
CD40—CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1)
Ramesh, N., Morio, T., Fuleihan, R., Worm, M., Horner, A. A., Tsitsikov, E. N., Castigli, E., & Geha, R. S. (1995) · Clinical Immunology and Immunopathology · doi:10.1016/s0090-1229(95)90252-x · Cited by 24
Structural and Biochemical Analysis of Signal Transduction by the TRAF Family of Adapter ProteinsPreprint
McWhirter, S. M., Pullen, S. S., WERNEBURG, B. G., Labadia, M. E., Ingraham, R. H., Crute, J. J., Kehry, M. R., & Alber, T. (1999) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1999.64.551 · Cited by 13
Flagged first, then by citations
Research works printed but not linked: 2
- Bruns, P. Die Heilwirkung des Erysipels auf Geschwulste. Beitr. Klin. Chir. 3, 443–446 (1868).
- Gratia, A. & Linz, R. C. R. Seances Soc. Biol. Ses Fil. 108, 421–428 (1931).
Cited by
Sorted by citations
Hayden, M. S., & Ghosh, S. (2004) · Genes & Development · doi:10.1101/gad.1228704 · Cited by 3,842
Aggarwal, B. B., & Harikumar, K. B. (2008) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2008.06.010 · Cited by 2,043
Self-citationInto the Eye of the Cytokine Storm
Tisoncik, J. R., Korth, M. J., Simmons, C. P., Farrar, J., Martin, T. R., & Katze, M. G. (2012) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.05015-11 · Cited by 1,940
Tumour necrosis factor and cancer
Balkwill, F. R. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2628 · Cited by 1,976
Molecular targets of dietary agents for prevention and therapy of cancer
Aggarwal, B. B., & Shishodia, S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.02.009 · Cited by 1,774
Self-citation
Metadata
- Authors
- Aggarwal, B. B.
- Affiliations
- The University of Texas MD Anderson Cancer Center (US)
- Corresponding author
- Aggarwal, Bharat B.
- ORCID
- Aggarwal, Bharat B.
- Venue
- Nature Reviews Immunology
- Published
- 2003-09
- Volume
- 3
- Issue
- 9
- Pages
- 745-756
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2095013915
- Cited by
- 2,793
- References
- 124
- Citations by year
- 2026: 74 · 2025: 107 · 2024: 82 · 2023: 121 · 2022: 125 · 2021: 114 · 2020: 132 · 2019: 113 · 2018: 114 · 2017: 130 · 2016: 108 · 2015: 142 · 2014: 128 · 2013: 116 · 2012: 159
- FWCI
- 9.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- TNF superfamily, TNF-α, TNF receptor, signaling pathways, carcinogenesis, graft rejection, septic shock, viral replication, bone resorption, rheumatoid arthritis, diabetes mellitus, apoptosis, TNF-alpha inhibitors, autoimmune disease, cytokines
- MeSH terms
- Animals, Autoimmune Diseases, Carrier Proteins, Humans, Ligands, Lymphotoxin-alpha, Membrane Proteins, Tumor Necrosis Factor-alpha, Signal Transduction, NF-kappa B, Receptors, Tumor Necrosis Factor, Mice
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