The DOI matches its Crossref record; 189 of the 189 references it cites were found in a registry or an index.
Adipokines in inflammation and metabolic disease
Open accessAbstract
The worldwide epidemic of obesity has brought considerable attention to research aimed at understanding the biology of adipocytes (fat cells) and the events occurring in adipose tissue (fat) and in the bodies of obese individuals. Accumulating evidence indicates that obesity causes chronic low-grade inflammation and that this contributes to systemic metabolic dysfunction that is associated with obesity-linked disorders. Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, known as adipose-derived secreted factors or adipokines, that have pro-inflammatory or anti-inflammatory activities. Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction can contribute to the pathogenesis of obesity-linked complications. In this Review, we focus on the role of adipokines in inflammatory responses and discuss their potential as regulators of metabolic function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Increased leptin levels have been found in the obese population, inducing a leptin-resistance state, accompanied by increased ROS, TNF-α, IL-6 and chemokine ligands.”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [216]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Additionally, it augments Th1 cytokines IL-2 and IFN-γ while suppressing Th2 cytokine IL-4 [216].”
The cited source says what the claim attributes to it.
In the citing paper
“In obesity, adiponectin levels are found to be reduced [216], given that its expression is inhibited by hypoxia, oxidative stress [228], insulin resistance [229], TNF-α, IL-6 [229], “catecholamine resistance” [239], fetuin A [148], and SeP [136].”
In the citing paper
“In the context of obesity, adipose tissue macrophages (ATM) change their phenotype from M2 to M1.”
From Sarcopenic obesity: epidemiology, pathophysiology, cardiovascular disease, mortality, and management (2023) · cites this paper as [19]
In the citing paper
“By acting on white adipocyte mass, mitochondrial uncouplers could protect against diabetes, as limiting hyperaccumulation of triacyglycerol (TAG) in these cells might limit organelle stress [91,273,274,275] and modifications in the expression pattern of genes encoding adipokines, which are known to communicate the level of adiposity to other organs [221,276].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [276]
In the citing paper
“Adiponectin is an antiatherogenic adipokine that also protects against metabolic disorders through improvements in insulin secretion and sensitivity [22].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedPositional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Cited by
Sorted by citations
Items 701–800 of 1,029
Effects of kefir or milk supplementation on zonulin in overweight subjects
Pražnikar, Z. J., Kenig, S., Vardjan, T., Bizjak, M. Č., & Petelin, A. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-17696 · Cited by 69
Functional Implications of DNA Methylation in Adipose Biology
Ma, X., & Kang, S. (2019) · Diabetes · doi:10.2337/dbi18-0057 · Cited by 69
The impacts of exercise on pediatric obesity
Headid, R. J., & Park, S. (2020) · Korean Journal of Pediatrics · doi:10.3345/cep.2020.00997 · Cited by 73
COVID-19: Is there a role for immunonutrition in obese patient?
Renzo, L. D., Gualtieri, P., Pivari, F., Soldati, L., Attinà, A., Leggeri, C., Cinelli, G., Tarsitano, M. G., Caparello, G., Carrano, E., et al. (2020) · Journal of Translational Medicine · doi:10.1186/s12967-020-02594-4 · Cited by 70
Regidor, P., Mueller, A., Sailer, M., Santos, F. G., Rizo, J. M., & Egea, F. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010384 · Cited by 70
Samargandy, S. J., Matthews, K. A., Brooks, M. M., Barinas‐Mitchell, E., Magnani, J. W., Janssen, İ., Kazlauskaite, R., & Khoudary, S. R. E. (2021) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0000000000001755 · Cited by 71
LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance
He, S., Ryu, J., Liu, J., Luo, H., Lv, Y., Langlais, P. R., Wen, J., Dong, F., Sun, Z., Xia, W., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148545 · Cited by 71
Gu, X., Wang, L., Liu, S., & Shan, T. (2022) · Metabolism · doi:10.1016/j.metabol.2022.155379 · Cited by 74
Daniele, A., Rosa, A. D., Nigro, E., Scudiero, O., Capasso, M., Masullo, M., de Laurentiis, G., Oriani, G., Sofia, M., & Bianco, A. (2012) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2011.12.016 · Cited by 69
Pereira, S. S., Teixeira, L. G., Aguilar, E. C., Oliveira, M. C., Savassi-Rocha, A. L., Pelaez, J. M. N., Capettini, L. D. S. A., Diniz, M. T. C., Ferreira, A. V. M., & Alvarez-Leite, J. I. (2013) · Nutrition · doi:10.1016/j.nut.2013.11.023 · Cited by 69
Than, A., Xu, S., Li, R., Leow, M. K., Sun, L., & Chen, P. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.22 · Cited by 69
Flores‐Costa, R., Alcaraz‐Quiles, J., Titos, E., López‐Vicario, C., Casulleras, M., Duran‐Güell, M., Rius, B., Díaz, A., Hall, K. M., Shea, C. M., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14137 · Cited by 69
A Unique Population: Adipose-Resident Regulatory T Cells
Zeng, Q., Sun, X., Xiao, L., Xie, Z., Bettini, M., & Deng, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02075 · Cited by 75
Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects
Biobaku, F., Ghanim, H., Monte, S. V., Caruana, J. A., & Dandona, P. (2020) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaa049 · Cited by 68
S100 proteins in obesity: liaisons dangereuses
Riuzzi, F., Chiappalupi, S., Arcuri, C., Giambanco, I., Sorci, G., & Donato, R. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03257-4 · Cited by 70
Payab, M., Abedi, M., Heravani, N. F., Hadavandkhani, M., Arabi, M., Tayanloo-Beik, A., Hosseini, M. S., Gerami, H., Khatami, F., Larijani, B. A., et al. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0616-5 · Cited by 69
Ringleb, M., Javelle, F., Haunhorst, S., Bloch, W., Fennen, L., Baumgart, S., Drube, S., Reuken, P. A., Pletz, M. W., Wagner, H., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202301619r · Cited by 73
Huang, W., Chang, W., Wu, S., Xu, P.-Y., Ting, N., & Liou, C. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300001 · Cited by 69
Adipokines as drug targets in joint and bone disease
Scotece, M., Conde, J., Vuolteenaho, K., Koskinen, A., López, V., Gómez-Reino, J. J., Lago, F., Moilanen, E., & Gualillo, O. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.07.012 · Cited by 69
Ginseng and obesity: observations and understanding in cultured cells, animals and humans
Zhang, L., Virgous, C. K., & Si, H. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.11.010 · Cited by 68
Effect of adiposity on tissue-specific adiponectin secretion
Reneau, J. A., Goldblatt, M. I., Gould, J. C., Kindel, T. L., Kastenmeier, A. S., Higgins, R. M., Rengel, L. R., Schoyer, K. D., James, R. G., Obi, B., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198889 · Cited by 70
Soluble defense collagens: Sweeping up immune threats
Casals, C., García-Fojeda, B., & Minutti, C. M. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.06.007 · Cited by 69
Guimarães, M. F. B. D. R., Rodrigues, C. E. M., Gomes, K. W. P., Machado, C. J., Brenol, C. V., Krampe, S. F., de Andrade, N. P. B., & Kakehasi, A. M. (2019) · Revista Brasileira de Reumatologia · doi:10.1186/s42358-019-0089-1 · Cited by 68
Costa, M. C., Lima, T. F. O., Arcaro, C. A., Inácio, M. D., Batista-Duharte, A., Carlos, I. Z., Spolidório, L. C., Assis, R. P., Brunetti, I. L., & Baviera, A. M. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108303 · Cited by 68
Aguilar‐Valles, A., Rodrigue, B., & Matta‐Camacho, E. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00852 · Cited by 73
Multiple sclerosis and obesity: The role of adipokines
Correale, J. D., & Marrodán, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1038393 · Cited by 67
Adipocytokines and obesity-linked disorders.
Ouchi, N., Ohashi, K., Shibata, R., & Murohara, T. (2012) · PubMed Central · doi:10.18999/nagjms.74.1-2.19 · Cited by 67
Self-citationShibata, R., Takahashi, R., Kataoka, Y., Ohashi, K., Ikeda, N., Kihara, S., Murohara, T., & Ouchi, N. (2011) · Hypertension Research · doi:10.1038/hr.2011.130 · Cited by 67
Self-citationAdipose‐derived protein omentin prevents neointimal formation after arterial injury
Uemura, Y., Shibata, R., Kanemura, N., Ohashi, K., Kambara, T., Hiramatsu‐Ito, M., Enomoto, T., Yuasa, D., Joki, Y., Matsuo, K., et al. (2014) · The FASEB Journal · doi:10.1096/fj.14-258129 · Cited by 67
Self-citationPeinado, J. R., Pardo, M., de la Rosa, O., & Malagón, M. M. (2012) · PROTEOMICS · doi:10.1002/pmic.201100355 · Cited by 67
Lipocalin 2 Regulates Brown Fat Activation via a Nonadrenergic Activation Mechanism
Zhang, Y., Guo, H., Deis, J. A., Mashek, M. G., Zhao, M., Ariyakumar, D. S., Armién, A. G., Bernlohr, D., Mashek, D. G., & Chen, X. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.559104 · Cited by 70
The relationship between body weight and inflammation: Lesson from anti-TNF-α antibody therapy
Peluso, I., & Palmery, M. (2015) · Human Immunology · doi:10.1016/j.humimm.2015.10.008 · Cited by 67
Akram, Z., Safii, S. H., Vaithilingam, R. D., Baharuddin, N. A., Javed, F., & Vohra, F. (2016) · Clinical Oral Investigations · doi:10.1007/s00784-016-1793-4 · Cited by 67
Immune Modulation of Brown(ing) Adipose Tissue in Obesity
van den Berg, S. M., van Dam, A. D., Rensen, P. C. N., de Winther, M. P. J., & Lutgens, E. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1066 · Cited by 69
Morinda citrifolia Linn. (Noni) and Its Potential in Obesity-Related Metabolic Dysfunction
Inada, A. C., Figueiredo, P. S., Eichler, R. A. D. S., Freitas, K. D. C., Hiane, P. A., de Castro, A. P., & Guimarães, R. D. C. A. (2017) · Nutrients · doi:10.3390/nu9060540 · Cited by 72
Leukocyte Heterogeneity in Adipose Tissue, Including in Obesity
Weinstock, A., Silva, H. M., Moore, K. J., Schmidt, A. M., & Fisher, E. A. A. (2020) · Circulation Research · doi:10.1161/circresaha.120.316203 · Cited by 68
Resistin: New serum marker for predicting severity of acute pancreatitis
Kibar, Y. İ., Albayrak, F., Arabul, M., Dursun, H., Albayrak, Y., & Öztürk, Y. (2016) · Journal of International Medical Research · doi:10.1177/0300060515605428 · Cited by 66
Fisiopatología de la obesidad: Perspectiva actual
Carmona, W. S., Sánchez-Oliver, A. J., & González-Jurado, J. A. (2017) · Revista chilena de nutrición · doi:10.4067/s0717-75182017000300226 · Cited by 97
Exercise activates vagal induction of dopamine and attenuates systemic inflammation
Shimojo, G. L., Joseph, B., Shah, R., Consolim‐Colombo, F. M., Angelis, K. D., & Ulloa, L. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.10.005 · Cited by 66
Intervention of five strains of Lactobacillus on obesity in mice induced by high-fat diet
Wang, M., Zhang, B., Hu, J., Nie, S., Xiong, T., & Xie, M. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2020.104078 · Cited by 66
Chen, D., Zhang, Y., Yidilisi, A., Xu, Y., Dong, Q., & Jiang, J. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac048 · Cited by 66
Adipocyte Regulation of Insulin Sensitivity and the Risk of Type 2 Diabetes
Santoro, A. N., & Kahn, B. B. (2023) · New England Journal of Medicine · doi:10.1056/nejmra2216691 · Cited by 66
Yu, W., Sun, S., Yan, Y., Zhou, H., Liu, Z., & Fu, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1519925 · Cited by 70
Menale, C., Piccolo, M. T., Cirillo, G., Calogero, R., Papparella, A., Mita, L., del Giudice, E. M., Diano, N., Crispi, S., & Mita, D. G. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-14-0282 · Cited by 66
Intracellular metabolic pathways control immune tolerance
Procaccini, C., Galgani, M., Rosa, V. D., & Matarese, G. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.09.002 · Cited by 67
van Wijk, J. P. H., & Cabezas, M. C. (2011) · International Journal of Vascular Medicine · doi:10.1155/2012/201027 · Cited by 66
CSF-1 signaling in macrophages: pleiotrophy through phosphotyrosine-based signaling pathways
Mouchemore, K. A., & Pixley, F. J. (2012) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2012.666845 · Cited by 70
Sexual Dimorphism in Alcohol Induced Adipose Inflammation Relates to Liver Injury
Fulham, M. A., & Mandrekar, P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164225 · Cited by 66
Fadaei, R., Moradi, N., Baratchian, M., Aghajani, H., Malek, M., Fazaeli, A., & Fallah, S. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168773 · Cited by 67
The role of visfatin in pathogenesis of gestational diabetes (GDM)
Radzicka, S., Pietryga, M., Iciek, R., & Brązert, J. (2018) · Ginekologia Polska · doi:10.5603/gp.a2018.0088 · Cited by 66
Cell-Specific Dysregulation of MicroRNA Expression in Obese White Adipose Tissue
Oger, F., Gheeraert, C., Mogilenko, D. A., Benomar, Y., Molendi‐Coste, O., Bouchaert, E., Caron, S., Dombrowicz, D., Pattou, F. N., Duez, H., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-4259 · Cited by 67
Significance of Simple Steatosis: An Update on the Clinical and Molecular Evidence
Mazzolini, G. D., Sowa, J., Atorrasagasti, C., Kücükoglu, Ö., Syn, W., & Canbay, A. E. (2020) · Cells · doi:10.3390/cells9112458 · Cited by 65
Anti-obesity effects of DHA and EPA in high fat-induced insulin resistant mice
Wei, W., Hu, M., Huang, J., Yu, S., Li, X., Li, Y., & Mao, L. (2020) · Food & Function · doi:10.1039/d0fo02448a · Cited by 65
Handakas, E., Lau, C. E., Alfano, R., Chatzi, V. L., Plusquin, M., Vineis, P., & Robinson, O. (2021) · Obesity Reviews · doi:10.1111/obr.13384 · Cited by 67
Park, D., Park, Y., Ko, S., Hyun, K.-S., Choi, Y., Min, D.-U., Han, K., & Koh, H.-S. (2023) · Scientific Reports · doi:10.1038/s41598-023-30727-4 · Cited by 65
Nourbakhsh, M., Nourbakhsh, M., Gholinejad, Z., & Razzaghy‐Azar, M. (2015) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.1003594 · Cited by 65
Inflammation in cancer cachexia: To resolve or not to resolve (is that the question?)
Seelaender, M. C. L., Júnior, M. L. B., Lira, F. S., Silvério, R., & Fanelli, F. R. (2012) · Clinical Nutrition · doi:10.1016/j.clnu.2012.01.011 · Cited by 65
Wang, M., Wang, D., Zhang, Y., Wang, X., Liu, Y., & Xia, M. (2013) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.01.017 · Cited by 66
Peripheral signalling involved in energy homeostasis control
Lancha, A., Frühbeck, G., & Gómez‐Ambrosi, J. (2012) · Nutrition Research Reviews · doi:10.1017/s0954422412000145 · Cited by 66
Jorge, A. S. B., Andrade, J. M. O., Paraíso, A. F., Batista-Jorge, G. C., Silveira, C. M., de Souza, L. R., dos Santos, E. P., Guimarães, A. L. S., Santos, S. H. S., & de Paula, A. M. B. (2016) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2016.03.009 · Cited by 65
GPR120: a critical role in adipogenesis, inflammation, and energy metabolism in adipose tissue
Song, T., Yang, Y., Zhou, Y., Wei, H., & Peng, J. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2492-2 · Cited by 67
Body–Brain Connections: The Effects of Obesity and Behavioral Interventions on Neurocognitive Aging
Stillman, C. M., Weinstein, A. M., Marsland, A. L., Gianaros, P. J., & Erickson, K. I. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00115 · Cited by 69
Yang, J. H., Choi, M., Yang, S. H., Cho, S. S., Park, S. J., Shin, H., & Ki, S. H. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b02203 · Cited by 65
Shoucri, B. M., Hung, V. T., Chamorro-García, R., Shioda, T., & Blumberg, B. (2018) · Endocrinology · doi:10.1210/en.2018-00056 · Cited by 67
Gu, M., Ping, Z., Zhang, S., Fan, S., Yang, L., Tong, Q., Ji, G., & Huang, C. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14570 · Cited by 65
Monk, J. M., Wu, W., Lepp, D., Wellings, H. R., Hutchinson, A. L., Liddle, D. M., Gräf, D., Pauls, K. P., Robinson, L. E., & Power, K. A. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.04.009 · Cited by 66
Kompella, P., & Vásquez, K. M. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.23048 · Cited by 66
The adipokines and inflammatory status in the era of pediatric obesity
Mărginean, C. O., Meliţ, L. E., Huţanu, A., Ghiga, D. V., & Săsăran, M. O. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154925 · Cited by 64
Woo, Y. R., Park, C. J., Kang, H., & Kim, J. E. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197041 · Cited by 64
Khalafi, M., Sakhaei, M. H., Kheradmand, S., Symonds, M. E., & Rosenkranz, S. K. (2022) · Advances in Nutrition · doi:10.1016/j.advnut.2022.10.001 · Cited by 73
Two regulatory T cell populations in the visceral adipose tissue shape systemic metabolism
Torres, S. V., Man, K., Elmzzahi, T., Malko, D., Chisanga, D., Liao, Y., Prout, M. S., Abbott, C. A., Tang, A., Jian, W., et al. (2024) · Nature Immunology · doi:10.1038/s41590-024-01753-9 · Cited by 65
Cardiometabolic effects of adiponectin
Parker, J., & Walsh, K. X. (2013) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2013.09.001 · Cited by 64
Self-citationvan Stijn, C. M. W., Kim, J., Barish, G. D., Tietge, U. J. F., & Tangirala, R. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086404 · Cited by 64
Obesity, diabetes and periodontitis – a triangular relationship?
Levine, R. S. (2013) · BDJ · doi:10.1038/sj.bdj.2013.627 · Cited by 64
Chiu, C., Chan, I.-L., Yang, T., Liu, S., & Chiang, M. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b00198 · Cited by 64
Shortcuts to a functional adipose tissue: The role of small non-coding RNAs
Brandão, B. B., Guerra, B. A., & Mori, M. A. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.020 · Cited by 67
Fujii, N., Narita, T., Okita, N., Kobayashi, M., Furuta, Y., Chujo, Y., Sakai, M., Yamada, A., Takeda, K., Konishi, T., et al. (2017) · Aging Cell · doi:10.1111/acel.12576 · Cited by 64
Liu, Y., Kongsuphol, P., Chiam, S. Y., Zhang, Q. X., Gourikutty, S. B. N., Saha, S., Biswas, S. K., & Ramadan, Q. (2018) · Lab on a Chip · doi:10.1039/c8lc00481a · Cited by 64
Leukocytes from obese individuals exhibit an impaired SPM signature
López‐Vicario, C., Titos, E., Walker, M. E., Alcaraz‐Quiles, J., Casulleras, M., Duran‐Güell, M., Flores‐Costa, R., Pérez, N., Forné, M., Dalli, J., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201802587r · Cited by 64
Chacińska, M., Zabielski, P., Książek, M., Szałaj, P., Jarząbek, K., Kojta, I., Chabowski, A., & Błachnio-Zabielska, A. U. (2019) · Nutrients · doi:10.3390/nu11040835 · Cited by 66
The Inflammatory Profile of Obesity and the Role on Pulmonary Bacterial and Viral Infections
Hornung, F., Rogal, J., Loskill, P., Löffler, B., & Deinhardt‐Emmer, S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22073456 · Cited by 63
Potential Effects of Soy Isoflavones on the Prevention of Metabolic Syndrome
Yamagata, K., & Yamori, Y. (2021) · Molecules · doi:10.3390/molecules26195863 · Cited by 63
Nutritional and health-promoting attributes of millet: current and future perspectives
Samtiya, M., Aluko, R. E., Dhaka, N., Dhewa, T., & Puniya, A. K. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac081 · Cited by 63
Putative Role of Adipose Tissue in Growth and Metabolism of Colon Cancer Cells
Schwartz, B., & Yehuda‐Shnaidman, E. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00164 · Cited by 65
Visceral adiposopathy: a vascular perspective
Farb, M. G., & Gokce, N. (2015) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0047 · Cited by 66
Human resistin and the RELM of Inflammation in diabesity
Hannan, F. A., & Culligan, K. (2015) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-015-0050-3 · Cited by 63
The Effect of Psychological Stress and Social Isolation on Neuroimmunoendocrine Communication
Cruces, J., Venero, C., Pereda-Pérez, I., & la Fuente, M. D. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140130205822 · Cited by 65
FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs
Kim, K. H., & Lee, M. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0160 · Cited by 66
Obesity and brain illness: from cognitive and psychological evidences to obesity paradox
Monda, V., Marra, M. L., Perrella, R., Caviglia, G., Iavarone, A., Chieffi, S., Messina, G., Carotenuto, M., Monda, M., & Messina, A. (2017) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s148392 · Cited by 75
Martini, D. J., Kline, M. R., Liu, Y., Shabto, J. M., Williams, M., Khan, A. I., Lewis, C. M., Collins, H., Akce, M., Kissick, H. T., et al. (2019) · Cancer · doi:10.1002/cncr.32576 · Cited by 63
Developing Phytocompounds from Medicinal Plants as Immunomodulators
Wen, C.-C., Chen, H., & Yang, N. (2012) · Advances in botanical research · doi:10.1016/b978-0-12-394591-4.00004-0 · Cited by 67
Morano, A. E. V. A., Dorneles, G. P., Peres, A., & Lira, F. S. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29228 · Cited by 63
Jeepipalli, S. P. K., Du, B., Sabitaliyevich, U. Y., & Xu, B. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126474 · Cited by 62
Effects of Grape Seed Proanthocyanidin Extract on Obesity
Liu, M., Yun, P., Hu, Y., Yang, J., Khadka, R. B., & Peng, X. (2020) · Obesity Facts · doi:10.1159/000502235 · Cited by 65
Adipocytes: active facilitators in epithelial ovarian cancer progression?
Dai, L., Song, K., & Di, W. J. (2020) · Journal of Ovarian Research · doi:10.1186/s13048-020-00718-4 · Cited by 63
Natural and Synthetic Estrogens in Chronic Inflammation and Breast Cancer
Maharjan, C. K., Mo, J., Wang, L. A., Kim, M., Wang, S., Borcherding, N. C., Vikas, P., & Zhang, W. (2021) · Cancers · doi:10.3390/cancers14010206 · Cited by 63
Wei, F., Oms, K. F., Kinzel, M., Perotti, L. E., Asiatico, J. T., Omer, M., Hovell, C., Reumers, V., & Coathup, M. J. (2022) · Bone Research · doi:10.1038/s41413-022-00234-9 · Cited by 62
A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance
Jun, L. S., Siddall, P., & Rosen, E. D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00147.2011 · Cited by 62
Benkhoff, S., Loot, A. E., Pierson, I., Sturza, A., Kohlstedt, K., Fleming, I., Shimokawa, H., Grisk, O., Brandes, R. P., & Schröder, K. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.251140 · Cited by 62
Therapeutic Targeting of the Interleukin-4/Interleukin-13 Signaling Pathway: In Allergy and Beyond
Karo‐Atar, D., Bitton, A., Benhar, I., & Munitz, A. (2018) · BioDrugs · doi:10.1007/s40259-018-0280-7 · Cited by 63
Metadata
- Authors
- Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K.
- Affiliations
- Nagoya University (JP)
- Boston University (US)
- Corresponding author
- Walsh, Kenneth
- Venue
- Nature Reviews Immunology
- Published
- 2011-01-21
- Volume
- 11
- Issue
- 2
- Pages
- 85-97
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3518031
- OpenAlex
- W2088940658
- Cited by
- 4,625
- References
- 188
- Citations by year
- 2026: 294 · 2025: 311 · 2024: 301 · 2023: 326 · 2022: 363 · 2021: 358 · 2020: 370 · 2019: 371 · 2018: 286 · 2017: 335 · 2016: 279 · 2015: 270 · 2014: 264 · 2013: 250 · 2012: 171
- FWCI
- 27.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG015052, R37AG015052, AG15052, AG34972, R01AG034972)
- National Heart, Lung, and Blood Institute (HL81587, R01HL086785, P01HL081587, HL 86785)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, adipose tissue, obesity, low-grade inflammation, metabolic disorders, adipocytes, adipose tissue dysfunction, adipose tissue endocrine function, metabolic dysfunction
- MeSH terms
- Humans, Inflammation, Obesity, Adipokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
