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Adipokines in inflammation and metabolic disease
Open accessAbstract
The worldwide epidemic of obesity has brought considerable attention to research aimed at understanding the biology of adipocytes (fat cells) and the events occurring in adipose tissue (fat) and in the bodies of obese individuals. Accumulating evidence indicates that obesity causes chronic low-grade inflammation and that this contributes to systemic metabolic dysfunction that is associated with obesity-linked disorders. Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, known as adipose-derived secreted factors or adipokines, that have pro-inflammatory or anti-inflammatory activities. Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction can contribute to the pathogenesis of obesity-linked complications. In this Review, we focus on the role of adipokines in inflammatory responses and discuss their potential as regulators of metabolic function.
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“Increased leptin levels have been found in the obese population, inducing a leptin-resistance state, accompanied by increased ROS, TNF-α, IL-6 and chemokine ligands.”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [216]
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“Additionally, it augments Th1 cytokines IL-2 and IFN-γ while suppressing Th2 cytokine IL-4 [216].”
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“In obesity, adiponectin levels are found to be reduced [216], given that its expression is inhibited by hypoxia, oxidative stress [228], insulin resistance [229], TNF-α, IL-6 [229], “catecholamine resistance” [239], fetuin A [148], and SeP [136].”
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“In the context of obesity, adipose tissue macrophages (ATM) change their phenotype from M2 to M1.”
From Sarcopenic obesity: epidemiology, pathophysiology, cardiovascular disease, mortality, and management (2023) · cites this paper as [19]
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“By acting on white adipocyte mass, mitochondrial uncouplers could protect against diabetes, as limiting hyperaccumulation of triacyglycerol (TAG) in these cells might limit organelle stress [91,273,274,275] and modifications in the expression pattern of genes encoding adipokines, which are known to communicate the level of adiposity to other organs [221,276].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [276]
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“Adiponectin is an antiatherogenic adipokine that also protects against metabolic disorders through improvements in insulin secretion and sensitivity [22].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [22]
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1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedPositional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
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Anthocyanins ameliorate palmitate‐induced inflammation and insulin resistance in 3T3‐L1 adipocytes
Muscarà, C., Molonia, M. S., Speciale, A., Bashllari, R., Cimino, F., Occhiuto, C., Saija, A., & Cristani, M. (2019) · Phytotherapy Research · doi:10.1002/ptr.6379 · Cited by 65
Jalili, V., Poorahmadi, Z., Ardekanizadeh, N. H., Gholamalizadeh, M., Ajami, M., Houshiarrad, A., Hajipour, A., Shafie, F., Alizadeh, A., Mokhtari, Z., et al. (2022) · Endocrinology Diabetes & Metabolism · doi:10.1002/edm2.367 · Cited by 61
Serum omentin level in patients with prostate cancer
Üyetürk, U., Sarıcı, H., Tekçe, B. K., Eroğlu, M., Kemahlı, E., Üyetürk, Ü., & Gücük, A. (2014) · Medical Oncology · doi:10.1007/s12032-014-0923-6 · Cited by 61
Role of aquaglyceroporins and caveolins in energy and metabolic homeostasis
Méndez-Giménez, L., Rodrı́guez, A., Balaguer, I., & Frühbeck, G. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.06.017 · Cited by 61
Back to the heart: The protective role of adiponectin
Caselli, C., D’Amico, A., Cabiati, M., Prescimone, T., Ry, S. D., & Giannessi, D. (2014) · Pharmacological Research · doi:10.1016/j.phrs.2014.03.003 · Cited by 61
Landrier, J., Kasiri, E., Karkeni, E., Mihály, J., Béke, G., Weiss, K., Lucas, R., Aydemir, G., Salles, J., Walrand, S., et al. (2016) · The FASEB Journal · doi:10.1096/fj.201600263rr · Cited by 61
A new role for extracellular vesicles: how small vesicles can feed tumors' big appetite
Lazar, I., Clement, E., Attané, C., Muller, C., & Nieto, L. (2018) · Journal of Lipid Research · doi:10.1194/jlr.r083725 · Cited by 64
Decreased adiponectin/leptin ratio relates to insulin resistance in adults with obesity
Castela, I., Morais, J., Barreiros-Mota, I., Silvestre, M. P., Marques, C., Rodrigues, C., Ismael, S., Araújo, J. R., Ângelo-Dias, M., Martins, C., et al. (2023) · American Journal of Physiology - Endocrinology and Metabolism · doi:10.1152/ajpendo.00273.2022 · Cited by 60
Obesity-Related Heart Failure with Preserved Ejection Fraction
Harada, T., & Obokata, M. (2020) · Heart Failure Clinics · doi:10.1016/j.hfc.2020.02.004 · Cited by 60
Obesity is associated with heavy menstruation that may be due to delayed endometrial repair
Reavey, J. J., Walker, C. A., Murray, A. A., Brito-Mutunayagam, S., Sweeney, S., Nicol, M. R., Cambursano, A., Critchley, H., & Maybin, J. A. (2021) · Journal of Endocrinology · doi:10.1530/joe-20-0446 · Cited by 60
Kobayashi, M., Deguchi, Y., Nozaki, Y., & Higami, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116025 · Cited by 63
Exercise, Physical Activity, and Cardiometabolic Health
Belanger, M. J., Rao, P., & Robbins, J. (2021) · Cardiology in Review · doi:10.1097/crd.0000000000000417 · Cited by 64
Adetunji, C. O., Michael, O. S., Rathee, S., Singh, K. R., Ajayi, O. O., Adetunji, J. B., Ojha, A., Singh, J., & Singh, R. P. (2021) · Materials Today Advances · doi:10.1016/j.mtadv.2021.100198 · Cited by 62
Ji, J., Fotros, D., Sohouli, M. H., Velu, P., Fatahi, S., & Liu, Y. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad175 · Cited by 67
BMP-9 as a potent brown adipogenic inducer with anti-obesity capacity
Kuo, M. M.-C., Kim, S., Tseng, C.-Y., Jeon, Y., Choe, S., & Lee, D. K. (2014) · Biomaterials · doi:10.1016/j.biomaterials.2013.12.063 · Cited by 62
Cardiovascular risk in patients with rheumatoid arthritis
Lauper, K., & Gabay, C. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0632-2 · Cited by 62
Wellness and the Role of Comorbidities in Multiple Sclerosis
Moss, B. P., Rensel, M. R., & Hersh, C. M. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0563-6 · Cited by 61
Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2018) · Neuroscience Bulletin · doi:10.1007/s12264-018-0219-5 · Cited by 62
Chen, V. C., Chen, C.-H., Chiu, Y.-H., Lin, T., Li, F.-C., & Lu, M. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.03.021 · Cited by 60
Fadaei, R., Moradi, N., Kazemi, T., Chamani, E., Azdaki, N., Moezibady, S. A., Shahmohamadnejad, S., & Fallah, S. (2018) · Cytokine · doi:10.1016/j.cyto.2018.09.019 · Cited by 60
Dludla, P. V., Orlando, P., Silvestri, S., Marcheggiani, F., Cirilli, I., Nyambuya, T. M., Mxinwa, V., Mokgalaboni, K., Nkambule, B. B., Johnson, R., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093247 · Cited by 60
Chenodeoxycholic acid, an endogenous FXR ligand alters adipokines and reverses insulin resistance
Shihabudeen, M. S., Roy, D., James, J., & Thirumurugan, K. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.07.012 · Cited by 60
Markers of inflammation in schizophrenia: association vs. causation
Manu, P., Correll, C. U., Wampers, M., Mitchell, A. J., Probst, M., Vancampfort, D., & De Hert, M. (2014) · World Psychiatry · doi:10.1002/wps.20117 · Cited by 59
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Jung, H. N., & Jung, C. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413529 · Cited by 63
Bioactive compounds with effects on inflammation markers in humans
Rosa, F. T., Zulet, M. Á., Marchini, J. S., & Martínez, J. A. (2012) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2011.649250 · Cited by 59
Metabolic Rescue of Obese Adipose-Derived Stem Cells by Lin28/Let7 Pathway
Pérez, L. M., Bernal, A., Martín, N. S., Lorenzo, M., Fernández‐Veledo, S., & Gálvez, B. G. (2013) · Diabetes · doi:10.2337/db12-1220 · Cited by 59
Lopez, H. L., Ziegenfuss, T. N., Hofheins, J. E., Habowski, S. M., Arent, S. M., Weir, J. P., & Ferrando, A. A. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-22 · Cited by 61
Westermeier, F., Sáez, P. J., Villalobos-Labra, R., Sobrevía, L., & Farías, M. (2014) · BioMed Research International · doi:10.1155/2014/917672 · Cited by 59
Wang, X., & Hai, C. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.012 · Cited by 59
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de Ruiter, K., Tahapary, D. L., Sartono, E., Soewondo, P., Supali, T., Smit, J. W. A., & Yazdanbakhsh, M. (2016) · Parasite Immunology · doi:10.1111/pim.12404 · Cited by 61
Lee-Ødegård, S., Norheim, F., Gulseth, H. L., Langleite, T. M., Kolnes, K. J., Tangen, D. S., Stadheim, H. K., Gilfillan, G. D., Holen, T., Birkeland, K. I., et al. (2017) · Physiological Reports · doi:10.14814/phy2.13183 · Cited by 59
Kuwahara, K., Honda, T., Nakagawa, T., Yamamoto, S., Hayashi, T., & Mizoue, T. (2017) · Scientific Reports · doi:10.1038/srep43521 · Cited by 59
Adipose crosstalk with other cell types in health and disease
Choi, C. H. J., & Cohen, P. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.04.022 · Cited by 60
Sex Steroid Hormones Regulate Leptin Transcript Accumulation and Protein Secretion in 3T3-L1 Cells
Jenks, M. Z., Fairfield, H. E., Johnson, E. C., Morrison, R. F., & Muday, G. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-07473-5 · Cited by 60
Liou, C., Wu, S., Chen, L., Yeh, K., Chen, C., & Huang, W. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00589 · Cited by 59
Yamashita, Y., Nakada, S., Yoshihara, T., Nara, T., Furuya, N., Miida, T., Hattori, N., & Arikawa‐Hirasawa, E. (2018) · Scientific Reports · doi:10.1038/s41598-018-25635-x · Cited by 61
Yadav, R., Yadav, R. K., Khadgawat, R., & Pandey, R. M. (2018) · Translational Behavioral Medicine · doi:10.1093/tbm/iby060 · Cited by 59
Obesity, weight loss, and influence on telomere length: New insights for personalized nutrition
Welendorf, C. R., Nicoletti, C. F., Pinhel, M. A. D. S., Noronha, N. Y., de Paula, B. M. F., & Nonino, C. B. (2019) · Nutrition · doi:10.1016/j.nut.2019.05.002 · Cited by 66
Lu, Y., Zhao, A., Wu, Y., Zhao, Y., & Yang, X. (2019) · Food & Function · doi:10.1039/c8fo02379d · Cited by 59
Pediatric Obesity and the Immune System
Umano, G. R., Pistone, C., Tondina, E., Moiraghi, A., Lauretta, D., del Giudice, E. M., & Brambilla, I. (2019) · Frontiers in Pediatrics · doi:10.3389/fped.2019.00487 · Cited by 61
The Role of Leptin in the Association between Obesity and Psoriasis
Hwang, J., Yoo, J. A., Yoon, H., Han, T., Yoon, J., An, S., Cho, J. Y., & Lee, J. (2020) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2020.054 · Cited by 62
Dludla, P. V., Nkambule, B. B., Mazibuko-Mbeje, S. E., Nyambuya, T. M., Mxinwa, V., Mokgalaboni, K., Ziqubu, K., Cirilli, I., Marcheggiani, F., Louw, J., et al. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105219 · Cited by 58
Campos-Peña, V., Toral-Rios, D., Becerril-Pérez, F., Sánchez-Torres, C., Delgado-Namorado, Y., Torres-Ossorio, E., Franco-Bocanegra, D., & Carvajal, K. (2017) · Antioxidants & Redox Signaling · doi:10.1089/ars.2016.6768 · Cited by 58
He, G., Chen, T., Huang, L., Zhang, Y., Feng, Y., Qu, S., Yin, X., Liang, L., Yan, J., & Liu, W. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1073350 · Cited by 59
Novel Adipokines and Their Role in Bone Metabolism: A Narrative Review
Deepika, F., Bathina, S., & Armamento‐Villareal, R. (2023) · Biomedicines · doi:10.3390/biomedicines11020644 · Cited by 58
Is Adipose Tissue Inflammation the Culprit of Obesity‐Associated Comorbidities?
Turner, L., Wanasinghe, A. I., Brunori, P., & Santosa, S. (2025) · Obesity Reviews · doi:10.1111/obr.13956 · Cited by 61
ROCK1 isoform-specific deletion reveals a role for diet-induced insulin resistance
Lee, S., Hu, H., Choi, K., Lee, D. H., Shi, J., Liu, T., Chun, K. H., Seo, J. A., Sousa‐Lima, I., Zabolotny, J. M., et al. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00619.2013 · Cited by 58
Human resistin in cardiovascular disease
Lee, S. E., & Kim, H.-S. (2012) · Journal of Smooth Muscle Research · doi:10.1540/jsmr.48.27 · Cited by 58
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Prete, A. D., Salvi, V., & Sozzani, S. (2014) · Mediators of Inflammation · doi:10.1155/2014/425068 · Cited by 58
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Shook, B. A., Rivera-Gonzalez, G. C., Ebmeier, S., Grisotti, G., Zwick, R. K., & Horsley, V. (2016) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-111315-125426 · Cited by 59
Mazur-Biały, A. I., & Pocheć, E. (2016) · Molecules · doi:10.3390/molecules21121724 · Cited by 58
Adipose‐tissue regulatory T cells: Critical players in adipose‐immune crosstalk
Becker, M., Levings, M. K., & Daniel, C. (2017) · European Journal of Immunology · doi:10.1002/eji.201646739 · Cited by 59
High-fat diet increases pain behaviors in rats with or without obesity
Song, Z., Xie, W., Chen, S., Strong, J. A., Print, M. S., Wang, J. I., Shareef, A., Ulrich‐Lai, Y. M., & Zhang, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-10458-z · Cited by 62
What’s Behind the Obesity Epidemic
Pozza, C., & Isidori, A. M. (2017) · Springer eBooks · doi:10.1007/978-3-319-49299-5_1 · Cited by 58
Lee, W., Rhee, E., Chang, Y., Sohn, C. I., Shin, H. C., Ryu, S., & Lee, W. (2017) · Metabolism · doi:10.1016/j.metabol.2017.11.014 · Cited by 58
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Mills, C. (2017) · Breast Cancer Basic and Clinical Research · doi:10.1177/1178223417743976 · Cited by 65
Cao, Y. L., Sun, Y., Zou, S., Duan, B., Sun, M., & Xu, X. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b04921 · Cited by 58
Moradi, N., Fadaei, R., Emamgholipour, S., Kazemian, E., Panahi, G., Vahedi, S., Saed, L., & Fallah, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192159 · Cited by 58
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Maccioni, R. B., González, A., Andrade, V., Cortés, N., Tapia, J. P., & Guzmán‐Martínez, L. (2018) · The Open Neurology Journal · doi:10.2174/1874205x01812010050 · Cited by 58
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Lin, T.-Y., Chiu, C.-J., Kuan, C., Chen, F. H., Shen, Y.-C., Wu, C., & Hsu, Y. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0262-9 · Cited by 59
Heiston, E. M., Eichner, N. Z. M., Gilbertson, N. M., & Malin, S. K. (2020) · Experimental Physiology · doi:10.1113/ep088158 · Cited by 58
Vrints, C. J., Krychtiuk, K. A., Craenenbroeck, E. M. V., Segers, V. F. M., Price, S., & Heidbüchel, H. (2020) · Acta cardiologica. Supplementum · doi:10.1080/00015385.2020.1846921 · Cited by 58
Murakami, S., Hirazawa, C., Ohya, T., Yoshikawa, R., Mizutani, T., Ma, N., Moriyama, M., Ito, T., & Matsuzaki, C. (2021) · Nutrients · doi:10.3390/nu13020551 · Cited by 58
Javaid, H. M. A., Ko, E. J., Joo, E. J., Kwon, S. H., Park, J., Shin, S., Cho, K. W., & Huh, J. Y. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155527 · Cited by 58
Omentin functions to attenuate cardiac hypertrophic response
Matsuo, K., Shibata, R., Ohashi, K., Kambara, T., Uemura, Y., Hiramatsu‐Ito, M., Enomoto, T., Yuasa, D., Joki, Y., Ito, M., et al. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.11.019 · Cited by 57
Self-citationClària, J. (2011) · Frontiers in Immunology · doi:10.3389/fimmu.2011.00049 · Cited by 64
ChemR23 knockout mice display mild obesity but no deficit in adipocyte differentiation
Rouger, L., Denis, R., Luangsay, S., & Parmentier, M. (2013) · Journal of Endocrinology · doi:10.1530/joe-13-0106 · Cited by 57
Jung, J. I., Kim, E. J., Kwon, G. T., Jung, Y. J., Park, T., Kim, Y., Yu, R., Choi, M., Chun, H. S., Kwon, S., et al. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv076 · Cited by 57
Aortic carboxypeptidase–like protein, a WNT ligand, exacerbates nonalcoholic steatohepatitis
Teratani, T., Tomita, K., Suzuki, T., Furuhashi, H., Irie, R., Nishikawa, M., Yamamoto, J., Hibi∥, T., Miura, S., Minamino, T., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci92863 · Cited by 57
Choe, E. K., Yi, J. W., Chai, Y. J., & Park, K. J. (2018) · Journal of Surgical Oncology · doi:10.1002/jso.25078 · Cited by 57
Effect of psoriasis activity on serum adiponectin and leptin levels
Baran, A. M., Flisiak, I., Jaroszewicz, J., & Świderska, M. (2015) · Advances in Dermatology and Allergology · doi:10.5114/pdia.2014.40960 · Cited by 57
Teratani, T., Tomita, K., Furuhashi, H., Sugihara, N., Higashiyama, M., Nishikawa, M., Irie, R., Takajo, T., Wada, A., Horiuchi, K., et al. (2019) · Hepatology Communications · doi:10.1002/hep4.1383 · Cited by 56
Inflammatory marker trajectories associated with frailty and ageing in a 20‐year longitudinal study
Samson, L. D., Buisman, A., Ferreira, J. A., Picavet, H. S. J., Verschuren, W. M. M., Boots, A. M. H., & Engelfriet, P. M. (2022) · Clinical & Translational Immunology · doi:10.1002/cti2.1374 · Cited by 58
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Kim, J. M., Oh, C., & Kim, H. (2023) · Biomedicines · doi:10.3390/biomedicines11092589 · Cited by 57
Schäfer, K., & Konstantinides, S. (2011) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2011.05589.x · Cited by 56
Waist-to-height ratio, inflammation and CVD risk in obese children
Olza, J., Aguilera, C. M., Gil‐Campos, M., Leis, R., Bueno, G., Valle, M., Cañete, R., Tojo, R., Moreno, L. A., & Gil, Á. (2014) · Public Health Nutrition · doi:10.1017/s1368980013003285 · Cited by 56
van den Berg, S. M., Seijkens, T. T. P., Kusters, P. J. H., Zarzycka, B. A., Beckers, L., den Toom, M., Gijbels, M. J., Chatzigeorgiou, A., Weber, C., de Winther, M. P. J., et al. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.198 · Cited by 56
Trellakis, S., Rydleuskaya, A., Fischer, C., Canbay, A. E., Tagay, S., Scherag, A., Bruderek, K., Schuler, P. J., & Brandau, S. (2012) · Obesity Facts · doi:10.1159/000339452 · Cited by 56
Adiponectin‐Mediated Modulation of Lymphatic Vessel Formation and Lymphedema
Shimizu, Y., Shibata, R., Ishii, M., Ohashi, K., Kambara, T., Uemura, Y., Yuasa, D., Kataoka, Y., Kihara, S., Murohara, T., et al. (2013) · Journal of the American Heart Association · doi:10.1161/jaha.113.000438 · Cited by 56
Self-citationZelenko, Z., & Gallagher, E. J. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.09.008 · Cited by 57
Kim, J.-K., Chung, K., Choi, C., Beloor, J., Ullah, I., Kim, N., Lee, K. Y., Lee, S., & Kumar, P. (2016) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2015.51 · Cited by 58
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Metadata
- Authors
- Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K.
- Affiliations
- Nagoya University (JP)
- Boston University (US)
- Corresponding author
- Walsh, Kenneth
- Venue
- Nature Reviews Immunology
- Published
- 2011-01-21
- Volume
- 11
- Issue
- 2
- Pages
- 85-97
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3518031
- OpenAlex
- W2088940658
- Cited by
- 4,625
- References
- 188
- Citations by year
- 2026: 294 · 2025: 311 · 2024: 301 · 2023: 326 · 2022: 363 · 2021: 358 · 2020: 370 · 2019: 371 · 2018: 286 · 2017: 335 · 2016: 279 · 2015: 270 · 2014: 264 · 2013: 250 · 2012: 171
- FWCI
- 27.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG015052, R37AG015052, AG15052, AG34972, R01AG034972)
- National Heart, Lung, and Blood Institute (HL81587, R01HL086785, P01HL081587, HL 86785)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, adipose tissue, obesity, low-grade inflammation, metabolic disorders, adipocytes, adipose tissue dysfunction, adipose tissue endocrine function, metabolic dysfunction
- MeSH terms
- Humans, Inflammation, Obesity, Adipokines
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