The DOI matches its Crossref record; 189 of the 189 references it cites were found in a registry or an index.
Adipokines in inflammation and metabolic disease
Open accessAbstract
The worldwide epidemic of obesity has brought considerable attention to research aimed at understanding the biology of adipocytes (fat cells) and the events occurring in adipose tissue (fat) and in the bodies of obese individuals. Accumulating evidence indicates that obesity causes chronic low-grade inflammation and that this contributes to systemic metabolic dysfunction that is associated with obesity-linked disorders. Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, known as adipose-derived secreted factors or adipokines, that have pro-inflammatory or anti-inflammatory activities. Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction can contribute to the pathogenesis of obesity-linked complications. In this Review, we focus on the role of adipokines in inflammatory responses and discuss their potential as regulators of metabolic function.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Increased leptin levels have been found in the obese population, inducing a leptin-resistance state, accompanied by increased ROS, TNF-α, IL-6 and chemokine ligands.”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [216]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Additionally, it augments Th1 cytokines IL-2 and IFN-γ while suppressing Th2 cytokine IL-4 [216].”
The cited source says what the claim attributes to it.
In the citing paper
“In obesity, adiponectin levels are found to be reduced [216], given that its expression is inhibited by hypoxia, oxidative stress [228], insulin resistance [229], TNF-α, IL-6 [229], “catecholamine resistance” [239], fetuin A [148], and SeP [136].”
In the citing paper
“In the context of obesity, adipose tissue macrophages (ATM) change their phenotype from M2 to M1.”
From Sarcopenic obesity: epidemiology, pathophysiology, cardiovascular disease, mortality, and management (2023) · cites this paper as [19]
In the citing paper
“By acting on white adipocyte mass, mitochondrial uncouplers could protect against diabetes, as limiting hyperaccumulation of triacyglycerol (TAG) in these cells might limit organelle stress [91,273,274,275] and modifications in the expression pattern of genes encoding adipokines, which are known to communicate the level of adiposity to other organs [221,276].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [276]
In the citing paper
“Adiponectin is an antiatherogenic adipokine that also protects against metabolic disorders through improvements in insulin secretion and sensitivity [22].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedPositional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Cited by
Sorted by citations
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662
Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis
Gimbrone, M. A., & García‐Cardeña, G. (2016) · Circulation Research · doi:10.1161/circresaha.115.306301 · Cited by 3,694
Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies
Keum, N., & Giovannucci, E. L. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0189-8 · Cited by 2,791
Pathophysiology of human visceral obesity: an update
Tchernof, A., & Després, J.-P. (2013) · Physiological Reviews · doi:10.1152/physrev.00033.2011 · Cited by 2,583
Gleeson, M., Bishop, N. C., Stensel, D. J., Lindley, M. R., Mastana, S. S., & Nimmo, M. A. (2011) · Nature Reviews Immunology · doi:10.1038/nri3041 · Cited by 2,470
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes
Esser, N., Legrand-Poels, S., Piette, J., Scheen, A. J., & Paquot, N. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.04.006 · Cited by 1,981
Jung, U. J., & Choi, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms15046184 · Cited by 1,971
Dietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832
Mechanisms of physiological and pathological cardiac hypertrophy
Nakamura, M., & Sadoshima, J. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0007-y · Cited by 1,709
Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement
Neeland, I. J., Ross, R., Després, J.-P., Matsuzawa, Y., Yamashita, S., Shai, I., Seidell, J., Magni, P., Santos, R. D., Arsenault, B., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30084-1 · Cited by 1,603
The cellular and signaling networks linking the immune system and metabolism in disease
Osborn, O., & Olefsky, J. M. (2012) · Nature Medicine · doi:10.1038/nm.2627 · Cited by 1,551
Inflammation, Oxidative Stress, and Obesity
Fernández-Sánchez, A., Madrigal‐Santillán, E., Bautista, M., Esquivel-Soto, J., Morales‐González, Á., Esquivel-Chirino, C., Durante-Montiel, I., Sánchez-Rivera, G., Valadez-Vega, M. D. C., & Morales‐González, J. A. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12053117 · Cited by 1,536
Hepatic stellate cells as key target in liver fibrosis
Higashi, T., Friedman, S. L., & Hoshida, Y. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.05.007 · Cited by 1,485
Incalza, M. A., D’Oria, R., Natalicchio, A., Perrini, S., Laviola, L., & Giorgino, F. (2017) · Vascular Pharmacology · doi:10.1016/j.vph.2017.05.005 · Cited by 1,419
Kandola, A., Ashdown-Franks, G., Hendrikse, J., Sabiston, C. M., & Stubbs, B. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.09.040 · Cited by 1,309
Metabolic Regulation of T Lymphocytes
MacIver, N. J., Michalek, R. D., & Rathmell, J. C. (2013) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095956 · Cited by 1,244
Manna, P., & Jain, S. K. (2015) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2015.0095 · Cited by 1,211
González‐Muniesa, P., Martínez‐González, M. Á., Hu, F. B., Després, J., Matsuzawa, Y., Loos, R. J. F., Moreno, L. A., Bray, G. A., & Martínez, J. A. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.34 · Cited by 1,184
State of the art paper Biochemistry of adipose tissue: an endocrine organ
Coelho, M., Oliveira, T., & Fernandes, R. (2013) · Archives of Medical Science · doi:10.5114/aoms.2013.33181 · Cited by 1,201
Makki, K., Froguel, P., & Wolowczuk, I. (2013) · ISRN Inflammation · doi:10.1155/2013/139239 · Cited by 1,085
The vagus nerve and the inflammatory reflex – linking immunity and metabolism
Pavlov, V. A., & Tracey, K. J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.189 · Cited by 1,040
Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis
Rolo, A. P., Teodoro, J. S., & Palmeira, C. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.003 · Cited by 955
Role of neuroinflammation in neurodegenerative diseases (Review)
Chen, W., Zhang, X., & Huang, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4948 · Cited by 961
Global Impacts of Western Diet and Its Effects on Metabolism and Health: A Narrative Review
Clemente‐Suárez, V. J., Beltrán-Velasco, A. I., Redondo-Flórez, L., Martín-Rodríguez, A., & Tornero-Aguilera, J. F. (2023) · Nutrients · doi:10.3390/nu15122749 · Cited by 933
Li, X., Fang, P., Mai, J., Choi, E. T., Wang, H., & Yang, X. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-19 · Cited by 860
Obesity and diabetes: the increased risk of cancer and cancer-related mortality
Gallagher, E. J., & LeRoith, D. (2015) · Physiological Reviews · doi:10.1152/physrev.00030.2014 · Cited by 806
Adipose tissue and adipocytes support tumorigenesis and metastasis
Nieman, K. M., Romero, I. L., Houten, B. V., & Lengyel, E. R. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2013.02.010 · Cited by 773
Mauer, J., Chaurasia, B., Goldau, J., Vogt, M. C., Ruud, J., Nguyen, K. D., Theurich, S., Hausen, A. C., Schmitz, J., Brönneke, H. S., et al. (2014) · Nature Immunology · doi:10.1038/ni.2865 · Cited by 727
Obesity-related glomerulopathy: clinical and pathologic characteristics and pathogenesis
D’Agati, V. D., Chagnac, A., de Vries, A. P. J., Levi, M., Porrini, E., Herman‐Edelstein, M., & Praga, M. (2016) · Nature Reviews Nephrology · doi:10.1038/nrneph.2016.75 · Cited by 735
Lee, B.-C., & Lee, J. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.05.017 · Cited by 714
Adipokines Mediate Inflammation and Insulin Resistance
Kwon, H., & Pessin, J. E. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00071 · Cited by 723
Circadian misalignment increases cardiovascular disease risk factors in humans
Morris, C. J., Purvis, T. E., Hu, K., & Scheer, F. A. J. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516953113 · Cited by 691
Body Fat Distribution, Incident Cardiovascular Disease, Cancer, and All-Cause Mortality
Britton, K. A., Massaro, J. M., Murabito, J. M., Kreger, B. E., Hoffmann, U., & Fox, C. S. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.06.027 · Cited by 687
Fuster, J. J., Ouchi, N., Gokce, N., & Walsh, K. X. (2016) · Circulation Research · doi:10.1161/circresaha.115.306885 · Cited by 691
Self-citationAdiposity and cancer risk: new mechanistic insights from epidemiology
Renehan, A. G., Zwahlen, M., & Egger, M. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3967 · Cited by 654
Pathological sequelae of long-haul COVID
Mehandru, S., & Mérad, M. (2022) · Nature Immunology · doi:10.1038/s41590-021-01104-y · Cited by 675
Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease
Pedersen, B. K. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12781 · Cited by 617
Adipokine dysregulation and adipose tissue inflammation in human obesity
Unamuno, X., Gómez‐Ambrosi, J., Rodríguez, A., Becerril, S., Frühbeck, G., & Catalán, V. (2018) · European Journal of Clinical Investigation · doi:10.1111/eci.12997 · Cited by 610
Natural product agonists of peroxisome proliferator-activated receptor gamma (PPARγ): a review
Wang, L., Waltenberger, B., Pferschy‐Wenzig, E., Blunder, M., Liu, X., Malainer, C., Blažević, T., Schwaiger, S., Rollinger, J. M., Heiß, E. H., et al. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.07.018 · Cited by 617
Adipokines: A link between obesity and cardiovascular disease
Nakamura, K., Fuster, J. J., & Walsh, K. X. (2013) · Journal of Cardiology · doi:10.1016/j.jjcc.2013.11.006 · Cited by 597
Self-citationArimatsu, K., Yamada, H., Miyazawa, H., Minagawa, T., Nakajima, M., Ryder, M. I., Gotoh, K., Motooka, D., Nakamura, S., Iida, T., et al. (2014) · Scientific Reports · doi:10.1038/srep04828 · Cited by 573
Clinical characteristics and outcomes of patients with severe COVID-19 with diabetes
Yan, Y., Yang, Y., Wang, F., Ren, H., Zhang, S., Shi, X., Yu, X., & Dong, K. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001343 · Cited by 572
Contribution of adipogenesis to healthy adipose tissue expansion in obesity
Vishvanath, L., & Gupta, R. K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129191 · Cited by 558
Obesity: A Chronic Low-Grade Inflammation and Its Markers
Khanna, D., Khanna, S., Khanna, P., Kahar, P., & Patel, B. M. (2022) · Cureus · doi:10.7759/cureus.22711 · Cited by 567
Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function
Tan, B. L., & Norhaizan, M. E. (2019) · Nutrients · doi:10.3390/nu11112579 · Cited by 546
Immunometabolism: an emerging frontier
Mathis, D. J., & Shoelson, S. E. (2011) · Nature reviews. Immunology · doi:10.1038/nri2922 · Cited by 544
Mitochondrial dysfunction in obesity
de Mello, A. H., Costa, A. B., Engel, J. D. G., & Rezin, G. T. (2018) · Life Sciences · doi:10.1016/j.lfs.2017.11.019 · Cited by 508
Cancer and Inflammation: An Old Intuition with Rapidly Evolving New Concepts
Trinchieri, G. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075008 · Cited by 522
The role of hepatokines in metabolism
Stefan, N., & Häring, H.-U. (2013) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.258 · Cited by 500
Immune Regulation of Metabolic Homeostasis in Health and Disease
Brestoff, J. R., & Artis, D. (2015) · Cell · doi:10.1016/j.cell.2015.02.022 · Cited by 510
The Role of Cytokines in Breast Cancer Development and Progression
Esquivel‐Velázquez, M., Ostoa‐Saloma, P., Arreola, M. I. P., Castro, K. E. N., Castro, J. I., & Morales‐Montor, J. (2014) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2014.0026 · Cited by 506
Zhao, L., Zhang, Q., Ma, W., Tian, F., Shen, H., & Zhou, M. (2017) · Food & Function · doi:10.1039/c7fo01383c · Cited by 501
Fattori, V., Hohmann, M. S., Rossaneis, A. C., Pinho-Ribeiro, F. A., & Verri, W. A., Jr. (2016) · Molecules · doi:10.3390/molecules21070844 · Cited by 512
Adaptive immunity in obesity and insulin resistance
Sell, H., Habich, C., & Eckel, J. (2012) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2012.114 · Cited by 486
NK cells link obesity-induced adipose stress to inflammation and insulin resistance
Wensveen, F. M., Jelenčić, V., Marinović, S., Šestan, M., Wensveen, T. T., Theurich, S., Glasner, A., Mendrila, D., Štimac, D., Wunderlich, F. T., et al. (2015) · Nature Immunology · doi:10.1038/ni.3120 · Cited by 505
Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases
Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476
“By acting on white adipocyte mass, mitochondrial uncouplers could protect against diabetes, as limiting hyperaccumulation of triacyglycerol (TAG) in these cells might limit organelle stress [91,273–275] and modifications in the expression pattern of genes encoding adipokines, which are known to communicate the level o…”
BackgroundThe relationship between obesity and cognitive health and decline
Dye, L., Boyle, N. B., Champ, C., & Lawton, C. (2017) · Proceedings of the Nutrition Society · doi:10.1017/s0029665117002014 · Cited by 469
Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases
Spite, M., Clària, J., & Serhan, C. N. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.10.006 · Cited by 464
The role of adipokines in health and disease
Clemente-Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Martín-Rodríguez, A., Martínez-Guardado, I., Navarro-Jiménez, E., Laborde-Cárdenas, C. C., & Tornero-Aguilera, J. F. (2023) · Biomedicines · doi:10.3390/biomedicines11051290 · Cited by 463
Obesity in IBD: epidemiology, pathogenesis, disease course and treatment outcomes
Singh, S., Dulai, P. S., Zarrinpar, A., Ramamoorthy, S. L., & Sandborn, W. J. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.181 · Cited by 467
The role of infiltrating immune cells in dysfunctional adipose tissue
Guzik, T. J., Skiba, D. S., Touyz, R. M., & Harrison, D. G. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx108 · Cited by 462
Global pandemics interconnected — obesity, impaired metabolic health and COVID-19
Stefan, N., Birkenfeld, A. L., & Schulze, M. B. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00462-1 · Cited by 452
Prevalence and sociodemographic correlates of antinuclear antibodies in the United States
Satoh, M., Chan, E. K. L., Ho, L. A., Rose, K. M., Parks, C. G., Cohn, R. D., Jusko, T. A., Walker, N. J., Germolec, D. R., Whitt, I. Z., et al. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34380 · Cited by 452
Role of “Western Diet” in Inflammatory Autoimmune Diseases
Manzel, A., Müller, D. N., Hafler, D. A., Erdman, S. E., Linker, R. A., & Kleinewietfeld, M. (2013) · Current Allergy and Asthma Reports · doi:10.1007/s11882-013-0404-6 · Cited by 477
Borlaug, B. A., Jensen, M. D., Kitzman, D. W., Lam, C. S. P., Obokata, M., & Rider, O. J. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvac120 · Cited by 450
Impact of Obesity on Influenza A Virus Pathogenesis, Immune Response, and Evolution
Honce, R., & Schultz‐Cherry, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01071 · Cited by 456
Obesity and cognitive decline: role of inflammation and vascular changes
Nguyen, J. C. D., Killcross, S., & Jenkins, T. A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00375 · Cited by 440
Simoni, Y., Fehlings, M., Kløverpris, H. N., McGovern, N. N., Koo, S., Loh, C. Y., Lim, S. H., Kurioka, A., Fergusson, J. R., Tang, C., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.11.005 · Cited by 429
NLRP3 inflammasomes link inflammation and metabolic disease
De Nardo, D., & Latz, E. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.05.004 · Cited by 425
The spectrum of T cell metabolism in health and disease
Bantug, G. R., Galluzzi, L., Kroemer, G., & Hess, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.99 · Cited by 436
Ectopic Fat Depots and Cardiovascular Disease
Britton, K. A., & Fox, C. S. (2011) · Circulation · doi:10.1161/circulationaha.111.077602 · Cited by 432
Huh, J. Y., Park, Y. J., Ham, M., & Kim, J. B. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0074 · Cited by 440
The S100B story: from biomarker to active factor in neural injury
Michetti, F., D’Ambrosi, N., Toesca, A., Puglisi, M. A., Serrano, A., Marchese, E., Corvino, V., & Geloso, M. C. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14574 · Cited by 426
Oxidative stress and inflammation interactions in human obesity
Bondia‐Pons, I., Ryan, L., & Martínez, J. A. (2012) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0154-2 · Cited by 420
Peirce, V. J., Carobbio, S., & Vidal‐Puig, A. (2014) · Nature · doi:10.1038/nature13477 · Cited by 430
Cortellini, A., Bersanelli, M., Buti, S., Cannita, K., Santini, D., Perrone, F., Giusti, R., Tiseo, M., Michiara, M., Di Marino, P., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0527-y · Cited by 413
Insulin resistance and cardiovascular disease
Kosmas, C. E., Bousvarou, M. D., Kostara, C. E., Papakonstantinou, E. J., Salamou, E., & Guzman, E. (2023) · Journal of International Medical Research · doi:10.1177/03000605231164548 · Cited by 434
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming
Yin, H., Zhang, X., Yang, P., Zhang, X., Peng, Y., Li, D., Yu, Y., Wu, Y., Wang, Y., Zhang, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21514-8 · Cited by 412
Versatile functions for IL-6 in metabolism and cancer
Mauer, J., Denson, J. L., & Brüning, J. C. (2015) · Trends in Immunology · doi:10.1016/j.it.2014.12.008 · Cited by 415
He, Y., Li, Z. A., Alexander, P. G., Ocasio-Nieves, B. D., Yocum, L., Lin, H., & Tuan, R. S. (2020) · Biology · doi:10.3390/biology9080194 · Cited by 420
The role of adipokines in chronic inflammation
Mancuso, P. (2016) · ImmunoTargets and Therapy · doi:10.2147/itt.s73223 · Cited by 405
Zoccali, C., Mallamaci, F., Adamczak, M., de Oliveira, R. B., Massy, Z. A., Sarafidis, P. A., Agarwal, R., Mark, P. B., Kotanko, P., Ferro, C. J., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad083 · Cited by 399
Influenza and obesity: its odd relationship and the lessons for COVID-19 pandemic
Luzi, L., & Radaelli, M. G. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01522-8 · Cited by 384
Metabolic adaptation and maladaptation in adipose tissue
Chouchani, E. T., & Kajimura, S. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0021-8 · Cited by 405
Deng, T., Lyon, C. J., Minze, L. J., Lin, J., Zou, J., Liu, J. Z., Ren, Y., Yin, Z., Hamilton, D. J., Reardon, P. R., et al. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.02.009 · Cited by 396
Ruiz‐Ojeda, F. J., Rupérez, A. I., Gómez‐Llorente, C., Gil, Á., & Aguilera, C. M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17071040 · Cited by 391
Adipsin Is an Adipokine that Improves β Cell Function in Diabetes
Lo, J. C., Ljubicic, S., Leibiger, B., Kern, M., Leibiger, I. B., Moede, T., Kelly, M. E., Bhowmick, D. C., Murano, I., Cohen, P., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.005 · Cited by 390
Dietary phytochemicals and their potential effects on obesity: A review
González-Castejón, M., & Rodríguez‐Casado, A. (2011) · Pharmacological Research · doi:10.1016/j.phrs.2011.07.004 · Cited by 375
Mitochondrial dysfunction in metabolic syndrome
Prasun, P. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165838 · Cited by 390
Review: Diabetes, Obesity, and Cancer—Pathophysiology and Clinical Implications
Lega, I. C., & Lipscombe, L. L. (2019) · Endocrine Reviews · doi:10.1210/endrev/bnz014 · Cited by 381
Toxicological Function of Adipose Tissue: Focus on Persistent Organic Pollutants
Merrill, M. A. L., Emond, C., Kim, M. J., Antignac, J., Bizec, B. L., Clément, K., Birnbaum, L. S., & Barouki, R. (2012) · Environmental Health Perspectives · doi:10.1289/ehp.1205485 · Cited by 390
Structural and biochemical characteristics of various white adipose tissue depots
Wrońska, A., & Kmieć, Z. (2012) · Acta Physiologica · doi:10.1111/j.1748-1716.2012.02409.x · Cited by 402
Sárvári, A. K., Hauwaert, E. L. V., Markussen, L. K., Gammelmark, E., Marcher, A.-B., Ebbesen, M. F., Nielsen, R., Brewer, J. R., Madsen, J. G. S., & Mandrup, S. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.004 · Cited by 377
Epigallocatechin Gallate: A Review of Its Beneficial Properties to Prevent Metabolic Syndrome
Legeay, S., Rodier, M., Fillon, L., Faure, S., & Clere, N. (2015) · Nutrients · doi:10.3390/nu7075230 · Cited by 358
Fukui, H. (2016) · Inflammatory Intestinal Diseases · doi:10.1159/000447252 · Cited by 358
Dahiya, D. K., Renuka, Puniya, M., Shandilya, U. K., Dhewa, T., Kumar, N., Kumar, S., Puniya, A. K., & Shukla, P. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00563 · Cited by 363
Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease
Ferreira, S. T., Clarke, J. R., Bomfim, T. R., & Felice, F. G. D. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.12.010 · Cited by 363
Abraham, T. M., Pedley, A., Massaro, J. M., Hoffmann, U., & Fox, C. S. (2015) · Circulation · doi:10.1161/circulationaha.114.015000 · Cited by 353
Mechanisms of thrombosis in obesity
Blokhin, I. O., & Lentz, S. R. (2013) · Current Opinion in Hematology · doi:10.1097/moh.0b013e3283634443 · Cited by 352
The complex role of adipokines in obesity, inflammation, and autoimmunity
Taylor, E. B. (2021) · Clinical Science · doi:10.1042/cs20200895 · Cited by 369
Metadata
- Authors
- Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K.
- Affiliations
- Nagoya University (JP)
- Boston University (US)
- Corresponding author
- Walsh, Kenneth
- Venue
- Nature Reviews Immunology
- Published
- 2011-01-21
- Volume
- 11
- Issue
- 2
- Pages
- 85-97
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3518031
- OpenAlex
- W2088940658
- Cited by
- 4,625
- References
- 188
- Citations by year
- 2026: 294 · 2025: 311 · 2024: 301 · 2023: 326 · 2022: 363 · 2021: 358 · 2020: 370 · 2019: 371 · 2018: 286 · 2017: 335 · 2016: 279 · 2015: 270 · 2014: 264 · 2013: 250 · 2012: 171
- FWCI
- 27.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG015052, R37AG015052, AG15052, AG34972, R01AG034972)
- National Heart, Lung, and Blood Institute (HL81587, R01HL086785, P01HL081587, HL 86785)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, adipose tissue, obesity, low-grade inflammation, metabolic disorders, adipocytes, adipose tissue dysfunction, adipose tissue endocrine function, metabolic dysfunction
- MeSH terms
- Humans, Inflammation, Obesity, Adipokines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
