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Adipokines in inflammation and metabolic disease
Open accessAbstract
The worldwide epidemic of obesity has brought considerable attention to research aimed at understanding the biology of adipocytes (fat cells) and the events occurring in adipose tissue (fat) and in the bodies of obese individuals. Accumulating evidence indicates that obesity causes chronic low-grade inflammation and that this contributes to systemic metabolic dysfunction that is associated with obesity-linked disorders. Adipose tissue functions as a key endocrine organ by releasing multiple bioactive substances, known as adipose-derived secreted factors or adipokines, that have pro-inflammatory or anti-inflammatory activities. Dysregulated production or secretion of these adipokines owing to adipose tissue dysfunction can contribute to the pathogenesis of obesity-linked complications. In this Review, we focus on the role of adipokines in inflammatory responses and discuss their potential as regulators of metabolic function.
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“Increased leptin levels have been found in the obese population, inducing a leptin-resistance state, accompanied by increased ROS, TNF-α, IL-6 and chemokine ligands.”
From The Role of Exercise in the Interplay between Myokines, Hepatokines, Osteokines, Adipokines, and Modulation of Inflammation for Energy Substrate Redistribution and Fat Mass Loss: A Review (2020) · cites this paper as [216]
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“Additionally, it augments Th1 cytokines IL-2 and IFN-γ while suppressing Th2 cytokine IL-4 [216].”
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“In obesity, adiponectin levels are found to be reduced [216], given that its expression is inhibited by hypoxia, oxidative stress [228], insulin resistance [229], TNF-α, IL-6 [229], “catecholamine resistance” [239], fetuin A [148], and SeP [136].”
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“In the context of obesity, adipose tissue macrophages (ATM) change their phenotype from M2 to M1.”
From Sarcopenic obesity: epidemiology, pathophysiology, cardiovascular disease, mortality, and management (2023) · cites this paper as [19]
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“By acting on white adipocyte mass, mitochondrial uncouplers could protect against diabetes, as limiting hyperaccumulation of triacyglycerol (TAG) in these cells might limit organelle stress [91,273,274,275] and modifications in the expression pattern of genes encoding adipokines, which are known to communicate the level of adiposity to other organs [221,276].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [276]
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“Adiponectin is an antiatherogenic adipokine that also protects against metabolic disorders through improvements in insulin secretion and sensitivity [22].”
From Bariatric surgery: remission of inflammation, cardiometabolic benefits, and common adverse effects (2020) · cites this paper as [22]
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1 retracted
Visfatin: A Protein Secreted by Visceral Fat That Mimics the Effects of Insulin
Fukuhara, A., Matsuda, M., Nishizawa, M., Segawa, K., Tanaka, M., Kishimoto, K., Matsuki, Y., Murakami, M., Ichisaka, T., Murakami, H., et al. (2005) · Science · doi:10.1126/science.1097243 · Cited by 1,906
RetractedPositional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199
The metabolic phenotype in obesity: Fat mass, body fat distribution, and adipose tissue function
Goossens, G. H. (2017) · Obesity Facts · doi:10.1159/000471488 · Cited by 8,481
Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
Hotamisligil, G. S., Shargill, N. S., & Spiegelman, B. M. (1993) · Science · doi:10.1126/science.7678183 · Cited by 7,518
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Chen, X., Xiu, M., Xing, J., Yu, S., Min, D., & Guo, F. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479439 · Cited by 5,760
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
Flagged first, then by citations
Cited by
Sorted by citations
Items 601–700 of 1,029
Piya, M. K., Harte, A. L., & McTernan, P. G. (2013) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32835b4431 · Cited by 84
Adropin regulates cardiac energy metabolism and improves cardiac function and efficiency
Altamimi, T., Gao, S., Karwi, Q. G., Fukushima, A., Rawat, S., Wagg, C. S., Zhang, L., & Lopaschuk, G. D. (2019) · Metabolism · doi:10.1016/j.metabol.2019.06.005 · Cited by 82
Dietary cocoa reduces metabolic endotoxemia and adipose tissue inflammation in high-fat fed mice
Gu, Y., Yu, S., Park, J. Y., Harvatine, K. J., & Lambert, J. D. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.12.004 · Cited by 83
Liu, W., Crott, J. W., Lyu, L., Pfalzer, A. C., Li, J., Choi, S., Yang, Y., Mason, J. B., & Liu, Z. (2016) · Journal of Cancer · doi:10.7150/jca.15792 · Cited by 81
Does C-C Motif Chemokine Ligand 2 (CCL2) Link Obesity to a Pro-Inflammatory State?
Dommel, S., & Blüher, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031500 · Cited by 82
Larsen, M. N., Krustrup, P., Póvoas, S. C. A., & Castagna, C. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247362 · Cited by 81
Martemucci, G., Fracchiolla, G., Muraglia, M., Tardugno, R., Dibenedetto, R. S., & D‘Alessandro, A. G. (2023) · Antioxidants · doi:10.3390/antiox12122091 · Cited by 89
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
Di Franco, S., Bianca, P., Sardina, D. S., Turdo, A., Gaggianesi, M., Veschi, V., Nicotra, A., Mangiapane, L. R., Lo Iacono, M., Pillitteri, I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25333-9 · Cited by 80
Liu, G., Ding, M., Chiuve, S. E., Rimm, E. B., Franks, P. W., Meigs, J. B., Hu, F. B., & Sun, Q. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308320 · Cited by 80
Unmet Needs in the Field of Psoriasis: Pathogenesis and Treatment
Boehncke, W., & Brembilla, N. C. (2017) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-017-8634-3 · Cited by 83
Rakotoarivelo, V., Lacraz, G., Mayhue, M., Brown, C., Rottembourg, D., Fradette, J., Ilangumaran, S., Menéndez, A., Langlois, M., & Ramanathan, S. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2018.03.004 · Cited by 86
Potential Immunological Links Between Psoriasis and Cardiovascular Disease
Sajja, A. P., Joshi, A. A., Teague, H., Dey, A. K., & Mehta, N. N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01234 · Cited by 80
Childhood Obesity and the Metabolic Syndrome
Nehus, E. J., & Mitsnefes, M. M. (2018) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2018.08.004 · Cited by 84
Bonet, M. L., Ribot, J., Galmés, S., Serra, F. A., & Palou, A. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158676 · Cited by 82
Immune inflammation and metabolic interactions in the pathogenesis of diabetic nephropathy
Hou, G., Dong, Y., Jiang, Y., Zhao, W., Zhou, L., Cao, S., & Li, W. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1602594 · Cited by 80
Pan, X., Wang, P., Luo, J., Wang, Z., Song, Y., Ye, J., & Hou, X. (2014) · Endocrine · doi:10.1007/s12020-014-0384-x · Cited by 81
Lin, S., Hirai, S., Yamaguchi, Y., Goto, T., Takahashi, N., Tani, F., Mutoh, C., Sakurai, T., Murakami, S., Yu, R., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300150 · Cited by 80
Proinflammatory, anti-inflammatory cytokines and adiponkines in students with central obesity
Elwakkad, A., Hassan, N. E., Sibaii, H., & El-Zayat, S. R. (2013) · Cytokine · doi:10.1016/j.cyto.2012.11.010 · Cited by 80
Stefan, N., Sun, Q., Fritsche, A., Machann, J., Schick, F., Gerst, F., Jeppesen, C., Joost, H., Hu, F. B., Boeing, H., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092238 · Cited by 80
Kawwass, J. F., Summer, R. S., & Kallen, C. B. (2015) · Molecular Human Reproduction · doi:10.1093/molehr/gav025 · Cited by 84
Redox-inflammatory synergy in the metabolic syndrome
Bryan, S., Baregzay, B., Spicer, D., Singal, P. K., & Khaper, N. (2013) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2012-0295 · Cited by 82
Obesity associated disease risk: the role of inherent differences and location of adipose depots
Hill, J. H., Solt, C., & Foster, M. T. (2018) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2018-0012 · Cited by 79
Prather, A. A., Gurfein, B., Moran, P., Daubenmier, J., Acree, M., Bacchetti, P., Sinclair, E., Lin, J., Blackburn, E., Hecht, F. M., et al. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2014.12.011 · Cited by 79
Li, S., Li, J., Mao, G., Wu, T., Hu, Y., Ye, X., Ding, T., Linhardt, R. J., & Chen, S. (2018) · Food & Function · doi:10.1039/c8fo01174e · Cited by 79
Inflammatory Effects of Subacute Exposure of Roundup in Rat Liver and Adipose Tissue
Pandey, A., Dabhade, P., & Anand, K. (2019) · Dose-Response · doi:10.1177/1559325819843380 · Cited by 82
Microbiome and Mental Health, Specifically as It Relates to Adolescents
Simkin, D. R. (2019) · Current Psychiatry Reports · doi:10.1007/s11920-019-1075-3 · Cited by 82
Zan, P., Than, A., Zhang, W., Cai, H. X., Zhao, W., & Chen, P. (2022) · ACS Nano · doi:10.1021/acsnano.1c06410 · Cited by 79
Kidney Damage Caused by Obesity and Its Feasible Treatment Drugs
Wang, M., Wang, Z., Chen, Y., & Dong, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020747 · Cited by 80
Exercise training as treatment in cancer cachexia
Lira, F. S., Neto, J. C. R., & Seelaender, M. C. L. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2013-0554 · Cited by 79
Serum levels of fibroblast growth factor‐21 are increased in chronic and acute renal dysfunction
Hindricks, J., Ebert, T., Bachmann, A., Kralisch, S., Lössner, U., Kratzsch, J., Stolzenburg, J., Dietel, A., Beige, J., Anders, M. S., et al. (2013) · Clinical Endocrinology · doi:10.1111/cen.12380 · Cited by 80
Follistatin-Like 1: A Potential Mediator of Inflammation in Obesity
Fan, N., Sun, H., Wang, Y., Wang, Y., Zhang, L., Xia, Z., Peng, L., Hou, Y., Shen, W., Liu, R., et al. (2013) · Mediators of Inflammation · doi:10.1155/2013/752519 · Cited by 83
Response of Adipose Tissue to Early Infection With Trypanosoma cruzi (Brazil Strain)
Nagajyothi, F., Desruisseaux, M. S., Machado, F. S., Upadhya, R., Zhao, D., Schwartz, G. J., Teixeira, M. M., Albanese, C., Lisanti, M. P., Chua, S. C., et al. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jir840 · Cited by 79
Role of bioactive lipid mediators in obese adipose tissue inflammation and endocrine dysfunction
Lopategi, A., López‐Vicario, C., Alcaraz‐Quiles, J., García‐Alonso, V., Rius, B., Titos, E., & Clària, J. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.09.033 · Cited by 81
Stratakis, N., Conti, D. V., Borràs, E., Sabidó, E., Roumeliotaki, T., Papadopoulou, E., Agier, L., Basagaña, X., Bustamante, M., Casas, M., et al. (2020) · JAMA Network Open · doi:10.1001/jamanetworkopen.2020.1007 · Cited by 81
Peres, S. H. D. C. S., de Azevedo‐Silva, L. J., Bonato, R. C. S., Sales-Peres, M. D. C., Pinto, A. C. D. S., & Santiago, J. F. (2020) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2020.07.007 · Cited by 78
Brettle, H., Tran, V., Drummond, G. R., Franks, A. E., Petrovski, S., Vinh, A., & Jelinic, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.971048 · Cited by 81
Binder, A. M., LaRocca, J. L., Lesseur, C., Marsit, C. J., & Michels, K. B. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0116-y · Cited by 80
Liu, M.-J., Bao, S., Bolin, E. R., Burris, D. L., Xu, X., Sun, Q., Killilea, D. W., Shen, Q., Ziouzenkova, O., Belury, M. A., et al. (2013) · Journal of Nutrition · doi:10.3945/jn.113.175158 · Cited by 80
Zong, G., Ye, X., Sun, L., Li, H., Yu, Z., Hu, F. B., Sun, Q., & Lin, X. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.112.040204 · Cited by 78
Spatial Cognition in Adult and Aged Mice Exposed to High-Fat Diet
Kesby, J. P., Kim, J. J., Scadeng, M., Woods, G. N., Kado, D. M., Olefsky, J. M., Jeste, D. V., Achim, C. L., & Semenova, S. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140034 · Cited by 78
Chen, Y., Wu, X., Wu, R., Sun, X., Yang, B., Wang, Y., & Xu, Y. (2016) · Scientific Reports · doi:10.1038/srep26174 · Cited by 78
Kabore, E., Guénancia, C., Vaz-Luís, I., Meglio, A. D., Pistilli, B., Coutant, C., Cottu, P. H., Lesur, A., Petit, T., Dalenc, F., et al. (2019) · PLoS Medicine · doi:10.1371/journal.pmed.1002989 · Cited by 77
Adipocytokines: Are they the Theory of Everything?
Maximus, P., Achkar, Z. A., Hamid, P., Hasnain, S. S., & Peralta, C. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155144 · Cited by 78
Drew, B. G., Hamidi, H., Zhou, Z., Villanueva, C. J., Krum, S. A., Calkin, A. C., Parks, B. W., Ribas, V., Kalajian, N. Y., Phun, J., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.606459 · Cited by 80
Cardiac Hypertrophy: From Pathophysiological Mechanisms to Heart Failure Development
Caturano, A., Vetrano, E., Galiero, R., Salvatore, T., Docimo, G., Epifani, R., Alfano, M., Sardu, C., Marfella, R., Rinaldi, L., et al. (2022) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2305165 · Cited by 77
Yarur, A. J., Bruss, A., Moosreiner, A., Beniwal-Patel, P. M., Núñez, L., Berens, B. E., Colombel, J., Targan, S. R., Fox, C., Melmed, G., et al. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.06.036 · Cited by 77
Adipokines influence the inflammatory balance in autoimmunity
Hutcheson, J. (2015) · Cytokine · doi:10.1016/j.cyto.2015.04.004 · Cited by 78
Caloric restriction and chronic inflammatory diseases
González, O. A., Tobia, C. M., Ebersole, J. L., & Novak, M. J. (2011) · Oral Diseases · doi:10.1111/j.1601-0825.2011.01830.x · Cited by 81
Yuan, G., Chen, X., & Li, D. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf505050c · Cited by 76
Regressive Effect of Myricetin on Hepatic Steatosis in Mice Fed a High-Fat Diet
Xia, S., Le, G., Wang, P., Qiu, Y., Jiang, Y., & Xue Ming, T. A. N. G. (2016) · Nutrients · doi:10.3390/nu8120799 · Cited by 76
A narrative review of obesity and hearing loss
Dhanda, N., & Taheri, S. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.32 · Cited by 76
Metabolically healthy obese individuals: Key protective factors
Gonçalves, C. G., Glade, M. J., & Meguid, M. M. (2015) · Nutrition · doi:10.1016/j.nut.2015.07.010 · Cited by 75
The relationship between depressive symptoms and BMI: 2005–2018 NHANES data
He, K., Pang, T., & Huang, H. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.06.046 · Cited by 75
Visceral fat and gut inflammation
Drouet, M., Dubuquoy, L., Desreumaux, P., & Bertin, B. (2011) · Nutrition · doi:10.1016/j.nut.2011.09.009 · Cited by 75
Pickens, C. A., Sordillo, L. M., Comstock, S. S., Harris, W. S., Hortos, K., Kovan, B., & Fenton, J. I. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.12.001 · Cited by 75
Priscilla, D. H., Jayakumar, M., & Thirumurugan, K. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.02.005 · Cited by 75
Zhang, L., Han, Y., Zhang, X., Wang, X., Bao, B., Qu, W., & Liu, J. (2016) · Diabetologia · doi:10.1007/s00125-016-4039-8 · Cited by 75
Implicating androgen excess in propagating metabolic disease in polycystic ovary syndrome
Kempegowda, P., Melson, E., Manolopoulos, K. N., Arlt, W., & O’Reilly, M. (2020) · Therapeutic Advances in Endocrinology and Metabolism · doi:10.1177/2042018820934319 · Cited by 78
Modeling Adipogenesis: Current and Future Perspective
Bahmad, H. F., Daouk, R., Azar, J. H., Sapudom, J., Teo, J. C. M., Abou-Kheir, W. G., & Al‐Sayegh, M. (2020) · Cells · doi:10.3390/cells9102326 · Cited by 74
Role of Obesity in Female Reproduction
Yong, W., Wang, J., Leng, Y., Li, L., & Wang, H. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.80189 · Cited by 74
Effect of bariatric surgery on systemic and adipose tissue inflammation
Sams, V. G., Blackledge, C. D., Wijayatunga, N. N., Barlow, P. B., Mancini, M. L., Mancini, G. J., & Moustaïd‐Moussa, N. (2015) · Surgical Endoscopy · doi:10.1007/s00464-015-4638-3 · Cited by 74
Influence of Obesity and Related Metabolic Alterations on Colorectal Cancer Risk
Aleksandrova, K., Nimptsch, K., & Pischon, T. (2012) · Current Nutrition Reports · doi:10.1007/s13668-012-0036-9 · Cited by 76
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Yanagisawa, R., Koike, E., Win‐Shwe, T., Yamamoto, M., & Takano, H. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1307421 · Cited by 75
Chadderdon, S. M., Belcik, J. T., Bader, L., Kirigiti, M. A., Peters, D., Kievit, P., Grove, K. L., & Lindner, J. R. (2013) · Circulation · doi:10.1161/circulationaha.113.003645 · Cited by 74
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Rossi, F., Bellini, G., Luongo, L., Manzo, I., Tolone, S., Tortora, C., Bernardo, M. E., Grandone, A., Conforti, A., Docimo, L., et al. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-4381 · Cited by 74
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Ahnstedt, H. W., Roy-O’Reilly, M. A., Spychala, M. S., Mobley, A. S., Bravo-Alegria, J. B., Chauhan, A., Aronowski, J. A., Marrelli, S. P., & McCullough, L. D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00659 · Cited by 73
Teng, K. T., McGreevy, P. D., Toribio, J.-A. L. M. L., Raubenheimer, D., Kendall, K., & Dhand, N. K. (2018) · Journal of Small Animal Practice · doi:10.1111/jsap.12905 · Cited by 80
Potential Role of Oxidative Stress in the Production of Volatile Organic Compounds in Obesity
Oyerinde, A. S., Selvaraju, V., Babu, J. R., & Geetha, T. (2023) · Antioxidants · doi:10.3390/antiox12010129 · Cited by 75
Basińska, K., Marycz, K., Śmieszek, A., & Nicpoń, J. (2015) · Journal of Veterinary Science · doi:10.4142/jvs.2015.16.1.113 · Cited by 73
Díaz‐Ruiz, A., Guzmán‐Ruiz, R., Moreno‐Castellanos, N., García‐Ríos, A., Delgado‐Casado, N., Membrives, A., Túnez, I., Bekay, R. E., Fernández‐Real, J. M., Tovar, S. A., et al. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5939 · Cited by 73
In Search of a Germ Theory Equivalent for Chronic Disease
Egger, G. J. (2012) · Preventing Chronic Disease · doi:10.5888/pcd9.110301 · Cited by 79
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Fall, T., Hägg, S., Ploner, A., Mägi, R., Fischer, K., Draisma, H. H. M., Sarin, A., Benyamin, B., Ladenvall, C., Åkerlund, M., et al. (2015) · Diabetes · doi:10.2337/db14-0988 · Cited by 73
Exercise and Adipose Tissue Macrophages: New Frontiers in Obesity Research?
Goh, J., Goh, K. P., & Abbasi, A. (2016) · Frontiers in Endocrinology · doi:10.3389/fendo.2016.00065 · Cited by 78
Wu, M.-Q., Liu, D., Zeng, R., Xian, T., Lü, Y., Zeng, G., Sun, Z., Huang, B.-W., & Huang, Q. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.12.006 · Cited by 74
Repple, J., Opel, N., Meinert, S., Redlich, R., Hahn, T., Winter, N. R., Flint, C., Emden, D., Leenings, R., Grotegerd, D., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.03.007 · Cited by 78
Liang, W. H., & Ye, D. D. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.06.002 · Cited by 75
Shah, D., Romero, F., Duong, M., Wang, N., Paudyal, B., Suratt, B. T., Kallen, C. B., Sun, J., Zhu, Y., Walsh, K. X., et al. (2015) · Scientific Reports · doi:10.1038/srep11362 · Cited by 73
Self-citationRetractedObesity, metabolic syndrome and diabetic retinopathy: Beyond hyperglycemia
Mbata, O., El‐Magd, N. F. A., & El‐Remessy, A. B. (2017) · World Journal of Diabetes · doi:10.4239/wjd.v8.i7.317 · Cited by 74
Association of Adipose Tissue and Adipokines with Development of Obesity-Induced Liver Cancer
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Eibl, G., & Rozengurt, E. (2021) · Cancers · doi:10.3390/cancers13205067 · Cited by 76
Frischmuth, T., Hindberg, K., Aukrust, P., Ueland, T., Brækkan, S. K., Hansen, J., & Morelli, V. M. (2022) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.15701 · Cited by 72
Obesity is associated with improved survival in community-acquired pneumonia
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Metadata
- Authors
- Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K.
- Affiliations
- Nagoya University (JP)
- Boston University (US)
- Corresponding author
- Walsh, Kenneth
- Venue
- Nature Reviews Immunology
- Published
- 2011-01-21
- Volume
- 11
- Issue
- 2
- Pages
- 85-97
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3518031
- OpenAlex
- W2088940658
- Cited by
- 4,625
- References
- 188
- Citations by year
- 2026: 294 · 2025: 311 · 2024: 301 · 2023: 326 · 2022: 363 · 2021: 358 · 2020: 370 · 2019: 371 · 2018: 286 · 2017: 335 · 2016: 279 · 2015: 270 · 2014: 264 · 2013: 250 · 2012: 171
- FWCI
- 27.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (R01AG015052, R37AG015052, AG15052, AG34972, R01AG034972)
- National Heart, Lung, and Blood Institute (HL81587, R01HL086785, P01HL081587, HL 86785)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adipokines, adipose tissue, obesity, low-grade inflammation, metabolic disorders, adipocytes, adipose tissue dysfunction, adipose tissue endocrine function, metabolic dysfunction
- MeSH terms
- Humans, Inflammation, Obesity, Adipokines
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