The complex link and disease between the gut microbiome and the immune system in infants
Open accessAbstract
The human gut microbiome is important for human health. The development of stable microbial communities in the gastrointestinal tract is closely related to the early growth and development of host immunity. After the birth of a baby, immune cells and the gut microbiome mature in parallel to adapt to the complex gut environment. The gut microbiome is closely linked to the immune system and influences each other. This interaction is associated with various diseases in infants and young children, such as asthma, food allergies, necrotizing colitis, obesity, and inflammatory bowel disease. Thus, the composition of the infant gut microbiome can predict the risk of disease development and progression. At the same time, the composition of the infant gut microbiome can be regulated in many ways and can be used to prevent and treat disease in infants by modulating the composition of the infant gut microbiome. The most important impacts on infant gut microbiota are maternal, including food delivery and feeding. The differences in the gut microbiota of infants reflect the maternal gut microbiota, which in turn reflects the gut microbiota of a given population, which is clinically significant.
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The GM is closely linked to the immune system, and they interact in several ways.
“The GM is therefore closely linked to the immune system, and they interact in several ways [reviewed recently (256, 257)].”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [257]
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The crosstalk between microbiome and asthma: Exploring associations and challenges
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Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
- Authors
- Zhang, H., Zhang, Z., Liao, Y., Zhang, W., & Tang, D.
- Affiliations
- Yangzhou University (CN)
- Northern Jiangsu People's Hospital (CN)
- Corresponding author
- Tang, Dong
- Venue
- Frontiers in Cellular and Infection Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2022-06-15
- Volume
- 12
- Pages
- 924119-924119
- ISSN
- 2235-2988 (ISSN-L)
- PMC
- PMC9241338
- OpenAlex
- W4285739838
- Cited by
- 45
- References
- 102
- Citations by year
- 2026: 11 · 2025: 11 · 2024: 18 · 2023: 5
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Cellular and Infection Microbiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Government of Jiangsu Province
- Division of Graduate Education
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- gut microbiota, infant immune development, host-microbe interactions, infant gut microbiota, asthma, food allergy, necrotizing enterocolitis, childhood obesity, inflammatory bowel disease, maternal gut microbiota, infant feeding, disease risk prediction, microbiota modulation
- MeSH terms
- Gastrointestinal Microbiome, Child, Child, Preschool, Colitis, Humans, Immune System, Infant, Inflammatory Bowel Diseases, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
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