Transcriptional regulation of macrophage polarization: enabling diversity with identity

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382

Exploring the full spectrum of macrophage activation

Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · cited 1×

Monocyte and macrophage heterogeneity

Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190

Histone H3K27ac separates active from poised enhancers and predicts developmental state

Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302

Alternative activation of macrophages: mechanism and functions

Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197

The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation

Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525

Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504

Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome

Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · cited 1×

CpG islands and the regulation of transcription

Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187

Macrophage-Driven Inflammation in Metabolic Osteoarthritis: Implications for Biomarker and Therapy Development

Warmink, K., Vinod, P., Korthagen, N. M., Weinans, H., & Rios, J. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076112 · Cited by 39

Loss of metabolic adaptation in lean MAFLD is driven by endotoxemia leading to epigenetic reprogramming

Alharthi, J., Pan, Z., Gloss, B., McLeod, D. J., Weltman, M., George, J., & Eslam, M. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155583 · Cited by 39

Construction of pH‐Sensitive Nanovaccines Encapsulating Tumor Cell Lysates and Immune Adjuvants for Breast Cancer Therapy

Ding, Y., Yang, J., Wei, H., Wang, J., Huang, S., Yang, S., Guo, Y., Li, B., & Shuai, X. (2023) · Small · doi:10.1002/smll.202301420 · Cited by 39

miR-511-3p, embedded in the macrophage mannose receptor gene, contributes to intestinal inflammation

Heinsbroek, S. E. M., Squadrito, M. L., Schilderink, R., Hilbers, F. W., Verseijden, C., Hofmann, M., Helmke, A., Boon, L., Wildenberg, M. E., Roelofs, J. J. T. H., et al. (2015) · Mucosal Immunology · doi:10.1038/mi.2015.113 · Cited by 39

Ovarian cancer stem-like cells elicit the polarization of M2 macrophages

Zhang, Q., CAI, D.-J., & Li, B. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3323 · Cited by 39

TRAM1 Promotes Microglia M1 Polarization

Wang, H., Liu, C., Han, M., Cheng, C., & Zhang, D. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0678-3 · Cited by 39

Vitamin D3-vitamin D receptor axis suppresses pulmonary emphysema by maintaining alveolar macrophage homeostasis and function

Hu, G., Dong, T., Wang, S., Jing, H., & Chen, J. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.039 · Cited by 39

Blood-brain barrier and innate immunity in the pathogenesis of Alzheimer's disease

Šimić, G., Španić, E., Horvat, L. L., & Hof, P. R. (2019) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2019.06.003 · Cited by 40

Amelioration of visual deficits and visual system pathology after mild TBI via the cannabinoid Type-2 receptor inverse agonism of raloxifene

Honig, M. G., Mar, N. A. D., Henderson, D. L., Ragsdale, T. D., Doty, J. B., Driver, J. H., Li, C., Fortugno, A. P., Mitchell, W. M., Perry, A. M., et al. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.113063 · Cited by 39

Decorin Secreted by Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Induces Macrophage Polarization via CD44 to Repair Hyperoxic Lung Injury

Kwon, J. H., Kim, M., Bae, Y. K., Kim, G.-H., Choi, S. J., Oh, W., Um, S., & Jin, H. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194815 · Cited by 39

Differential immune response modulation in early Leishmania amazonensis infection of BALB/c and C57BL/6 macrophages based on transcriptome profiles

Aoki, J. I., Muxel, S. M., Zampieri, R. A., Müller, K. E., Nerland, A. H., & Floeter‐Winter, L. M. (2019) · Scientific Reports · doi:10.1038/s41598-019-56305-1 · Cited by 39

Macrophage Function and the Role of GSK3

Patel, S., & Werstuck, G. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042206 · Cited by 39

STAT6 Signaling Mediates PPARγ Activation and Resolution of Acute Sterile Inflammation in Mice

Lee, Y.-J., Kim, B.-M., Ahn, Y.-H., Choi, J. H., Choi, Y.-H., & Kang, J. L. (2021) · Cells · doi:10.3390/cells10030501 · Cited by 39

Normalization of the tumor microvasculature based on targeting and modulation of the tumor microenvironment

Li, Z., Ning, F., Wang, C., Yu, H., Ma, Q., & Sun, Y. (2021) · Nanoscale · doi:10.1039/d1nr03387e · Cited by 39

The Role of cGAS-STING in Age-Related Diseases from Mechanisms to Therapies

Zheng, W., Feng, D., Xiong, X., Liao, X., Wang, S., Xu, H., Le, W., Wei, Q., & Yang, L. (2023) · Aging and Disease · doi:10.14336/ad.2023.0117 · Cited by 39

Myeloid HIF-1 Is Protective in Helicobacter pylori–Mediated Gastritis

Matak, P., Heinis, M., Mathieu, J. R. R., Corriden, R., Cuvellier, S., Delga, S., Mounier, R., Rouquette, A., Raymond, J., Lamarque, D., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401260 · Cited by 39

Interleukin-1 Receptor-associated Kinase-4 (IRAK4) Promotes Inflammatory Osteolysis by Activating Osteoclasts and Inhibiting Formation of Foreign Body Giant Cells

Katsuyama, E., Miyamoto, H., Kobayashi, T., Sato, Y., Wu, H., Kanagawa, H., Fujie, A., Tando, T., Watanabe, R., Morita, M., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.568360 · Cited by 39

Suppression of the hyaluronic acid pathway induces M1 macrophages polarization via STAT1 in glioblastoma

Yan, T., Wang, K., Li, J., Hu, H., He, Y., Cai, M., Liu, R., Li, H., Wang, N., Shi, Y. K., et al. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00973-y · Cited by 38

Exploiting E3 ubiquitin ligases to reeducate the tumor microenvironment for cancer therapy

Li, X.-M., Zhao, Z., Xiao, Y., Xia, Q., Zhou, P., Wang, S., Wu, H., & Hu, J. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00394-2 · Cited by 40

Macrophage Ablation Reduces M2-Like Populations and Jeopardizes Tumor Growth in a MAFIA-Based Glioma Model

Gabrusiewicz, K. R., Hossain, M. B., Cortes‐Santiago, N., Fan, X., Kaminska, B., Marini, F. C., Fueyo-Margareto, J., & Gomez‐Manzano, C. (2015) · Neoplasia · doi:10.1016/j.neo.2015.03.003 · Cited by 38

A transcriptional perspective on human macrophage biology

Schultze, J. L., Freeman, T. C., Hume, D. A., & Latz, E. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.02.001 · Cited by 39

Prostaglandin E2 promotes M2 polarization of macrophages via a cAMP/CREB signaling pathway and deactivates granulocytes in teleost fish

Montero, J., Gómez-Abellán, V., Arizcún, M., Mulero, V., & Sepulcre, M. P. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.06.044 · Cited by 38

Regulation of Epigenetic Modifiers, Including KDM6B, by Interferon-γ and Interleukin-4 in Human Macrophages

Yıldırım-Buharalıoğlu, G., Bond, M., Sala‐Newby, G. B., Hindmarch, C. C. T., & Newby, A. C. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00092 · Cited by 38

MiR-30a Positively Regulates the Inflammatory Response of Microglia in Experimental Autoimmune Encephalomyelitis

Xue, F., Sun, D., Wang, Z., Yu, Z., Liu, W., Pu, Y., Wang, D., Huang, A., Liu, M., Xiang, Z., et al. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0153-y · Cited by 38

Human Cytomegalovirus Utilizes a Nontraditional Signal Transducer and Activator of Transcription 1 Activation Cascade via Signaling through Epidermal Growth Factor Receptor and Integrins To Efficiently Promote the Motility, Differentiation, and Polarization of Infected Monocytes

Collins-McMillen, D. K., Stevenson, E. V., Kim, J. H., Lee, B.-J., Cieply, S. J., Nogalski, M. T., Chan, G. C. T., Frost, R. W., Spohn, C. R., & Yurochko, A. D. (2017) · Journal of Virology · doi:10.1128/jvi.00622-17 · Cited by 40

Oxylipin Profiles as Functional Characteristics of Acute Inflammatory Responses in Astrocytes Pre-Treated with IL-4, IL-10, or LPS

Chistyakov, D. V., Gavrish, G. E., Goriainov, S. V., Chistyakov, V. V., Astakhova, A. A., Azbukina, N. V., & Sergeeva, M. G. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051780 · Cited by 40

The involving progress of MSCs based therapy in atherosclerosis

Lin, Y., Zhu, W. P., & Chen, X. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01728-1 · Cited by 38

MEK5/ERK5 signaling mediates IL-4-induced M2 macrophage differentiation through regulation of c-Myc expression

Luiz, J. P. M., Toller-Kawahisa, J. E., Viacava, P. R., Nascimento, D. C., Pereira, P. A. T., Saraiva, A. L., Prado, D. D. S., Bert, M. L., Giurisato, E., Tournier, C., et al. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.1ma0520-016r · Cited by 40

cAMP Signaling in Pathobiology of Alcohol Associated Liver Disease

Elnagdy, M., Barve, S. S., McClain, C. J., & Gobejishvili, L. (2020) · Biomolecules · doi:10.3390/biom10101433 · Cited by 38

Network Analysis Reveals a Distinct Axis of Macrophage Activation in Response to Conflicting Inflammatory Cues

Liu, X., Zhang, J., Zeigler, A. C., Nelson, A. R., Lindsey, M. L., & Saucerman, J. J. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.1901444 · Cited by 38

M2 Macrophage Co-Expression Factors Correlate With Immune Phenotype and Predict Prognosis of Bladder Cancer

Wang, Y., Yan, K., Wang, J., Lin, J., & Bi, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.609334 · Cited by 38

Macrophage Polarization in the Skin Lesion Caused by Neotropical Species of Leishmania sp

Pacheco, C. M. S., Flores, G. V. A., González, K., Gomes, C. M. D. C., Passero, L., Tomokane, T. Y., Sosa-Ochoa, W. H., Zúniga, C., Calzada, J., Saldaña, A., et al. (2021) · Journal of Immunological Research · doi:10.1155/2021/5596876 · Cited by 28

Roles of the Functional Interaction between Brain Cholinergic and Dopaminergic Systems in the Pathogenesis and Treatment of Schizophrenia and Parkinson’s Disease

Acharya, S., & Kim, K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094299 · Cited by 40

The Activated Macrophage – A Tough Fortress for Virus Invasion: How Viruses Strike Back

Banete, A., Barilo, J., Whittaker, R., & Basta, S. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.803427 · Cited by 38

CD14-Dependent Monocyte Isolation Enhances Phagocytosis of Listeria monocytogenes by Proinflammatory, GM-CSF-Derived Macrophages

Neu, C., Sedlag, A., Bayer, C., Förster, S., Crauwels, P., Niess, J. H., van Zandbergen, G., Frascaroli, G., & Riedel, C. U. (2013) · PLoS ONE · doi:10.1371/journal.pone.0066898 · Cited by 38

The Dynamic Duo–Inflammatory M1 macrophages and Th17 cells in Rheumatic Diseases

Li, J. (2013) · Journal of Orthopedics & Rheumatology · doi:10.13188/2334-2846.1000002 · Cited by 37

Tumor-derived small extracellular vesicles promote breast cancer progression by upregulating PD-L1 expression in macrophages

Xu, D., Chen, W., Liang, M., Chen, X., Liu, Z., Fei, Y., Shao, X.-Y., Wu, Y. F., Zhang, W., & Tang, J. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02980-0 · Cited by 37

Macrophage membrane-camouflaged biomimetic nanoparticles for rheumatoid arthritis treatment via modulating macrophage polarization

Zhou, R., Xue, S., Cheng, Y., Chen, Y., Wang, Y., Xing, J., Liu, H., Xu, Y., Lin, Y., Pei, Z., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02822-9 · Cited by 37

The Regulatory Network of Transcription Factors in Macrophage Polarization

Liu, J., Wang, M., & Zhao, Y. X. (2025) · ImmunoTargets and Therapy · doi:10.2147/itt.s494550 · Cited by 38

Corticosteroids, Heart Failure, and Hypertension: A Role for Immune Cells?

Shen, J., & Young, M. J. (2012) · Endocrinology · doi:10.1210/en.2012-1780 · Cited by 39

Regulation of Macrophage Polarization by RON Receptor Tyrosine Kinase Signaling

Chaudhuri, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00546 · Cited by 37

Induction of protumoral CD 11chigh macrophages by glioma cancer stem cells through GM ‐ CSF

Kokubu, Y., Tabu, K., Muramatsu, N., Wang, W., Murota, Y., Nobuhisa, I., Jinushi, M., & Taga, T. (2016) · Genes to Cells · doi:10.1111/gtc.12333 · Cited by 37

The homeobox protein VentX reverts immune suppression in the tumor microenvironment

Le, Y., Gao, H., Bleday, R., & Zhu, Z. (2018) · Nature Communications · doi:10.1038/s41467-018-04567-0 · Cited by 37

Distinct mechanisms regulate IL1B gene transcription in lymphoid CD4 T cells and monocytes

Pulugulla, S. H., Packard, T. A., Galloway, N. L. K., Grimmett, Z. W., Doitsh, G., Adamik, J., Galson, D. L., Greene, W. C., & Auron, P. E. (2018) · Cytokine · doi:10.1016/j.cyto.2018.10.001 · Cited by 37

STAT1 regulates macrophage number and phenotype and prevents renal fibrosis after ischemia-reperfusion injury

Kemmner, S., Bachmann, Q., Steiger, S., Lorenz, G., Honarpisheh, M. M., Foresto‐Neto, O., Wang, S., Carbajo-Lozoya, J., Alt, V., Schulte, C., et al. (2018) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00004.2018 · Cited by 38

Endoplasmic reticulum stress, a new wrestler, in the pathogenesis of idiopathic pulmonary fibrosis.

Zhang, L., Wang, Y., Pandupuspitasari, N. S., Wu, G., Xiang, X., Gong, Q., Xiong, W., Wang, C., Yang, P. C., & Ren, B. (2017) · Europe PMC (PubMed Central) · Cited by 38

Heparin inhibits proinflammatory and promotes anti-inflammatory macrophage polarization under hyperglycemic stress

Abbadi, A., Loftis, J., Wang, A., Yu, M., Wang, Y., Shakya, S., Li, X., Maytin, E. V., & Hascall, V. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012419 · Cited by 37

Targeting macrophage priming by polyphyllin VII triggers anti-tumor immunity via STING-governed cytotoxic T-cell infiltration in lung cancer

Yu, J., Deng, H., & Xu, Z. (2020) · Scientific Reports · doi:10.1038/s41598-020-77800-w · Cited by 39

Microglia in Neurodegenerative Events—An Initiator or a Significant Other?

Harry, G. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115818 · Cited by 37

Interleukin-22: a potential therapeutic target in atherosclerosis

Luo, J., Hu, Y., Liu, J., Yang, H. M., & Huang, P. (2021) · Molecular Medicine · doi:10.1186/s10020-021-00353-9 · Cited by 36

Role of Vitamin E and the Orexin System in Neuroprotection

Torre, M. E. L., Villano, I., Monda, M., Messina, A., Cibelli, G., Valenzano, A. A., Pisanelli, D., Panaro, M. A., Tartaglia, N., Ambrosi, A., et al. (2021) · Brain Sciences · doi:10.3390/brainsci11081098 · Cited by 37

Macrophage neogenin deficiency exacerbates myocardial remodeling and inflammation after acute myocardial infarction through JAK1-STAT1 signaling

Zhang, J., Xu, Y. Q., Cheng, W., Yin, Z., Pan, W. D., Zhao, M., Ding, W., Xu, S., Liu, J., Yu, J., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04974-7 · Cited by 38

Polarized Macrophages Have Distinct Roles in the Differentiation and Migration of Embryonic Spinal-cord-derived Neural Stem Cells After Grafting to Injured Sites of Spinal Cord

Zhang, K., Zheng, J., Bian, G., Liu, L., Xue, Q., Liu, F., Yu, C., Zhang, H., Song, B., Chung, S. K., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.46 · Cited by 38

Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis

Municio, C., Palacios, B. S., Estrada‐Capetillo, L., Benguría, A., Dopazo, A., García-Lorenzo, E., Fernández‐Arroyo, S., Joven, J., Miranda‐Carús, M., González‐Álvaro, I., et al. (2016) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2015-208736 · Cited by 37

INT-HA induces M2-like macrophage differentiation of human monocytes via TLR4-miR-935 pathway

Zhang, B., Du, Y., He, Y., Liu, Y., Zhang, G., Yang, C., & Gao, F. (2018) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-018-2261-6 · Cited by 37

Going ballistic: Leishmania nuclear subversion of host cell plasticity

Lecoeur, H., Prina, E., Gutiérrez-Sanchez, M., & Späth, G. F. (2021) · Trends in Parasitology · doi:10.1016/j.pt.2021.09.009 · Cited by 38

Molecular mechanisms underlying the high mortality of hypervirulent Klebsiella pneumoniae and its effective therapy development

Xu, Q., Xie, M., Liu, X., Heng, H., Wang, H., Yang, C., Chan, E. W., Zhang, R., Yang, G., & Chen, S. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01490-9 · Cited by 36

Atmosphere-inspired multilayered nanoarmor with modulable protection and delivery of Interleukin-4 for inflammatory microenvironment modulation

Ge, X., Hu, J., Peng, Y., Zeng, Z., He, D., Li, X., Chen, Y., Luo, G., Deng, J., Xu, Z., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122254 · Cited by 36

ncRNA-regulated immune response and its role in inflammatory lung diseases

Xie, N., & Liu, G. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00286.2015 · Cited by 36

Neutrophil degranulation differentially modulates phenotype and function of bovine monocyte subsets

Hussen, J., Koy, M., Petzl, W., & Schuberth, H. (2015) · Innate Immunity · doi:10.1177/1753425915620911 · Cited by 36

Foldable glycoprobes capable of fluorogenic crosslinking of biomacromolecules

Li, K.-B., Li, N., Zang, Y., Chen, G., Li, J. X., James, T. D., He, X., & Tian, H. (2016) · Chemical Science · doi:10.1039/c6sc02366e · Cited by 36

Pathologic evaluation of tumor-associated macrophage density and vessel inflammation in invasive breast carcinomas

Morita, Y., Zhang, R., Leslie, M., Adhikari, S., Hasan, N., Chervoneva, I., Rui, H., & Tanaka, T. (2017) · Oncology Letters · doi:10.3892/ol.2017.6466 · Cited by 36

Neorogioltriol and Related Diterpenes from the Red Alga Laurencia Inhibit Inflammatory Bowel Disease in Mice by Suppressing M1 and Promoting M2-Like Macrophage Responses

Daskalaki, M., Vyrla, D., Harizani, M., Doxaki, C., Eliopoulos, A. G., Roussis, V., Ioannou, E., Tsatsanis, C., & Kampranis, S. C. (2019) · Marine Drugs · doi:10.3390/md17020097 · Cited by 36

Hyperglycemia‐Triggered Sphingosine‐1‐Phosphate and Sphingosine‐1‐Phosphate Receptor 3 Signaling Worsens Liver Ischemia/Reperfusion Injury by Regulating M1/M2 Polarization

Hu, Y., Yang, C., Shen, G., Yang, S., Cheng, X., Cheng, F., Rao, J., & Wang, X. (2019) · Liver Transplantation · doi:10.1002/lt.25470 · Cited by 36

Immunomodulatory Effect of Imiquimod Through CCL22 Produced by Tumor-associated Macrophages in B16F10 Melanomas

Furudate, S., Fujimura, T., Kambayashi, Y., Kakizaki, A., Hidaka, T., & Aiba, S. (2017) · Anticancer Research · doi:10.21873/anticanres.11714 · Cited by 36

MicroRNA-21 Inhibition Suppresses Alveolar M2 Macrophages in an Ovalbumin-Induced Allergic Asthma Mice Model

Lee, H. Y., Hur, J., Kang, J. Y., Rhee, C. K., & Lee, S. Y. (2021) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2021.13.2.312 · Cited by 36

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization

Zhang, L., Zhang, K., Zhang, J., Zhu, J., Xi, Q., Wang, H., Zhang, Z., Cheng, Y., Yang, G., Liu, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24610-x · Cited by 36

Host Immune-Metabolic Adaptations Upon Mycobacterial Infections and Associated Co-Morbidities

Llibre, A., Dedicoat, M. J., Burel, J. G., Demangel, C., O’Shea, M. K., & Mauro, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.747387 · Cited by 37

Exosomal miR-500 Derived From Lipopolysaccharide-Treated Macrophage Accelerates Liver Fibrosis by Suppressing MFN2

Chen, L., Huang, Y., Duan, Z., Huang, P.-Q., Yao, H., Zhou, Y., Ji, Q., & Liu, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.716209 · Cited by 38

Engineering DNA Nanostructures to Manipulate Immune Receptor Signaling and Immune Cell Fates

Tseng, C., Wang, W. X., Douglas, T. R., & Chou, L. Y. T. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101844 · Cited by 36

Male Macrophages and Fibroblasts from C57/BL6J Mice Are More Susceptible to Inflammatory Stimuli

Barcena, M. L., Niehues, M. H., Christiansen, C., Estepa, M., Haritonow, N., Sadighi, A. H., Müller‐Werdan, U., Ladilov, Y. V., & Regitz‐Zagrosek, V. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.758767 · Cited by 36

NK Cell Anti-Tumor Surveillance in a Myeloid Cell-Shaped Environment

Russo, E., Laffranchi, M., Tomaipitinca, L., Prete, A. D., Santoni, A., Sozzani, S., & Bernardini, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.787116 · Cited by 36

Influence of Natural Polysaccharides on Intestinal Microbiota in Inflammatory Bowel Diseases: An Overview

Li, Q., Li, L., Li, Q., Wang, J., Nie, S., & Xie, M. (2022) · Foods · doi:10.3390/foods11081084 · Cited by 38

The evolution of our understanding of macrophages and translation of findings toward the clinic

Martínez, F. O., & Gordon, S. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2015.985658 · Cited by 43

Xuebijing Injection Promotes M2 Polarization of Macrophages and Improves Survival Rate in Septic Mice

Liu, Y., Yao, F.-H., Chai, Y., Dong, N., Sheng, Z.-Y., & Yao, Y.-M. (2015) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2015/352642 · Cited by 35

Nanotherapeutics for anti-inflammatory delivery

Marzio, L. D., Ventura, C. A., Cosco, D., Paolino, D., Stefano, A. D., Stancanelli, R., Tommasini, S., Cannavà, C., Celia, C., & Fresta, M. (2015) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2015.10.011 · Cited by 35

A polarizing view on posttraumatic brain injury inflammatory response

Rosi, S. (2016) · Brain Circulation · doi:10.4103/2394-8108.192517 · Cited by 35

Loss of periostin ameliorates adipose tissue inflammation and fibrosis in vivo

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Goulding, D. S., Vogel, R. C., Pandya, C. D., Shula, C., Gensel, J. C., Mangano, F. T., Goto, J., & Miller, B. A. (2020) · Journal of Neurosurgery Pediatrics · doi:10.3171/2019.12.peds19625 · Cited by 35

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Wen, H., Peng, L., & Chen, Y. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16686 · Cited by 35

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Wang, X., Xu, Y., Sun, Q., Zhou, X., Ma, W., Wu, J., Zhuang, J., & Sun, C. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113343 · Cited by 35

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Wang, Y., Zhao, C., Wang, R.-Y., Du, Q.-X., Liu, J., & Pan, J. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03199-y · Cited by 35

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Kumar, D., Pandit, R., & Yurdagul, A. (2023) · Immunometabolism · doi:10.1097/in9.0000000000000017 · Cited by 37

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Freitas, M. S., Oliveira, A. F., da Silva, T. A., Fernandes, F. F., Gonçales, R. A., Almeida, F. B. D. R., & Roque‐Barreira, M. C. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01003 · Cited by 37

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Shang, M., Ni, L., Shan, X., Cui, Y., Hu, P., Ji, Z., Shen, L., Zhang, Y., Zhou, J., Chen, B., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112481 · Cited by 34

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Tozihi, M., Shademan, B., Yousefi, H., Avcı, Ç. B., Nourazarian, A., & Dehghan, G. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1227513 · Cited by 34

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Chen, H., Sévin, D. C., Griffith, G. R., Vappiani, J., Booty, L. M., van Roomen, C. P. A. A., Kuiper, J., den Dunnen, J., de Jonge, W. J., Prinjha, R. K., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114741 · Cited by 35

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Zhang, H., Zhang, W., Sun, X., Dang, R., Zhou, R., Bai, H., Ben, J., Zhu, X., Zhang, Y., Yang, Q., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10318 · Cited by 34

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Macrophages in melanoma: A double‑edged sword and targeted therapy strategies (Review)

Zhou, Q., Fang, T., Wei, S., Chai, S., Yang, H., Tao, M., & Cao, Y. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11577 · Cited by 35

Sialic acids promote macrophage M1 polarization and atherosclerosis by upregulating ROS and autophagy blockage

Hu, X., Li, Y., Chen, Q., Wang, T., Ma, L., Zhang, W., Yu, R., Zhang, J., Wan, J., Yu, C., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110410 · Cited by 34

IL ‐4 and IL ‐13 inhibit IL ‐1β and TNF ‐α induced kinin B1 and B2 receptors through a STAT6 ‐dependent mechanism

Souza, P., Brechter, A. B., Reis, R. I., Costa, C., Lundberg, P., & Lerner, U. H. (2013) · British Journal of Pharmacology · doi:10.1111/bph.12116 · Cited by 35

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Hoeksema, M. A., Neele, A. E., Prange, K. H. M., Glass, C. K., & de Winther, M. P. J. (2026) · Science Immunology · doi:10.1126/sciimmunol.aec1740 · Cited by 3

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Transcriptional control of macrophage diversity and specialization

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Transcriptional profiling identifies novel regulators of macrophage polarization

Gerrick, K. Y., Gerrick, E. R., Gupta, A. K., Wheelan, S. J., Yegnasubramanian, S., & Jaffee, E. M. (2018) · PLoS ONE · doi:10.1371/journal.pone.0208602 · Cited by 105