The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Transcriptional regulation of macrophage polarization: enabling diversity with identity
Abstract
In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone. Also, marked changes in the activity and gene expression programmes of macrophages can occur when they come into contact with invading microorganisms or injured tissues. Therefore, the macrophage lineage includes a remarkable diversity of cells with different functions and functional states that are specified by a complex interplay between microenvironmental signals and a hardwired differentiation programme that determines macrophage identity. In this Review, we summarize the current knowledge of transcriptional and chromatin-mediated control of macrophage polarization in physiology and disease.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“previous studies have reported that MAPK signaling cascades are the central pathway in the M1 polarization of macrophages.24,25”
From Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization (2024) · cites this paper as [24]
In the citing paper
“During the transition to the chronic stage of FBR macrophages switch from a pro-inflammatory activation phenotype (M1 macrophages) to an anti-inflammatory and tissue generation phenotype (M2 macrophages) (Mantovani et al., 2004; Lawrence and Natoli, 2011; Sridharan et al., 2015).”
From Foreign Body Reaction to Implanted Biomaterials and Its Impact in Nerve Neuroprosthetics (2021) · cites this paper as Lawrence and Natoli, 2011
In the citing paper
“Lawrence et al has suggested that MCSF receptor activates IRF4 transcription factor to promote M2 differentiation of macrophages [37].”
From Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo (2014) · cites this paper as [37]
In the citing paper
“While the mechanisms that underlie this observed plasticity are not well understood, recent studies have shown that a number of mutually exclusive and feed forward signaling pathways may play a role [19].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [19]
Citations
Cites
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · cited 1×
“Stimulation of the IFNγ receptor triggers JAK-mediated tyrosine phosphorylation and subsequent dimerization of STAT1, which binds as a homodimer to cis elements known as gamma-activated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among other”
BackgroundMonocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · cited 1×
“Genomic regions that are active as enhancers in a given cell type can be identified by their association with specific histone modifications, in particular monomethylation of lysine 4 in histone H3 (H3K4me1), although the precise functional effects of such modifications in terms of enhancer activity are still unknow”
BackgroundCpG islands and the regulation of transcription
Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187
Flagged first, then by citations
Cited by
Sorted by citations
Items 1,001–1,005 of 1,005
Wang, Y., Chu, T., Meng, C., Bian, Y., & Li, J. (2025) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2025.101495 · Cited by 32
Perdiguero, E., Kharraz, Y., Serrano, A. L., & Muñoz-Cánoves, P. (2012) · Cell Cycle · doi:10.4161/cc.11.5.19374 · Cited by 30
Li, M., Kim, Y.-M., Koh, J. H., Park, J., Kwon, H. M., Park, J.-H., Jin, J., Park, Y., Kim, D., & Kim, W.-U. (2024) · Journal of Clinical Investigation · doi:10.1172/jci167835 · Cited by 25
Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization
Ding, X., Zhang, X., Cao, J., Chen, S., Chen, Y., Yuan, K., Chen, B., Yang, G., Li, S., Yang, J., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.101406 · Cited by 23
ADAP Y571 Phosphorylation Is Required to Prime STAT3 for Activation in TLR4-Stimulated Macrophages
Yang, N., Xiong, Y., Wang, Y., Yi, Y., Zhu, J., Ma, F., Li, J., & Liu, H. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2000569 · Cited by 11
Metadata
- Authors
- Lawrence, T., & Natoli, G.
- Affiliations
- Centre d’Immunologie de Marseille-Luminy (FR)
- European Institute of Oncology (IT)
- Corresponding author
- Lawrence, Toby
- Natoli, Gioacchino
- Venue
- Nature Reviews Immunology
- Published
- 2011-10-25
- Volume
- 11
- Issue
- 11
- Pages
- 750-761
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2081810806
- Cited by
- 2,284
- References
- 90
- Citations by year
- 2026: 124 · 2025: 147 · 2024: 194 · 2023: 180 · 2022: 190 · 2021: 203 · 2020: 158 · 2019: 139 · 2018: 149 · 2017: 166 · 2016: 165 · 2015: 158 · 2014: 140 · 2013: 108 · 2012: 58
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- macrophage polarization, macrophage identity, transcription factors, chromatin regulation, macrophage heterogeneity, tissue-resident macrophages, macrophage differentiation, macrophage lineage
- MeSH terms
- Interferon Regulatory Factor-4, Gene Expression Regulation, Humans, Macrophages, Promoter Regions, Genetic, Protein Binding, PPAR gamma, STAT1 Transcription Factor, STAT6 Transcription Factor, Interferon Regulatory Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
