Cited by 2,284Immune cells in cancerGenomics and Chromatin DynamicsPeroxisome Proliferator-Activated Receptors

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Transcriptional regulation of macrophage polarization: enabling diversity with identity

Lawrence, Toby, Natoli, Gioacchino·2011·Nature Reviews Immunology

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Abstract

In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone. Also, marked changes in the activity and gene expression programmes of macrophages can occur when they come into contact with invading microorganisms or injured tissues. Therefore, the macrophage lineage includes a remarkable diversity of cells with different functions and functional states that are specified by a complex interplay between microenvironmental signals and a hardwired differentiation programme that determines macrophage identity. In this Review, we summarize the current knowledge of transcriptional and chromatin-mediated control of macrophage polarization in physiology and disease.

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Authors: Lawrence, T., & Natoli, G.
Affiliations: Centre d’Immunologie de Marseille-Luminy (FR)
European Institute of Oncology (IT)
Corresponding author: Lawrence, Toby
Natoli, Gioacchino
ORCID: Lawrence, Toby
Natoli, Gioacchino
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-10-25
Volume: 11
Issue: 11
Pages: 750-761
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3088
OpenAlex: W2081810806
Cited by: 2,284
References: 90
Citations by year: 2026: 124 · 2025: 147 · 2024: 194 · 2023: 180 · 2022: 190 · 2021: 203 · 2020: 158 · 2019: 139 · 2018: 149 · 2017: 166 · 2016: 165 · 2015: 158 · 2014: 140 · 2013: 108 · 2012: 58
FWCI: 8.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Agence Nationale de la Recherche
Institut National de la Santé et de la Recherche Médicale
Centre National de la Recherche Scientifique
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: macrophage polarization, macrophage identity, transcription factors, chromatin regulation, macrophage heterogeneity, tissue-resident macrophages, macrophage differentiation, macrophage lineage
MeSH terms: Interferon Regulatory Factor-4, Gene Expression Regulation, Humans, Macrophages, Promoter Regions, Genetic, Protein Binding, PPAR gamma, STAT1 Transcription Factor, STAT6 Transcription Factor, Interferon Regulatory Factors

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Transcriptional regulation of macrophage polarization: enabling diversity with identity

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