Cited by 2,284Immune cells in cancerGenomics and Chromatin DynamicsPeroxisome Proliferator-Activated Receptors

The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.

Transcriptional regulation of macrophage polarization: enabling diversity with identity

Lawrence, Toby, Natoli, Gioacchino·2011·Nature Reviews Immunology

Open this paper in CoChat — free account

Abstract

In terms of both phenotype and function, macrophages have remarkable heterogeneity, which reflects the specialization of tissue-resident macrophages in microenvironments as different as liver, brain and bone. Also, marked changes in the activity and gene expression programmes of macrophages can occur when they come into contact with invading microorganisms or injured tissues. Therefore, the macrophage lineage includes a remarkable diversity of cells with different functions and functional states that are specified by a complex interplay between microenvironmental signals and a hardwired differentiation programme that determines macrophage identity. In this Review, we summarize the current knowledge of transcriptional and chromatin-mediated control of macrophage polarization in physiology and disease.

Integrity signals

Registry

Crossref · 10.1038/nri3088

Cites

90 of 90 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080 · cited 1×
“Stimulation of the IFNγ receptor triggers JAK-mediated tyrosine phosphorylation and subsequent dimerization of STAT1, which binds as a homodimer to cis elements known as gamma-activated sequences in the promoters of the genes encoding NOS2, the MHC class II transactivator (CIITA) and IL-12, among other”
Background
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302
Alternative activation of macrophages: mechanism and functions
Gordon, S., & Martinez, F. O. (2010) · Immunity · doi:10.1016/j.immuni.2010.05.007 · Cited by 4,197
The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., & Glass, C. K. (1998) · Nature · doi:10.1038/34178 · Cited by 3,525
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398 · cited 1×
“Genomic regions that are active as enhancers in a given cell type can be identified by their association with specific histone modifications, in particular monomethylation of lysine 4 in histone H3 (H3K4me1), although the precise functional effects of such modifications in terms of enhancer activity are still unknow”
Background
CpG islands and the regulation of transcription
Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187

Flagged first, then by citations

Show all 90 references

Sorted by citations

Items 501–600 of 1,005

Emodin Bidirectionally Modulates Macrophage Polarization and Epigenetically Regulates Macrophage Memory
Iwanowycz, S., Wang, J., Altomare, D., Hui, Y. Y., & Fan, D. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.702092 · Cited by 81
Regulation of the IL-10-driven macrophage phenotype under incoherent stimuli
Chuang, Y., Hung, M. E., Cangelose, B. K., & Leonard, J. N. (2016) · Innate Immunity · doi:10.1177/1753425916668243 · Cited by 85
Transcriptional control of apoptotic cell clearance by macrophage nuclear receptors
Rőszer, T. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1310-x · Cited by 80
Macrophage polarization plays roles in bone formation instructed by calcium phosphate ceramics
Li, M., Guo, X., Qi, W., Wu, Z., de Bruijn, J. D., Xiao, Y. M., Bao, C., & Yuan, H. (2020) · Journal of Materials Chemistry B · doi:10.1039/c9tb02932j · Cited by 80
RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization
Meng, Y., Zhou, W., Jin, L., Liu, L.-B., Chang, K., Mei, J., Li, H., Wang, J., Li, D., & Li, M. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.505 · Cited by 80
M2 polarization of macrophages by Oncostatin M in hypoxic tumor microenvironment is mediated by mTORC2 and promotes tumor growth and metastasis
Shrivastava, R., Asif, M., Singh, V., Dubey, P., Malik, S. A., Lone, M. D., Tewari, B. N., Baghel, K. S., Pal, S., Nagar, G. K., et al. (2018) · Cytokine · doi:10.1016/j.cyto.2018.03.032 · Cited by 80
Type 2 Immune Mechanisms in Carbon Nanotube-Induced Lung Fibrosis
Dong, J., & Ma, Q. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01120 · Cited by 80
Colorectal cancer triple co-culture spheroid model to assess the biocompatibility and anticancer properties of polymeric nanoparticles
Bauleth-Ramos, T., Feijão, T., Gonçalves, A., Shahbazi, M.-A., Liu, Z., Barrias, C., Oliveira, M. J., Granja, P., Santos, H. A., & Sarmento, B. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.025 · Cited by 79
The macrophage marker translocator protein (TSPO) is down-regulated on pro-inflammatory ‘M1’ human macrophages
Narayan, N., Mandhair, H., Smyth, E., Dakin, S. G., Kiriakidis, S., Wells, L., Owen, D., Sabokbar, A., & Taylor, P. (2017) · PLOS ONE · doi:10.1371/journal.pone.0185767 · Cited by 79
Neuroimmunological communication via CGRP promotes the development of a regulatory phenotype in TLR4‐stimulated macrophages
Baliu‐Piqué, M., Jusek, G., & Holzmann, B. (2014) · European Journal of Immunology · doi:10.1002/eji.201444553 · Cited by 79
Tumor‐associated CD 204+ M2 macrophages are unfavorable prognostic indicators in uterine cervical adenocarcinoma
Kawachi, A., Yoshida, H., Kitano, S., Ino, Y., Kato, T., & Hiraoka, N. (2017) · Cancer Science · doi:10.1111/cas.13476 · Cited by 79
Procyanidin B2 Activates PPARγ to Induce M2 Polarization in Mouse Macrophages
Tian, Y., Yang, C., Yao, Q., Lei, Q., Liu, J., Xie, X., Ma, W., Nie, X., Lai, B., Xiao, L., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01895 · Cited by 79
Macrophage Responses to Environmental Stimuli During Homeostasis and Disease
Rasheed, A., & Rayner, K. J. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab004 · Cited by 83
The role of irreversible electroporation in promoting M1 macrophage polarization via regulating the HMGB1-RAGE-MAPK axis in pancreatic cancer
He, C., Sun, S., Zhang, Y., Xie, F., & Li, S. (2021) · OncoImmunology · doi:10.1080/2162402x.2021.1897295 · Cited by 79
Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis
Jha, M. K., Song, G. J., Lee, M., Jeoung, N. H., Go, Y., Harris, R. A., Park, D. H., Kook, H. Y., Lee, I., & Suk, K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.1910-15.2015 · Cited by 79
Mild Traumatic Brain Injury Produces Neuron Loss That Can Be Rescued by Modulating Microglial Activation Using a CB2 Receptor Inverse Agonist
Bu, W., Ren, H., Deng, Y., Mar, N. D., Guley, N., Moore, B. M., II, Honig, M. G., & Reiner, A. J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00449 · Cited by 82
Hmgb1 participates in LPS-induced acute lung injury by activating the aim2 inflammasome in macrophages and inducing polarization of m1 macrophages via TLR2, TLR4, and RAGE/NF-κB signaling pathways
Wang, J., Li, R., Peng, Z., Hu, B., Rao, X., & Li, J. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4402 · Cited by 78
Macrophage polarization: an effective approach to targeted therapy of inflammatory bowel disease
Du, Y., Rong, L., Cong, Y., Shen, L., Zhang, N., & Wang, B. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1901079 · Cited by 81
The Role of Tissue-Resident Macrophages in the Development and Treatment of Inflammatory Bowel Disease
Ma, S., Zhang, J., Liu, H., Li, S., & Wang, Q. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.896591 · Cited by 81
GPNMB: a potent inducer of immunosuppression in cancer
Lazaratos, A.-M., Annis, M. G., & Siegel, P. M. (2022) · Oncogene · doi:10.1038/s41388-022-02443-2 · Cited by 78
MCPIP1 restrains mucosal inflammation by orchestrating the intestinal monocyte to macrophage maturation via an ATF3-AP1S2 axis
Lu, H., Zhang, C., Wu, W. H., Chen, H., Lin, R., Sun, R., Gao, X., Li, G., He, Q., Gao, H., et al. (2022) · Gut · doi:10.1136/gutjnl-2022-327183 · Cited by 78
Targeting conserved TIM3 + VISTA + tumor-associated macrophages overcomes resistance to cancer immunotherapy
Vanmeerbeek, I., Naulaerts, S., Sprooten, J., Laureano, R. S., Govaerts, J., Trotta, R., Pretto, S., Zhao, S., Cafarello, S. T., Verelst, J., et al. (2024) · Science Advances · doi:10.1126/sciadv.adm8660 · Cited by 80
Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability
Xu, R., Li, C., Wu, Y., Shen, L., Ma, J., Qian, J., & Ge, J. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.308461 · Cited by 80
Targeting Tumor-Associated Macrophages in Cancer Immunotherapy
Petty, A. J., Owen, D. H., Yang, Y., & Huang, X. (2021) · Cancers · doi:10.3390/cancers13215318 · Cited by 79
Targeting macrophage TFEB-14-3-3 epsilon Interface by naringenin inhibits abdominal aortic aneurysm
Jia, Y., Zhang, L., Liu, Z., Mao, C., Ma, Z., Li, W., Yu, F., Wang, Y., Huang, Y., Zhang, W., et al. (2022) · Cell Discovery · doi:10.1038/s41421-021-00363-1 · Cited by 77
Tofacitinib Promotes Functional Recovery after Spinal Cord Injury by Regulating Microglial Polarization via JAK/STAT Signaling Pathway
Ma, H., Wang, C., Han, L., Kong, F., Liu, Z., Zhang, B., Chu, W., Wang, H., Wang, L., Li, Q., et al. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.84564 · Cited by 77
Fractionation of an ECM hydrogel into structural and soluble components reveals distinctive roles in regulating macrophage behavior
Slivka, P. F., Dearth, C. L., Keane, T. J., Meng, F. W., Medberry, C. J., Riggio, R. T., Reing, J. E., & Badylak, S. F. (2014) · Biomaterials Science · doi:10.1039/c4bm00189c · Cited by 77
Identification of Differentially Expressed Long Non-coding RNAs in Polarized Macrophages
Huang, Z., Luo, Q., Yao, F., Cheng, Q., Ye, J., Deng, Y., & Li, J. (2016) · Scientific Reports · doi:10.1038/srep19705 · Cited by 77
Circulating mir‐320a promotes immunosuppressive macrophages M2 phenotype associated with lung cancer risk
Fortunato, O., Borzi, C., Milione, M., Centonze, G., Conte, D., Boeri, M., Verri, C., Moro, M., Facchinetti, F., Andriani, F., et al. (2018) · International Journal of Cancer · doi:10.1002/ijc.31988 · Cited by 76
Tumor-Associated Macrophages in Hematologic Malignancies: New Insights and Targeted Therapies
Petty, A. J., & Yang, Y. (2019) · Cells · doi:10.3390/cells8121526 · Cited by 77
The role of the Hippo pathway in the pathogenesis of inflammatory bowel disease
Xie, Z., Wang, Y., Yang, G., Han, J., Zhu, L., Li, L., & Zhang, S. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03395-3 · Cited by 78
Exosome-Mediated Crosstalk Between Tumor and Tumor-Associated Macrophages
Chen, Q., Li, Y., Gao, W., Chen, L., Xu, W., & Zhu, X. (2021) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.764222 · Cited by 76
Microglial polarization in TBI: Signaling pathways and influencing pharmaceuticals
Li, Y., Ren, X., Zhang, L., Wang, Y., & Chen, T. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.901117 · Cited by 77
Pathogenic and protective role of macrophages in kidney disease
Cao, Q., Wang, Y., & Harris, D. C. H. (2013) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00122.2013 · Cited by 76
Nucleic Acid–Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation
Sharma, S., Fitzgerald, K. A., Cancro, M. P., & Marshak‐Rothstein, A. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500964 · Cited by 77
Heterogeneity of Bovine Peripheral Blood Monocytes
Hussen, J., & Schuberth, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01875 · Cited by 76
Recombinant tissue plasminogen activator promotes, and progesterone attenuates, microglia/macrophage M1 polarization and recruitment of microglia after MCAO stroke in rats
Won, S., Lee, J., & Stein, D. G. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.06.007 · Cited by 76
MSCs’ conditioned media cytokine and growth factor profiles and their impact on macrophage polarization
Peshkova, M., Korneev, A., Suleimanov, S., Vlasova, I. I., Svistunov, A., Kosheleva, N., & Timashev, P. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03381-w · Cited by 75
Tumor Cells Induce LAMP2a Expression in Tumor-Associated Macrophage for Cancer Progression
Wang, R., Liu, Y., Liu, L., Chen, M., Wang, X., Yang, H. J., Gong, Y., Ding, B., Wei, Y., & Wei, X. (2018) · EBioMedicine · doi:10.1016/j.ebiom.2019.01.045 · Cited by 76
Distinct Features of Brain-Resident Macrophages: Microglia and Non-Parenchymal Brain Macrophages
Lee, E., Eo, J.-C., Lee, C., & Yu, J. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0060 · Cited by 83
TcpC Inhibits M1 but Promotes M2 Macrophage Polarization via Regulation of the MAPK/NF-κB and Akt/STAT6 Pathways in Urinary Tract Infection
Fang, J., Ou, Q., Wu, B., Li, S., Wu, M., Qiu, J., Cen, N., Hu, K., Che, Y., Ma, Y., et al. (2022) · Cells · doi:10.3390/cells11172674 · Cited by 77
Antimicrobial Biomaterials for Chronic Wound Care
Miron, A., Giurcăneanu, C., Mihai, M. M., Beiu, C., Voiculescu, V. M., Popescu, M. N., Soare, E., & Popa, L. G. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15061606 · Cited by 79
Serotonin Modulation of Macrophage Polarization: Inflammation and Beyond
Casas-Engel, M. D. L., & Corbí, A. L. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-07320-0_9 · Cited by 76
Anti-inflammatory mechanisms of neutrophil membrane-coated nanoparticles without drug loading
Zhang, Q., Hu, C., Feng, J., Long, H., Wang, Y., Wang, P., Hu, C., Yue, Y., Zhang, C., Liu, Z., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.03.030 · Cited by 74
Fragile TIM-4–expressing tissue resident macrophages are migratory and immunoregulatory
Thornley, T. B., Fang, Z., Balasubramanian, S., Larocca, R. A., Gong, W., Gupta, S., Csizmadia, E., Degauque, N., Kim, B. S., Koulmanda, M., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73527 · Cited by 74
Allies or Enemies—The Multifaceted Role of Myeloid Cells in the Tumor Microenvironment
Haas, L., & Obenauf, A. C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02746 · Cited by 79
Modulating inflammatory macrophages with an apoptotic body-inspired nanoparticle.
Kraynak, C., Yan, D. J., & Suggs, L. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.03.041 · Cited by 68
Enhanced M1 and Impaired M2 Macrophage Polarization and Reduced Mitochondrial Biogenesis via Inhibition of AMP Kinase in Chronic Kidney Disease
Li, C., Ding, X. Y., Xiang, D. M., Xu, J., Huang, X. L., Hou, F. F., & Zhou, Q. G. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000430106 · Cited by 76
Reprogramming of Monocytes by GM-CSF Contributes to Regulatory Immune Functions during Intestinal Inflammation
Däbritz, J., Weinhage, T., Varga, G., Wirth, T., Walscheid, K., Brockhausen, A., Schwarzmaier, D., Brückner, M., Ross, M., Bettenworth, D., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401482 · Cited by 73
Molecular Pathways Regulating Macrophage Polarization: Implications for Atherosclerosis
Hoeksema, M. A., Stöger, J. L., & de Winther, M. P. J. (2012) · Current Atherosclerosis Reports · doi:10.1007/s11883-012-0240-5 · Cited by 77
Immunoproteasome dysfunction augments alternative polarization of alveolar macrophages
Chen, S., Kammerl, I. E., Vosyka, O., Baumann, T., Yu, Y., Wu, Y., Irmler, M., Overkleeft, H. S., Beckers, J., Eickelberg, O., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.3 · Cited by 74
Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages
Eichenfield, D. Z., Troutman, T. D., Link, V. M., Lam, M. T. Y., Cho, H., Gosselin, D., Spann, N. J., Lesch, H. P., Tao, J., Muto, J., et al. (2016) · eLife · doi:10.7554/elife.13024 · Cited by 75
MiR-146a modulates macrophage polarization in systemic juvenile idiopathic arthritis by targeting INHBA
Li, D., Duan, M., Feng, Y., Geng, L., Li, X., & Zhang, W. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.08.007 · Cited by 73
Cytokines and Long Noncoding RNAsPreprint
Carpenter, S. B., & Fitzgerald, K. A. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028589 · Cited by 74
Deficiency of GATA3-Positive Macrophages Improves Cardiac Function Following Myocardial Infarction or Pressure Overload Hypertrophy
Yang, M., Song, L., Wang, L., Yukht, A., Ruther, H., Li, F., Qin, M., Ghiasi, H., Sharifi, B. G., & Shah, P. K. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.05.061 · Cited by 73
RETRACTED ARTICLE: In vitro and in vivo responses of macrophages to magnesium-doped titanium
Li, B., Cao, H., Zhao, Y., Cheng, M., Qin, H., Cheng, T., Hu, Y., Zhang, X., & Liu, X. (2017) · Scientific Reports · doi:10.1038/srep42707 · Cited by 72
Retracted
The estrogen–macrophage interplay in the homeostasis of the female reproductive tract
Pepe, G., Locati, M., Torre, S. D., Mornata, F., Cignarella, A., Maggi, A. C., & Vegeto, E. (2018) · Human Reproduction Update · doi:10.1093/humupd/dmy026 · Cited by 78
Rheumatiod Arthritis: An Updated Overview of Latest Therapy and Drug Delivery
Kesharwani, D., Paliwal, R., Satapathy, T., & Paul, S. D. (2019) · Journal of pharmacopuncture · doi:10.3831/kpi.2019.22.029 · Cited by 72
Thymosin α1 reverses oncolytic adenovirus-induced M2 polarization of macrophages to improve antitumor immunity and therapeutic efficacy
Liu, K., Kong, L., Cui, H., Zhang, L., Xin, Q., Zhuang, Y., Guo, C., Yao, Y., Tao, J., Gu, X., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101751 · Cited by 72
Dysfunction of Inflammation-Resolving Pathways Is Associated with Exaggerated Postoperative Cognitive Decline in a Rat Model of the Metabolic Syndrome
Su, X., Feng, X., Terrando, N., Yan, Y., Chawla, A., Koch, L. G., Britton, S. L., Matthay, M. A., & Maze, M. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00351 · Cited by 72
Macrophage-targeted delivery systems for nucleic acid therapy of inflammatory diseases
Singh, A. K., Talekar, M., Raikar, A., & Amiji, M. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.04.021 · Cited by 73
MicroRNA-720 suppresses M2 macrophage polarization by targeting GATA3
Zhong, Y., & Yi, C. (2016) · Bioscience Reports · doi:10.1042/bsr20160105 · Cited by 72
Specific function and modulation of teleost monocytes/macrophages: polarization and phagocytosis
Lu, X., & Chen, J. (2019) · 动物学研究 · doi:10.24272/j.issn.2095-8137.2019.035 · Cited by 72
Role of macrophages in the endocrine system
Rehman, A., Pacher, P., & Haskó, G. (2021) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2020.12.001 · Cited by 71
Fluorescent glycoprobes: a sweet addition for improved sensing
He, X., Zang, Y., James, T. D., Li, J. X., Chen, G., & Xie, J. (2016) · Chemical Communications · doi:10.1039/c6cc06875h · Cited by 71
Atherosclerosis: Insights into Vascular Pathobiology and Outlook to Novel Treatments
Wolf, M., & Hunziker, P. (2020) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-020-09961-y · Cited by 74
Insights into the Effect of Catalytic Intratumoral Lactate Depletion on Metabolic Reprogramming and Immune Activation for Antitumoral Activity
Zhao, J., Tian, Z., Zhao, S., Feng, D., Guo, Z., Wen, L., Zhu, Y., Xu, F., Zhu, J., Ma, S., et al. (2022) · Advanced Science · doi:10.1002/advs.202204808 · Cited by 73
Damage-mediated macrophage polarization in sterile inflammation
Koncz, G., Jenei, V., Tóth, M., Váradi, E., Kardos, B., Bácsi, A., & Mázló, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1169560 · Cited by 74
Monocyte Chemoattractant Protein-1 (MCP-1) Regulates Macrophage Cytotoxicity in Abdominal Aortic Aneurysm
Wang, Q., Ren, J. P., Morgan, S., Liu, Z., Dou, C., & Liu, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092053 · Cited by 72
Innate immune regulation by STAT ‐mediated transcriptional mechanisms
Li, H. S., & Watowich, S. S. (2014) · Immunological Reviews · doi:10.1111/imr.12198 · Cited by 72
Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype
Xia, H., Chen, L., Liu, H., Sun, Z., Yang, W., Yang, Y., Cui, S.-N., Li, S., Wang, Y., Song, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-00103-0 · Cited by 75
Deficient Surveillance and Phagocytic Activity of Myeloid Cells Within Demyelinated Lesions in Aging Mice Visualized byEx VivoLive Multiphoton Imaging
Rawji, K. S., Kappen, J., Tang, W., Teo, W., Plemel, J. R., Stys, P. K., & Yong, V. W. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.2341-17.2018 · Cited by 75
Epigenetic Modulation in Periodontitis: Interaction of Adiponectin and JMJD3‐IRF4 Axis in Macrophages
Xuan, D., Han, Q., Tu, Q., Zhang, L., Yu, L., Murry, D., Tu, T., Tang, Y., Lian, J. B., Stein, G. S., et al. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.25201 · Cited by 70
Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections
Shen, Y. H., & LeMaire, S. A. (2017) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2017.01.001 · Cited by 72
Targeting macrophage polarization as a promising therapeutic strategy for the treatment of osteoarthritis
Wang, W., Chu, Y., Zhang, P., Liang, Z., Fan, Z., Guo, X., Zhou, G., & Ren, W. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109790 · Cited by 70
Inflammatory transcription factors as activation markers and functional readouts in immune-to-brain communication
Rummel, C. D. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.09.003 · Cited by 73
Local Injection of Lenti–BDNF at the Lesion Site Promotes M2 Macrophage Polarization and Inhibits Inflammatory Response After Spinal Cord Injury in Mice
Ji, X., Dang, Y., Gao, H., Wang, Z., Gao, M., Yang, Y., Zhang, H., & Xu, R. (2015) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0182-x · Cited by 70
Pyropia yezoensis glycoprotein promotes the M1 to M2 macrophage phenotypic switch via the STAT3 and STAT6 transcription factors
Choi, J., Kwon, M., Kim, I., Kim, Y., Lee, M., & Nam, T. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2656 · Cited by 70
Peritumoral stromal neutrophils are essential for c-Met-elicited metastasis in human hepatocellular carcinoma
He, M. Y., Peng, A., Huang, X.-Z., Shi, D.-C., Wang, J., Zhao, Q., Lin, H., Kuang, D., Ke, P., & Lao, X. (2016) · OncoImmunology · doi:10.1080/2162402x.2016.1219828 · Cited by 71
Melatonin protects mice against stress-induced inflammation through enhancement of M2 macrophage polarization
Yi, W.-J., & Kim, T. S. (2017) · International Immunopharmacology · doi:10.1016/j.intimp.2017.05.006 · Cited by 75
Perturbed microRNA Expression by Mycobacterium tuberculosis Promotes Macrophage Polarization Leading to Pro-survival Foam Cell
Ahluwalia, P. K., Pandey, R. K., Sehajpal, P. K., & Prajapati, V. K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00107 · Cited by 71
Transforming a toxic drug into an efficacious nanomedicine using a lipoprodrug strategy for the treatment of patient-derived melanoma xenografts
Shi, L., Wang, Y., Wang, Q., Jiang, Z., Ren, L., Yan, Y., Liu, Z., Wan, J., Huang, L., Cen, B., et al. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.025 · Cited by 69
Adaptogenic flower buds exert cancer preventive effects by enhancing the SCFA-producers, strengthening the epithelial tight junction complex and immune responses
Xia, W., Khan, I., Li, X., Huang, G., Yu, Z., Leong, W. K., Han, R., Ho, L. T., & Hsiao, W. L. W. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104809 · Cited by 70
Immune system of the inner ear as a novel therapeutic target for sensorineural hearing loss
Okano, T. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00205 · Cited by 69
Computational Approach To Characterize Causative Factors and Molecular Indicators of Chronic Wound Inflammation
Nagaraja, S., Wallqvist, A., Jaques Reifman, A., & Mitrophanov, A. Y. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302481 · Cited by 73
Polarization of Immune Cells in the Pathologic Response to Inhaled Particulates
Ma, Q. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01060 · Cited by 71
Monocytes in Tumorigenesis and Tumor Immunotherapy
Chen, X., Li, Y., Xia, H., & Chen, Y. H. (2023) · Cells · doi:10.3390/cells12131673 · Cited by 69
Peritumoral brain zone in glioblastoma: biological, clinical and mechanical features
Ballestín, A., Armocida, D., Ribecco, V., & Seano, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1347877 · Cited by 70
Obesity-driven inflammation and cancer risk: role of myeloid derived suppressor cells and alternately activated macrophages.
Okwan-Duodu, D. K., Umpierrez, G. E., Brawley, O. W., & Diaz, R. (2013) · Europe PMC (PubMed Central) · Cited by 68
ABCA1 Protein Enhances Toll-like Receptor 4 (TLR4)-stimulated Interleukin-10 (IL-10) Secretion through Protein Kinase A (PKA) Activation
Ma, L., Dong, F., Zaid, M., Kumar, A., & Zha, X. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.413245 · Cited by 68
Polarization and Repolarization of Macrophages
Brundu, S. (2015) · Journal of Clinical & Cellular Immunology · doi:10.4172/2155-9899.1000319 · Cited by 74
Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE
Kurte, M., Vega-Letter, A. M., Luz‐Crawford, P., Djouad, F., Noël, D., Khoury, M., & Carrión, F. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01840-2 · Cited by 67
The relation between the gut microbiome and osteoarthritis: A systematic review of literature
Chisari, E., Wouthuyzen‐Bakker, M., Friedrich, A. W., & Parvizi, J. (2021) · PLoS ONE · doi:10.1371/journal.pone.0261353 · Cited by 72
Human Chorionic Villous Differentiation and Placental Development
Kojima, J., Ono, M., Kuji, N., & Nishi, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23148003 · Cited by 74
Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target
Cho, H., Kwon, H., Sharma, A., Lee, S. H., Liu, X., Miyamoto, N., Kim, J.-J., Im, S., Kang, N., & Chang, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-33526-z · Cited by 67
Distinct pathogenic roles for resident and monocyte-derived macrophages in lupus nephritis
Richoz, N., Tuong, Z. K., Loudon, K. W., Patiño‐Martínez, E., Ferdinand, J. R., Romo‐Tena, J., Portet, A., Bashant, K. R., Thevenon, E., Rucci, F., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.159751 · Cited by 72
Mechanisms of microbial infection and wound healing in diabetic foot ulcer: pathogenicity in the inflammatory-proliferative phase, chronicity, and treatment strategies
Wang, Q., Liu, C., An, J., Liu, J., Wang, Y., & Cai, Y. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1657928 · Cited by 69
Towards understanding the antibacterial activity of Ag nanoparticles: electron microscopy in the analysis of the materials-biology interface in the lung
Heras, I. L., Theodorou, I. G., Leo, B. F., Ryan, M. P., & Porter, A. E. (2015) · Environmental Science Nano · doi:10.1039/c5en00051c · Cited by 69
Temporal and spatial characterization of mononuclear phagocytes in circulating, lung alveolar and interstitial compartments in a mouse model of bleomycin-induced pulmonary injury
Ji, W.-J., Ma, Y.-Q., Zhou, X., Zhang, Y.-D., Lu, R., Sun, H.-Y., Guo, Z.-Z., Zhang, Z., Li, Y., & Wei, L.-Q. (2013) · Journal of Immunological Methods · doi:10.1016/j.jim.2013.11.012 · Cited by 69
Epigenetic mechanisms of macrophage activation in type 2 diabetes
Ahmed, M., de Winther, M. P. J., & den Bossche, J. V. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.08.011 · Cited by 67

Authors: Lawrence, T., & Natoli, G.
Affiliations: Centre d’Immunologie de Marseille-Luminy (FR)
European Institute of Oncology (IT)
Corresponding author: Lawrence, Toby
Natoli, Gioacchino
ORCID: Lawrence, Toby
Natoli, Gioacchino
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-10-25
Volume: 11
Issue: 11
Pages: 750-761
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3088
OpenAlex: W2081810806
Cited by: 2,284
References: 90
Citations by year: 2026: 124 · 2025: 147 · 2024: 194 · 2023: 180 · 2022: 190 · 2021: 203 · 2020: 158 · 2019: 139 · 2018: 149 · 2017: 166 · 2016: 165 · 2015: 158 · 2014: 140 · 2013: 108 · 2012: 58
FWCI: 8.84
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Agence Nationale de la Recherche
Institut National de la Santé et de la Recherche Médicale
Centre National de la Recherche Scientifique
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: macrophage polarization, macrophage identity, transcription factors, chromatin regulation, macrophage heterogeneity, tissue-resident macrophages, macrophage differentiation, macrophage lineage
MeSH terms: Interferon Regulatory Factor-4, Gene Expression Regulation, Humans, Macrophages, Promoter Regions, Genetic, Protein Binding, PPAR gamma, STAT1 Transcription Factor, STAT6 Transcription Factor, Interferon Regulatory Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Transcriptional regulation of macrophage polarization: enabling diversity with identity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks