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Transcriptional control of effector and memory CD8+ T cell differentiation
Open accessAbstract
During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8(+) T cells have started to be characterized, and this Review discusses the major advances in these areas.
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“IL-10– and IL-21–mediated STAT3 activation”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Kaech and Cui, 2012
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“Eomes in particular has been correlated with Tcm cell development [228]”
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“In acute infections, antigen-specific CD8 T cells differentiate into functional cytotoxic effector and memory T cells2.”
From An autoimmune stem-like CD8 T cell population drives type 1 diabetes (2022) · cites this paper as [2]
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Metadata
- Authors
- Kaech, S. M., & Cui, W.
- Affiliations
- Yale University (US)
- Corresponding author
- Kaech, Susan M.
- Venue
- Nature Reviews Immunology
- Published
- 2012-10-19
- Volume
- 12
- Issue
- 11
- Pages
- 749-761
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4137483
- OpenAlex
- W2043793366
- Cited by
- 1,628
- References
- 140
- Citations by year
- 2026: 134 · 2025: 125 · 2024: 139 · 2023: 126 · 2022: 125 · 2021: 164 · 2020: 105 · 2019: 120 · 2018: 119 · 2017: 100 · 2016: 119 · 2015: 116 · 2014: 74 · 2013: 55 · 2012: 3
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases (R21AI081150, R21AI097767, R01AI074699, R01AI066232)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- CD8+ T cells, effector T cell differentiation, memory T cell differentiation, transcriptional regulation, costimulatory molecules, inflammatory cytokines, T cell metabolism, T cell fate, T cell heterogeneity, infection immunity
- MeSH terms
- Animals, Cell Differentiation, Gene Expression Regulation, Humans, Immunologic Memory, Infections, Lymphocyte Activation, Transcription, Genetic, Signal Transduction, CD8-Positive T-Lymphocytes
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