Cited by 1,628T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

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Transcriptional control of effector and memory CD8+ T cell differentiation

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Kaech, Susan M., Cui, Weiguo·2012·Nature Reviews Immunology

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Abstract

During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8(+) T cells have started to be characterized, and this Review discusses the major advances in these areas.

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Authors: Kaech, S. M., & Cui, W.
Affiliations: Yale University (US)
Corresponding author: Kaech, Susan M.
ORCID: Kaech, Susan M.
Cui, Weiguo
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2012-10-19
Volume: 12
Issue: 11
Pages: 749-761
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3307
PMC: PMC4137483
OpenAlex: W2043793366
Cited by: 1,628
References: 140
Citations by year: 2026: 134 · 2025: 125 · 2024: 139 · 2023: 126 · 2022: 125 · 2021: 164 · 2020: 105 · 2019: 120 · 2018: 119 · 2017: 100 · 2016: 119 · 2015: 116 · 2014: 74 · 2013: 55 · 2012: 3
FWCI: 7.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Allergy and Infectious Diseases (R21AI081150, R21AI097767, R01AI074699, R01AI066232)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: CD8+ T cells, effector T cell differentiation, memory T cell differentiation, transcriptional regulation, costimulatory molecules, inflammatory cytokines, T cell metabolism, T cell fate, T cell heterogeneity, infection immunity
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Immunologic Memory, Infections, Lymphocyte Activation, Transcription, Genetic, Signal Transduction, CD8-Positive T-Lymphocytes

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Transcriptional control of effector and memory CD8+ T cell differentiation

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