Cited by 1,628T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

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Transcriptional control of effector and memory CD8+ T cell differentiation

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Kaech, Susan M., Cui, Weiguo·2012·Nature Reviews Immunology

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Abstract

During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8(+) T cells have started to be characterized, and this Review discusses the major advances in these areas.

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
T cell exhaustion
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103
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Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets
Michalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Self-citation
Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor
Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861
Self-citation
Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
Kaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830
Self-citation
Immunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
Schluns, K. S., Kieper, W. C., Jameson, S. C., & Lefrançois, L. (2000) · Nature Immunology · doi:10.1038/80868 · Cited by 1,619

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Palmer, C. S., Hussain, T., Duette, G., Weller, T. J., Ostrowski, M., Sada‐Ovalle, I., & Crowe, S. M. (2015) · International Reviews of Immunology · doi:10.3109/08830185.2015.1082178 · Cited by 79
Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice
Linch, S. N., Kasiewicz, M. J., McNamara, M. J., Hilgart-Martiszus, I., Farhad, M. E., & Redmond, W. L. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1510518113 · Cited by 79
Immune modules shared by innate lymphoid cells and T cells
Robinette, M. L., & Colonna, M. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.09.006 · Cited by 78
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Solouki, S., Huang, W., Elmore, J. P., Limper, C., Huang, F., & August, A. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901167 · Cited by 82
Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function
Kurachi, M., Kurachi, J., Chen, Z., Johnson, J. L., Khan, O., Bengsch, B., Stelekati, E., Attanasio, J., McLane, L. M., Tomura, M., et al. (2017) · Nature Protocols · doi:10.1038/nprot.2017.083 · Cited by 78
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Tippalagama, R., Singhania, A., Dubelko, P., Arlehamn, C. S. L., Crinklaw, A., Pomaznoy, M., Seumois, G., Silva, A. D. D., Premawansa, S., Vidanagama, D. S., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100011 · Cited by 74
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Fournier, C., Martin, F., Zitvogel, L., Kroemer, G., Galluzzi, L., & Apétoh, L. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1363139 · Cited by 79
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Isoyama, S., Mori, S., Sugiyama, D., Kojima, Y., Tada, Y., Shitara, K., Hinohara, K., Dan, S., & Nishikawa, H. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002279 · Cited by 76
Stepwise activities of mSWI/SNF family chromatin remodeling complexes direct T cell activation and exhaustion
Battistello, E., Hixon, K., Comstock, D. E., Collings, C. K., Chen, X., Rodriguez-Hernaez, J., Lee, S., Cervantes, K. S., Hinkley, M. M., Ntatsoulis, K., et al. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.02.026 · Cited by 78
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Chen, Z., Stelekati, E., Kurachi, M., Yu, S., Cai, Z., Manne, S., Khan, O., Yang, X., & Wherry, E. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.060 · Cited by 75
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Gattinoni, L., & Restifo, N. P. (2013) · Blood · doi:10.1182/blood-2012-11-468660 · Cited by 84
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Ma, W., & Chen, D. (2019) · Clinical Science · doi:10.1042/cs20181123 · Cited by 76
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Miao, T., Symonds, A. L. J., Singh, R. K., Symonds, J. D., Ogbe, A., Omodho, B., Zhu, B., Li, S., & Wang, P. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160553 · Cited by 74
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Qin, Y., Zheng, X., Gao, W., Wang, B., & Wu, Y. (2021) · Molecular Therapy — Oncolytics · doi:10.1016/j.omto.2021.01.011 · Cited by 76
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Li, X., Shen, Y., Zhang, L., Guo, X., & Wu, J. H. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188720 · Cited by 73
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Zhong, Y., Walker, S. K., Pritykin, Y., Leslie, C. S., Rudensky, A. Y., & van der Veeken, J. (2021) · Nature Immunology · doi:10.1038/s41590-021-01086-x · Cited by 67
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Modulation of asymmetric cell division as a mechanism to boost CD8 + T cell memory
Borsa, M., Barnstorf, I., Baumann, N. S., Pallmer, K., Yermanos, A., Gräbnitz, F., Barandun, N., Hausmann, A., Sandu, I., Barral, Y., et al. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav1730 · Cited by 58
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Palucka, K., & Banchereau, J. (2013) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.05.001 · Cited by 57
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Willoughby, J. E., Kerr, J. P., Rogel, A., Taraban, V. Y., Buchan, S. L., Johnson, P., & Al‐Shamkhani, A. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301217 · Cited by 54
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van Aalderen, M. C., Remmerswaal, E. B. M., Verstegen, N. J. M., Hombrink, P., ten Brinke, A., Pircher, H., Kootstra, N. A., ten Berge, I. J. M., & van Lier, R. A. W. (2015) · Journal of Virology · doi:10.1128/jvi.03478-14 · Cited by 55
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Gupta, S. S., Sharp, R., Hofferek, C. J., Kuai, L., Dorn, G. W., Wang, J., & Chen, M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.10.032 · Cited by 56
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Damasio, M. P. S., Marchingo, J. M., Spinelli, L., Hukelmann, J. L., Cantrell, D. A., & Howden, A. J. M. (2020) · Biochemical Journal · doi:10.1042/bcj20200661 · Cited by 56

Authors: Kaech, S. M., & Cui, W.
Affiliations: Yale University (US)
Corresponding author: Kaech, Susan M.
ORCID: Kaech, Susan M.
Cui, Weiguo
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2012-10-19
Volume: 12
Issue: 11
Pages: 749-761
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3307
PMC: PMC4137483
OpenAlex: W2043793366
Cited by: 1,628
References: 140
Citations by year: 2026: 134 · 2025: 125 · 2024: 139 · 2023: 126 · 2022: 125 · 2021: 164 · 2020: 105 · 2019: 120 · 2018: 119 · 2017: 100 · 2016: 119 · 2015: 116 · 2014: 74 · 2013: 55 · 2012: 3
FWCI: 7.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Howard Hughes Medical Institute
National Institute of Allergy and Infectious Diseases (R21AI081150, R21AI097767, R01AI074699, R01AI066232)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: CD8+ T cells, effector T cell differentiation, memory T cell differentiation, transcriptional regulation, costimulatory molecules, inflammatory cytokines, T cell metabolism, T cell fate, T cell heterogeneity, infection immunity
MeSH terms: Animals, Cell Differentiation, Gene Expression Regulation, Humans, Immunologic Memory, Infections, Lymphocyte Activation, Transcription, Genetic, Signal Transduction, CD8-Positive T-Lymphocytes

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Transcriptional control of effector and memory CD8+ T cell differentiation

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