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Transcriptional control of effector and memory CD8+ T cell differentiation
Open accessAbstract
During an infection, T cells can differentiate into multiple types of effector and memory T cells, which help to mediate pathogen clearance and provide long-term protective immunity. These cells can vary in their phenotype, function and location, and in their long-term fate in terms of their ability to populate the memory T cell pool. Over the past decade, the signalling pathways and transcriptional programmes that regulate the formation of heterogeneous populations of effector and memory CD8(+) T cells have started to be characterized, and this Review discusses the major advances in these areas.
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“IL-10– and IL-21–mediated STAT3 activation”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Kaech and Cui, 2012
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“Eomes in particular has been correlated with Tcm cell development [228]”
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“In acute infections, antigen-specific CD8 T cells differentiate into functional cytotoxic effector and memory T cells2.”
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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
Wherry, E. J., Ha, S.-J., Kaech, S. M., Haining, W. N., Sarkar, S., Kalia, V., Subramaniam, S., Blattman, J. N., Barber, D. L., & Ahmed, R. (2007) · Immunity · doi:10.1016/j.immuni.2007.09.006 · Cited by 2,103
Self-citationMichalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Self-citationJoshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861
Self-citationKaech, S. M., Tan, J. T., Wherry, E. J., Konieczny, B. T., Surh, C. D., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni1009 · Cited by 1,830
Self-citationImmunological memory and protective immunity: understanding their relation
Ahmed, R., & Gray, D. (1996) · Science · doi:10.1126/science.272.5258.54 · Cited by 1,775
Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo
Schluns, K. S., Kieper, W. C., Jameson, S. C., & Lefrançois, L. (2000) · Nature Immunology · doi:10.1038/80868 · Cited by 1,619
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Gao, S., Liang, X., Wang, H., Bao, B., Zhang, K., Zhu, Y., & Shao, Q. (2021) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104273 · Cited by 31
Xu, T., Schutte, A., Jimenez, L., Gonçalves, A. N. A., Keller, A., Pipkin, M. E., Nakaya, H. I., Pereira, R. M., & Martínez, G. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2001459 · Cited by 31
Riggan, L., Ma, F., Li, J. H., Fernandez, E., Nathanson, D. A., Pellegrini, M. A., & O’Sullivan, T. E. (2022) · Nature Immunology · doi:10.1038/s41590-022-01150-0 · Cited by 37
Guo, W., Chen, Z., Li, Z., Huang, H., Ren, Y., Li, Z., Zhao, B., Li, G., & Hu, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.140868 · Cited by 32
Inhibition of TGF-β1 Signaling Promotes Central Memory T Cell Differentiation
Takai, S., Schlom, J., Tucker, J., Tsang, K. Y., & Greiner, J. W. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300472 · Cited by 36
Shehata, H. M., Khan, S., Chen, E., Fields, P. E., Flavell, R. A., & Sanjabi, S. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1808320115 · Cited by 31
Cardinal features of immune memory in innate lymphocytes
Santosa, E. K., & Sun, J. C.-Y. (2023) · Nature Immunology · doi:10.1038/s41590-023-01607-w · Cited by 32
Functionalized nanowires for miRNA-mediated therapeutic programming of naïve T cells
Mon, K. J. Y., Kim, S., Dai, Z., West, J. D., Zhu, H., Jain, R., Grimson, A., Rudd, B. D., & Singh, A. K. (2024) · Nature Nanotechnology · doi:10.1038/s41565-024-01649-7 · Cited by 32
A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors
Liu, H., Noguera-Ortega, E., Dong, X., Lee, W. D., Chang, J., Aday, S., Li, Y., Shin, Y., Shi, X., Liousia, M., et al. (2025) · Nature Biotechnology · doi:10.1038/s41587-025-02845-z · Cited by 41
Molecular adjuvant IL-33 enhances the potency of a DNA vaccine in a lethal challenge model
Villarreal, D. O., Svoronos, N., Wise, M. C., Shedlock, D. J., Morrow, M. P., Conejo-Garcia, J. R., & Weiner, D. B. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.03.086 · Cited by 31
The Characteristics of Naive-like T Cells in Tumor-infiltrating Lymphocytes From Human Lung Cancer
Sheng, S. Y., Gu, Y., Lu, C. G., Tang, Y., Zou, J. Y., Zhang, Y. Q., Wang, R. F., & Hong, H. Y. (2016) · Journal of Immunotherapy · doi:10.1097/cji.0000000000000147 · Cited by 31
CD8+ T cells lack local signals to produce IFN-γ in the skin during leishmania infection
Novais, F. O., Wong, A. C., Villareal, D. O., Beiting, D. P., & Scott, P. (2018) · Journal of Immunology · doi:10.4049/jimmunol.1701597 · Cited by 32
Heterodimeric Fc-fused IL12 shows potent antitumor activity by generating memory CD8+T cells
Jung, K., Ha, J.-H., Kim, J., Kim, J.-A., Kim, Y., Kim, Y., & Kim, Y. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1438800 · Cited by 31
Buggert, M., Nguyen, S., McLane, L. M., Steblyanko, M. A., Anikeeva, N., Paquin‐Proulx, D., Estrada, P. M. D. R., Ablanedo‐Terrazas, Y., Noyan, K., Reuter, M. A., et al. (2018) · PLoS Pathogens · doi:10.1371/journal.ppat.1006973 · Cited by 31
RetractedWatanabe, T., Gaedicke, S., Guffart, E., Firat, E., & Niedermann, G. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-0476 · Cited by 30
Sun, Y., Preiss, N. K., Valenteros, K. B., Kamal, Y., Usherwood, Y.-K., Frost, H. R., & Usherwood, E. J. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000459 · Cited by 34
Volberding, P. J., Xin, G., Kasmani, M. Y., Khatun, A., Brown, A. K., Nguyen, C. P., Stancill, J. S., Martinez, E., Corbett, J. A., & Cui, W. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109160 · Cited by 30
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Shen, Q., Wang, Y., Chen, J., Ma, L., Huang, X., Tang, S. C. W., Lan, H., Jiang, H., & Chen, J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.693608 · Cited by 32
Regulatory roles of MicroRNA in shaping T cell function, differentiation and polarization
Naqvi, R. A., Datta, M., Khan, S. H., & Naqvi, A. R. (2021) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2021.08.003 · Cited by 32
Immunological perspectives on spatial and temporal vaccine delivery
Zhu, M. (2021) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.113966 · Cited by 32
Interleukin-10 induces interferon-γ-dependent emergency myelopoiesis
Cardoso, A., Martins, A. C. M., Maceiras, A. R., Liu, W., Castro, I., Castro, A. G., Bandeira, A., Santo, J. P. D., Cumano, A., Li, Y., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109887 · Cited by 36
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Gräbnitz, F., Stark, D., Shlesinger, D., Petkidis, A., Borsa, M., Yermanos, A., Carr, A., Barandun, N., Wehling, A., Baláž, M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112468 · Cited by 31
Krummey, S. M., Floyd, T. L., Liu, D., Wagener, M. E., Song, M., & Ford, M. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1301332 · Cited by 31
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Garyu, J., Uduman, M., Stewart, A., Rui, J., Deng, S., Shenson, J. A., Staron, M. M., Kaech, S. M., Kleinstein, S. H., & Herold, K. C. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.713362 · Cited by 32
Self-citationYang, J., Zhang, P., Krishna, S., Wang, J., Lin, X., Huang, H., Xie, D., Gorentla, B. K., Huang, R. H., Gao, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8164 · Cited by 32
Seo, Y., Jothikumar, P., Suthar, M. S., Zhu, C., & Grakoui, A. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.024 · Cited by 31
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Dijkgraaf, F. E., Kok, L., & Schumacher, T. N. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a038117 · Cited by 33
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Zou, D., Li, X. C., & Chen, W. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01321-7 · Cited by 30
Chen, Z., Zhu, Z., Hu, T., Yao, C., & Wu, T. (2025) · Cellular and Molecular Immunology · doi:10.1038/s41423-025-01378-4 · Cited by 37
Boulet, S., Daudelin, J., & Labrecque, N. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302365 · Cited by 30
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Kulinski, J. M., Tarakanova, V. L., & Verbsky, J. W. (2013) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2013007909 · Cited by 29
Trans-presentation of IL-15 modulates STAT5 activation and Bcl-6 expression in TH1 cells
Cooley, I. D., Read, K. A., & Oestreich, K. J. (2015) · Scientific Reports · doi:10.1038/srep15722 · Cited by 29
Zhao, H., Han, Q., Wang, G., Lin, A., Xu, D., Wang, Y., Zhao, L., Tian, Z., & Zhang, J. (2019) · Gut · doi:10.1136/gutjnl-2017-315588 · Cited by 32
Grau, M., Valsesia, S., Mafille, J., Djebali, S., Tomkowiak, M., Mathieu, A., Laubreton, D., de Bernard, S., Jouve, P.-E., Ventre, E., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701698 · Cited by 30
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Chu, K.-L., Batista, N. V., Girard, M., & Watts, T. H. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901046 · Cited by 33
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Zhao, H., Wang, H., Hu, Y., Xu, D., Yin, C., Han, Q., & Zhang, J. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s317113 · Cited by 30
Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C
Sumida, K., Shimoda, S., Iwasaka, S., Hisamoto, S., Kawanaka, H., Akahoshi, T., Ikegami, T., Shirabe, K., Shimono, N., Maehara, Y., et al. (2013) · Clinical & Experimental Immunology · doi:10.1111/cei.12158 · Cited by 28
Opata, M. M., Carpio, V. H., Ibitokou, S. A., Dillon, B., Obiero, J. M., & Stephens, R. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403216 · Cited by 30
Scott, P. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a038059 · Cited by 29
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Xiang, M., Li, H., Zhan, Y., Ma, D., Gao, Q., & Fang, Y. (2024) · Molecular Cancer · doi:10.1186/s12943-024-01987-z · Cited by 29
Terrabuio, E., Pietronigro, E. C., Bani, A., Bianca, V. D., Laudanna, C., Rossi, B., Finotti, G., Santos-Lima, B., Zenaro, E., Turano, E., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-62405-6 · Cited by 33
Huber, M., & Lohoff, M. D. (2015) · Allergo Journal International · doi:10.1007/s40629-015-0038-4 · Cited by 29
Pan, H., Xu, L., Ouyang, D., Wang, Y., Zha, Q.-B., Hou, X., & He, X. (2014) · Inflammation · doi:10.1007/s10753-013-9794-9 · Cited by 30
An, N., Wang, H., Jia, W., Wang, J., Liu, C., Zhu, H., & Yu, J. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-02160-7 · Cited by 29
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Pace, L., & Amigorena, S. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.01.002 · Cited by 30
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Griffiths, J., Hussain, K., Smith, H. L., Sanders, T. J., Cox, K. L., Semmrich, M., Mårtensson, L., Kim, J., Inzhelevskaya, T., Penfold, C., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001557 · Cited by 31
Beider, K., Itzhaki, O., Schachter, J., Grushchenko-Polaq, A. H., Voevoda-Dimenshtein, V., Rosenberg, E., Ostrovsky, O., Devillers, O., Frommer, R. S., Zeltzer, L., et al. (2022) · Cells · doi:10.3390/cells11071140 · Cited by 30
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Eberwine, J. H., & Kim, J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.07.004 · Cited by 30
Hickey, J. W., Agmon, E., Horowitz, N. B., Tan, T.-K., Lamore, M., Sunwoo, J. B., Covert, M. W., & Nolan, G. P. (2024) · Cell Systems · doi:10.1016/j.cels.2024.03.004 · Cited by 32
Chang, K., Traum, D., Park, J., Ho, S., Ojiro, K., Wong, D., Wahed, A. S., Terrault, N. A., Khalili, M., Sterling, R. K., et al. (2019) · PLoS Pathogens · doi:10.1371/journal.ppat.1007715 · Cited by 29
Fousteri, G., & Kuka, M. (2020) · Molecular Immunology · doi:10.1016/j.molimm.2020.01.007 · Cited by 28
Brusko, M., Stewart, J. M., Posgai, A. L., Wasserfall, C. H., Atkinson, M. A., Brusko, T. M., & Keselowsky, B. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.574447 · Cited by 29
Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8+ T cells in skin
Hochheiser, K., Wiede, F., Wagner, T., Freestone, D., Enders, M. H., Olshansky, M., Russ, B., Nüssing, S., Bawden, E., Braun, A., et al. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20200940 · Cited by 27
Hou, Y., Zhou, Y., Gack, M. U., Luo, Y., Jehi, L., Chan, T. A.-T., Yu, H., Eng, C., Pieper, A. A., & Cheng, F. (2022) · Aging Cell · doi:10.1111/acel.13544 · Cited by 22
Chaudhary, O., Trotta, D., Wang, K., Wang, X., Chu, X., Bradley, C., Okulicz, J. F., Maves, R. C., Kronmann, K., Schofield, C. M., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004564 · Cited by 29
Self-citationLeroux‐Roels, I., Waerlop, G., Tourneur, J., Boever, F. D., Maes, C., Bruhwyler, J., Guyon-Gellin, D., Moris, P., del Campo, J. M., Willems, P., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.852904 · Cited by 28
Quon, S., Yu, B., Russ, B. E., Tsyganov, K., Nguyen, H., Toma, C., Heeg, M., Hocker, J. D., Milner, J. J., Crotty, S., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.03.017 · Cited by 28
Hegde, M., Kumar, A., Girisa, S., Alqahtani, M. S., Abbas, M. A. E., Goel, A., Hui, K. M., Sethi, G., & Kunnumakkara, A. B. (2023) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2023.06.001 · Cited by 28
Oyesola, O. O., Hilligan, K. L., Namasivayam, S., Howard, N., Clancy, C. S., Zhao, M., Oland, S. D., Kiwanuka, K. N., Garza, N. L., Lafont, B. A. P., et al. (2023) · Science Immunology · doi:10.1126/sciimmunol.adf8161 · Cited by 33
Thompson, E. A., Beura, L. K., Nelson, C. E., Anderson, K. G., & Vezys, V. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1501797 · Cited by 27
Villegas-Méndez, A., Inkson, C. A., Shaw, T. N., Strangward, P., & Couper, K. N. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600968 · Cited by 28
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Raynor, J. L., Chapman, N. M., & Chi, H. (2021) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037770 · Cited by 28
Katopodi, T., Petanidis, S., Anestakis, D., Charalampidis, C., Chatziprodromidou, I. P., Floros, G., Eskitzis, P., Zarogoulidis, P., Koulouris, C., Sevva, C. D., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1325360 · Cited by 28
Yang, D., Su, M., Guo, D., Zhao, F., Wang, M., Liu, J., Zhou, J., Sun, Y., Yang, X., Qi, S., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c00809 · Cited by 27
Xu, W., Hu, M., Lu, X., Lao, Y., Ma, N., Wang, Y., Li, J., Chen, X., Liu, S., Liu, J., et al. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.93668 · Cited by 27
Chinese Immune Multi-Omics Atlas
Yin, J., Zheng, Y., Huang, Z., Zhou, W., Yuan, Y., Cai, P., Bai, Y., Yang, S., Gao, Y., Duan, S., et al. (2026) · Science · doi:10.1126/science.adt3130 · Cited by 36
Hope, J. L., Stairiker, C. J., Spantidea, P. I., Gracias, D. T., Carey, A. J., Fike, A. J., van Meurs, M., Brouwers-Haspels, I., Rijsbergen, L. C., Fraietta, J. A., et al. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01696 · Cited by 27
Backer, R. A., Hombrink, P., Helbig, C., & Amsen, D. (2018) · Advances in immunology · doi:10.1016/bs.ai.2017.12.003 · Cited by 27
Desai, P., Tahiliani, V., Hutchinson, T. E., Dastmalchi, F., Stanfield, J., Abboud, G., Thomas, P. G., Ware, C. F., Song, J. J., Croft, M., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701499 · Cited by 27
Kavazović, I., Polić, B., & Wensveen, F. M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02831 · Cited by 29
Yu, X., Zhang, L., Chaudhry, A., Rapaport, A. S., & Ouyang, W. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.6mr0320-234r · Cited by 25
mTORC1 Signaling Controls TLR2-Mediated T-Cell Activation by Inducing TIRAP Expression
Imanishi, T., Unno, M., Kobayashi, W., Yoneda, N., Akira, S., & Saito, T. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107911 · Cited by 26
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Joedicke, J. J., Großkinsky, U., Gerlach, K., Künkele, A., Höpken, U. E., & Rehm, A. (2021) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2021.12.005 · Cited by 27
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Lagumdzic, E., Pernold, C. P. S., Viano, M., Olgiati, S., Schmitt, M. W., Mair, K. H., & Saalmüller, A. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.849922 · Cited by 27
Stelekati, E., Cai, Z., Manne, S., Chen, Z., Beltra, J., Buchness, L. A., Leng, X., Ristin, S., Nzingha, K., Ekshyyan, V., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2106083119 · Cited by 24
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Perdomo-Celis, F., Passaes, C., Monceaux, V., Volant, S., Boufassa, F., de Truchis, P., Marcou, M., Bourdic, K., Weiss, L., Jung, C., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 27
Quaney, M. J., Pritzl, C. J., Luera, D., Newth, R. J., Knudson, K. M., Saxena, V., Guldenpfennig, C., Gil, D., Rae, C. S., Lauer, P., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2205049120 · Cited by 30
da Silva, J. G., Ferreira, D. P., Dumez, A., Wyss, T., Veber, R., Danilo, M., Pinschewer, D. D., Charmoy, M., & Held, W. (2023) · Science Immunology · doi:10.1126/sciimmunol.adh3113 · Cited by 27
Loh, L., Carcy, S., Krovi, S. H., Domenico, J. M., Spengler, A., Lin, Y., Torres, J., Prabakar, R. K., Palmer, W. H., Norman, P. J., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114705 · Cited by 30
Defining the molecular blueprint that drives CD8+ T cell differentiation in response to infection
Russ, B. E., Denton, A. E., Hatton, L. A., Croom, H. A., Olson, M. R., & Turner, S. (2012) · Front. Immun. · doi:10.3389/fimmu.2012.00371 · Cited by 31
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Takeda, Y., Yoshida, S., Takashima, K., Ishii‐Mugikura, N., Shime, H., Seya, T., & Matsumoto, M. (2018) · Cancer Science · doi:10.1111/cas.13649 · Cited by 27
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Adam, L., Rosenbaum, P., Quentric, P., Parizot, C., Bonduelle, O., Guillou, N., Corneau, A., Dorgham, K., Miyara, M., Luyt, C. E., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.151571 · Cited by 25
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Tejero, J. D., Hesterberg, R. S., Drápela, S., Ilter, D., Raizada, D., Lazure, F., Kashfi, H., Liu, M., Silvane, L., Avram, D., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03191-1 · Cited by 26
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Metadata
- Authors
- Kaech, S. M., & Cui, W.
- Affiliations
- Yale University (US)
- Corresponding author
- Kaech, Susan M.
- Venue
- Nature Reviews Immunology
- Published
- 2012-10-19
- Volume
- 12
- Issue
- 11
- Pages
- 749-761
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4137483
- OpenAlex
- W2043793366
- Cited by
- 1,628
- References
- 140
- Citations by year
- 2026: 134 · 2025: 125 · 2024: 139 · 2023: 126 · 2022: 125 · 2021: 164 · 2020: 105 · 2019: 120 · 2018: 119 · 2017: 100 · 2016: 119 · 2015: 116 · 2014: 74 · 2013: 55 · 2012: 3
- FWCI
- 7.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases (R21AI081150, R21AI097767, R01AI074699, R01AI066232)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- CD8+ T cells, effector T cell differentiation, memory T cell differentiation, transcriptional regulation, costimulatory molecules, inflammatory cytokines, T cell metabolism, T cell fate, T cell heterogeneity, infection immunity
- MeSH terms
- Animals, Cell Differentiation, Gene Expression Regulation, Humans, Immunologic Memory, Infections, Lymphocyte Activation, Transcription, Genetic, Signal Transduction, CD8-Positive T-Lymphocytes
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