Cited by 910T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

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Human memory T cells: generation, compartmentalization and homeostasis

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Farber, Donna L., Yudanin, Naomi A., Restifo, Nicholas P.·2014·Nature Reviews Immunology

DOI 10.1038/nri3567PMC PMC4032067

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Abstract

Memory T cells constitute the most abundant lymphocyte population in the body for the majority of a person's lifetime; however, our understanding of memory T cell generation, function and maintenance mainly derives from mouse studies, which cannot recapitulate the exposure to multiple pathogens that occurs over many decades in humans. In this Review, we discuss studies focused on human memory T cells that reveal key properties of these cells, including subset heterogeneity and diverse tissue residence in multiple mucosal and lymphoid tissue sites. We also review how the function and the adaptability of human memory T cells depend on spatial and temporal compartmentalization.

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Authors: Farber, D. L., Yudanin, N. A., & Restifo, N. P.
Affiliations: Columbia University Irving Medical Center (US)
National Institutes of Health (US)
ORCID: Yudanin, Naomi A.
Restifo, Nicholas P.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2013-12-13
Volume: 14
Issue: 1
Pages: 24-35
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3567
PMC: PMC4032067
OpenAlex: W2033505817
Cited by: 897
References: 153
Citations by year: 2026: 50 · 2025: 53 · 2024: 81 · 2023: 64 · 2022: 78 · 2021: 91 · 2020: 85 · 2019: 86 · 2018: 78 · 2017: 83 · 2016: 69 · 2015: 54 · 2014: 25
FWCI: 4.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (U01AI100119, AI106697, U19AI083022, P01AI106697, R01AI100119, AI100119, AI 083022)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: memory T cells, immunological memory, human T cells, T cell subsets, T cell heterogeneity, mucosal immunity, lymphoid tissue, spatial compartmentalization, T cell homeostasis, T cell generation
MeSH terms: Animals, Antigens, Cross Reactions, Homeostasis, Humans, Immunologic Memory, Lymphoid Tissue, Vaccines, T-Lymphocyte Subsets, Models, Immunological, Immunity, Mucosal, Mice, Adaptive Immunity, Microbiota

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Human memory T cells: generation, compartmentalization and homeostasis

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