Cited by 910T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

The DOI matches its Crossref record; 154 of the 154 references it cites were found in a registry or an index.

Human memory T cells: generation, compartmentalization and homeostasis

Open access

Farber, Donna L., Yudanin, Naomi A., Restifo, Nicholas P.·2014·Nature Reviews Immunology

DOI 10.1038/nri3567PMC PMC4032067

Open this paper in CoChat — free account

Abstract

Memory T cells constitute the most abundant lymphocyte population in the body for the majority of a person's lifetime; however, our understanding of memory T cell generation, function and maintenance mainly derives from mouse studies, which cannot recapitulate the exposure to multiple pathogens that occurs over many decades in humans. In this Review, we discuss studies focused on human memory T cells that reveal key properties of these cells, including subset heterogeneity and diverse tissue residence in multiple mucosal and lymphoid tissue sites. We also review how the function and the adaptability of human memory T cells depend on spatial and temporal compartmentalization.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/nri3567

Cites

154 of 154 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M. (1996) · Science · doi:10.1126/science.274.5284.94 · Cited by 3,544
Central Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
Single-Cell Mass Cytometry of Differential Immune and Drug Responses Across a Human Hematopoietic Continuum
Bendall, S. C., Simonds, E. F., Qiu, P., Amir, E.-A. D., Krutzik, P. O., Finck, R., Bruggner, R. V., Melamed, R., Trejo, A., Ornatsky, O. I., et al. (2011) · Science · doi:10.1126/science.1198704 · Cited by 2,279
A human memory T cell subset with stem cell–like properties
Gattinoni, L., Lugli, E., Ji, Y., Pos, Z., Paulos, C. M., Quigley, M. F., Almeida, J. R., Gostick, E., Yu, Z., Carpenito, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2446 · Cited by 1,974
Self-citation
Preferential Localization of Effector Memory Cells in Nonlymphoid Tissue
Masopust, D., Vezys, V., Marzo, A. L., & Lefrançois, L. (2001) · Science · doi:10.1126/science.1058867 · Cited by 1,952
Counting Antigen-Specific CD8 T Cells: A Reevaluation of Bystander Activation during Viral Infection
Murali‐Krishna, K., Altman, J. D., Suresh, M., Sourdive, D. J. D., Zajac, A. J., Miller, J. D., Slansky, J. E., & Ahmed, R. (1998) · Immunity · doi:10.1016/s1074-7613(00)80470-7 · Cited by 1,918
HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation
Chomont, N., Far, M. E., Ancuța, P., Trautmann, L., Procopio, F. A., Yassine‐Diab, B., Boucher, G., Boulassel, M., Ghattas, G., Brenchley, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1972 · Cited by 1,775
Reciprocal interactions of the intestinal microbiota and immune system
Maynard, C. L., Elson, C. O., Hatton, R. D., & Weaver, C. T. (2012) · Nature · doi:10.1038/nature11551 · Cited by 1,598
T-cell quality in memory and protection: implications for vaccine design
Seder, R. A., Darrah, P. A., & Roederer, M. (2008) · Nature reviews. Immunology · doi:10.1038/nri2274 · Cited by 1,565

Flagged first, then by citations

Show all 153 references

Sorted by citations

Mechanisms of resistance to immune checkpoint inhibitors
Jenkins, R. W., Barbie, D. A., & Flaherty, K. T. (2018) · British Journal of Cancer · doi:10.1038/bjc.2017.434 · Cited by 1,383
Immunosenescence: molecular mechanisms and diseases
Liu, Z., Liang, Q., Ren, Y., Guo, C., Ge, X., Wang, L., Cheng, Q., Luo, P., Zhang, Y., & Han, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01451-2 · Cited by 1,082
Therapeutic T cell engineering
Sadelain, M., Rivière, I., & Riddell, S. R. (2017) · Nature · doi:10.1038/nature22395 · Cited by 906
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
Goel, R. R., Painter, M. M., Apostolidis, S. A., Mathew, D., Meng, W., Rosenfeld, A. M., Lundgreen, K. A., Reynaldi, A., Khoury, D. S., Pattekar, A., et al. (2021) · Science · doi:10.1126/science.abm0829 · Cited by 873
Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
Szabo, P. A., Levitin, H. M., Miron, M., Snyder, M. E., Senda, T., Yuan, J., Cheng, Y. L., Bush, E. C., Dogra, P., Thapa, P., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12464-3 · Cited by 756
Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance
Steinert, E. M., Schenkel, J. M., Fraser, K. A., Beura, L. K., Manlove, L. S., Igyártó, B. Z., Southern, P. J., & Masopust, D. (2015) · Cell · doi:10.1016/j.cell.2015.03.031 · Cited by 685
Mechanisms of Resistance to Immune Checkpoint Blockade: Why Does Checkpoint Inhibitor Immunotherapy Not Work for All Patients?
Fares, C. M., Allen, E. M. V., Drake, C. G., Allison, J. P., & Hu‐Lieskovan, S. (2019) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_240837 · Cited by 665
T memory stem cells in health and disease
Gattinoni, L., Speiser, D. E., Lichterfeld, M. D., & Bonini, C. (2017) · Nature Medicine · doi:10.1038/nm.4241 · Cited by 648
Spatial map of human T cell compartmentalization and maintenance over decades of life
Thome, J. J. C., Yudanin, N., Ohmura, Y., Kubota, M., Grinshpun, B., Sathaliyawala, T., Kato, T., Lerner, H., Shen, Y., & Farber, D. L. (2014) · Cell · doi:10.1016/j.cell.2014.10.026 · Cited by 587
Self-citation
Resistance to PD1/PDL1 checkpoint inhibition
O’Donnell, J. S., Long, G. V., Scolyer, R. A., Teng, M. W. L., & Smyth, M. J. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.11.007 · Cited by 587
Epigenetic Modification and Antibody-Dependent Expansion of Memory-like NK Cells in Human Cytomegalovirus-Infected Individuals
Lee, J., Zhang, T., Hwang, I., Kim, A., Nitschke, L., Kim, M. J., Scott, J. M., Kamimura, Y., Lanier, L. L., & Kim, S. (2015) · Immunity · doi:10.1016/j.immuni.2015.02.013 · Cited by 561
Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
Kishton, R. J., Sukumar, M., & Restifo, N. P. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.06.016 · Cited by 548
Self-citation
Emerging insights into natural killer cells in human peripheral tissues
Björkström, N. K., Ljunggren, H., & Michaëlsson, J. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.34 · Cited by 466
A safe and potent anti-CD19 CAR T cell therapy
Ying, Z., Huang, X. F., Xiang, X., Liu, Y., Kang, X., Song, Y., Guo, X., Liu, H., Ding, N., Zhang, T., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0421-7 · Cited by 451
mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer
Cafri, G., Gartner, J. J., Zaks, T., Hopson, K., Levin, N., Paria, B. C., Parkhurst, M. R., Yossef, R., Lowery, F. J., Jafferji, M. S., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci134915 · Cited by 427
Successful and Maladaptive T Cell Aging
Goronzy, J. J., & Weyand, C. M. (2017) · Immunity · doi:10.1016/j.immuni.2017.03.010 · Cited by 362
Ontogeny of early life immunity
Dowling, D. J., & Levy, O. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.007 · Cited by 376
Regulatory T cell memory
Rosenblum, M. D., Way, S. S., & Abbas, A. K. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.1 · Cited by 358
Heterogeneity of Human CD4 + T Cells Against Microbes
Sallusto, F. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112056 · Cited by 336
Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation
Hegazy, A. N., West, N. R., Stubbington, M. J. T., Wendt, E., Suijker, K. I. M., Datsi, A., This, S., Danne, C., Campion, S., Duncan, S. H., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.07.047 · Cited by 338
Targeting the Latent Reservoir for HIV-1
Sengupta, S., & Siliciano, R. F. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.030 · Cited by 352
High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors
Brummelman, J., Mazza, E. M. C., Alvisi, G., Colombo, F. S., Grilli, A., Mikulak, J., Mavilio, D., Alloisio, M., Ferrari, F., Lopci, E., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20180684 · Cited by 334
Memory T cells: strategies for optimizing tumor immunotherapy
Liu, Q., Sun, Z., & Chen, L. (2020) · Protein & Cell · doi:10.1007/s13238-020-00707-9 · Cited by 348
Differentiation and Regulation of TH Cells: A Balancing Act for Cancer Immunotherapy
Basu, A. B., Ramamoorthi, G., Albert, G. K., Gallen, C., Beyer, A., Snyder, C., Koski, G. K., Disis, M. L., Czerniecki, B. J., & Kodumudi, K. N. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.669474 · Cited by 329
CAR-T cell manufacturing: Major process parameters and next-generation strategies
Ceja, M. A., Khericha, M., Harris, C. M., Puig-Saus, C., & Chen, Y. Y. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20230903 · Cited by 349
Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues
Thome, J. J. C., Bickham, K. L., Ohmura, Y., Kubota, M., Matsuoka, N., Gordon, C., Granot, T., Griesemer, A., Lerner, H., Kato, T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4008 · Cited by 305
Virus-specific memory T cells populate tumors and can be repurposed for tumor immunotherapy
Rosato, P. C., Wijeyesinghe, S., Stolley, J. M., Nelson, C. E., Davis, R. L., Manlove, L. S., Pennell, C. A., Blazar, B. R., Chen, C. C., Geller, M. A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08534-1 · Cited by 304
Integrative Physiology of Pneumonia
Quinton, L. J., Walkey, A. J., & Mizgerd, J. P. (2018) · Physiological Reviews · doi:10.1152/physrev.00032.2017 · Cited by 330
Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors
Patin, É., Hasan, M., Bergstedt, J., Rouilly, V., Libri, V., Urrutia, A., Alanio, C., Šćepanović, P., Hammer, C., Jönsson, F., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0049-7 · Cited by 305
Cross-reactive CD4 + T cells enhance SARS-CoV-2 immune responses upon infection and vaccination
Loyal, L., Braun, J., Henze, L., Kruse, B., Dingeldey, M., Reimer, U., Kern, F., Schwarz, T., Mangold, M., Unger, C., et al. (2021) · Science · doi:10.1126/science.abh1823 · Cited by 293
Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology
Masopust, D., Sivula, C. P., & Jameson, S. C. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700453 · Cited by 315
Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells
Enamorado, M., Iborra, S., Priego, E., Cueto, F. J., Quintana, J. A., Martínez-Cano, S., Mejías‐Pérez, E., Estéban, M., Melero, I., Hidalgo, A., et al. (2017) · Nature Communications · doi:10.1038/ncomms16073 · Cited by 303
Developmental plasticity allows outside-in immune responses by resident memory T cells
Fonseca, R., Beura, L. K., Quarnstrom, C. F., Ghoneim, H. E., Fan, Y., Zebley, C. C., Scott, M. C., Fares-Frederickson, N. J., Wijeyesinghe, S., Thompson, E. A., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0607-7 · Cited by 286
Obesity accelerates T cell senescence in murine visceral adipose tissue
Shirakawa, K., Yan, X., Shinmura, K., Endo, J., Kataoka, M., Katsumata, Y., Yamamoto, T., Anzai, A., Isobe, S., Yoshida, N., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci88606 · Cited by 271
Fatty acid metabolic reprogramming via mTOR-mediated inductions of PPARγ directs early activation of T cells
Angela, M., Endo, Y., Asou, H. K., Yamamoto, T., Tumes, D. J., Tokuyama, H., Yokote, K., & Nakayama, T. (2016) · Nature Communications · doi:10.1038/ncomms13683 · Cited by 267
Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory
Beura, L. K., Mitchell, J. S., Thompson, E. A., Schenkel, J. M., Mohammed, J., Wijeyesinghe, S., Fonseca, R., Burbach, B. J., Hickman, H. D., Vezys, V., et al. (2018) · Nature Immunology · doi:10.1038/s41590-017-0029-3 · Cited by 258
Individualized, heterologous chimpanzee adenovirus and self-amplifying mRNA neoantigen vaccine for advanced metastatic solid tumors: phase 1 trial interim results
Palmer, C. D., Rappaport, A., Davis, M. J., Hart, M. G., Scallan, C. D., Hong, S., Gitlin, L., Kraemer, L. D., Kounlavouth, S., Yang, A., et al. (2022) · Nature Medicine · doi:10.1038/s41591-022-01937-6 · Cited by 257
Single-cell transcriptome profiling of an adult human cell atlas of 15 major organs
He, S., Wang, L.-H., Liu, Y., Li, Y., Chen, H.-T., Xu, J.-H., Peng, W., Lin, G.-W., Wei, P.-P., Li, B., et al. (2020) · Genome biology · doi:10.1186/s13059-020-02210-0 · Cited by 237
Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity
Wang, D., Aguilar, B., Starr, R., Alizadeh, D., Brito, A., Sarkissian, A., Ostberg, J. R., Forman, S. J., & Brown, C. E. (2018) · JCI Insight · doi:10.1172/jci.insight.99048 · Cited by 233
Age related human T cell subset evolution and senescence
Li, M., Yao, D., Zeng, X., Kasakovski, D., Zhang, Y., Chen, S., Zha, X., Li, Y., & Xu, L. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0165-8 · Cited by 230
Memory CD4+ T Cells in Immunity and Autoimmune Diseases
Raphael, I., Robinson, R. R., & Forsthuber, T. G. (2020) · Cells · doi:10.3390/cells9030531 · Cited by 241
Tissue-resident memory T cells in tumor immunity and immunotherapy
Okła, K., Färber, D. L., & Zou, W. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20201605 · Cited by 239
FOXO1 is a master regulator of memory programming in CAR T cells
Doan, A. E., Mueller, K. P., Chen, A. Y., Rouin, G. T., Chen, Y., Dániel, B., Lattin, J., Markovska, M., Mozarsky, B., Arias-Umana, J., et al. (2024) · Nature · doi:10.1038/s41586-024-07300-8 · Cited by 241
Role of memory T cell subsets for adoptive immunotherapy
Busch, D. H., Fräßle, S. P., Sommermeyer, D., Buchholz, V. R., & Riddell, S. R. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.02.001 · Cited by 232
Evolving models of the immunopathogenesis of T cell–mediated drug allergy: The role of host, pathogens, and drug response
White, K. D., Chung, W., Chung, W., Mallal, S. A., & Phillips, E. J. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.050 · Cited by 229
The Regulation of Inflammation by Innate and Adaptive Lymphocytes
Cronkite, D. A., & Strutt, T. M. (2018) · Journal of Immunology Research · doi:10.1155/2018/1467538 · Cited by 239
Senescence‐associated β‐galactosidase reveals the abundance of senescent CD8+ T cells in aging humans
Martínez‐Zamudio, R. I., Dewald, H. K., Vasilopoulos, T., Gittens‐Williams, L., Fitzgerald‐Bocarsly, P., & Herbig, U. (2021) · Aging Cell · doi:10.1111/acel.13344 · Cited by 213
Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8+ T cells
Mastelic-Gavillet, B., Rodrigo, B. N., Décombaz, L., Wang, H., Ercolano, G., Ahmed, R., Lozano, L. E., Ianaro, A., Derré, L., Valério, M., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-019-0719-5 · Cited by 226
SARS-CoV-2 infection generates tissue-localized immunological memory in humans
Poon, M. M. L., Rybkina, K., Kato, Y., Kubota, M., Matsumoto, R., Bloom, N. I., Zhang, Z., Hastie, K. M., Grifoni, A., Weiskopf, D., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abl9105 · Cited by 220
Memory CD8+ T cell responses to cancer
Han, J., Khatwani, N., Searles, T. G., Turk, M. J., & Angeles, C. V. (2020) · Seminars in Immunology · doi:10.1016/j.smim.2020.101435 · Cited by 236
Understanding HIV Latency: The Road to an HIV Cure
Dahabieh, M. S., Battivelli, E., & Verdin, E. M. (2015) · Annual Review of Medicine · doi:10.1146/annurev-med-092112-152941 · Cited by 215
A Pck1-directed glycogen metabolic program regulates formation and maintenance of memory CD8+ T cells
Ma, R., Ji, T., Zhang, Y., Dong, W., Chen, X., Xu, P., Chen, D., Liang, X., Yin, X., Liu, Y., et al. (2017) · Nature Cell Biology · doi:10.1038/s41556-017-0002-2 · Cited by 211
Bioinformatic and Statistical Analysis of Adaptive Immune Repertoires
Greiff, V., Miho, E., Menzel, U., & Reddy, S. T. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.09.006 · Cited by 210
Early pediatric atopic dermatitis shows only a cutaneous lymphocyte antigen (CLA)+ TH2/TH1 cell imbalance, whereas adults acquire CLA+ TH22/TC22 cell subsets
Czarnowicki, T., Esaki, H., Gonzalez, J., Malajian, D., Shemer, A., Noda, S., Talasila, S., Berry, A., Gray, J., Becker, L., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.049 · Cited by 211
A guide to adaptive immune memory
Lam, N., Lee, Y. S., & Färber, D. L. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01040-6 · Cited by 236
Mucosal Resident Memory CD4 T Cells in Protection and Immunopathology
Turner, D., & Färber, D. L. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00331 · Cited by 204
Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments
Nail, H. M., Chiu, C., Leung, C., Ahmed, M. M. M., & Wang, H. (2023) · Journal of Biomedical Science · doi:10.1186/s12929-023-00964-w · Cited by 203
The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets
Hohlfeld, R., Dornmair, K., Meinl, E., & Wekerle, H. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00334-8 · Cited by 205
Development, application and computational analysis of high-dimensional fluorescent antibody panels for single-cell flow cytometry
Brummelman, J., Haftmann, C., Núñez, N. G., Alvisi, G., Mazza, E. M. C., Becher, B., & Lugli, E. (2019) · Nature Protocols · doi:10.1038/s41596-019-0166-2 · Cited by 194
How many TCR clonotypes does a body maintain?
Lythe, G., Callard, R. E., Hoare, R. L., & Molina-París, C. (2016) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2015.10.016 · Cited by 175
Differential Effects of Environmental and Genetic Factors on T and B Cell Immune Traits
Aguirre‐Gamboa, R., Joosten, I., Urbano, P. C. M., Molen, R. G. V. D., van Rijssen, E., van Cranenbroek, B., Oosting, M., Smeekens, S. P., Jaeger, M., Zorro, M. M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.10.053 · Cited by 191
Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection
Tu, W., & Rao, S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02111 · Cited by 192
Immune checkpoint inhibitors and elderly people: A review
Daste, A., Domblides, C., Gross‐Goupil, M., Chakiba, C., Quivy, A., Cochin, V., de Monès, E., Larmonier, N., Soubeyran, P., & Ravaud, A. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.05.044 · Cited by 194
The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research
Hohlfeld, R., Dornmair, K., Meinl, E., & Wekerle, H. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00313-0 · Cited by 185
Curing HIV: Seeking to Target and Clear Persistent Infection
Margolis, D. M., Archin, N. M., Cohen, M. S., Eron, J. J., Ferrari, G., García, J. V., Gay, C. L., Goonetilleke, N. P., Joseph, S., Swanstrom, R. I., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.005 · Cited by 179
Characterizing immune repertoires by high throughput sequencing: strategies and applications
Calis, J. J. A., & Rosenberg, B. R. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.09.004 · Cited by 190
In vivo tracking of T cells in humans unveils decade-long survival and activity of genetically modified T memory stem cells
Biasco, L., Scala, S., Basso Ricci, L., Dionisio, F., Baricordi, C., Calabria, A., Giannelli, S., Cieri, N., Barzaghi, F., Pajno, R., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.3010314 · Cited by 175
The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases
DeMaio, A., Mehrotra, S., Sambamurti, K., & Husain, S. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02605-9 · Cited by 192
Long-term maintenance of human naive T cells through in situ homeostasis in lymphoid tissue sites
Thome, J. J. C., Grinshpun, B., Kumar, B. V., Kubota, M., Ohmura, Y., Lerner, H., Sempowski, G. D., Shen, Y., & Farber, D. L. (2016) · Science Immunology · doi:10.1126/sciimmunol.aah6506 · Cited by 162
The known unknowns of T cell immunity to COVID-19
Karlsson, A. C., Humbert, M., & Buggert, M. (2020) · Science Immunology · doi:10.1126/sciimmunol.abe8063 · Cited by 165
TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials
Choucair, K., Morand, S. M., Stanbery, L., Edelman, G. M., Dworkin, L. D., & Nemunaitis, J. J. (2020) · Cancer Gene Therapy · doi:10.1038/s41417-020-0174-y · Cited by 170
Mitochondrial activity in T cells
Desdín-Micó, G., Soto‐Heredero, G., & Mittelbrunn, M. (2017) · Mitochondrion · doi:10.1016/j.mito.2017.10.006 · Cited by 171
The Latent Reservoir for HIV-1: How Immunologic Memory and Clonal Expansion Contribute to HIV-1 Persistence
Murray, A. J., Kwon, K. J., Färber, D. L., & Siliciano, R. F. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600343 · Cited by 160
Understanding immunosenescence and its impact on vaccination of older adults
Allen, J. C., Toapanta, F. R., Chen, W. H., & Tennant, S. M. (2020) · Vaccine · doi:10.1016/j.vaccine.2020.11.002 · Cited by 161
TET2 guards against unchecked BATF3-induced CAR T cell expansion
Jain, N., Zhao, Z., Feucht, J., Koche, R. P., Iyer, A., Dobrin, A., Mansilla‐Soto, J., Yang, J. L., Zhan, Y. A., Lopez, M. A., et al. (2023) · Nature · doi:10.1038/s41586-022-05692-z · Cited by 159
Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade
Banchereau, R., Chitre, A. S., Scherl, A., Wu, T. D., Patil, N. S., de Almeida, P. E., Kadel, E. E., Madireddi, S., Au‐Yeung, A., Takahashi, C., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002231 · Cited by 153
A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults
Pillet, S., Aubin, É., Trépanier, S., Bussière, D., Dargis, M., Poulin, J., Yassine‐Diab, B., Ward, B. J., & Landry, N. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.03.008 · Cited by 146
Emerging concepts in tissue-resident T cells: lessons from humans
Thome, J. J. C., & Färber, D. L. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.05.003 · Cited by 151
Optimizing Manufacturing Protocols of Chimeric Antigen Receptor T Cells for Improved Anticancer Immunotherapy
Stock, S., Schmitt, M. W., & Sellner, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20246223 · Cited by 146
Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility
Brandt, E. B., Myers, J. M. B., Acciani, T. H., Ryan, P., Sivaprasad, U., Ruff, B. P., LeMasters, G. K., Bernstein, D. I., Lockey, J. E., Cras, T. D. L., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.11.043 · Cited by 145
Role of Th22 Cells in the Pathogenesis of Autoimmune Diseases
Jiang, Q., Yang, G., Xiao, F., Xie, J., Wang, S., Lu, L., & Cui, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.688066 · Cited by 145
Leukocyte-mediated Delivery of Nanotherapeutics in Inflammatory and Tumor Sites
Dong, X., Chu, D., & Wang, Z. (2017) · Theranostics · doi:10.7150/thno.18069 · Cited by 137
Exploiting Mucosal Immunity for Antiviral Vaccines
Iwasaki, A. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112315 · Cited by 138
Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2
McKinstry, K. K., Strutt, T. M., Bautista, B., Zhang, W., Kuang, Y., Cooper, A. M., & Swain, S. L. (2014) · Nature Communications · doi:10.1038/ncomms6377 · Cited by 134
Designing and Interpreting Limiting Dilution Assays: General Principles and Applications to the Latent Reservoir for Human Immunodeficiency Virus-1
Rosenbloom, D. I. S., Elliott, O., Hill, A. L., Henrich, T. J., Siliciano, J. D., & Siliciano, R. F. (2015) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofv123 · Cited by 126
Mesenchymal Stem Cells Improve Rheumatoid Arthritis Progression by Controlling Memory T Cell Response
Luque‐Campos, N., Contreras-López, R. A., Paredes-Martínez, M. J., Torres, M. J., Bahraoui, S., Wei, M., Espinoza, F., Djouad, F., Elizondo-Vega, R. J., & Luz‐Crawford, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00798 · Cited by 132
Retrograde migration supplies resident memory T cells to lung-draining LN after influenza infection
Stolley, J. M., Johnston, T. S., Soerens, A. G., Beura, L. K., Rosato, P. C., Joag, V., Wijeyesinghe, S., Langlois, R. A., Osum, K. C., Mitchell, J. S., et al. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20192197 · Cited by 126
TCR sequencing paired with massively parallel 3′ RNA-seq reveals clonotypic T cell signatures
Tu, A. A., Gierahn, T. M., Monian, B., Morgan, D. M., Mehta, N. K., Ruiter, B., Shreffler, W. G., Shalek, A. K., & Love, J. C. (2019) · Nature Immunology · doi:10.1038/s41590-019-0544-5 · Cited by 128
PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation
Petrelli, A., Mijnheer, G., van Konijnenburg, D. P. H., van der Wal, M. M., Giovannone, B., Mocholi, E., Vazirpanah, N., Broen, J. C., Hijnen, D., Oldenburg, B., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96107 · Cited by 126
Vaccine-induced systemic and mucosal T cell immunity to SARS-CoV-2 viral variants
Kingstad-Bakke, B. A., Lee, W., Chandrasekar, S., Gasper, D. J., Salas-Quinchucua, C., Cleven, T., Sullivan, J. A., Talaat, A. M., Osorio, J. E., & Suresh, M. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118312119 · Cited by 119
Mapping the Diversity of Follicular Helper T Cells in Human Blood and Tonsils Using High-Dimensional Mass Cytometry Analysis
Wong, M. T., Chen, J., Narayanan, S., Lin, W., Anicete, R., Tan, H. K. K., de Lafaille, M. A. C., Poidinger, M., & Newell, E. W. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.05.022 · Cited by 126
Anti-CTLA-4 antibody-functionalized dendritic cell-derived exosomes targeting tumor-draining lymph nodes for effective induction of antitumor T-cell responses
Phung, C. D., Pham, T. T., Nguyen, H. T., Nguyen, T. T., Ou, W., Jeong, J., Choi, H., Ku, S., Yong, C. S., & Kim, J. O. (2020) · Acta Biomaterialia · doi:10.1016/j.actbio.2020.08.008 · Cited by 124
Low interleukin-2 concentration favors generation of early memory T cells over effector phenotypes during chimeric antigen receptor T-cell expansion
Kaartinen, T., Luostarinen, A., Maliniemi, P., Keto, J., Arvas, M., Belt, H., Koponen, J., Loskog, A., Mustjoki, S. M., Porkka, K., et al. (2017) · Cytotherapy · doi:10.1016/j.jcyt.2017.03.067 · Cited by 126
Ammonia-induced lysosomal and mitochondrial damage causes cell death of effector CD8+ T cells
Zhang, H., Liu, J., Yuan, W., Zhang, Q., Luo, X. L., Li, Y., Peng, Y., Feng, J., Liu, X., Chen, J., et al. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01503-x · Cited by 127
The Skin Immune Atlas: Three-Dimensional Analysis of Cutaneous Leukocyte Subsets by Multiphoton Microscopy
Tong, P. L., Roediger, B., Kolesnikoff, N., Biro, M., Tay, S. S., Jain, R., Shaw, L. E., Grimbaldeston, M. A., & Weninger, W. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.289 · Cited by 122
Elevation and persistence of CD8 T‐cells in HIV infection: the Achilles heel in the ART era
Cao, W., Mehraj, V., Kaufmann, D., Li, T., & Routy, J. (2016) · Journal of the International AIDS Society · doi:10.7448/ias.19.1.20697 · Cited by 119
Defining features of protective CD4 T cell responses to Mycobacterium tuberculosis
Sakai, S., Mayer-Barber, K. D., & Barber, D. L. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.06.003 · Cited by 118
A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
Wu, Y., Biswas, D., Usaite, I., Angelova, M., Boeing, S., Karasaki, T., Veeriah, S., Czyzewska-Khan, J., Morton, C., Joseph, M., et al. (2022) · Nature Cancer · doi:10.1038/s43018-022-00376-z · Cited by 126
Delineation of a molecularly distinct terminally differentiated memory CD8 T cell population
Milner, J. J., Nguyen, H., Omilusik, K. D., Reina‐Campos, M., Tsai, M. S., Toma, C., Delpoux, A., Boland, B. S., Hedrick, S. Μ., Chang, J. T., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2008571117 · Cited by 115
Multifunctional Nanodrug Mediates Synergistic Photodynamic Therapy and MDSCs‐Targeting Immunotherapy of Colon Cancer
Ding, D., Zhong, H., Liang, R., Lan, T., Zhu, X., Huang, S., Wang, Y., Shao, J., Shuai, X., & Wei, B. (2021) · Advanced Science · doi:10.1002/advs.202100712 · Cited by 117

Authors: Farber, D. L., Yudanin, N. A., & Restifo, N. P.
Affiliations: Columbia University Irving Medical Center (US)
National Institutes of Health (US)
ORCID: Yudanin, Naomi A.
Restifo, Nicholas P.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2013-12-13
Volume: 14
Issue: 1
Pages: 24-35
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3567
PMC: PMC4032067
OpenAlex: W2033505817
Cited by: 897
References: 153
Citations by year: 2026: 50 · 2025: 53 · 2024: 81 · 2023: 64 · 2022: 78 · 2021: 91 · 2020: 85 · 2019: 86 · 2018: 78 · 2017: 83 · 2016: 69 · 2015: 54 · 2014: 25
FWCI: 4.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Allergy and Infectious Diseases (U01AI100119, AI106697, U19AI083022, P01AI106697, R01AI100119, AI100119, AI 083022)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: memory T cells, immunological memory, human T cells, T cell subsets, T cell heterogeneity, mucosal immunity, lymphoid tissue, spatial compartmentalization, T cell homeostasis, T cell generation
MeSH terms: Animals, Antigens, Cross Reactions, Homeostasis, Humans, Immunologic Memory, Lymphoid Tissue, Vaccines, T-Lymphocyte Subsets, Models, Immunological, Immunity, Mucosal, Mice, Adaptive Immunity, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Human memory T cells: generation, compartmentalization and homeostasis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks