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Human memory T cells: generation, compartmentalization and homeostasis
Open accessAbstract
Memory T cells constitute the most abundant lymphocyte population in the body for the majority of a person's lifetime; however, our understanding of memory T cell generation, function and maintenance mainly derives from mouse studies, which cannot recapitulate the exposure to multiple pathogens that occurs over many decades in humans. In this Review, we discuss studies focused on human memory T cells that reveal key properties of these cells, including subset heterogeneity and diverse tissue residence in multiple mucosal and lymphoid tissue sites. We also review how the function and the adaptability of human memory T cells depend on spatial and temporal compartmentalization.
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“In such cases, memory B and T cells can be rapidly reactivated, resulting in the enhanced control of initial viral replication and limiting viral dissemination in the host (24, 25).”
From mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern (2021) · cites this paper as [25]
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“Seeding into tissues occurs in childhood, and the resident population persists throughout adulthood”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Farber et al., 2014
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“Resident memory T cells in lungs, skin, and submucosal sites account for a large fraction of memory cells numbering more than 5 × 1010 cells in an individual.”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Farber et al., 2014
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Metadata
- Authors
- Farber, D. L., Yudanin, N. A., & Restifo, N. P.
- Affiliations
- Columbia University Irving Medical Center (US)
- National Institutes of Health (US)
- Venue
- Nature Reviews Immunology
- Published
- 2013-12-13
- Volume
- 14
- Issue
- 1
- Pages
- 24-35
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4032067
- OpenAlex
- W2033505817
- Cited by
- 897
- References
- 153
- Citations by year
- 2026: 50 · 2025: 53 · 2024: 81 · 2023: 64 · 2022: 78 · 2021: 91 · 2020: 85 · 2019: 86 · 2018: 78 · 2017: 83 · 2016: 69 · 2015: 54 · 2014: 25
- FWCI
- 4.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (U01AI100119, AI106697, U19AI083022, P01AI106697, R01AI100119, AI100119, AI 083022)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- memory T cells, immunological memory, human T cells, T cell subsets, T cell heterogeneity, mucosal immunity, lymphoid tissue, spatial compartmentalization, T cell homeostasis, T cell generation
- MeSH terms
- Animals, Antigens, Cross Reactions, Homeostasis, Humans, Immunologic Memory, Lymphoid Tissue, Vaccines, T-Lymphocyte Subsets, Models, Immunological, Immunity, Mucosal, Mice, Adaptive Immunity, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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