The DOI matches its Crossref record; 175 of the 175 references it cites were found in a registry or an index.
Periodontitis: from microbial immune subversion to systemic inflammation
Open accessAbstract
Periodontitis is a dysbiotic inflammatory disease with an adverse impact on systemic health. Recent studies have provided insights into the emergence and persistence of dysbiotic oral microbial communities that can mediate inflammatory pathology at local as well as distant sites. This Review discusses the mechanisms of microbial immune subversion that tip the balance from homeostasis to disease in oral or extra-oral sites.
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“Recent studies have also highlighted that the mineralized structure of calculus may promote a dysbiotic shift in the microbial community, contributing to persistent inflammation and disease progression [4].”
From In vitro biomimetic development of artificial dental calculus: a proof of concept study (2025) · cites this paper as [4]
In the citing paper
“Periodontal disease is caused by dysbiosis of subgingival microbial communities that adversely affects the host immune system such that it creates and maintains unmitigated inflammation in gingival and periodontal tissues, thus preventing immune subversion and tissue recovery.10”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [10]
In the citing paper
“It is speculated that aspiration pneumonia is also closely related to oral microorganisms due to the aspiration of oropharyngeal secretions (Hajishengallis, 2015).”
From Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection (2020) · cites this paper as Hajishengallis, 2015
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Pihlstrom, B. L., Michalowicz, B. S., & Johnson, N. W. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67728-8 · Cited by 3,718
Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654
Self-citationDewhirst, F. E., Chen, T., Izard, J., Paster, B. J., Tanner, A. C. R., Yu, W.-H., Lakshmanan, A., & Wade, W. G. (2010) · Journal of Bacteriology · doi:10.1128/jb.00542-10 · Cited by 3,352
Mechanisms and Functions of Inflammasomes
Lamkanfi, M., & Dixit, V. M. (2014) · Cell · doi:10.1016/j.cell.2014.04.007 · Cited by 2,579
Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043
Prevalence of Periodontitis in Adults in the United States: 2009 and 2010
Eke, P. I., Dye, B. A., Wei, L., Thornton‐Evans, G. O., & Genco, R. J. (2012) · Journal of Dental Research · doi:10.1177/0022034512457373 · Cited by 1,831
The keystone-pathogen hypothesis
Hajishengallis, G., Darveau, R. P., & Curtis, M. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2873 · Cited by 1,790
Self-citationSocransky, S. S., & Haffajee, A. D. (2005) · Periodontology 2000 · doi:10.1111/j.1600-0757.2005.00107.x · Cited by 1,691
Periodontitis: a polymicrobial disruption of host homeostasis
Darveau, R. P. (2010) · Nature Reviews Microbiology · doi:10.1038/nrmicro2337 · Cited by 1,688
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Smolen, J. S., Aletaha, D., Barton, A. C., Burmester, G. R., Emery, P., Firestein, G. S., Kavanaugh, A., McInnes, I. B., Solomon, D. H., Strand, V., et al. (2018) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2018.1 · Cited by 2,534
The Oral Microbiota: Dynamic Communities and Host Interactions
Lamont, R. J., Koo, H., & Hajishengallis, G. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0089-x · Cited by 2,217
Self-citationLocal and systemic mechanisms linking periodontal disease and inflammatory comorbidities
Hajishengallis, G., & Chavakis, T. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00488-6 · Cited by 1,871
Self-citationMicrobial Hub Taxa Link Host and Abiotic Factors to Plant Microbiome Variation
Agler, M. T., Ruhe, J., Kroll, S., Morhenn, C., Kim, S., Weigel, D., & Kemen, E. M. (2016) · PLoS Biology · doi:10.1371/journal.pbio.1002352 · Cited by 1,423
The immune response to Prevotella bacteria in chronic inflammatory disease
Larsen, J. M. (2017) · Immunology · doi:10.1111/imm.12760 · Cited by 1,343
Metadata
- Authors
- Hajishengallis, G.
- Affiliations
- University of Pennsylvania (US)
- Corresponding author
- Hajishengallis, George
- Venue
- Nature Reviews Immunology
- Published
- 2014-12-23
- Volume
- 15
- Issue
- 1
- Pages
- 30-44
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4276050
- OpenAlex
- W2021838232
- Cited by
- 3,046
- References
- 175
- Citations by year
- 2026: 400 · 2025: 359 · 2024: 348 · 2023: 394 · 2022: 291 · 2021: 318 · 2020: 262 · 2019: 215 · 2018: 135 · 2017: 144 · 2016: 131 · 2015: 46
- FWCI
- 18.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (AI 068730, P01AI068730)
- National Institute of Dental and Craniofacial Research (DE-015254, DE017138, R01DE015254, R01DE024716, DE021685, R01DE021685, R01DE017138)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Keywords
- periodontitis, systemic inflammation, rheumatoid arthritis, oral dysbiosis, oral microbiota, oral-systemic disease link, host-pathogen interaction
- MeSH terms
- Animals, Antibiosis, Arthritis, Rheumatoid, Cardiovascular Diseases, Female, Humans, Immunity, Periodontitis, Pregnancy, Pregnancy Outcome, Respiratory Tract Diseases, Symbiosis
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