Periodontitis: from microbial immune subversion to systemic inflammation

Periodontal diseases

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Complement: a key system for immune surveillance and homeostasis

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The Human Oral Microbiome

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Mechanisms and Functions of Inflammasomes

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Fusobacterium nucleatum Promotes Colorectal Carcinogenesis by Modulating E-Cadherin/β-Catenin Signaling via its FadA Adhesin

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Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma

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Prevalence of Periodontitis in Adults in the United States: 2009 and 2010

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The keystone-pathogen hypothesis

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Periodontal microbial ecology

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Periodontitis: a polymicrobial disruption of host homeostasis

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Treatment of periodontitis and endothelial function

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Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology

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Infection in the Pathogenesis and Course of Chronic Obstructive Pulmonary Disease

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Low-Abundance Biofilm Species Orchestrates Inflammatory Periodontal Disease through the Commensal Microbiota and Complement

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Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

Hajishengallis, G. (2014) · Trends in Immunology · doi:10.1016/j.it.2013.09.001 · Cited by 1,150

Identification of Periodontal Pathogens in Atheromatous Plaques

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The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation

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Distinct and complex bacterial profiles in human periodontitis and health revealed by 16S pyrosequencing

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The role of reactive oxygen and antioxidant species in periodontal tissue destruction

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The prevalence and incidence of coronary heart disease is significantly increased in periodontitis: A meta-analysis

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Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α‐enolase: Implications for autoimmunity in rheumatoid arthritis

Wegner, N., Wait, R., Sroka, A., Eick, S., Nguyen, K.-A. T., Lundberg, K., Kinloch, A., Culshaw, S., Potempa, J., & Venables, P. J. (2010) · Arthritis & Rheumatism · doi:10.1002/art.27552 · Cited by 690

Sequencing ancient calcified dental plaque shows changes in oral microbiota with dietary shifts of the Neolithic and Industrial revolutions

Adler, C. J., Dobney, K., Weyrich, L. S., Kaidonis, J., Walker, A. W., Haak, W., Bradshaw, C. J. A., Townsend, G., Sołtysiak, A., Alt, K. W., et al. (2013) · Nature Genetics · doi:10.1038/ng.2536 · Cited by 621

Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen

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Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota

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Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer—Response

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Autoantibody Epitope Spreading in the Pre-Clinical Phase Predicts Progression to Rheumatoid Arthritis

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Citrullination: A posttranslational modification in health and disease

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Antagonist Antibodies to PD-1 and B7-H1 (PD-L1) in the Treatment of Advanced Human Cancer

Sznol, M., & Chen, L. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2063 · Cited by 501

Mobile Microbiome

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Pathogens: raft hijackers

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Human Atherosclerotic Plaque Contains Viable Invasive Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis

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Implantation of Bacteroides gingivalis in Nonhuman Primates Initiates Progression of Periodontitis

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Fusobacterium nucleatum Induces Premature and Term Stillbirths in Pregnant Mice: Implication of Oral Bacteria in Preterm Birth

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Porphyromonas gingivalis Manipulates Complement and TLR Signaling to Uncouple Bacterial Clearance from Inflammation and Promote Dysbiosis

Maekawa, T., Krauss, J. L., Abe, T., Jotwani, R., Triantafilou, M., Triantafilou, K., Hashim, A., Hoch, S., Curtis, M. A., Nussbaum, G., et al. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.05.012 · Cited by 450

Porphyromonas gingivalis as a Potential Community Activist for Disease

Darveau, R. P., Hajishengallis, G., & Curtis, M. A. (2012) · Journal of Dental Research · doi:10.1177/0022034512453589 · Cited by 439

“ Gum Bug, Leave My Heart Alone !”—Epidemiologic and Mechanistic Evidence Linking Periodontal Infections and Atherosclerosis

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The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss

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Plasma antibodies to oral bacteria and risk of pancreatic cancer in a large European prospective cohort study

Michaud, D. S., Izard, J., Wilhelm-Benartzi, C. S., You, D.-H., Grote, V. A., Tjønneland, A. M., Dahm, C. C., Overvad, K., Jenab, M., Fedirko, V., et al. (2012) · Gut · doi:10.1136/gutjnl-2012-303006 · Cited by 412

Multiple infections in carotid atherosclerotic plaques

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The inflammophilic character of the periodontitis-associated microbiota

Hajishengallis, G. (2014) · Molecular Oral Microbiology · doi:10.1111/omi.12065 · Cited by 407

Silencing of CXCR4 Blocks Breast Cancer Metastasis

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Association of periodontal disease and tooth loss with rheumatoid arthritis in the US population.

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Antibodies to citrullinated α‐enolase peptide 1 are specific for rheumatoid arthritis and cross‐react with bacterial enolase

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Periodontitis and Porphyromonas gingivalis in Patients With Rheumatoid Arthritis

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Metatranscriptomics of the Human Oral Microbiome during Health and Disease

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Oral biofilms, periodontitis, and pulmonary infections

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Newly Identified Pathogens Associated with Periodontitis

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The microflora associated with human oral carcinomas

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Breaking bad: Manipulation of the host response by P orphyromonas gingivalis

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Oral health and mortality risk from pneumonia in the elderly

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Periodontitis in RA—the citrullinated enolase connection

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Periodontal disease, Porphyromonas gingivalis serum antibody levels and orodigestive cancer mortality

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Subgingival microbiota in healthy, well‐maintained elder and periodontitis subjects

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A New Inflammatory Cytokine on the Block: Re-thinking Periodontal Disease and the Th1/Th2 Paradigm in the Context of Th17 Cells and IL-17

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Innate Immune Recognition of Invasive Bacteria Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice

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Oral Bacteria and Cancer

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Defective Neutrophil Recruitment in Leukocyte Adhesion Deficiency Type I Disease Causes Local IL-17–Driven Inflammatory Bone Loss

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Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)

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Term Stillbirth Caused by Oral Fusobacterium nucleatum

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Evidence of a direct relationship between neutrophil collagenase activity and periodontal tissue destruction in vivo: role of active enzyme in human periodontitis

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Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis

Stabholz, A., Soskolne, W. A., & Shapira, L. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2010.00340.x · Cited by 282

Cutting Edge: TLR2 Is Required for the Innate Response to Porphyromonas gingivalis : Activation Leads to Bacterial Persistence and TLR2 Deficiency Attenuates Induced Alveolar Bone Resorption

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Genetic susceptibility to periodontitis

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Results From the Periodontitis and Vascular Events (PAVE) Study: A Pilot Multicentered, Randomized, Controlled Trial to Study Effects of Periodontal Therapy in a Secondary Prevention Model of Cardiovascular Disease

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Porphyromonas gingivalis promotes invasion of oral squamous cell carcinoma through induction of proMMP9 and its activation

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Intrinsic apoptotic pathways of gingival epithelial cells modulated by Porphyromonas gingivalis

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Periodontitis and adverse pregnancy outcomes: consensus report of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases

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Exploring the genetic basis of chronic periodontitis: a genome-wide association study

Divaris, K., Monda, K. L., North, K. E., Olshan, A. F., Reynolds, L. M., Hsueh, W.-C., Lange, E. M., MOSS, K. L., Barros, S. P., Weyant, R. J., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt065 · Cited by 249

Presence of Porphyromonas gingivalis in gingival squamous cell carcinoma

Katz, J., Onate, M. D., Pauley, K. M., Bhattacharyya, I., & Cha, S. (2011) · International Journal of Oral Science · doi:10.4248/ijos11075 · Cited by 246

Rat Model of Polymicrobial Infection, Immunity, and Alveolar Bone Resorption in Periodontal Disease

Kesavalu, L. N., Sathishkumar, S., Bakthavatchalu, V., Matthews, C. R., Dawson, D. R., Steffen, M. J., & Ebersole, J. L. (2007) · Infection and Immunity · doi:10.1128/iai.00733-06 · Cited by 246

Adverse pregnancy outcomes (APOs) and periodontal disease: pathogenic mechanisms

Madianos, P., Bobetsis, Y. A., & Offenbacher, S. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.1340015 · Cited by 243

Periodontal bacterial invasion and infection: contribution to atherosclerotic pathology

Reyes, L., Herrera, D., Kozarov, E., Roldán, S., & Progulske‐Fox, A. (2013) · Journal of Clinical Periodontology · doi:10.1111/jcpe.12079 · Cited by 237

The Link Between Periodontal Disease and Rheumatoid Arthritis: An Updated Review

Kozieł, J., Mydel, P. M., & Potempa, J. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-014-0408-9 · Cited by 235

Microbial Hijacking of Complement–Toll-Like Receptor Crosstalk

Wang, M., Krauss, J. L., Domon, H., Hosur, K. B., Liang, S., Magotti, P., Triantafilou, M., Triantafilou, K., Lambris, J. D., & Hajishengallis, G. (2010) · Science Signaling · doi:10.1126/scisignal.2000697 · Cited by 229

Interleukin-10 and Immunity against Prokaryotic and Eukaryotic Intracellular Pathogens

Cyktor, J. C., & Turner, J. (2011) · Infection and Immunity · doi:10.1128/iai.00047-11 · Cited by 227

Mouse model of experimental periodontitis induced by Porphyromonas gingivalis / Fusobacterium nucleatum infection: bone loss and host response

Polak, D., Wilensky, A., Shapira, L., Halabi, A., Goldstein, D., Weiss, E. I., & Houri‐Haddad, Y. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01393.x · Cited by 220

Historical and contemporary hypotheses on the development of oral diseases: are we there yet?

Rosier, B. T., de Jager, M., Zaura, E., & Krom, B. P. (2014) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2014.00092 · Cited by 214

The chronicles of Porphyromonas gingivalis: the microbium, the human oral epithelium and their interplay

Yilmaz, Ö. (2008) · Microbiology · doi:10.1099/mic.0.2008/021220-0 · Cited by 214

The American Journal of Cardiology and Journal of Periodontology Editors' Consensus: Periodontitis and Atherosclerotic Cardiovascular Disease††Published simultaneously in the Journal of Periodontology, the Official Journal of the American Academy of Periodontology.

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Porphyromonas gingivalis promotes Th17 inducing pathways in chronic periodontitis

Moutsopoulos, N. M., Kling, H. M., Angelov, N., Jin, W., Palmer, R. J., Jr., Nares, S., Osorio, M., & Wahl, S. M. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.03.003 · Cited by 212

Periodontitis and risk for atherosclerosis: an update on intervention trials

Tonetti, M. S. (2009) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2009.01417.x · Cited by 211

Denture Wearing during Sleep Doubles the Risk of Pneumonia in the Very Elderly

Iinuma, T., Arai, Y., Abe, Y., Takayama, M., Fukumoto, M., Fukui, Y., Iwase, T., Takebayashi, T., Hirose, N., Gionhaku, N., et al. (2014) · Journal of Dental Research · doi:10.1177/0022034514552493 · Cited by 204

How has neutrophil research improved our understanding of periodontal pathogenesis?

Nussbaum, G., & Shapira, L. (2011) · Journal Of Clinical Periodontology · doi:10.1111/j.1600-051x.2010.01678.x · Cited by 203

Comparison of neutrophil functions in aggressive and chronic periodontitis

Ryder, M. I. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00327.x · Cited by 199

Active Invasion of Oral and Aortic Tissues by Porphyromonas gingivalis in Mice Causally Links Periodontitis and Atherosclerosis

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Fimbrial Proteins of Porphyromonas gingivalis Mediate In Vivo Virulence and Exploit TLR2 and Complement Receptor 3 to Persist in Macrophages

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The role of T cells in periodontal disease: homeostasis and autoimmunity

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P. gingivalis accelerates gingival epithelial cell progression through the cell cycle

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Genetic Relationships between Respiratory Pathogens Isolated from Dental Plaque and Bronchoalveolar Lavage Fluid from Patients in the Intensive Care Unit Undergoing Mechanical Ventilation

Heo, S., Haase, E. M., Lesse, A. J., Gill, S. R., & Scannapieco, F. A. (2008) · Clinical Infectious Diseases · doi:10.1086/593193 · Cited by 189

Reducing the risk of CVD in patients with periodontitis

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Fusobacterium nucleatum Induces Fetal Death in Mice via Stimulation of TLR4-Mediated Placental Inflammatory Response

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Porphyromonas gingivalis Bacteremia Induces Coronary and Aortic Atherosclerosis in Normocholesterolemic and Hypercholesterolemic Pigs

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Role for Periodontitis in the Progression of Lipid Deposition in an Animal Model

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Biphasic Effect of Gingipains from Porphyromonas gingivalis on the Human Complement System

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Microbial Carriage State of Peripheral Blood Dendritic Cells (DCs) in Chronic Periodontitis Influences DC Differentiation, Atherogenic Potential

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Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4′-phosphatase activities

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The C5a Receptor Impairs IL-12–Dependent Clearance of Porphyromonas gingivalis and Is Required for Induction of Periodontal Bone Loss

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Neutrophil Homeostasis and Periodontal Health in Children and Adults

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ATP scavenging by the intracellular pathogen Porphyromonas gingivalis inhibits P2X 7 -mediated host-cell apoptosis

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Porphyromonas gingivalis Participates in Pathogenesis of Human Abdominal Aortic Aneurysm by Neutrophil Activation. Proof of Concept in Rats

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Hemin-Dependent Modulation of the Lipid A Structure of Porphyromonas gingivalis Lipopolysaccharide

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Oral Hygiene Reduces the Mortality from Aspiration Pneumonia in Frail Elders

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Quantifying oral inflammatory load: oral neutrophil counts in periodontal health and disease

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Porphyromonas gingivalisinfection sequesters pro-apoptotic Bad through Akt in primary gingival epithelial cells

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Structural Dissection and In Vivo Effectiveness of a Peptide Inhibitor of Porphyromonas gingivalis Adherence to Streptococcus gordonii

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Induction of Bone Loss by Pathobiont-Mediated Nod1 Signaling in the Oral Cavity

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Porphyromonas gingivalis and Treponema denticola Exhibit Metabolic Symbioses

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Porphyromonas gingivalis Induction of MicroRNA-203 Expression Controls Suppressor of Cytokine Signaling 3 in Gingival Epithelial Cells

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B7-H1 and B7-DC receptors of oral squamous carcinoma cells are upregulated by Porphyromonas gingivalis

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TLR2 Transmodulates Monocyte Adhesion and Transmigration via Rac1- and PI3K-Mediated Inside-Out Signaling in Response to Porphyromonas gingivalis Fimbriae

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Interpain A, a Cysteine Proteinase from Prevotella intermedia, Inhibits Complement by Degrading Complement Factor C3

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Pseudomonas aeruginosa –Induced Apoptosis Is Defective in Respiratory Epithelial Cells Expressing Mutant Cystic Fibrosis Transmembrane Conductance Regulator

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Porphyromonas gingivalis Peptidylarginine Deiminase, a Key Contributor in the Pathogenesis of Experimental Periodontal Disease and Experimental Arthritis

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Fimbria-dependent activation of pro-inflammatory molecules in Porphyromonas gingivalis infected human aortic endothelial cells

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Distinct Lipid A Moieties Contribute to Pathogen-Induced Site-Specific Vascular Inflammation

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Tobacco Smoke Augments Porphyromonas gingivalis - Streptococcus gordonii Biofilm Formation

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A Metalloproteinase Karilysin Present in the Majority of Tannerella forsythia Isolates Inhibits All Pathways of the Complement System

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Serine Lipids of Porphyromonas gingivalis Are Human and Mouse Toll-Like Receptor 2 Ligands

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Porphyromonas gingivalisinduces its uptake by human macrophages and promotes foam cell formation in vitro

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A Novel Class of Lipoprotein Lipase-Sensitive Molecules Mediates Toll-Like Receptor 2 Activation by Porphyromonas gingivalis

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Periodontal disease and subgingival microbiota as contributors for rheumatoid arthritis pathogenesis

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Porphyromonas gingivalis Mediates Inflammasome Repression in Polymicrobial Cultures through a Novel Mechanism Involving Reduced Endocytosis

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Pathogen-Mediated Inflammatory Atherosclerosis Is Mediated in Part via Toll-Like Receptor 2-Induced Inflammatory Responses

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Temperature-Dependent Modulation of Porphyromonas gingivalis Lipid A Structure and Interaction with the Innate Host Defenses

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Targeting of DC-SIGN on Human Dendritic Cells by Minor Fimbriated Porphyromonas gingivalis Strains Elicits a Distinct Effector T Cell Response

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Lipid raft-dependent uptake, signalling and intracellular fate ofPorphyromonas gingivalisin mouse macrophages

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Suppression of T-Cell Chemokines by Porphyromonas gingivalis

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The Native 67-Kilodalton Minor Fimbria of Porphyromonas gingivalis Is a Novel Glycoprotein with DC-SIGN-Targeting Motifs

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Anti-cardiolipin Antibodies in Sera from Patients with Periodontitis

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Protective Role for TLR4 Signaling in Atherosclerosis Progression as Revealed by Infection with a Common Oral Pathogen

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Porphyromonas gingivalis antagonises Campylobacter rectus induced cytokine production by human monocytes

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Inactivation of Epidermal Growth Factor by Porphyromonas gingivalis as a Potential Mechanism for Periodontal Tissue Damage

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TLR2 Signaling and Th2 Responses Drive Tannerella forsythia-Induced Periodontal Bone Loss

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CXCR4, a Key Modulator of Vascular Progenitor Cells

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Association between periodontitis and anti‐cardiolipin antibodies in Buerger disease

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Structure of Factor H-binding Protein B (FhbB) of the Periopathogen, Treponema denticola

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The Atherogenic BacteriumPorphyromonas gingivalisEvades Circulating Phagocytes by Adhering to Erythrocytes

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Porphyromonas gingivalis modulates Pseudomonas aeruginosa-induced apoptosis of respiratory epithelial cells through the STAT3 signaling pathway

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Porphyromonas gingivalis lipopolysaccharide increases lipid accumulation by affecting CD36 and ATP-binding cassette transporter A1 in macrophages

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Porphyromonas gingivalis Lipid A Phosphatase Activity Is Critical for Colonization and Increasing the Commensal Load in the Rabbit Ligature Model

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Anticardiolipin in Porphyromonas gingivalis Antisera Causes Fetal Loss in Mice

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