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Understanding nucleosome dynamics and their links to gene expression and DNA replication
Open accessAbstract
Advances in genomics technology have provided the means to probe myriad chromatin interactions at unprecedented spatial and temporal resolution. This has led to a profound understanding of nucleosome organization within the genome, revealing that nucleosomes are highly dynamic. Nucleosome dynamics are governed by a complex interplay of histone composition, histone post-translational modifications, nucleosome occupancy and positioning within chromatin, which are influenced by numerous regulatory factors, including general regulatory factors, chromatin remodellers, chaperones and polymerases. It is now known that these dynamics regulate diverse cellular processes ranging from gene transcription to DNA replication and repair.
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Metadata
- Authors
- Lai, W. K. M., & Pugh, B. F.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Pugh, B. Franklin
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2017-05-24
- Volume
- 18
- Issue
- 9
- Pages
- 548-562
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- PMC
- PMC5831138
- OpenAlex
- W2618569629
- Cited by
- 495
- References
- 178
- Citations by year
- 2026: 36 · 2025: 54 · 2024: 55 · 2023: 46 · 2022: 54 · 2021: 63 · 2020: 61 · 2019: 66 · 2018: 53 · 2017: 7
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of General Medical Sciences (R01GM059055)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Keywords
- nucleosome dynamics, nucleosome positioning, nucleosome occupancy, chromatin structure, histone modifications, histone composition, chromatin remodeling, gene transcription, DNA replication, DNA repair, polymerase
- MeSH terms
- Animals, Chromatin, DNA Repair, DNA Replication, Gene Expression Regulation, Humans, Nucleosomes, Protein Processing, Post-Translational, Transcription, Genetic, Histone Code
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