The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Helping Wingless take flight: how WNT proteins are secreted
Abstract
How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The porcupine protein has been shown to play an important role in the palmitolation of the Wnt proteins, and their secretion is regulated by the wntless or evenness interrupted proteins and the retromer complex.11–14”
From Wnt signal transduction pathways (2008) · cites this paper as [13]
Citations
Cites
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359
Rijsewijk, F. A. M., Schuermann, M., Wagenaar, E., Parren, P. W. H. I., Weigel, D., & Nusse, R. (1987) · Cell · doi:10.1016/0092-8674(87)90038-9 · Cited by 931
Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion
Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., & Takada, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.003 · Cited by 809
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764
Self-citationDirect and Long-Range Action of a Wingless Morphogen Gradient
Zecca, M., Basler, K., & Struhl, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81991-1 · Cited by 732
Self-citationLipoprotein particles are required for Hedgehog and Wingless signalling
Panáková, D., Sprong, H., Marois, É., Thiele, C., & Eaton, S. (2005) · Nature · doi:10.1038/nature03504 · Cited by 703
Flagged first, then by citations
Research works printed but not linked: 1
- Miller, J. R. The Wnts. Genome Biol. 3, reviews3001.1–reviews3001.15 (2002).
Cited by
Sorted by citations
Items 101–148 of 148
The Exocytic Pathway and Development
Schotman, H., & Rabouille, C. (2009) · Springer eBooks · doi:10.1007/978-0-387-93877-6_20 · Cited by 5
Sokol, S. Y., & Wharton, K. A. (2007) · Development · doi:10.1242/dev.008169 · Cited by 6
Sun, M., Zhu, H., Yu, Y., Yao, Y., Li, H.-Y., Feng, F., Wang, Q., Liu, R.-J., & Sun, C.-G. (2025) · International Journal of Oncology · doi:10.3892/ijo.2025.5742 · Cited by 8
Advancement of Wnt signal pathway and the target of breast cancer
Liang, Q., Li, W., Zhao, Z., & Fu, Q. (2016) · Open Life Sciences · doi:10.1515/biol-2016-0013 · Cited by 5
Michaux, G., & Borgne, R. L. (2009) · médecine/sciences · doi:10.1051/medsci/2009256-7617 · Cited by 4
Han, J., & Na, K. (2011) · InTech eBooks · doi:10.5772/21221 · Cited by 3
Kiewisz, J., Pawłowska, A., Winiarska, A., Perkowska‐Ptasińska, A., Skowrońska, A., Godlewski, J., Kmieć, Z., & Stompór, T. P. (2021) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/143543 · Cited by 2
Vitamin D and Wnt/β-Catenin Signaling
González‐Sancho, J. M., Larriba, M. J., & Múñoz, A. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-381978-9.10013-7 · Cited by 2
Ferrying Wingless across the Synaptic Cleft
Zarnescu, D. C., & Zinsmaier, K. E. (2009) · Cell · doi:10.1016/j.cell.2009.09.032 · Cited by 2
The TRPP Signaling Module: TRPP2/Polycystin-1 and TRPP2/PKD1L1
Hofherr, A. (2012) · Methods in pharmacology and toxicology · doi:10.1007/978-1-62703-077-9_10 · Cited by 2
Roles of Retromer Complex and SNX Protein Family in Development and Diseases
Li, X., YanZe, S. O. N. G., Wu, Y., Lin, X.-H., LiBo, S. U., & Shen, C. (2016) · Scientia Sinica Vitae · doi:10.1360/n052015-00221 · Cited by 1
Linke, F. (2016) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-5710 · Cited by 2
Leichtweis, K. S., Predes, D., Carvalho, M., Mauricio, H., de Jesus, B. S. M., Charlier, C. F., da Silva, R. C., Passos, G. F., Oliveira, L. F. S., Nogueira, C. O., et al. (2025) · Pharmaceuticals · doi:10.3390/ph18111680 · Cited by 1
Beyond the target: implications of Wnt pathway inhibitors on bone health
Nachef, C., Vanjak, A., Haÿ, E., Cohen-Solal, M. E., & Funck‐Brentano, T. (2026) · Journal of Molecular Medicine · doi:10.1007/s00109-026-02697-3 · Cited by 2
The Wnt signaling network in cancer
Apfel-Starke, J., Parikh, J. R., Reischmann, P., Ewing, R. M., Müller, O. J., Xia, Y., & Dominguez, I. M. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9780511979811.016 · Cited by 2
Matrix Biology: Gradients and Patterns within the Extracellular Matrix
Domowicz, M. S., Cortes, M., & Schwartz, N. B. (2015) · Royal Society of Chemistry eBooks · doi:10.1039/9781839168956-00031 · Cited by 1
Post-translational modifications and secretion of Wnt proteins
Lu, Y. (2018) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2018.09.001824 · Cited by 1
Liu, C., Régimbald‐Dumas, Y., Zhang, X., & He, X. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-394447-4.30008-6 · Cited by 1
Fontenete, S., Christensen, J., Martínez-Silgado, A., Zarzuela, E., Muñoz, J., Megı́as, D., Castellana, D., Loewe, R. P., & Pérez‐Moreno, M. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.17.209338 · Cited by 1
Functional networks of events that modulate phenotypic manifestation of cancer
Thiagalingam, S. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9780511979811.012
Arató, K. (2010) · Repositori digital de la UPF (Universitat Pompeu Fabra)
Kritikou, E. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2345
Deciphering the Wingless gradient
Neame, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2644
Molecular interactions underlying neuronal ceroid lipofuscinoses CLN1 and CLN5
Lyly, A. (2008) · Työväentutkimus Vuosikirja
Investigating the role of WNTless (Wls) in wingless (Wg) gradient formation
Basiri, B. (2012) · Library, Museums and Press - UDSpace (University of Delaware)
deux acteurs clés de la signalisation WNT
Michaux, G., & Borgne, R. L. (2009)
Applied molecular recognition of HECA-452 and Wnt5a in pathological inflammation.
Kummitha, C. M. (2010) · OhioLink ETD Center (Ohio Library and Information Network)
Katoh, M. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139046947.021
Mesodermal Differentiation of Skin-derived Precursor cells
Lavoie, J.-F. (2010) · TSpace (University of Toronto)
Bhatia, T. N., Ghumatkar, P. J., & Sathaye, S. S. (2016) · IOSR Journal of Pharmacy and Biological Sciences · doi:10.9790/3008-1105028797
Turki, R. (2012) · QSpace (Queen's University Library)
The Search for Novel Wnt Pathway Modulators
Poliszczuk, P. (2011) · TSpace (University of Toronto)
Ramachandran, P. (2009) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/e8pg-tq46
The Role of Wnt/Beta-Catenin Pathway, SATB1 and SATB2 in Endometrial Cancer PatientsPreprint
Sadłecki, P., Bodnar, M., Marszałek, A., & Walentowicz‐Sadlecka, M. (2021) · Preprints.org · doi:10.20944/preprints202109.0105.v1
Ghosh, N., Chatterjee, S., & Sil, P. C. (2021) · Springer eBooks · doi:10.1007/978-3-030-57401-7_230
Katoh, M. (2008) · AfCS-Nature Molecule Pages · doi:10.1038/mp.a002375.01
Ghosh, N., Chatterjee, S., & Sil, P. C. (2021) · Springer eBooks · doi:10.1007/978-3-030-21573-6_230-1
Role of Wnt Ligand Secretion Mediator Signaling in Cancer Development
Chuang, K., Wang, L., & Hsu, S. (2023) · Journal of Cancer Research and Practice · doi:10.4103/ejcrp.ejcrp-d-22-00029
Strope, A. M., Phillips, C., Khadgi, S., Jenkinson, S. A., Coschigano, K. T., & Malgor, R. (2024) · PubMed · doi:10.14670/hh-18-723
Mebarki, S. (2013) · theses.fr (ABES) · doi:10.70675/4ef645b5z7dc2z4553zac58zecf84e9d2c83
Role of Wnt signaling in the polarization of neuronal precursors in the C. elegans embryo
Kaur, S. (2018) · theses.fr (ABES) · doi:10.70675/2f0f57b8z5525z48a8z9c69z90d6e94c149b
Voie de signalisation WNT/ β-catenin et différenciation des cellules germinales chez les mammifères
Rolle, M. L. (2019) · theses.fr (ABES) · doi:10.70675/fe50a059z8f58z4591za5e0zd9c9260561e5
Blandin, C. (2023) · theses.fr (ABES) · doi:10.70675/bedafc9ez5195z4b52z913bz548743c18b89
GPC6 Lipid Shielding Sustains WNT5A Gradients to Prevent a RASopathy-like Developmental StatePreprint
Kim, Y., Zhao, Y., Xu, A. X., Nakhuda, A., Androniciuc, A.-M., Tenin, G., Keavney, B. D., Jones, E. Y., & McGough, I. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.20.752969
BindingDB Entry 50046836: The use of porcupine inhibitors to target Wnt-driven cancers.
BindingDB (2016) · UC San Diego · doi:10.7270/q21838c2
Korkut, C. (2012) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/vqef-8314
Metadata
- Authors
- Hausmann, G., Bänziger, C., & Basler, K.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Basler, Konrad
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-03-07
- Volume
- 8
- Issue
- 4
- Pages
- 331-336
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2065824248
- Cited by
- 147
- References
- 59
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 5 · 2016: 11 · 2015: 12 · 2014: 7 · 2013: 11 · 2012: 10
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt secretion, Wnt signaling, EVI, SRT, retromer complex, lipoprotein particles, protein secretion mechanism
- MeSH terms
- Animals, Golgi Apparatus, Humans, Lipoproteins, Membrane Proteins, Models, Biological, Endosomes, Signal Transduction, Protein Transport, Wnt Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
