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Helping Wingless take flight: how WNT proteins are secreted
Abstract
How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.
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“The porcupine protein has been shown to play an important role in the palmitolation of the Wnt proteins, and their secretion is regulated by the wntless or evenness interrupted proteins and the retromer complex.11–14”
From Wnt signal transduction pathways (2008) · cites this paper as [13]
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Metadata
- Authors
- Hausmann, G., Bänziger, C., & Basler, K.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Basler, Konrad
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-03-07
- Volume
- 8
- Issue
- 4
- Pages
- 331-336
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2065824248
- Cited by
- 147
- References
- 59
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 5 · 2016: 11 · 2015: 12 · 2014: 7 · 2013: 11 · 2012: 10
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt secretion, Wnt signaling, EVI, SRT, retromer complex, lipoprotein particles, protein secretion mechanism
- MeSH terms
- Animals, Golgi Apparatus, Humans, Lipoproteins, Membrane Proteins, Models, Biological, Endosomes, Signal Transduction, Protein Transport, Wnt Proteins
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