The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Helping Wingless take flight: how WNT proteins are secreted
Abstract
How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.
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“The porcupine protein has been shown to play an important role in the palmitolation of the Wnt proteins, and their secretion is regulated by the wntless or evenness interrupted proteins and the retromer complex.11–14”
From Wnt signal transduction pathways (2008) · cites this paper as [13]
Citations
Cites
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568
The Wnt Signaling Pathway in Development and Disease
Logan, C. Y., & Nusse, R. (2004) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.20.010403.113126 · Cited by 5,325
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257
Nusse, R., & VARMUS, H. E. (1982) · Cell · doi:10.1016/0092-8674(82)90409-3 · Cited by 1,864
Veeman, M. T., Axelrod, J. D., & Moon, R. T. (2003) · Developmental Cell · doi:10.1016/s1534-5807(03)00266-1 · Cited by 1,359
Rijsewijk, F. A. M., Schuermann, M., Wagenaar, E., Parren, P. W. H. I., Weigel, D., & Nusse, R. (1987) · Cell · doi:10.1016/0092-8674(87)90038-9 · Cited by 931
Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion
Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T., & Takada, S. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.10.003 · Cited by 809
Bänziger, C., Soldini, D., Schütt, C., Zipperlen, P., Hausmann, G., & Basler, K. (2006) · Cell · doi:10.1016/j.cell.2006.02.049 · Cited by 764
Self-citationDirect and Long-Range Action of a Wingless Morphogen Gradient
Zecca, M., Basler, K., & Struhl, G. (1996) · Cell · doi:10.1016/s0092-8674(00)81991-1 · Cited by 732
Self-citationLipoprotein particles are required for Hedgehog and Wingless signalling
Panáková, D., Sprong, H., Marois, É., Thiele, C., & Eaton, S. (2005) · Nature · doi:10.1038/nature03504 · Cited by 703
Research works printed but not linked: 1
- Miller, J. R. The Wnts. Genome Biol. 3, reviews3001.1–reviews3001.15 (2002).
Cited by
Sorted by citations
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
MacDonald, B. T., Tamai, K., & He, X. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.016 · Cited by 5,583
Wnt signal transduction pathways
Komiya, Y., & Habas, R. (2008) · Organogenesis · doi:10.4161/org.4.2.5851 · Cited by 1,528
Wnt signalling and its impact on development and cancer
Klaus, A., & Birchmeier, W. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2389 · Cited by 1,595
Grigoryan, T., Wend, P., Klaus‐Bergmann, A., & Birchmeier, W. (2008) · Genes & Development · doi:10.1101/gad.1686208 · Cited by 573
Linking Aβ and Tau in Late-Onset Alzheimer's Disease: A Dual Pathway Hypothesis
Small, S. A., & Duff, K. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.007 · Cited by 546
Metadata
- Authors
- Hausmann, G., Bänziger, C., & Basler, K.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Basler, Konrad
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-03-07
- Volume
- 8
- Issue
- 4
- Pages
- 331-336
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2065824248
- Cited by
- 147
- References
- 59
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 5 · 2016: 11 · 2015: 12 · 2014: 7 · 2013: 11 · 2012: 10
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Wnt secretion, Wnt signaling, EVI, SRT, retromer complex, lipoprotein particles, protein secretion mechanism
- MeSH terms
- Animals, Golgi Apparatus, Humans, Lipoproteins, Membrane Proteins, Models, Biological, Endosomes, Signal Transduction, Protein Transport, Wnt Proteins
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