Cited by 148Wnt/β-catenin signaling in development and cancerDrug Transport and Resistance MechanismsDevelopmental Biology and Gene Regulation

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Helping Wingless take flight: how WNT proteins are secreted

Hausmann, George, Bänziger, Carla, Basler, Konrad·2007·Nature Reviews Molecular Cell Biology

DOI 10.1038/nrm2141

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Abstract

How functional WNT proteins are made and how their secretion is regulated is becoming a focal point for the WNT-signalling field. Recently, lipoprotein particles, WNT lipid modifications, the conserved transmembrane protein Wntless (WLS; also known as EVI and SRT) and the retromer complex have been implicated in WNT secretion. Our aim is to synthesize ideas from these new findings for the mechanisms that underlie WNT secretion.

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Authors: Hausmann, G., Bänziger, C., & Basler, K.
Affiliations: University of Zurich (CH)
Corresponding author: Basler, Konrad
ORCID: Hausmann, George
Basler, Konrad
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2007-03-07
Volume: 8
Issue: 4
Pages: 331-336
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2141
OpenAlex: W2065824248
Cited by: 147
References: 59
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 5 · 2022: 3 · 2021: 9 · 2020: 3 · 2019: 4 · 2018: 5 · 2016: 11 · 2015: 12 · 2014: 7 · 2013: 11 · 2012: 10
FWCI: 1.18
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: Wnt secretion, Wnt signaling, EVI, SRT, retromer complex, lipoprotein particles, protein secretion mechanism
MeSH terms: Animals, Golgi Apparatus, Humans, Lipoproteins, Membrane Proteins, Models, Biological, Endosomes, Signal Transduction, Protein Transport, Wnt Proteins

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Helping Wingless take flight: how WNT proteins are secreted

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