The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Werner and Hutchinson–Gilford progeria syndromes: mechanistic basis of human progeroid diseases
Abstract
Progeroid syndromes have been the focus of intense research in part because they might provide a window into the pathology of normal ageing. Werner syndrome and Hutchinson-Gilford progeria syndrome are two of the best characterized human progeroid diseases. Mutated genes that are associated with these syndromes have been identified, mouse models of disease have been developed, and molecular studies have implicated decreased cell proliferation and altered DNA-damage responses as common causal mechanisms in the pathogenesis of both diseases.
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In the citing paper
“The aberrantly processed protein produced is called progerin, a truncated form of lamin A with a hydrophobic farnesylated C-terminal 105–112.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [107]
In the citing paper
“Hutchison-Gilford progeria syndrome (HGPS) patients suffer from a variety of laminopathy ailments due to a sporadic deficiency in the proteolytic processing of the precursor form of lamin A into the mature protein.”
From Xeroderma Pigmentosa Group A (XPA), Nucleotide Excision Repair and Regulation by ATR in Response to Ultraviolet Irradiation (2017) · cites this paper as [107]
In the citing paper
“Interestingly, HGPS and RD are laminopathy-based diseases; they arise not from mutated DNA metabolism genes but from mutations causing altered processing/maturation of lamin A, an intermediate-filament protein component of the nuclear lamina [6,11-16].”
From Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A (2009) · cites this paper as [6]
In the citing paper
“Progerin and FC-prelamin A, the mutant forms of lamin A in HGPS and RD cells, respectively (Figure 1; [6,11-16]), are known to disrupt normal nuclear structure including the perinucleolar lamin A/C granules containing the replicative proteins PCNA and polymerase δ [33].”
From Genomic instability and DNA damage responses in progeria arising from defective maturation of prelamin A (2009) · cites this paper as [6]
In the citing paper
“Nonetheless, changes in chromatin state have been strongly implicated in ageing by progeroid syndromes, which disrupt the nuclear lamina and its associated regulation of heterochromatin structure142,143.”
From Measuring biological age using omics data (2022) · cites this paper as [142]
In the citing paper
“Werner syndrome (WS) is a premature aging disorder caused by WRN protein deficiency.”
From A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging (2015) · cites this paper as [1]
Citations
Cites
Friedberg, E. C., Walker, G. C., Siede, W., Wood, R. D., Schultz, R. A., & Ellenberger, T. (2005) · doi:10.1128/9781555816704 · Cited by 5,683
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors
Campisi, J. (2005) · Cell · doi:10.1016/j.cell.2005.02.003 · Cited by 2,379 · cited 1×
“Therefore, the pathogenesis of WS might reflect the progressive accumulation of mutant or senescent cells that have lost cell-specific functions, as well as trophic or regulatory interactions with adjacent epithelial or stromal cell”
BackgroundRecurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
Eriksson, M., Brown, W. T., Gordon, L. B., Glynn, M. W., Singer, J., Scott, L., Erdos, M. R., Robbins, C. M., Moses, T. Y., Berglund, P., et al. (2003) · Nature · doi:10.1038/nature01629 · Cited by 1,990
The stem-cell niche as an entity of action
Scadden, D. T. (2006) · Nature · doi:10.1038/nature04957 · Cited by 1,902
Positional Cloning of the Werner's Syndrome Gene
Yu, C., Oshima, J., Fu, Y., Wijsman, E. M., Hisama, F. M., Alisch, R. S., Matthews, S., Nakura, J., Miki, T., Ouais, S. G., et al. (1996) · Science · doi:10.1126/science.272.5259.258 · Cited by 1,705
Lamin a truncation in Hutchinson-Gilford progeria
De Sandre-Giovannoli, A., Bernard, R., Cau, P., Navarro, C., Amiel, J., Boccaccio, I., Lyonnet, S., Stewart, C. L., Munnich, A., Le Merrer, M., et al. (2003) · Science · doi:10.1126/science.1084125 · Cited by 1,346
The plasticity of aging: insights from long-lived mutants
Kenyon, C. (2005) · Cell · doi:10.1016/j.cell.2005.02.002 · Cited by 1,338
Loss of a-Type Lamin Expression Compromises Nuclear Envelope Integrity Leading to Muscular Dystrophy
Sullivan, T. L., Escalante‐Alcalde, D., Bhatt, H., Anver, M. R., BHAT, N. K., Nagashima, K., Stewart, C. L., & Burke, B. E. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.147.5.913 · Cited by 1,197
Lamin A-dependent nuclear defects in human aging
Scaffidi, P., & Misteli, T. (2006) · Science · doi:10.1126/science.1127168 · Cited by 1,125
Lamin A/C deficiency causes defective nuclear mechanics and mechanotransduction
Lammerding, J., Schulze, P. C., Takahashi, T., Kozlov, S. V., Sullivan, T. L., Kamm, R. D., Stewart, C. L., & Lee, R. T. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419670 · Cited by 1,105
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- Schellenberg, G. D., Miki, T. Yu, C. E. & Nakura, J. in The Metabolic and Molecular Basis of Inherited Disease (eds Scriver, C. R., Beaudet, A. L., Sly, W. S. & Valle, D.) 785–797 (McGraw-Hill, New York, 2001).
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Dechat, T., Pfleghaar, K., Sengupta, K., Shimi, T., Shumaker, D. K., Solimando, L., & Goldman, R. D. (2008) · Genes & Development · doi:10.1101/gad.1652708 · Cited by 940
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Liu, G.-H., Barkho, B. Z., Ruiz, S., Diep, D., Qu, J., Yang, S.-L., Panopoulos, A. D., Suzuki, K., Kurian, L., Walsh, C., et al. (2011) · Nature · doi:10.1038/nature09879 · Cited by 575
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Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., et al. (2015) · Science · doi:10.1126/science.aaa1356 · Cited by 551
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Resurrection of endogenous retroviruses during aging reinforces senescence
Liu, X., Liu, Z., Wu, Z., Ren, J., Fan, Y., Sun, L., Cao, G., Niu, Y., Zhang, B., Ji, Q., et al. (2023) · Cell · doi:10.1016/j.cell.2022.12.017 · Cited by 390
Progeria syndromes and ageing: what is the connection?
Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386
Self-citationRagnauth, C. D., Warren, D. T., Liu, Y., McNair, R., Tajsic, T., Figg, N., Shroff, R., Skepper, J., & Shanahan, C. M. (2010) · Circulation · doi:10.1161/circulationaha.109.902056 · Cited by 350
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Liu, G.-H., Qu, J., Suzuki, K., Nivet, E., Li, M., Montserrat, N., Yi, F., Xu, X., Ruiz, S., Zhang, W., et al. (2012) · Nature · doi:10.1038/nature11557 · Cited by 339
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Gravina, S., & Vijg, J. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-009-0730-7 · Cited by 329
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Ren, R., Ocampo, A., Liu, G., & Belmonte, J. C. I. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.019 · Cited by 286
Yoshida, H., Nagaoka, A., Kusaka-Kikushima, A., Tobiishi, M., Kawabata, K., Sayo, T., Sakai, S., Sugiyama, Y., Enomoto, H., Okada, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1215432110 · Cited by 265
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Wu, Y., & Brosh, R. M. (2010) · FEBS Journal · doi:10.1111/j.1742-4658.2010.07760.x · Cited by 265
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Jones, D. L., & Rando, T. A. (2011) · Nature Cell Biology · doi:10.1038/ncb0511-506 · Cited by 256
Chen, C., Chi, Y., Mutalif, R., Starost, M. F., Myers, T. G., Anderson, S. A., Stewart, C. L., & Jeang, K. (2012) · Cell · doi:10.1016/j.cell.2012.01.059 · Cited by 221
Verstraeten, V. L. R. M., Ji, J. Y., Cummings, K., Lee, R. T., & Lammerding, J. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2008.00382.x · Cited by 223
Barascu, A., Le Chalony, C., Pennarun, G., Genet, D., Imam, N., Lopez, B., & Bertrand, P. (2012) · The EMBO Journal · doi:10.1038/emboj.2011.492 · Cited by 206
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Aging by epigenetics—A consequence of chromatin damage?
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Kudlow, B. A., Stanfel, M. N., Burtner, C. R., Johnston, E. D., & Kennedy, B. K. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0492 · Cited by 125
Self-citationMusich, P. R., & Zou, Y. (2009) · Aging · doi:10.18632/aging.100012 · Cited by 117
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Roos, A., Buchkremer, S., Kollipara, L., Labisch, T., Gatz, C., Zitzelsberger, M., Brauers, E., Nolte, K. W., Schröder, J. M., Kirschner, J., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1224-4 · Cited by 65
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Doherty, E. L., Aw, W. Y., Hickey, A. J., & Polacheck, W. J. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.624435 · Cited by 53
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Self-citation
Metadata
- Authors
- Kudlow, B. A., Kennedy, B. K., & Monnat, R. J.
- Affiliations
- University of Washington (US)
- Corresponding author
- Kennedy, Brian K.
- Monnat, Raymond J.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-05
- Volume
- 8
- Issue
- 5
- Pages
- 394-404
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W2163819508
- Cited by
- 304
- References
- 110
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 12 · 2023: 12 · 2022: 17 · 2021: 11 · 2020: 14 · 2019: 13 · 2018: 18 · 2017: 12 · 2016: 17 · 2015: 14 · 2014: 10 · 2013: 14 · 2012: 14
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Werner syndrome, Hutchinson-Gilford progeria syndrome, progeroid syndromes, premature aging, DNA damage response, cell proliferation, mouse models of human disease, genetic mutations, normal aging
- MeSH terms
- Werner Syndrome Helicase, Aging, Animals, Disease Models, Animal, DNA Damage, Exodeoxyribonucleases, Humans, Models, Biological, Phenotype, Progeria, Protein Processing, Post-Translational, Werner Syndrome, Lamin Type A, RecQ Helicases
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