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The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Insulin-like growth factor 1 treatment extends longevity in a mouse model of human premature aging by restoring somatotroph axis function

Mariño, Guillermo, Ugalde, Alejandro P., Fernández, Álvaro F., Osorio, Fernando G., Fueyo, Antonio, Freije, José M. P., López-Otín, Carlos·2010·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.1002696107
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Abstract

Zmpste24 (also called FACE-1) is a metalloproteinase involved in the maturation of lamin A, an essential component of the nuclear envelope. Zmpste24-deficient mice exhibit multiple defects that phenocopy human accelerated aging processes such as Hutchinson–Gilford progeria syndrome. In this work, we report that progeroid Zmpste24 -/ − mice present profound transcriptional alterations in genes that regulate the somatotroph axis, together with extremely high circulating levels of growth hormone (GH) and a drastic reduction in plasma insulin-like growth factor 1 (IGF-1). We also show that recombinant IGF-1 treatment restores the proper balance between IGF-1 and GH in Zmpste24 -/ − mice, delays the onset of many progeroid features, and significantly extends the lifespan of these progeroid animals. Our findings highlight the importance of IGF/GH balance in longevity and may be of therapeutic interest for devastating human progeroid syndromes associated with nuclear envelope abnormalities.

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Crossref · 10.1073/pnas.1002696107

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  • Restoration of the somatotrophic axis through hormonal treatments or inhibition of NF-κB signaling extends lifespan in progeroid mice.

    “Restoration of the somatotrophic axis through hormonal treatments or inhibition of NF-κB signaling also extends lifespan in these progeroid mice (Marino et al., 2010; Osorio et al., 2012).”

    From The Hallmarks of Aging (2013) · cites this paper as Marino et al., 2010

  • Stress pathways elicited by aberrations in the nuclear lamina characteristic of HGPS include activation of p53, deregulation of the somatotrophic axis, and attrition of adult stem cells.

    “These pathways include the activation of p53 (Varela et al., 2005), deregulation of the somatotrophic axis (Marino et al., 2010), and attrition of adult stem cells (Espada et al., 2008; Scaffidi and Misteli, 2008).”

    From The Hallmarks of Aging (2013) · cites this paper as Marino et al., 2010

  • In progeroid mice with very low levels of IGF-1, supplementation of IGF-1 can ameliorate premature aging.

    “there are cases of progeroid mice with very low levels of IGF-1, in which supplementation of IGF-1 can ameliorate premature aging”

    From The Hallmarks of Aging (2013) · cites this paper as Marino et al., 2010

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Metadata

Authors
Mariño, G., Ugalde, A. P., Fernández, Á. F., Osorio, F. G., Fueyo, A., Freije, J. M. P., & López-Otín, C.
Affiliations
  • Departamento de Bioquímica y Biología Molecular and
  • Biología Funcional, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, 33006 Oviedo, Spain
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2010-08-30
Volume
107
Issue
37
Pages
16268-16273
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.1002696107
Cited by
131
References
10
Language
en

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