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Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
Abstract
Nearly unlimited supplies of energy-dense foods and technologies that encourage sedentary behaviour have introduced a new threat to the survival of our species: obesity and its co-morbidities. Foremost among the co-morbidities is type 2 diabetes, which is projected to afflict 300 million people worldwide by 2020. Compliance with lifestyle modifications such as reduced caloric intake and increased physical activity has proved to be difficult for the general population, meaning that pharmacological intervention may be the only recourse for some. This epidemiological reality heightens the urgency for gaining a deeper understanding of the processes that cause metabolic failure of key tissues and organ systems in type 2 diabetes, as reviewed here.
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“More recent metabolomic studies now suggest that enhanced fat metabolism seen with high-fat feeding leads to high levels of β-oxidation products that alter mitochondria in a way that restrict the ability to switch to glucose oxidation (228).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [228]
In the citing paper
“Moreover, the importance of fuel selectivity is underscored by studies indicating that “metabolic inflexibility” or impaired capacity to switch between nutrient utilization, in particular between fatty acid and glucose oxidation, has a pathogenic role in the insulin resistance commonly seen in type 2 diabetes and obesity (228).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [228]
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Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
Nissen, S. E., & Wolski, K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072761 · Cited by 4,675
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639
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Mathematical models of mechanisms underlying long-term type 2 diabetes progression
Graham, E. J. (2012) · J. Willard Marriott Library · doi:10.26053/0h-aeh1-q5g0 · Cited by 4
Metabolomics and Transcriptomics of Metabolic Disorders
Paternain, L., & Campión, J. (2013) · Current Nutrition Reports · doi:10.1007/s13668-013-0062-2 · Cited by 4
X-box binding protein 1: A new metabolic mediator and drug target of metformin?
Lou, K., Sun, P., Zhang, C., Jiang, Q., & Pang, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1013218 · Cited by 3
Phytochemicals in Life Style Associated Human Diseases
Verma, H., Gangwar, P., Yadav, A., Yadav, B., Rao, R., Kumari, S., Kaur, S., Dhiman, M., & Mantha, A. K. (2025) · Advances in Science, Technology & Innovation/Advances in science, technology & innovation · doi:10.1007/978-3-031-80973-6_19 · Cited by 3
Feng, X., Li, R., Yan, M., Yuan, C., & Wu, Y. (2025) · Nutrients · doi:10.3390/nu17172870 · Cited by 3
Mlyneková, E., Zaťko, S., Halo, M., Imrich, I., & Halo, M. (2026) · Animals · doi:10.3390/ani16020267 · Cited by 3
Exercise modulates redox homeostasis in cardiovascular and metabolic diseases: from bench to clinic
Wang, J., Zhang, J., Zhang, H., Yu, F., Tian, Z., & Jia, D. (2026) · Cardiovascular Diabetology · doi:10.1186/s12933-026-03131-1 · Cited by 4
Gao, Y., Gao, C., Zhu, J., & Han, Y. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1774965 · Cited by 3
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Trandafir, M.-F., Savu, O., & Gheorghiu, M. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13133687 · Cited by 3
Rani, D., Priyadarshi, N., Singhal, N. K., & Goyal, B. (2025) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5c00269 · Cited by 3
Mapping cellular cytosolic pH in vivo under physiological and pathophysiological conditions
Zhang, S., Hu, X., Zhang, B., Liu, J., Feng, H., Liu, C., Hui, Y., Fang, Y., Liu, L., & Zhang, X. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110637 · Cited by 3
Singh, T., Kalamajski, S., Cunha, J. G. D., Hladkou, S., Roberts, F. L., Gheibi, S., Soltanian, A., Farahmand, K. Y., Ekström, O., Mamidi, A., et al. (2025) · Journal of Pineal Research · doi:10.1111/jpi.70073 · Cited by 3
Zhang, D., Sun, X., Wang, H., & Chen, L. (2025) · Foods · doi:10.3390/foods14223871 · Cited by 4
Perspectivas da terapia com células-tronco para o diabetes mellitus tipo 2
Leal, A. M. O., & Voltarelli, J. C. (2010) · Revista Brasileira de Hematologia e Hemoterapia · doi:10.1590/s1516-84842010005000088 · Cited by 3
Venkataraman, B., Jayaraman, S., Sathish, S., Mayilvanan, C., & Balasubramanian, K. (2012) · Journal of Evidence-Based Complementary & Alternative Medicine · doi:10.1177/2156587212460047 · Cited by 3
Oxidative and endoplasmic reticulum stress in b-cell dysfunction in diabetes
Hasnain, S. Z., Prins, J. B., & McGuckin, M. A. (2016) · Cited by 3
Gerazova‐Efremova, K., Dinevska-Ќovkarovska, S., Domazetovska, S., & Miova, B. (2020) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2020.102645 · Cited by 3
Balducci, S., Haxhi, J., Vitale, M., Mattia, L., Bollanti, L., Conti, F., Cardelli, P., Sacchetti, M., Orlando, G., Zanuso, S., et al. (2022) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2022.110140 · Cited by 3
Wang, Y., Wu, D., Wang, Y., Sun, J., Wang, X., Huang, Y., & Sun, M. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1339973 · Cited by 3
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Abdur, R., & Huang, Z. (2015) · Topics in medicinal chemistry · doi:10.1007/7355_2015_87 · Cited by 3
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Amaral, S., & Ramalho‐Santos, J. (2014) · Springer eBooks · doi:10.1007/978-3-642-30018-9_115 · Cited by 3
Lauenborg, J., JØRGENSEN, M. K., Damm, P., Major‐Pedersen, A., Eiberg, H., Urhammer, S. A., Pedersen, O. B., & Hansen, T. F. (2011) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.1111/j.1600-0412.2011.01276.x · Cited by 3
Effects of Dietary Lipid Intake on Diabetes
Kadegowda, A. K. G., & Yu, L. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-247-1.00006-5 · Cited by 5
Maternal Diet and Exercise: Influences on Obesity and Insulin Resistance
Carter, L. G., Tamashiro, K. L., & Pearson, K. J. (2014) · Oxidative stress and disease · doi:10.1201/b17530-4 · Cited by 3
Glucose enhances rat islet function via stimulating CART expression
Wan, X., Zhang, Y., Bai, M., Zhou, F., Deng, R., Ji, X., Zhang, J., Liu, Y., Zhou, L., & Wang, X. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.012 · Cited by 3
A Comparison of Biomarkers in the Assessment of Glycemic Control in Diabetes: Reviewing the Evidence
Aga, S. S., Banday, M. Z., Nissar, S., & Saeed, S. A. (2019) · Current Diabetes Reviews · doi:10.2174/1389557519666190408197922 · Cited by 3
Tabozzi, S. A., Santo, S. G. D., Franchini, F., Ratto, F., Luchi, M., Filiputti, B., Ardigò, L. P., & Lafortuna, C. L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00710 · Cited by 3
Islet isograft transplantation improves insulin sensitivity in a murine model of type 2 diabetes
Choi, M. Y., Lim, S. J., Kim, M. J., Wee, Y., Kwon, H., Jung, C. H., Kim, Y. H., Han, D. J., & Shin, S. H. (2021) · Endocrine · doi:10.1007/s12020-021-02655-8 · Cited by 3
Arvidsson, D., Lindblad, U., Sundquist, J., Sundquist, K., Groop, L., & Bennet, L. (2014) · Journal of Physical Activity and Health · doi:10.1123/jpah.2013-0222 · Cited by 3
Effect of Mediterranean Diet Components on Type 2 Diabetes and Metabolic Syndrome
Farooqui, A. A., & Farooqui, T. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-811959-4.00013-4 · Cited by 3
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Bombardier, É. (2010) · UWSpace (University of Waterloo) · Cited by 3
Optimizing nicotinic acid delivery for durable antilipolysis and improved metabolic control
Kroon, T. (2016) · Epsilon Open Archive (Sveriges lantbruksuniversitet biblioteket (Swedish University of Agricultural Sciences)) · Cited by 3
Zhang, Y., Yang, C., Liu, J., He, D., Zuo, J., Yan, L., Thring, R. W., Wu, M., Gao, Y., & Tong, H. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.26.116715 · Cited by 3
Adapting the NIMHD Research Framework for Type 2 Diabetes-Related Disparities
Díaz, M., Braxton, M. E., Owolabi, E. O., Godfrey, T. M., Singh, M., Rascón, A. M., & Shaibi, G. Q. (2025) · Current Diabetes Reports · doi:10.1007/s11892-025-01580-8 · Cited by 3
Jeong, M., McColl, T. J., & Clarke, D. C. (2025) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2025-0017 · Cited by 4
Sulaj, A., Nguyen, P., Poschet, G., Kliemank, E., Fleming, T., Henke, L., Neibig, W., Kopf, S., Hell, R., Longo, V. D., et al. (2025) · Molecular Metabolism · doi:10.1016/j.molmet.2025.102257 · Cited by 2
Dinatale, B., González, F. B., Bottasso, O., & Pérez, A. R. (2026) · Seminars in Immunology · doi:10.1016/j.smim.2026.102028 · Cited by 2
Nurlybek, T., Altaeva, N., Kazhiyakhmetova, B., Seitkumarova, Z., Baidildina, Y., Vizigina, A., & Kashkinbayev, Y. (2026) · Biology · doi:10.3390/biology15100794 · Cited by 2
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Nyman, E., Strålfors, P., & Cedersund, G. (2011) · Springer eBooks · doi:10.1007/978-3-7091-0418-7_14 · Cited by 2
He, E. C. L. (2014) · Pediatrics & Therapeutics · doi:10.4172/2161-0665.1000200 · Cited by 2
Jeong, J. W., Kim, M., Lee, J., Lee, H.-K., Ko, Y., Kim, H.-K., & Fang, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113824 · Cited by 3
Inducing and measuring apoptotic cell death in mouse pancreatic β-cells and in isolated islets
McKimpson, W. M., & Kitsis, R. N. (2022) · STAR Protocols · doi:10.1016/j.xpro.2022.101287 · Cited by 2
Araújo, T. R., Santiago, D., Simões, P., Guimarães, F., Zoppi, C. C., & Carneiro, E. M. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-93337-1_28 · Cited by 2
Kim, Y. (2022) · PLoS ONE · doi:10.1371/journal.pone.0274794 · Cited by 2
Effects of fish oil on insulin resistance in the brains of rats with alcoholic liver damage
Liu, Z., Xiao, Q., Chen, Y.-H., Shirakawa, H., Lai, J.-H., Chiang, Y. H., & Yang, S. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106369 · Cited by 2
Mrosewski, I., Mantel, V., Urbank, M., Schulze-Tanzil, G. G., Werner, C., Gögele, C., Kokozidou, M., & Bertsch, T. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e40826 · Cited by 2
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Kömürcü-Bayrak, E. (2012) · InTech eBooks · doi:10.5772/51595 · Cited by 2
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Oslowski, C. M. (2012) · The Journal of the American Medical Association (JAMA) Network (American Medical Association) · doi:10.13028/mj81-rb58 · Cited by 2
Lugli, A. K., Donatelli, F., Schricker, T., Wykes, L., & Carli, F. (2011) · Nutrition and Cancer · doi:10.1080/01635581.2011.587228 · Cited by 2
Chen, C. A., Carolan, P. C., & Annes, J. P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044600 · Cited by 2
Effects of the High Calorie Diet on the Development of Chronic Visceral Disease
Farooqui, A. A. (2015) · Springer eBooks · doi:10.1007/978-3-319-15254-7_8 · Cited by 2
Comprehensive Metabolic Analysis for Understanding of Disease
Newgard, C. B., Stevens, R. D., Wenner, B. R., Burgess, S. C., Ilkayeva, O., Muehlbauer, M. J., Sherry, A. D., & Bain, J. R. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374934-5.00009-x · Cited by 2
Self-citationLiu, X., Shen, M., Huang, R., & Xie, J. (2021) · Springer eBooks · doi:10.1007/978-981-15-8791-7_7 · Cited by 2
Insulin Resistance and Atherosclerosis
Singh, K., & Raghavan, V. A. (2013) · Contemporary diabetes · doi:10.1007/978-1-4614-7554-5_3 · Cited by 2
Lee, Y.-W., Lin, Y., Weng, S., Hsu, C., Huang, C., Lin, Y.-P., & Hsieh, Y.-S. (2022) · Medicine · doi:10.1097/md.0000000000030092 · Cited by 2
Rahul, R., Stinchcombe, A. R., Joseph, J. W., & Ingalls, B. (2023) · IET Systems Biology · doi:10.1049/syb2.12077 · Cited by 1
Patil, R. R., Bhise, S. B., Aswar, M. K., & Ramnath, N. S. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00492-6 · Cited by 2
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Vidaković, M., Garrido, E. C., Mihailović, M., Jovanović, J., Sinadinović, M., Rajić, J., Uskoković, A., Dinić, S., Grdović, N., Djordjevic, M., et al. (2018) · Archives of Biological Sciences · doi:10.2298/abs170711040v · Cited by 2
Idoko, A. S., Zaharaddeen, A. S., ILOUNO, L. E., Ibrahim, M. A., Arinola, A. M., Dabai, T. A., & Okereke, G. E. (2018) · Nigerian Journal of Basic and Applied Sciences · doi:10.4314/njbas.v26i2.2 · Cited by 3
micro RNAs as Therapeutic Agents and Targets
Karolina, D. S., & Jeyaseelan, K. (2013) · Wiley eBooks · doi:10.1002/9781118610749.ch19 · Cited by 2
Energy Balance, Obesity and Type‐2 Diabetes
Lane, M. D. (2009) · Encyclopedia of Life Sciences · doi:10.1002/9780470015902.a0021317 · Cited by 2
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Kilpeläinen, T. O. (2009) · UEF eRepo (University of Eastern Finland) · Cited by 2
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Janabi, A. M. (2017) · Figshare · doi:10.13140/rg.2.2.30079.30888 · Cited by 2
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Suleiman, K. Y. (2009) · Nelson Mandela University Research Repository · Cited by 2
Uclés, R. M. (2018) · Louisiana State University · doi:10.31390/gradschool_dissertations.4802 · Cited by 2
McConnell, B. V., Liu, Y., Biswas, A. K., Bettcher, B. M., Medenblik, L. M., Broussard, J. L., Lucey, B. P., Ramos, A. R., & Kheyfets, V. O. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.27.581950 · Cited by 2
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Lysiuk, R., Olіinyk, S., Boiko, A., Lozynska, I., Oliynyk, P. V., & Boiko, A. (2024) · doi:10.1002/9781394241576.ch6 · Cited by 2
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Moss, L. G., & Newgard, C. B. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.009 · Cited by 1
Self-citationZia, A., Shams, S., Shah, M., Afridi, S. G., & Khan, A. (2022) · Biochemical Genetics · doi:10.1007/s10528-022-10247-y · Cited by 1
Chida, D., Toyama, T., Chiba, T., Kaneko, T., Arisawa, K., & Saito, Y. (2022) · BPB Reports · doi:10.1248/bpbreports.5.4_74 · Cited by 1
Immuno-Metabolic Interplay in Health and Disease
Agrahari, R., Mohapatra, S., Kumar, K. S., Mohanty, D., Kumar, R. K., & Merugu, R. (2024) · Interdisciplinary biotechnological advances · doi:10.1007/978-981-97-5508-0_11 · Cited by 1
Advances in Aggrephagy: Mechanisms, Disease Implications, and Therapeutic Strategies
Zhuang, H., & Ma, X. (2025) · Journal of Cellular Physiology · doi:10.1002/jcp.31512 · Cited by 3
Maternal obesity promotes impaired renal autophagic process and kidney injury in male offspring
Phengpol, N., Promsan, S., Pengrattanachot, N., Jaruan, O., Sutthasupha, P., & Lungkaphin, A. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01751-3 · Cited by 1
Advances in in vivo magnetic resonance spectroscopy for metabolic disorders
Kupriyanova, Y., & Schrauwen‐Hinderling, V. B. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1578333 · Cited by 1
Paternal contributions to telomere reprogramming in fetal development
Farrukh, S. (2025) · International Journal of Biochemistry and Molecular Biology · doi:10.62347/tsgo8987 · Cited by 1
Zhu, Y., Zhou, E., Tang, Y., Li, Q., & Wu, L. (2025) · Foods · doi:10.3390/foods15010096 · Cited by 1
Ren, X., Guo, Y., Li, B., Xu, T., Wang, B., Yang, L., Han, J. Z., Zhou, Y., & Zhou, B. (2026) · Environmental Science & Technology · doi:10.1021/acs.est.5c15793 · Cited by 1
Oraebosi, M. I., Baucom, C., & Cao, R. (2026) · Diabetology · doi:10.3390/diabetology7070122 · Cited by 2
PQBP1-dependent alternative RNA splicing underlies high calorie diet-induced cognitive impairment
Huang, Y., Homma, H., Yoshioka, Y., Watanabe, T., Fujino, S., Matsuyama, K., Chen, X., Fujita, K., Shiwaku, H., Spada, A. R. L., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03868-x · Cited by 1
Obafemi, T. O., Ayeleso, A. O., Ekundayo, B. E., Obafemi, B. A., Adewale, O. B., Lebelo, S. L., & Ntwasa, M. M. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12876-7 · Cited by 1
Wireless electrocatalytic closed-loop system for drug-free management of diabesity
Maity, D., Ray, P. G., Buchmann, P., Hamri, G. C., & Fussenegger, M. (2026) · Science · doi:10.1126/science.ady8560 · Cited by 1
Offspring and Maternal Health Benefits of Exercise during Pregnancy
Carter, L. G. (2013) · UKnowledge (University of Kentucky) · Cited by 1
Danial, N. N. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511976094.019 · Cited by 1
HEAT SHOCK PROTEINS: NOVEL THERAPEUTIC TARGETS AGAINST INSULIN RESISTANCE AND TYPE 2 DIABETES
Gupte, A. A. (2009) · Cited by 1
Xu, L., Chen, L., Zhang, L., Wan, L., Xu, J., Li, W., Qu, X., Tai, J., Feng, C., Zhang, F., et al. (2012) · Genomics · doi:10.1016/j.ygeno.2012.07.013 · Cited by 1
Expression of microRNAs differed in the omental adipose tissue of obese rats.
Zhi, C., Huang, Y., Qi, W., Shen, J., Tan, J., Hu, H., & Zhang, D. (2015) · PubMed Central · Cited by 1
5-Hydroxytryptamine in the Endocrine Pancreas
Fex, M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-800050-2.00004-8 · Cited by 1
Cell and Tissue Destruction in Selected Disorders
Arnhold, J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816388-7.00009-7 · Cited by 1
Folias, A. E., & Hebrok, M. (2014) · Springer eBooks · doi:10.1007/978-3-7091-0715-7_25 · Cited by 1
Antevska, A., Long, C. C., Dupuy, S. D., Collier, J. J., Karlstad, M. D., & Do, T. D. (2022) · Journal of Proteome Research · doi:10.1021/acs.jproteome.2c00668 · Cited by 2
Singh, V. (2022) · Biomedical Materials & Devices · doi:10.1007/s44174-022-00054-9 · Cited by 1
Bourebaba, Y., Mularczyk, M., Kornicka‐Garbowska, K., Marycz, K., Bourebaba, L., & Kowalczuk, A. P. (2023) · Current Bioactive Compounds · doi:10.2174/1573407219666230120103107 · Cited by 1
Güçlü-Geyik, F., Köseoğlu, P. K., Güven, G., Can, G., Kaya, A., Çoban, N., Kömürcü-Bayrak, E., & Erginel‐Ünaltuna, N. (2023) · Biochemical Genetics · doi:10.1007/s10528-023-10371-3 · Cited by 1
Nooreen, Z., Rai, A. K., Sumayya, F., & Tandon, S. (2023) · Current Diabetes Reviews · doi:10.2174/1573399820666230829094724 · Cited by 1
Physiotherapy in the treatment of the metabolic syndrome associated with the right-sided scoliosis
Riabenko, I., Galicheva, К., Beloshenko, K., Riabtsev, R., & Voroshylova, Y. (2023) · Physical rehabilitation and recreational health technologies · doi:10.15391/prrht.2023-8(3).02 · Cited by 1
Obesity-mediated insulin resistance in target tissues: role of adiponectin, fetuin-A, and irisin
Mukherjee, S., Das, S., Chattopadhyay, D., & Mukhopadhyay, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85732-1.00041-4 · Cited by 2
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Metadata
- Authors
- Muoio, D. M., & Newgard, C. B.
- Affiliations
- Duke University (US)
- Corresponding author
- Newgard, Christopher B.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2008-03
- Volume
- 9
- Issue
- 3
- Pages
- 193-205
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1657478053
- Cited by
- 1,177
- References
- 135
- Citations by year
- 2026: 31 · 2025: 33 · 2024: 49 · 2023: 66 · 2022: 51 · 2021: 59 · 2020: 62 · 2019: 67 · 2018: 65 · 2017: 74 · 2016: 77 · 2015: 81 · 2014: 83 · 2013: 64 · 2012: 75
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, insulin resistance, beta-cell failure, pancreatic beta cells, obesity, metabolic failure, molecular mechanisms, pharmacological interventions
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin, Insulin Resistance, Signal Transduction, Insulin-Secreting Cells
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