Cited by 1,177Pancreatic function and diabetesMetabolism, Diabetes, and CancerDiabetes Treatment and Management

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Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

Muoio, Deborah M., Newgard, Christopher B.·2008·Nature Reviews Molecular Cell Biology

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Abstract

Nearly unlimited supplies of energy-dense foods and technologies that encourage sedentary behaviour have introduced a new threat to the survival of our species: obesity and its co-morbidities. Foremost among the co-morbidities is type 2 diabetes, which is projected to afflict 300 million people worldwide by 2020. Compliance with lifestyle modifications such as reduced caloric intake and increased physical activity has proved to be difficult for the general population, meaning that pharmacological intervention may be the only recourse for some. This epidemiological reality heightens the urgency for gaining a deeper understanding of the processes that cause metabolic failure of key tissues and organ systems in type 2 diabetes, as reviewed here.

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Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Handbook of Physiology.
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
Nissen, S. E., & Wolski, K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072761 · Cited by 4,675
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639
A central role for JNK in obesity and insulin resistance
Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359
Critical nodes in signalling pathways: insights into insulin action
Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760
Cellular mechanisms of insulin resistance
Shulman, G. I. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10583 · Cited by 2,714
Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes
Özcan, U., Yilmaz, E., Özcan, L., Furuhashi, M., Vaillancourt, E., Smith, R. O., Görgün, C. Z., & Hotamisligil, G. S. (2006) · Science · doi:10.1126/science.1128294 · Cited by 2,413
Dysfunction of Mitochondria in Human Skeletal Muscle in Type 2 Diabetes
Kelley, D. E., He, J., Menshikova, E. V., & Ritov, V. B. (2002) · Diabetes · doi:10.2337/diabetes.51.10.2944 · Cited by 2,321
Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB
Cai, D., Yuan, M., Frantz, D. F., Melendez, P. A., Hansen, L., Lee, J., & Shoelson, S. E. (2005) · Nature Medicine · doi:10.1038/nm1166 · Cited by 2,245
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
Koves, T. R., Ussher, J. R., Noland, R. C., Slentz, D., Mosedale, M., Ilkayeva, O., Bain, J., Stevens, R., Dyck, J. R. B., Newgard, C. B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.013 · Cited by 1,990
Self-citation
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
Patti, M. E., Butte, A. J., Crunkhorn, S., Cusi, K., Berria, R., Kashyap, S., Miyazaki, Y., Kohane, I., Costello, M., Saccone, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1032913100 · Cited by 1,952
The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin
Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S.-H., Bardeesy, N., DePinho, R. A., Montminy, M., & Cantley, L. C. (2005) · Science · doi:10.1126/science.1120781 · Cited by 1,950
Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ
Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884
IKK-β links inflammation to obesity-induced insulin resistance
Arkan, M. C., Hevener, A. L., Greten, F. R., Maeda, S., Li, Z.-W., Long, J. M., Wynshaw-Boris, A., Poli, G., Olefsky, J., & Karin, M. (2005) · Nature Medicine · doi:10.1038/nm1185 · Cited by 1,773
Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40
Itoh, Y., Kawamata, Y., Harada, M., Kobayashi, M., Fujii, R., Fukusumi, S., Ogi, K., Hosoya, M., Tanaka, Y., Uejima, H., et al. (2003) · Nature · doi:10.1038/nature01478 · Cited by 1,538
Banting Lecture 2001
McGarry, J. D. (2002) · Diabetes · doi:10.2337/diabetes.51.1.7 · Cited by 1,435
Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis
Scheuner, D. L., Song, B., McEwen, E. L., Liu, C., Laybutt, D. R., Gillespie, P. J., Saunders, T. L., Bonner‐Weir, S., & Kaufman, R. J. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00265-9 · Cited by 1,355
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.
Cooper, G. J., Willis, A. C., Clark, A., Turner, R. C., Sim, R. B., & Reid, K. B. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.23.8628 · Cited by 1,299
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
Abel, E. D., Peroni, O. D., Kim, J. K., Kim, Y., Boss, O., Hadro, E., Minnemann, T., Shulman, G. I., & Kahn, B. B. (2001) · Nature · doi:10.1038/35055575 · Cited by 1,276
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Griffin, M. E., Marcucci, M. J., Cline, G. W., Bell, K., Barucci, N., Lee, D., Goodyear, L. J., Kraegen, E. W., White, M. F., & Shulman, G. I. (1999) · Diabetes · doi:10.2337/diabetes.48.6.1270 · Cited by 1,267
Leptin-Replacement Therapy for Lipodystrophy
Oral, E. A., Simha, V., Ruiz, E., Andewelt, A., Premkumar, A., Snell, P., Wagner, A. J., DePaoli, A. M., Reitman, M. L., Taylor, S. I., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012437 · Cited by 1,247
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
Holland, W. L., Brozinick, J. T., Wang, L.-P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.01.002 · Cited by 1,232
Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival
Harding, H. P., Zeng, H., Zhang, Y., Jungries, R., Chung, P., Plesken, H., Sabatini, D. D., & Ron, D. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00264-7 · Cited by 1,217
The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids
Briscoe, C. P., Tadayyon, M., Andrews, J. L., Benson, W. G., Chambers, J. K., Eilert, M. M., Ellis, C. E., Elshourbagy, N. A., Goetz, A. S., Minnick, D. T., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211495200 · Cited by 1,128
Disordered lipid metabolism and the pathogenesis of insulin resistance.
Savage, D. B., Petersen, K. F., & Shulman, G. I. (2007) · Physiological Reviews · doi:10.1152/physrev.00024.2006 · Cited by 1,107
Lipotoxicity in the Pathogenesis of Obesity-Dependent NIDDM: Genetic and Clinical Implications
Unger, R. H. (1995) · Diabetes · doi:10.2337/diab.44.8.863 · Cited by 1,100
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss
Kelley, D. E., Goodpaster, B., Wing, R. R., & Simoneau, J.-A. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.6.e1130 · Cited by 1,096
Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
Shimomura, I., Hammer, R. E., Ikemoto, S., Brown, M. S., & Goldstein, J. L. (1999) · Nature · doi:10.1038/43448 · Cited by 1,038
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β-cell dysfunction, and type 2 diabetes.
Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00378-6 · Cited by 917
Reversal of Nonalcoholic Hepatic Steatosis, Hepatic Insulin Resistance, and Hyperglycemia by Moderate Weight Reduction in Patients With Type 2 Diabetes
Petersen, K. F., Dufour, S., Befroy, D., Lehrke, M., Hendler, R. E., & Shulman, G. I. (2005) · Diabetes · doi:10.2337/diabetes.54.3.603 · Cited by 911
Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
Ritov, V. B., Menshikova, E. V., He, J., Ferrell, R. E., Goodpaster, B. H., & Kelley, D. E. (2005) · Diabetes · doi:10.2337/diabetes.54.1.8 · Cited by 887
Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
Morino, K., Petersen, K. F., & Shulman, G. I. (2006) · Diabetes · doi:10.2337/db06-s002 · Cited by 853
Minireview: Secondary β-Cell Failure in Type 2 Diabetes—A Convergence of Glucotoxicity and Lipotoxicity
Poitout, V., & Robertson, R. P. (2002) · Endocrinology · doi:10.1210/endo.143.2.8623 · Cited by 743 · cited 1×
“Similarly, exposure of islets to elevated levels of fatty acids does not impair GSIS unless the islets are cultured at or above a threshold concentration of glucose (usually ∼8 mM”
Background
Prevention of fat-induced insulin resistance by salicylate
Kim, J. K., Kim, Y.-J., Fillmore, J. J., Chen, Y., Moore, I., Lee, J., Yuan, M., Li, Z. W., Karin, M., Perret, P., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11559 · Cited by 737
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1
Um, S. H., D'Alessio, D., & Thomas, G. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.003 · Cited by 690
Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.
Zhou, Y. P., & Grill, V. E. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117042 · Cited by 677
Surgical implantation of adipose tissue reverses diabetes in lipoatrophic mice
Gavrilova, O., Marcus-Samuels, B., Graham, D., Kim, J. K., Shulman, G. I., Castle, A. L., Vinson, C., Eckhaus, M., & Reitman, M. L. (2000) · Journal of Clinical Investigation · doi:10.1172/jci7901 · Cited by 676
Insulin signaling pathways in time and space
Saltiel, A. R., & Pessin, J. E. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02207-3 · Cited by 627
Adipose Tissue-Derived Factors: Impact on Health and Disease
Trujillo, M. E., & Scherer, P. E. (2006) · Endocrine Reviews · doi:10.1210/er.2006-0033 · Cited by 624
Thematic review series: Adipocyte Biology. Adipose tissue function and plasticity orchestrate nutritional adaptation
Sethi, J. K., & Vidal‐Puig, A. (2007) · Journal of Lipid Research · doi:10.1194/jlr.r700005-jlr200 · Cited by 582
METABOLIC COUPLING FACTORS IN PANCREATIC β-CELL SIGNAL TRANSDUCTION
Newgard, C. B., & McGarry, J. (1995) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.64.070195.003353 · Cited by 547
Self-citation
PKC-θ knockout mice are protected from fat-induced insulin resistance
Kim, J. K., Fillmore, J. J., Sunshine, M. J., Albrecht, B., Higashimori, T., Kim, D.-W., Liu, Z.-X., Soos, T. J., Cline, G. W., O’Brien, W. R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200422230 · Cited by 500
Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes
Chavez, J. A., & Summers, S. A. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.020 · Cited by 498
Inhibition of protein kinase Cε prevents hepatic insulin resistance in nonalcoholic fatty liver disease
Samuel, V. T., Liu, Z.-X., Wang, A., Beddow, S. A., Geisler, J. G., Kahn, M., Zhang, X.-M., Monia, B. P., Bhanot, S., & Shulman, G. I. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30400 · Cited by 497
Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1α transcription coactivator
Li, X., Monks, B., Ge, Q., & Birnbaum, M. J. (2007) · Nature · doi:10.1038/nature05861 · Cited by 487
Inflammation and the IKKβ/IκB/NF-κB axis in obesity- and diet-induced insulin resistance
Shoelson, S. E., Lee, J., & Yuan, M. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802501 · Cited by 474
Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency
Koves, T. R., Li, P., An, J., Akimoto, T., Slentz, D., Ilkayeva, O., Dohm, G. L., Yan, Z., Newgard, C. B., & Muoio, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507621200 · Cited by 464
Self-citation
Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance
An, J., Muoio, D. M., Shiota, M., Fujimoto, Y., Cline, G. W., Shulman, G. I., Koves, T. R., Stevens, R., Millington, D., & Newgard, C. B. (2004) · Nature Medicine · doi:10.1038/nm995 · Cited by 450
Self-citation
Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2
Savage, D. B. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27300 · Cited by 447
Malonyl-CoA Signaling, Lipid Partitioning, and Glucolipotoxicity
Prentki, M., Joly, E. C., El-Assaad, W., & Roduit, R. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s405 · Cited by 428
Metabolic Fate of Glucose in Purified Islet Cells
Schuit, F., De Vos, A., Farfari, S., Moens, K., Pipeleers, D., Brun, T., & Prentki, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18572 · Cited by 421
The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse
Steneberg, P., Rubins, N. E., Bartoov-Shifman, R., WALKER, M. D., & Edlund, H. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.03.007 · Cited by 416
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
Scheuner, D., Mierde, D. V., Song, B., Flamez, D., Creemers, J. W. M., Tsukamoto, K., Ribick, M., Schuit, F. C., & Kaufman, R. J. (2005) · Nature Medicine · doi:10.1038/nm1259 · Cited by 413
Mechanism of Amino Acid-Induced Skeletal Muscle Insulin Resistance in Humans
Krebs, M., Krssak, M., Bernroider, E., Anderwald, C., Brehm, A., Meyerspeer, M., Nowotny, P., Roth, E., Waldhäusl, W., & Roden, M. (2002) · Diabetes · doi:10.2337/diabetes.51.3.599 · Cited by 392
Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets
Abu-Elheiga, L., Oh, W., Kordari, P., & Wakil, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1733877100 · Cited by 389
β-Cell Mass Dynamics in Zucker Diabetic Fatty Rats
Finegood, D. T., McArthur, M. D., Kojwang, D., Thomas, M. J., Topp, B. G., Leonard, T. B., & Buckingham, R. E. (2001) · Diabetes · doi:10.2337/diabetes.50.5.1021 · Cited by 375
Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability
Tremblay, F., Krebs, M., Dombrowski, L., Brehm, A., Bernroider, E., Roth, E., Nowotny, P., Waldhäusl, W., Marette, A., & Roden, M. (2005) · Diabetes · doi:10.2337/diabetes.54.9.2674 · Cited by 370
Upregulation of myocellular DGAT1 augments triglyceride synthesis in skeletal muscle and protects against fat-induced insulin resistance
Liu, L., Zhang, Y., Chen, N., Shi, X., Tsang, B., & Yu, Y.-H. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30565 · Cited by 356
Obesity-related derangements in metabolic regulation
Muoio, D. M., & Newgard, C. B. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142512 · Cited by 345
Self-citation
Regulation of Blood Glucose by Hypothalamic Pyruvate Metabolism
Lam, T. K. T., Gutierrez-Juarez, R., Pocai, A., & Rossetti, L. (2005) · Science · doi:10.1126/science.1112085 · Cited by 341
Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane
Sano, H., Eguez, L., Teruel, M. N., Fukuda, M., Chuang, T. D., Chavez, J. A., Lienhard, G. E., & McGraw, T. E. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.03.001 · Cited by 340
Skeletal muscle lipid metabolism with obesity
Hulver, M. W., Berggren, J. R., Cortright, R. N., Dudek, R. W., Thompson, R. P., Pories, W. J., MacDonald, K. G., Cline, G. W., Shulman, G. I., Dohm, G. L., et al. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00514.2002 · Cited by 339
Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet β cell
Robertson, R. P., & Harmon, J. S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.04.030 · Cited by 329
A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity?
Dulubova, I., Lou, X., Lu, J., Huryeva, I., Alam, A., Schneggenburger, R., Südhof, T. C., & Rizo, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600753 · Cited by 289
Feasibility of a Mitochondrial Pyruvate Malate Shuttle in Pancreatic Islets
MacDonald, M. J. (1995) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94588-6 · Cited by 274
A potential link between muscle peroxisome proliferator- activated receptor-α signaling and obesity-related diabetes
Finck, B. N., Bernal-Mizrachi, C., Han, D. H., Coleman, T., Sambandam, N., LaRiviere, L. L., Holloszy, J. O., Semenkovich, C. F., & Kelly, D. P. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.01.006 · Cited by 270
13 C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)
Lu, D., Mulder, H., Zhao, P., Burgess, S. C., Jensen, M. V., Kamzolova, S. V., Newgard, C. B., & Sherry, A. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052005699 · Cited by 268
Self-citation
GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo
Latour, M. G., Alquier, T., Oseid, E. A., Tremblay, C. C., Jetton, T. L., Luo, J., Lin, D. C.-H., & Poitout, V. (2007) · Diabetes · doi:10.2337/db06-1532 · Cited by 264
Neuronal Pathway from the Liver Modulates Energy Expenditure and Systemic Insulin Sensitivity
Uno, K., Katagiri, H., Yamada, T., Ishigaki, Y., Ogihara, T., Imai, J., Hasegawa, Y., Gao, J., Kaneko, K., Iwasaki, H., et al. (2006) · Science · doi:10.1126/science.1126010 · Cited by 262
Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice
Neschen, S., Morino, K., Hammond, L. E., Zhang, D., Liu, Z.-X., Romanelli, A. J., Cline, G. W., Pongratz, R. L., Zhang, X.-M., Choi, C. S., et al. (2005) · Cell Metabolism · doi:10.1016/j.cmet.2005.06.006 · Cited by 261
Islet amyloid in type 2 human diabetes mellitus and adult diabetic cats contains a novel putative polypeptide hormone.
Westermark, P., Wernstedt, C., O’Brien, T. D., Hayden, D. W., & Johnson, K. H. (1987) · PubMed Central · Cited by 261
Cellular mechanism of insulin resistance: potential links with inflammation
Perseghin, G., Petersen, K. F., & Shulman, G. I. (2003) · International Journal of Obesity · doi:10.1038/sj.ijo.0802491 · Cited by 260
Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in insulin secretion
MacDonald, M. J., Fahien, L. A., Brown, L. J., Hasan, N. M., Buss, J. D., & Kendrick, M. A. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00218.2004 · Cited by 241
Transgenic Overexpression of Leptin Rescues Insulin Resistance and Diabetes in a Mouse Model of Lipoatrophic Diabetes
Ebihara, K., Ogawa, Y., Masuzaki, H., Shintani, M., Miyanaga, F., Aizawa‐Abe, M., Hayashi, T., Hosoda, K., Inoue, G., Yoshimasa, Y., et al. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1440 · Cited by 240
Regulation of glucose transporter messenger RNA in insulin-deficient states
Sivitz, W. I., DeSautel, S. L., Kayano, T., Bell, G. I., & Pessin, J. E. (1989) · Nature · doi:10.1038/340072a0 · Cited by 239
A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase Regulates Glucose-stimulated Insulin Secretion
Ronnebaum, S. M., Ilkayeva, O., Burgess, S. C., Joseph, J. W., Lu, D., Stevens, R. D., Becker, T. C., Sherry, A. D., Newgard, C. B., & Jensen, M. V. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511908200 · Cited by 237
Self-citation
Molecular disruption of hypothalamic nutrient sensing induces obesity
He, W., Lam, T. K. T., Obici, S., & Rossetti, L. (2006) · Nature Neuroscience · doi:10.1038/nn1626 · Cited by 233
Impaired Gene and Protein Expression of Exocytotic Soluble N -Ethylmaleimide Attachment Protein Receptor Complex Proteins in Pancreatic Islets of Type 2 Diabetic Patients
Ostenson, C.-G., Gaisano, H., Sheu, L., Tibell, A., & Bartfai, T. (2006) · Diabetes · doi:10.2337/diabetes.55.02.06.db04-1575 · Cited by 232
Diet Induction of Monocyte Chemoattractant Protein‐1 and its Impact on Obesity
Chen, A., Mumick, S., Zhang, C., Lamb, J., Dai, H., Weingarth, D., Mudgett, J., Chen, H., MacNeil, D. J., Reitman, M. L., et al. (2005) · Obesity Research · doi:10.1038/oby.2005.159 · Cited by 231
The twentieth century struggle to decipher insulin signalling
Cohen, P. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2043 · Cited by 228
Acid Ceramidase Overexpression Prevents the Inhibitory Effects of Saturated Fatty Acids on Insulin Signaling
Chavez, J. A., Holland, W. L., Bär, J., Sandhoff, K., & Summers, S. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m412769200 · Cited by 220
Uncoupling Protein 2 Knockout Mice Have Enhanced Insulin Secretory Capacity After a High-Fat Diet
Joseph, J. W., Koshkin, V., Zhang, C.-Y., Wang, J., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3211 · Cited by 220
Splanchnic glucose and amino acid metabolism in obesity.
Felig, P., Wahren, J., Hendler, R., & Brundin, T. (1974) · Journal of Clinical Investigation · doi:10.1172/jci107593 · Cited by 209
Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration
Kohlroser, J., Mathai, J., Reichheld, J., Banner, B. F., & Bonkovsky, H. L. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01707.x · Cited by 209
Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression
Joseph, J. W., Koshkin, V., Saleh, M. C., Sivitz, W. I., Zhang, C.-Y., Lowell, B. B., Chan, C. B., & Wheeler, M. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409189200 · Cited by 206
Heterogeneity of pig intestinal d-glucose transport systems
Halaihel, N., Gerbaud, D., Vasseur, M., & Alvarado, F. (1999) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1999.277.6.c1130 · Cited by 199
Hierarchy of the β‐cell signals controlling insulin secretion
Henquin, J. C., Ravier, M. A., Nenquin, M., Jonas, J., & Gilon, P. (2003) · European Journal of Clinical Investigation · doi:10.1046/j.1365-2362.2003.01207.x · Cited by 180
Mitochondrial GTP regulates glucose-stimulated insulin secretion.
Kibbey, R., Pongratz, R. L., Romanelli, A. J., Wollheim, C., Cline, G., & Shulman, G. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.008 · Cited by 178
Interaction of ATP Sensor, cAMP Sensor, Ca2+ Sensor, and Voltage-dependent Ca2+ Channel in Insulin Granule Exocytosis
Shibasaki, T., Sunaga, Y., Fujimoto, K., Kashima, Y., & Seino, S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309068200 · Cited by 175
β-Cell Adaptation to Insulin Resistance
Liu, Y. Q., Jetton, T. L., & Leahy, J. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m207157200 · Cited by 173
Improved Glucose Homeostasis in Mice with Muscle-Specific Deletion of Protein-Tyrosine Phosphatase 1B
Delibegović, M., Bence, K. K., Mody, N., Hong, E., Ko, H. J., Kim, J. K., Kahn, B. B., & Neel, B. G. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00959-07 · Cited by 173
The Mitochondrial Citrate/Isocitrate Carrier Plays a Regulatory Role in Glucose-stimulated Insulin Secretion
Joseph, J. W., Jensen, M. V., Ilkayeva, O., Palmieri, F., Alarcón, C., Rhodes, C. J., & Newgard, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602606200 · Cited by 163
Self-citation
Uncoupling Protein 2 and Islet Function
Chan, C. B., Saleh, M. C., Koshkin, V., & Wheeler, M. B. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s136 · Cited by 161
Transplantation of Adipose Tissue Lacking Leptin Is Unable to Reverse the Metabolic Abnormalities Associated With Lipoatrophy
Colombo, C., Cutson, J. J., Yamauchi, T., Vinson, C., Kadowaki, T., Gavrilova, O., & Reitman, M. L. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2727 · Cited by 147
Compensatory Responses to Pyruvate Carboxylase Suppression in Islet β-Cells
Jensen, M. V., Joseph, J. W., Ilkayeva, O., Burgess, S. C., Lu, D., Ronnebaum, S. M., Odegaard, M. L., Becker, T. C., Sherry, A. D., & Newgard, C. B. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604350200 · Cited by 144
Self-citation
β-Cell Deficit Due to Increased Apoptosis in the Human Islet Amyloid Polypeptide Transgenic (HIP) Rat Recapitulates the Metabolic Defects Present in Type 2 Diabetes
Matveyenko, A. V., & Butler, P. C. (2006) · Diabetes · doi:10.2337/db05-1672 · Cited by 144
Fatty Acids Rapidly Induce the Carnitine Palmitoyltransferase I Gene in the Pancreatic β-Cell Line INS-1
Assimacopoulos‐Jeannet, F., Thumelin, S., Roche, E., Esser, V., McGarry, J., & Prentki, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.3.1659 · Cited by 136
Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue
Boucher, A., Lu, D., Burgess, S. C., Telemaque-Potts, S., Jensen, M. V., Mulder, H., Wang, M.-Y., Unger, R. H., Sherry, A. D., & Newgard, C. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401167200 · Cited by 136
Self-citation
Induction by Glucose of Genes Coding for Glycolytic Enzymes in a Pancreatic β-Cell Line (INS-1)
Roche, E., Assimacopoulos‐Jeannet, F., Witters, L. A., Perruchoud, B., Yaney, G. C., Corkey, B. E., Asfari, M., & Prentki, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.5.3091 · Cited by 136
Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance
Nagle, C. A., An, J., Shiota, M., Torres, T. P., Cline, G. W., Liu, Z., Wang, S., Catlin, R. L., Shulman, G. I., Newgard, C. B., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m611550200 · Cited by 136
Self-citation
Direct and indirect effects of amino acids on hepatic glucose metabolism in humans
Krebs, M., Brehm, A., Krššák, M., Anderwald, C. H., Bernroider, E., Nowotny, P., Roth, E., Chandramouli, V., Landau, B. R., Waldh�usl, W., et al. (2003) · Diabetologia · doi:10.1007/s00125-003-1129-1 · Cited by 135
Genetic obesity unmasks nonlinear interactions between murine type 2 diabetes susceptibility loci.
Stoehr, J. P., Nadler, S. T., Schueler, K. L., Rabaglia, M. E., Yandell, B. S., Metz, S. A., & Attie, A. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1946 · Cited by 135
Both Triggering and Amplifying Pathways Contribute to Fuel-induced Insulin Secretion in the Absence of Sulfonylurea Receptor-1 in Pancreatic β-Cells*
Nenquin, M., Szollosi, A., Aguilar-Bryan, L., Bryan, J., & Henquin, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402076200 · Cited by 123
13C NMR Isotopomer Analysis of Anaplerotic Pathways in INS-1 Cells
Cline, G. W., Pongratz, R. L., Papas, K. K., Kibbey, R. G., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311842200 · Cited by 123
Regulation of the Uncoupling Protein-2 Gene in INS-1 β-Cells by Oleic Acid
Medvedev, A. V., Robidoux, J., Bai, X., Cao, W., Floering, L. M., Daniel, K. W., & Collins, S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m208645200 · Cited by 122
Antagonism of Rat β-Cell Voltage-dependent K+ Currents by Exendin 4 Requires Dual Activation of the cAMP/Protein Kinase A and Phosphatidylinositol 3-Kinase Signaling Pathways
MacDonald, P. E., Wang, X., Xia, F., El-kholy, W., Targonsky, E. D., Tsushima, R. G., & Wheeler, M. B. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307612200 · Cited by 118
Drug Treatment of the Overweight Patient
Bray, G. A., & Ryan, D. H. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.053 · Cited by 115
Lipid phosphatases as drug discovery targets for type 2 diabetes
Lazar, D. F., & Saltiel, A. R. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2007 · Cited by 114
Increased glucose sensitivity of both triggering and amplifying pathways of insulin secretion in rat islets cultured for 1 wk in high glucose
Khaldi, M. Z., Guiot, Y., Gilon, P., Henquin, J. C., & Jonas, J. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00426.2003 · Cited by 110
Mitochondrial Glycerol-3-phosphate Acyltransferase-1 Is Essential inLiver for the Metabolism of ExcessAcyl-CoAs
Hammond, L. E., Neschen, S., Romanelli, A. J., Cline, G. W., Ilkayeva, O., Shulman, G. I., Muoio, D. M., & Coleman, R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503181200 · Cited by 104
Self-citation
α-Ketoisocaproate-Induced Hypersecretion of Insulin by Islets from Diabetes-Susceptible Mice
Rabaglia, M. E., Gray-Keller, M. P., Frey, B. L., Shortreed, M. R., Smith, L. M., & Attie, A. D. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00573.2004 · Cited by 96
Evidence Against the Involvement of Oxidative Stress in Fatty Acid Inhibition of Insulin Secretion
Moore, P. C., Ugas, M. A., Hagman, D. K., Parazzoli, S. D., & Poitout, V. (2004) · Diabetes · doi:10.2337/diabetes.53.10.2610 · Cited by 92
Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells
Segall, L., Davis‐Lameloise, N., Assimacopoulos‐Jeannet, F., Roche, E., Corkey, P., Thumelin, S., Corkey, B. E., & Prentki, M. (1999) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1999.277.3.e521 · Cited by 92
Palmitate-Induced β-Cell Insensitivity to Glucose is Coupled to Decreased Pyruvate Dehydrogenase Activity and Enhanced Kinase Activity in Rat Pancreatic Islets
Zhou, Y.-P., & Grill, V. (1995) · Diabetes · doi:10.2337/diab.44.4.394 · Cited by 91
Quantifying the Carboxylation of Pyruvate in Pancreatic Islets
Khan, A., Ling, Z. C., & Landau, B. R. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2539 · Cited by 86
Estimates of Glycolysis, Pyruvate (De)Carboxylation, Pentose Phosphate Pathway, and Methyl Succinate Metabolism in Incapacitated Pancreatic Islets
MacDonald, M. J. (1993) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1993.1413 · Cited by 83
A is for adipokine
Muoio, D. M., & Newgard, C. B. (2005) · Nature · doi:10.1038/436337a · Cited by 83
Self-citation
MONOGENIC DIABETES MELLITUS IN YOUTH
Winter, W. E., Nakamura, M., & House, D. V. (1999) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(05)70101-8 · Cited by 74
Normal Flux through ATP-Citrate Lyase or Fatty Acid Synthase Is Not Required for Glucose-stimulated Insulin Secretion
Joseph, J. W., Odegaard, M. L., Ronnebaum, S. M., Burgess, S. C., Muehlbauer, J. D., Sherry, A. D., & Newgard, C. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706080200 · Cited by 72
Self-citation
Protein-tyrosine Phosphatase 1B Deficiency Reduces Insulin Resistance and the Diabetic Phenotype in Mice with Polygenic Insulin Resistance
Xue, B., Kim, Y., Lee, A., Toschi, E., Bonner‐Weir, S., Kahn, C. R., Neel, B. G., & Kahn, B. B. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609680200 · Cited by 68
Inactivation of PKCθ leads to increased susceptibility to obesity and dietary insulin resistance in mice
Gao, Z., Wang, Z., Zhang, X., Butler, A. A., Zuberi, A. R., Gawrońska‐Kozak, B., Lefevre, M., York, D., Ravussin, É., Berthoud, H., et al. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00178.2006 · Cited by 66
Transgenic mice with dominant negative PKC‐theta in skeletal muscle: A new model of insulin resistance and obesity
Serra, C., Federici, M., Buongiorno, A. M., Senni, M., Morelli, S., Segratella, E., Pascuccio, M., Tiveron, C., Mattei, E., Tatangelo, L., et al. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10278 · Cited by 62
Regulatory effects of glucose on the catalytic activity and cellular content of glucokinase in the pancreatic beta cell. Study using cultured rat islets.
Chen, C., Hosokawa, H., Bumbalo, L. M., & Leahy, J. L. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117503 · Cited by 61
A-ZIP/F-1 mice lacking white fat: a model for understanding lipoatrophic diabetes
Reitman, M. L., & Gavrilova, O. (2000) · International Journal of Obesity · doi:10.1038/sj.ijo.0801493 · Cited by 57
Glucose-fatty acid cycle to inhibit glucose utilization and oxidation is not operative in fatty acid-cultured islets.
Liu, Y. Q., Tornheim, K., & Leahy, J. L. (1999) · Diabetes · doi:10.2337/diabetes.48.9.1747 · Cited by 45
Intermediate Filament Protein Domain Interactions as Revealed by Two-hybrid Screens
Meng, J.-J., Khan, S., & Ip, W. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.3.1599 · Cited by 40
Effects of prostaglandin synthesis inhibitors on human insulin secretion and carbohydrate tolerance
Chen, M., & Robertson, R. P. (1979) · Prostaglandins · doi:10.1016/0090-6980(79)90023-6 · Cited by 39

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Authors: Muoio, D. M., & Newgard, C. B.
Affiliations: Duke University (US)
Corresponding author: Newgard, Christopher B.
ORCID: Muoio, Deborah M.
Newgard, Christopher B.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-03
Volume: 9
Issue: 3
Pages: 193-205
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2327
OpenAlex: W1657478053
Cited by: 1,177
References: 135
Citations by year: 2026: 31 · 2025: 33 · 2024: 49 · 2023: 66 · 2022: 51 · 2021: 59 · 2020: 62 · 2019: 67 · 2018: 65 · 2017: 74 · 2016: 77 · 2015: 81 · 2014: 83 · 2013: 64 · 2012: 75
FWCI: 13.64
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: type 2 diabetes, insulin resistance, beta-cell failure, pancreatic beta cells, obesity, metabolic failure, molecular mechanisms, pharmacological interventions
MeSH terms: Animals, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin, Insulin Resistance, Signal Transduction, Insulin-Secreting Cells

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Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

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