The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes
Abstract
Nearly unlimited supplies of energy-dense foods and technologies that encourage sedentary behaviour have introduced a new threat to the survival of our species: obesity and its co-morbidities. Foremost among the co-morbidities is type 2 diabetes, which is projected to afflict 300 million people worldwide by 2020. Compliance with lifestyle modifications such as reduced caloric intake and increased physical activity has proved to be difficult for the general population, meaning that pharmacological intervention may be the only recourse for some. This epidemiological reality heightens the urgency for gaining a deeper understanding of the processes that cause metabolic failure of key tissues and organ systems in type 2 diabetes, as reviewed here.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“More recent metabolomic studies now suggest that enhanced fat metabolism seen with high-fat feeding leads to high levels of β-oxidation products that alter mitochondria in a way that restrict the ability to switch to glucose oxidation (228).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [228]
In the citing paper
“Moreover, the importance of fuel selectivity is underscored by studies indicating that “metabolic inflexibility” or impaired capacity to switch between nutrient utilization, in particular between fatty acid and glucose oxidation, has a pathogenic role in the insulin resistance commonly seen in type 2 diabetes and obesity (228).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [228]
Citations
Cites
Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388
Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760
Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes
Nissen, S. E., & Wolski, K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072761 · Cited by 4,675
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143
Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice
Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017
β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011
Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes
Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844
Biology of Incretins: GLP-1 and GIP
Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639
Flagged first, then by citations
Cited by
Sorted by citations
Items 701–800 of 1,001
Global research trends on the links between insulin resistance and obesity: a visualization analysis
Zyoud, S. H., Shakhshir, M. H., Abushanab, A. S., Koni, A. A., Shahwan, M. J., Jairoun, A. A., & Al‐Jabi, S. W. (2022) · Translational Medicine Communications · doi:10.1186/s41231-022-00124-6 · Cited by 16
The role of heat shock proteins (HSPs) in type 2 diabetes mellitus pathophysiology
Esmaeilzadeh, A., Mohammadi, V., Elahi, R., & Rezakhani, N. (2023) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2023.108564 · Cited by 16
Yeo, R. W. Y., Yang, K., Li, G., & Lim, S. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044988 · Cited by 17
Rodrigues, L., Crisóstomo, J., Matafome, P. N., Louro, T. M., Nunes, E., & Seiça, R. M. F. (2011) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-011-0108-0 · Cited by 16
Ribel-Madsen, A., Hellgren, L. I., Brøns, C., Ribel‐Madsen, R., Newgard, C. B., & Vaag, A. A. (2016) · Physiological Reports · doi:10.14814/phy2.13044 · Cited by 15
Self-citationHu, J., & Easley, C. J. (2017) · Analytical Chemistry · doi:10.1021/acs.analchem.7b02229 · Cited by 16
Singh, V. (2019) · Materials Letters · doi:10.1016/j.matlet.2019.07.122 · Cited by 16
Protective role of osteocalcin in diabetes pathogenesis
Desentis-Desentis, M. F., Rivas‐Carrillo, J. D., & Sánchez‐Enríquez, S. (2020) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-020-01130-0 · Cited by 16
Morais, T., Seabra, A. L., Patrício, B. G., Guimarães, M., Nora, M. C., Oliveira, P. F., Alves, M. G., & Monteiro, M. P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115695 · Cited by 16
Taghizadeh, M., Kargarfard, M., Braune, S., Jung, F., & Naderi, M. (2021) · Clinical Hemorheology and Microcirculation · doi:10.3233/ch-211209 · Cited by 16
Metabolism and Vascular Fatty Acid Transport
Muoio, D. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmcibr1005397 · Cited by 16
Self-citationWang, J., Hu, S., Wang, J., Li, S., & Jiang, W. (2016) · Food Science and Biotechnology · doi:10.1007/s10068-016-0042-6 · Cited by 16
Wang, X. (2015) · Journal of Diabetes & Metabolism · doi:10.4172/2155-6156.s13-010 · Cited by 16
The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells
Torii, S., Kubota, C., Saito, N., Kawano, A., Hou, N., Kobayashi, M., Torii, R., Hosaka, M., Kitamura, T., Takeuchi, T., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.000301 · Cited by 16
Mahrooz, A., Qujeq, D., Alizadeh, A., & Boorank, R. (2018) · Journal of Research in Medical Sciences · doi:10.4103/jrms.jrms_88_18 · Cited by 16
Adipokines as key players in β cell function and failure
Gómez-Banoy, N., & Lo, J. C. (2019) · Clinical Science · doi:10.1042/cs20190523 · Cited by 16
Król, E., Krejpcio, Z., & Iwanik, K. (2014) · Biological Trace Element Research · doi:10.1007/s12011-013-9877-3 · Cited by 16
Amjad, W., SHALAUROVA, I. Y., Garcia, E., Gruppen, E. G., Dullaart, R. P. F., DePaoli, A. M., Jiang, Z. G., Lai, M., & Connelly, M. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713332 · Cited by 14
Sun, Y., Lu, B., Su, W., Song, X., Shang, X., Zheng, J., Wang, J., & Yun, H. (2024) · Medicine · doi:10.1097/md.0000000000037494 · Cited by 15
Irvin, M. R., Wiener, H. W., Perry, R. P., Savage, R. M., & Go, R. C. P. (2009) · Schizophrenia Research · doi:10.1016/j.schres.2009.07.008 · Cited by 16
Pillai, R., Paglialunga, S., Hoang, M., Cousteils, K., Prentice, K. J., Bombardier, É., Huang, M., Gonzalez, F. J., Tupling, A. R., Wheeler, M. B., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3768-4 · Cited by 14
Impact of PPAR-α induction on glucose homoeostasis in alcohol-fed mice
Lebrun, V., Molendi‐Coste, O., Lanthier, N., Sempoux, C. L., Cani, P. D., van Rooijen, N., Stärkel, P., Horsmans, Y., & Leclercq, I. A. (2013) · Clinical Science · doi:10.1042/cs20130064 · Cited by 15
Plasma Amino Acids and Incident Type 2 Diabetes in Patients With Coronary Artery Disease
McCann, A., Giil, L. M., Ulvik, A., Seifert, R., Rebnord, E. W., Pedersen, E. R., Svingen, G. F. T., Meyer, K., Strand, E., Dankel, S. N., et al. (2019) · Diabetes Care · doi:10.2337/dc18-2217 · Cited by 15
Circadian Governance of Cardiac Growth
Latimer, M. N., & Young, M. E. (2022) · Cells · doi:10.3390/cells11091494 · Cited by 16
Endoplasmic reticulum stress in diabetes: New insights of clinical relevance
Balasubramanyam, M., Lenin, R. R., & Monickaraj, F. (2010) · Indian Journal of Clinical Biochemistry · doi:10.1007/s12291-010-0022-1 · Cited by 15
Ansarullah, M., Free, C., Christopherson, J., Chen, Q., Gao, J., Liu, C., Naji, A., Rabinovitch, A., & Guo, Z. (2016) · Journal of Diabetes Research · doi:10.1155/2016/1620821 · Cited by 15
2,4-Thiazolidinediones as PTP 1B Inhibitors: A Mini Review (2012-2018)
Verma, S. K., Yadav, Y. S., & Thareja, S. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557518666181026092029 · Cited by 15
Anti-Diabetic Effects of Oleuropein
Iantomasi, M., Terzo, M., & Tsiani, E. (2024) · Metabolites · doi:10.3390/metabo14110581 · Cited by 15
How Perturbated Metabolites in Diabetes Mellitus Affect the Pathogenesis of Hypertension?
Ning, Z., Song, Z., Wang, C., Peng, S., Wan, X., Liu, Z., & Lü, A. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.705588 · Cited by 15
Łuniewski, M., Matyjaszek‐Matuszek, B., & Lenart-Lipińska, M. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12134431 · Cited by 15
Ca2+ signaling and metabolic stress-induced pancreatic β-cell failure
Magnuson, M. A., & Osipovich, A. B. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1412411 · Cited by 14
The Effects of Several Halophytes on Insulin Resistance in Otsuka Long-evans Tokushima Fatty Rats
Cho, J., Huang, Z., Park, S.-Y., Park, K., Pai, T.-K., Kim, S.-Y., Kim, H.-R., & Ham, K. (2014) · Korean Journal of Food Science and Technology · doi:10.9721/kjfst.2014.46.1.100 · Cited by 14
Bram, Y., Peled, S., Brahmachari, S., Harlev, M., & Gazit, E. (2017) · Scientific Reports · doi:10.1038/s41598-017-14311-1 · Cited by 14
George, G., Draycott, S. A. V., Muir, R., Clifford, B. L., Elmes, M. J., & Langley‐Evans, S. C. (2019) · Scientific Reports · doi:10.1038/s41598-019-46518-9 · Cited by 16
Wei Min, N. I., Glenn, D. J., & Gardner, D. G. (2015) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.09.017 · Cited by 14
Zhu, L., Wang, B., Guo, T., Tan, J., Zhou, X., Ling Zhi, X. I. A. O., & Liu, X. (2015) · Pharmacognosy Magazine · doi:10.4103/0973-1296.149741 · Cited by 14
Singh, V. P., Gurunathan, C., Singh, S., Singh, B., Lakshmi, B. J., Mishra, A. P., & Kumar, S. (2014) · Diabetologia · doi:10.1007/s00125-014-3438-y · Cited by 14
Crisóstomo, J., Rodrigues, L., Matafome, P. N., Amaral, C., Nunes, E., Louro, T. M., Monteiro, P. F., & Seiça, R. M. F. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000164 · Cited by 14
Moss, L. G., Caplan, T. V., & Moss, J. B. (2013) · Zebrafish · doi:10.1089/zeb.2012.0813 · Cited by 14
Teodoro, J. S., Gomes, A. P., Varela, A. T. I. F., Duarte, F. V., Rolo, A. P., & Palmeira, C. M. (2016) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2016.1222643 · Cited by 14
Oral nitrite restores age-dependent phenotypes in eNOS-null mice
Τενοπούλου, Μ., Doulias, P., Nakamoto, K., Berríos, K. N., Zura, G., Li, C., Faust, M., Yakovishina, V., Evans, P., Tan, L., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.122156 · Cited by 13
López-Pérez, D., Redruello-Romero, A., García-Rubio, J., Arana, C., García-Escudero, L. Á., Tamayo, F., Puentes-Pardo, J. D., Moreno-SanJuan, S., Salmerón, J., Blanco, A. J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.664576 · Cited by 14
Visceral Adiposity, Insulin Resistance, and Type 2 Diabetes
Griffith, M. L., Younk, L. M., & Davis, S. N. (2010) · American Journal of Lifestyle Medicine · doi:10.1177/1559827609360959 · Cited by 14
Feng, S., Wang, J., Peng, Q., Zhang, P., Jiang, Y., Zhang, H., Song, X., Li, Y., Huang, W., Zhang, D., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156348 · Cited by 13
Ensenauer, R. E., Fingerhut, R., Schriever, S. C., Fink, B., Becker, M., Sellerer, N. C., Pagel, P., Kirschner, A., Dame, T., Olgemöller, B., et al. (2012) · Journal of Lipid Research · doi:10.1194/jlr.d022608 · Cited by 13
Desai, S. M., Sanap, A. P., & Bhonde, R. R. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110034 · Cited by 13
Metformin use in prediabetes: is earlier intervention better?
Warrilow, A., Somerset, S. M., Pumpa, K. L., & Fleet, R. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01559-9 · Cited by 13
Machado, N. M., Torrinhas, R. S., Sala, P., Ishida, R. K., Guarda, I. F. M. S., de Moura, E. G. H., Sakai, P., Santo, M. A., & Waitzberg, D. L. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1960 · Cited by 14
Li, L., Li, Y., & Wang, P. (2023) · Foods · doi:10.3390/foods12152854 · Cited by 13
Choi, H. Y., Park, J., Jang, W. B., Ji, S. T., Jung, S. Y., Kim, D. Y., Kang, S., Kim, Y. J., Yun, J., Kim, J. H., et al. (2016) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2016.097 · Cited by 12
Abhishek, M., Somashekaraiah, B. V., & Dharmesh, S. M. (2019) · South African Journal of Botany · doi:10.1016/j.sajb.2018.12.006 · Cited by 13
Xu, L., Huang, Y. H., Wang, D., Zhu, S., Wang, Z., Yang, Y., & Guo, Y. (2019) · Journal of Materials Science Materials in Medicine · doi:10.1007/s10856-019-6287-x · Cited by 13
Schiano, E., Maisto, M., Piccolo, V., Novellino, E., Annunziata, G., Ciampaglia, R., Montesano, C., Croce, M., Caruso, G., Iannuzzo, F., et al. (2022) · Foods · doi:10.3390/foods11172637 · Cited by 13
Haffner, C. D., Thomson, S. A., Guo, Y. C., Petrov, K. G., Larkin, A. L., Banker, P., Schaaf, G. M., Dickerson, S. H., Gobel, J., Gillie, D., et al. (2010) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2010.09.131 · Cited by 13
Metabolic Syndrome and Breast Cancer Risk: Is There a Role for Metformin?
Ibarra-Drendall, C., Dietze, E. C., & Seewaldt, V. L. (2011) · Current Breast Cancer Reports · doi:10.1007/s12609-011-0050-8 · Cited by 13
Serum Ethanolamine Plasmalogen and Urine Myo-Inositol as Cognitive Decline Markers
Maeba, R., Araki, A., & Fujiwara, Y. (2018) · Advances in clinical chemistry · doi:10.1016/bs.acc.2018.08.001 · Cited by 15
Arsenic and diabetes mellitus: a putative role for the immune system
Liu, J., Hermon, T., Gao, X., Dixon, D., & Xiao, H. (2023) · All Life · doi:10.1080/26895293.2023.2167869 · Cited by 12
Histone deacetylase functions and therapeutic implications for adult skeletal muscle metabolism
Molinari, S., Imbriano, C., Moresi, V., Renzini, A., Belluti, S., Lozanoska‐Ochser, B., Gigli, G., & Cedola, A. (2023) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2023.1130183 · Cited by 12
Sahariah, P., Bora, J., Malik, S., Syiem, D., Bhan, S., Hussain, A., Sadier, N. S., Rustagi, S., Haque, S., Singh, N. K., et al. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2805105 · Cited by 12
Coumarin linked to 2-phenylbenzimidazole derivatives as potent α-glucosidase inhibitors
Ganjeh, M. S., Mazlomifar, A., Shahvelayati, A. S., & Khalil-Moghaddam, S. (2024) · Scientific Reports · doi:10.1038/s41598-024-57673-z · Cited by 12
Insulin resistance in vitamin D-deficient mice is alleviated by n-acetylcysteine
Cui, Z., Yuan, Q., Mao, L., Chen, F., Ji, F., & Tao, S. (2017) · Oncotarget · doi:10.18632/oncotarget.18793 · Cited by 12
Dong, W., Moon, S. J., Kelleher, J. K., & Stephanopoulos, G. N. (2019) · Industrial & Engineering Chemistry Research · doi:10.1021/acs.iecr.9b05154 · Cited by 14
Ilić, I., Oršolić, N., Rođak, E., Odeh, D., Lovrić, M., Mujkić, R., Aždajić, M. D., Grgić, A., Levak, M. T., Vargek, M., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0238600 · Cited by 13
Wang, S., Wang, X., Bai, F., Shi, X., Zhou, T., & Li, F. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13914 · Cited by 12
RetractedBritsemmer, J. H., Krause, C., Taege, N., Geißler, C., López‐Alcántara, N., Schmidtke, L., Naujack, A.-M., Wagner, J., Wolter, S., Mann, O., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076417 · Cited by 12
Gao, W., Zhou, Y., Li, Q., Zhou, Q., Tan, L., Song, Y., Zhao, X., Yu, M., Zheng, S., Ye, H., et al. (2015) · Diabetologia · doi:10.1007/s00125-014-3481-8 · Cited by 12
Detection of Autofluorescent Mycobacterium Chelonae in Living Zebrafish
Whipps, C. M., Moss, L. G., Sisk, D. M., Murray, K. N., Tobin, D. M., & Moss, J. B. (2014) · Zebrafish · doi:10.1089/zeb.2012.0863 · Cited by 12
Budiman, A., Sofian, F. F., Santi, N. M. W. S., & Aulifa, D. L. (2020) · Journal of Pharmacy And Bioallied Sciences · doi:10.4103/jpbs.jpbs_219_19 · Cited by 12
Effect of l-serine on oxidative stress markers in the kidney of streptozotocin-induced diabetic mice
Langroudi, F. E., Narani, M. S., Kheirollahi, A., Vatannejad, A., Shokrpoor, S., & Alizadeh, S. (2023) · Amino Acids · doi:10.1007/s00726-023-03270-9 · Cited by 11
Zhao, S., Li, Y., & Su, C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1265719 · Cited by 11
Absence of Slc39a14/Zip14 in mouse pancreatic beta cells results in hyperinsulinemia
Hung, Y.-H., Kim, Y., Mitchell, S. B., Thorn, T. L., & Aydemir, T. B. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00117.2023 · Cited by 11
Exploring the Mechanistic Link Between Obesity and Heart Failure
Özkan, B., & Ndumele, C. E. (2023) · Current Diabetes Reports · doi:10.1007/s11892-023-01526-y · Cited by 12
CaMK4: Structure, physiological functions, and therapeutic potential
Xu, H., Liang, Y., Gao, X., Chen, Y., Wang, Y., Wang, F., & Hou, X. (2024) · Biochemical Pharmacology · doi:10.1016/j.bcp.2024.116204 · Cited by 11
The role of dietary sugars in cancer risk: A comprehensive review of current evidence
Hasan, N., Yazdanpanah, O., Khaleghi, B., Benjamin, D. J., & Kalebasty, A. R. (2025) · Cancer Treatment and Research Communications · doi:10.1016/j.ctarc.2025.100876 · Cited by 13
Association of Type 2 Diabetes Genetic Variants with Breast Cancer Survival among Chinese Women
Bao, P., Zhao, Z., Gao, Y., Zheng, Y., Zhang, B., Cai, H., Zheng, W., Shu, X., & Lu, W. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117419 · Cited by 11
Farhadi‐Azar, M., Ghahremani, M., Mahboobifard, F., Noroozzadeh, M., Yaghmaei, P., & Tehrani, F. R. (2022) · Biomedical Journal · doi:10.1016/j.bj.2022.05.003 · Cited by 11
Feldman, F., Koudoufio, M., El-Jalbout, R., Sauvé, M. F., Ahmarani, L., Sané, A. T., Ould-Chikh, N.-E.-H., Ntimbane, T., Patey, N., Desjardins, Y., et al. (2022) · Antioxidants · doi:10.3390/antiox12010090 · Cited by 11
Enriched biological activity of copper oxide nanoparticles derived from Aloe vera extract
Narayanan, M., Natarajan, R. K., Jeyaleela, G. D., Paramasivan, R., Balakumar, S., Ahmad, Z., & Khan, F. S. (2023) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-023-04589-9 · Cited by 11
Bio-Hacking Better Health—Leveraging Metabolic Biochemistry to Maximise Healthspan
Cooper, I. D., Kyriakidou, Y., Petagine, L., Edwards, K., & Elliott, B. (2023) · Antioxidants · doi:10.3390/antiox12091749 · Cited by 11
An approach to the etiology of metabolic syndrome.
Contreras, A. M. M., Berrío, G. B., & R, C. M. V. (2013) · Europe PMC (PubMed Central) · Cited by 11
Adult tissue sources for new β cells
Nichols, R. J., New, C., & Annes, J. P. (2013) · Translational research · doi:10.1016/j.trsl.2013.11.012 · Cited by 11
Hu, S., Li, S., Song, W., Ji, L., Cai, L., Wang, Y., & Jiang, W. (2016) · Food Science and Technology Research · doi:10.3136/fstr.22.507 · Cited by 11
Yunn, N.-O., Kim, J. J., Kim, Y., Leibiger, I. B., Berggren, P., & Ryu, S. H. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.12.005 · Cited by 11
Botanical Interventions to Improve Glucose Control and Options for Diabetes Therapy
Smoak, P., Burke, S. J., & Collier, J. J. (2021) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-021-01034-8 · Cited by 14
Singh, V. P., Lakshmi, B. J., Singh, S., Shah, V., Goel, S., Sarathi, D. P., & Kumar, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038685 · Cited by 11
Insulin Resistance and the Metabolic Syndrome
Banerji, M. A., & Chaiken, R. L. (2009) · Springer eBooks · doi:10.1007/978-0-387-09841-8_34 · Cited by 12
Schwanstecher, C., & Schwanstecher, M. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-17214-4_1 · Cited by 11
Modulating the Glucose Transport by Engineering Gold Nanoparticles
Bhattacharyya, S., & Kattel, K. (2016) · Journal of Nanomedicine & Biotherapeutic Discovery · doi:10.4172/2155-983x.1000141 · Cited by 10
Sekiya, M., Ma, Y., Kainoh, K., Saito, K., Yamazaki, D., Tsuyuzaki, T., Chen, W., Putri, P. I. P. A., Ohno, H., Miyamoto, T., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112914 · Cited by 10
Diabetes and Infectious Diseases with a Focus on Melioidosis
Kumar, A. U., Zan, M. A., Ng, C.-L., Chieng, S., & Nathan, S. (2024) · Current Microbiology · doi:10.1007/s00284-024-03748-z · Cited by 10
Insulin Resistance and Urolithiasis as a Challenge for a Dietitian
Lubawy, M., & Formanowicz, D. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19127160 · Cited by 10
Tony, S. K., Hassan, M. S., Ismail, H. A., El-Naem, G. F. A., & Gazwi, H. S. S. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-27827-z · Cited by 12
Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle
Rodriguez, S., Ellis, J. M., & Wolfgang, M. J. (2014) · BMC Biochemistry · doi:10.1186/1471-2091-15-20 · Cited by 11
Huang, P., Yeku, O., Zong, H., Tsang, P., Su, W., Yu, X., Teng, S., Osisami, M., Kanaho, Y., Pessin, J. E., et al. (2011) · Diabetes · doi:10.2337/db10-0614 · Cited by 10
4-Hydroxyalkenal-activated PPARδ mediates hormetic interactions in diabetes
Sasson, S. (2016) · Biochimie · doi:10.1016/j.biochi.2016.10.007 · Cited by 10
Current status of G-protein coupled receptors as potential targets against type 2 diabetes mellitus
Hoque, M., Ali, S., & Hoda, M. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.07.091 · Cited by 9
Insulin signaling as a therapeutic target in Alzheimer’s disease: Efficacy of apomorphine
Ohyagi, Y., & Takei, S. (2020) · Neurology and Clinical Neuroscience · doi:10.1111/ncn3.12369 · Cited by 10
Paredes-Juarez, G. A., de Vos, P., & Bulte, J. W. M. (2017) · Expert Review of Precision Medicine and Drug Development · doi:10.1080/23808993.2017.1302305 · Cited by 10
Cardiovascular Aging and Physical Activity: Insights From Metabolomics
Lim, R. M. H., & Koh, A. S.-M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.728228 · Cited by 10
Metadata
- Authors
- Muoio, D. M., & Newgard, C. B.
- Affiliations
- Duke University (US)
- Corresponding author
- Newgard, Christopher B.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2008-03
- Volume
- 9
- Issue
- 3
- Pages
- 193-205
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1657478053
- Cited by
- 1,177
- References
- 135
- Citations by year
- 2026: 31 · 2025: 33 · 2024: 49 · 2023: 66 · 2022: 51 · 2021: 59 · 2020: 62 · 2019: 67 · 2018: 65 · 2017: 74 · 2016: 77 · 2015: 81 · 2014: 83 · 2013: 64 · 2012: 75
- FWCI
- 13.64
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- type 2 diabetes, insulin resistance, beta-cell failure, pancreatic beta cells, obesity, metabolic failure, molecular mechanisms, pharmacological interventions
- MeSH terms
- Animals, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin, Insulin Resistance, Signal Transduction, Insulin-Secreting Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review