Cited by 1,177Pancreatic function and diabetesMetabolism, Diabetes, and CancerDiabetes Treatment and Management

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Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

Muoio, Deborah M., Newgard, Christopher B.·2008·Nature Reviews Molecular Cell Biology

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Abstract

Nearly unlimited supplies of energy-dense foods and technologies that encourage sedentary behaviour have introduced a new threat to the survival of our species: obesity and its co-morbidities. Foremost among the co-morbidities is type 2 diabetes, which is projected to afflict 300 million people worldwide by 2020. Compliance with lifestyle modifications such as reduced caloric intake and increased physical activity has proved to be difficult for the general population, meaning that pharmacological intervention may be the only recourse for some. This epidemiological reality heightens the urgency for gaining a deeper understanding of the processes that cause metabolic failure of key tissues and organ systems in type 2 diabetes, as reviewed here.

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Authors: Muoio, D. M., & Newgard, C. B.
Affiliations: Duke University (US)
Corresponding author: Newgard, Christopher B.
ORCID: Muoio, Deborah M.
Newgard, Christopher B.
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-03
Volume: 9
Issue: 3
Pages: 193-205
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2327
OpenAlex: W1657478053
Cited by: 1,177
References: 135
Citations by year: 2026: 31 · 2025: 33 · 2024: 49 · 2023: 66 · 2022: 51 · 2021: 59 · 2020: 62 · 2019: 67 · 2018: 65 · 2017: 74 · 2016: 77 · 2015: 81 · 2014: 83 · 2013: 64 · 2012: 75
FWCI: 13.64
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords: type 2 diabetes, insulin resistance, beta-cell failure, pancreatic beta cells, obesity, metabolic failure, molecular mechanisms, pharmacological interventions
MeSH terms: Animals, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin, Insulin Resistance, Signal Transduction, Insulin-Secreting Cells

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Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

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