Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

Positional cloning of the mouse obese gene and its human homologue

Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419

Handbook of Physiology.

Plum, F. (1960) · Archives of Neurology · doi:10.1001/archneur.1960.03840090124020 · Cited by 10,388

PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

Mootha, V. K., Lindgren, C. M., Eriksson, K.-F., Subramanian, A., Sihag, S., Lehar, J., Puigserver, P., Carlsson, E., Ridderstråle, M., Laurila, E., et al. (2003) · Nature Genetics · doi:10.1038/ng1180 · Cited by 10,197

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

Nissen, S. E., & Wolski, K. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072761 · Cited by 4,675

Inflammation, stress, and diabetes

Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143

Effects of the obese Gene Product on Body Weight Regulation in ob / ob Mice

Pelleymounter, M. A., Cullen, M. J., Baker, M. B., Hecht, R., Winters, D., Boone, T., & Collins, F. (1995) · Science · doi:10.1126/science.7624776 · Cited by 4,017

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

Butler, A. E., Janson, J., Bonner-Weir, S., Ritzel, R., Rizza, R. A., & Butler, P. C. (2003) · Diabetes · doi:10.2337/diabetes.52.1.102 · Cited by 4,011

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844

Biology of Incretins: GLP-1 and GIP

Baggio, L. L., & Drucker, D. J. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.054 · Cited by 3,639

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

Newgard, C. B., An, J., Bain, J. R., Muehlbauer, M. J., Stevens, R. D., Lien, L. F., Haqq, A. M., Shah, S. H., Arlotto, M., Slentz, C. A., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.02.002 · Cited by 3,165

Myocardial Fatty Acid Metabolism in Health and Disease

Lopaschuk, G. D., Ussher, J. R., Folmes, C. D. L., Jaswal, J. S., & Stanley, W. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00015.2009 · Cited by 2,228

Sirtuins as regulators of metabolism and healthspan

Houtkooper, R. H., Pirinen, E., & Auwerx, J. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3293 · Cited by 2,008

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Morris, A. P., Voight, B. F., Teslovich, T. M., Ferreira, T., Segrè, A. V., Steinthorsdottir, V., Strawbridge, R. J., Khan, H., Grallert, H., et al. (2012) · Nature Genetics · doi:10.1038/ng.2383 · Cited by 1,912

Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus

Tangvarasittichai, S. (2015) · World Journal of Diabetes · doi:10.4239/wjd.v6.i3.456 · Cited by 1,284

Metabolism disrupting chemicals and metabolic disorders

Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101

Interplay between lipids and branched-chain amino acids in development of insulin resistance

Newgard, C. B. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.024 · Cited by 1,080

MicroRNAs 103 and 107 regulate insulin sensitivity

Trajkovski, M., Hausser, J., Soutschek, J., Bhat, B., Akin, A., Zavolan, M., Heim, M. H., & Stoffel, M. (2011) · Nature · doi:10.1038/nature10112 · Cited by 1,000

Beta Cell Dysfunction and Insulin Resistance

Cerf, M. E. (2013) · Frontiers in Endocrinology · doi:10.3389/fendo.2013.00037 · Cited by 964

Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer

Jiralerspong, S., Palla, S. L., Giordano, S. H., Meric-Bernstam, F., Liedtke, C., Barnett, C. M., Hsu, L., Hung, M.-C., Hortobagyi, G. N., & Gonzalez-Angulo, A. M. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.19.6410 · Cited by 880

Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

Dunn, W. B., Broadhurst, D., Atherton, H. J., Goodacre, R., & Griffin, J. L. (2010) · Chemical Society Reviews · doi:10.1039/b906712b · Cited by 909

Pathophysiology of diabetes: An overview

Aga, S. S., Banday, M. Z., & Nissar, S. (2020) · Avicenna Journal of Medicine · doi:10.4103/ajm.ajm_53_20 · Cited by 939

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

Sivitz, W. I., & Yorek, M. A. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2531 · Cited by 742

The randle cycle revisited: a new head for an old hat.

Hue, L., & Taegtmeyer, H. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00093.2009 · Cited by 743

Obesity, Insulin Resistance, and Type 2 Diabetes: Associations and Therapeutic Implications

Wondmkun, Y. T. (2020) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s275898 · Cited by 706

Novel biomarkers for pre-diabetes identified by metabolomics

Wang‐Sattler, R., Yu, Z., Herder, C., Messias, A. C., Floegel, A., He, Y., Heim, K., Campillos, M., Holzapfel, C., Thorand, B., et al. (2012) · Molecular Systems Biology · doi:10.1038/msb.2012.43 · Cited by 701

Excessive Hepatic Mitochondrial TCA Cycle and Gluconeogenesis in Humans with Nonalcoholic Fatty Liver Disease

Sunny, N. E., Parks, E. J., Browning, J. D., & Burgess, S. C. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.11.004 · Cited by 672

Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease

Cao, X. (2015) · Nature reviews. Immunology · doi:10.1038/nri.2015.8 · Cited by 671

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

Jheng, H.-F., Tsai, P.-J., Guo, S.-M., Kuo, L.-H., Chang, C.-S., Su, I.-J., Chang, C.-R., & Tsai, Y.-S. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.05603-11 · Cited by 650

Plasma Acylcarnitine Profiles Suggest Incomplete Long-Chain Fatty Acid β-Oxidation and Altered Tricarboxylic Acid Cycle Activity in Type 2 Diabetic African-American Women

Adams, S. H., Hoppel, C. L., Lok, K. H., Zhao, L., Wong, S. W., Minkler, P. E., Hwang, D. H., Newman, J. W., & Garvey, W. T. (2009) · The Journal of Nutrition · doi:10.3945/jn.108.103754 · Cited by 598

A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

Musselman, L. P., Fink, J. L., Narzinski, K., Ramachandran, P. V., Hathiramani, S. S., Cagan, R. L., & Baranski, T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.007948 · Cited by 564

Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways

Huynh, K., Bernardo, B. C., McMullen, J. R., & Ritchie, R. H. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.01.003 · Cited by 556

Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer

Hart, P. A., Bellin, M. D., Andersen, D. K., Bradley, D., Cruz-Monserrate, Z., Forsmark, C. E., Goodarzi, M. O., Habtezion, A., Korc, M., Kudva, Y. C., et al. (2016) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(16)30106-6 · Cited by 551

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

Würtz, P., Soininen, P., Kangas, A. J., Rönnemaa, T., Lehtimäki, T. J., Kähönen, M. A. P., Viikari, J. S. A., Raitakari, O. T., & Ala‐Korpela, M. (2012) · Diabetes Care · doi:10.2337/dc12-0895 · Cited by 562

Carnitine and Acylcarnitines

Reuter, S. E., & Evans, A. M. (2012) · Clinical Pharmacokinetics · doi:10.1007/bf03261931 · Cited by 507

Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment

Ackerman, D., & Simon, M. C. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.06.001 · Cited by 510

Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men

Tai, E. S., Tan, M. L. S., Stevens, R. D., Low, Y.-L., Muehlbauer, M. J., Goh, D. L. M., Ilkayeva, O., Wenner, B. R., Bain, J. R., Lee, J. J. M., et al. (2010) · Diabetologia · doi:10.1007/s00125-009-1637-8 · Cited by 479

A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives

Reed, J., Bain, S., & Kanamarlapudi, V. (2021) · Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy · doi:10.2147/dmso.s319895 · Cited by 441

Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

Muoio, D. M. (2014) · Cell · doi:10.1016/j.cell.2014.11.034 · Cited by 438

Plasma Metabolomic Profiles Reflective of Glucose Homeostasis in Non-Diabetic and Type 2 Diabetic Obese African-American Women

Fiehn, O., Garvey, W. T., Newman, J. W. I., Lok, K. H., Hoppel, C. L., & Adams, S. H. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015234 · Cited by 424

Chlorinated Persistent Organic Pollutants, Obesity, and Type 2 Diabetes

Lee, D., Porta, M. S., Jacobs, D. R., & Vandenberg, L. N. (2014) · Endocrine Reviews · doi:10.1210/er.2013-1084 · Cited by 432

Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women

Huffman, K. M., Shah, S. H., Stevens, R. D., Bain, J. R., Muehlbauer, M., Slentz, C. A., Tanner, C. J., Kuchibhatla, M., Houmard, J. A., Newgard, C. B., et al. (2009) · Diabetes Care · doi:10.2337/dc08-2075 · Cited by 410

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

Satapati, S., Sunny, N. E., Kucejova, B., Fu, X., He, T. T., Méndez-Lucas, A., Shelton, J. M., Perales, J. C., Browning, J. D., & Burgess, S. C. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m023382 · Cited by 407

PPARγ in adipocyte differentiation and metabolism – Novel insights from genome‐wide studies

Siersbæk, R., Nielsen, R., & Mandrup, S. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.06.010 · Cited by 416

Correlation between Oxidative Stress, Nutrition, and Cancer Initiation

Saha, S. K., Lee, S. B., Won, J., Choi, H. Y., Kim, K., Yang, G., Dayem, A. A., & Cho, S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071544 · Cited by 416

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes

Lo, J. C., Ljubicic, S., Leibiger, B., Kern, M., Leibiger, I. B., Moede, T., Kelly, M. E., Bhowmick, D. C., Murano, I., Cohen, P., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.005 · Cited by 390

Clinical application of probiotics in type 2 diabetes mellitus: A randomized, double-blind, placebo-controlled study

Tonucci, L. B., dos Santos, K. M. O., de Oliveira, L. L., Ribeiro, S. M. R., & Martino, H. S. D. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.11.011 · Cited by 402

Molecular Physiology of Mammalian Glucokinase

Iynedjian, P. B. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8322-9 · Cited by 365

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

Ussher, J. R., Koves, T. R., Cadete, V. J. J., Zhang, L., Jaswal, J. S., Swyrd, S. J., Lopaschuk, D. G., Proctor, S. D., Keung, W., Muoio, D. M., et al. (2010) · Diabetes · doi:10.2337/db09-1293 · Cited by 381

The Emerging Role of Metabolomics in the Diagnosis and Prognosis of Cardiovascular Disease

Ussher, J. R., Elmariah, S., Gerszten, R. E., & Dyck, J. R. B. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.09.972 · Cited by 363

SIRT1 and insulin resistance

Liang, F.-X., Kume, S., & Koya, D. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.101 · Cited by 358

Deletion of Cavin/PTRF causes global loss of caveolae, dyslipidemia and glucose intolerance

Liu, L.-B., Brown, D., Mckee, M., LeBrasseur, N., Yang, D., Albrecht, K. H., Ravid, K., & Pilch, P. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.07.008 · Cited by 350

Nkx6.1 Is Essential for Maintaining the Functional State of Pancreatic Beta Cells

Taylor, B. L., Liu, F., & Sander, M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.010 · Cited by 360

Metabolic syndrome: from epidemiology to systems biology

Lusis, A. J., Attie, A., & Reue, K. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2468 · Cited by 345

Toll-like receptors: linking inflammation to metabolism

Könner, A. C., & Brüning, J. C. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.08.007 · Cited by 338

Regulation of Tissue Growth through Nutrient Sensing

Hietakangas, V., & Cohen, S. M. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134815 · Cited by 341

Metabolomics Applied to Diabetes Research

Bain, J. R., Stevens, R. D., Wenner, B. R., Ilkayeva, O., Muoio, D. M., & Newgard, C. B. (2009) · Diabetes · doi:10.2337/db09-0580 · Cited by 336

Network biology concepts in complex disease comorbidities

Hu, J. X., Thomas, C. E., & Brunak, S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.87 · Cited by 328

High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

Yamamoto, T., Takabatake, Y., Takahashi, A., Kimura, T., Namba‐Hamano, T., Matsuda, J., Minami, S., Kaimori, J., Matsui, I., Matsusaka, T., et al. (2016) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016070731 · Cited by 311

Metabolic Signatures of Insulin Resistance in 7,098 Young Adults

Würtz, P., Mäkinen, V., Soininen, P., Kangas, A. J., Tukiainen, T., Kettunen, J., Savolainen, M. J., Tammelin, T., Viikari, J. S. A., Rönnemaa, T., et al. (2012) · Diabetes · doi:10.2337/db11-1355 · Cited by 308

Ginsenoside Rb1 as an Anti-Diabetic Agent and Its Underlying Mechanism Analysis

Zhou, P., Xie, W., He, S., Sun, Y., Meng, X., Sun, G., & Sun, X. (2019) · Cells · doi:10.3390/cells8030204 · Cited by 309

Selective Insulin and Leptin Resistance in Metabolic Disorders

Könner, A. C., & Brüning, J. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.004 · Cited by 320

Health-promoting effects of konjac glucomannan and its practical applications: A critical review

Devaraj, R. D., Reddy, C. K., & Xu, B. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.12.203 · Cited by 319

Control of Pancreatic β Cell Regeneration by Glucose Metabolism

Porat, S., Weinberg-Corem, N., Tornovsky-Babaey, S., Schyr, R. B., Hija, A., Stolovich-Rain, M., Dadon, D., Granot, Z., Ben-Hur, V., White, P., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.02.012 · Cited by 306

Stigma in People With Type 1 or Type 2 Diabetes

Liu, N. F., Brown, A. S., Folias, A. E., Younge, M. F., Guzman, S., Close, K. L., & Wood, R. (2017) · Clinical Diabetes · doi:10.2337/cd16-0020 · Cited by 302

Cytosolic pH is a second messenger for glucose and regulates the PKA pathway through V‐ATPase

Dechant, R. C., Binda, M., Lee, S. S., Pelet, S. B., Winderickx, J., & Peter, M. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.138 · Cited by 294

Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity

Ritov, V. B., Menshikova, E. V., Azuma, K., Wood, R., Toledo, F. G. S., Goodpaster, B. H., Ruderman, N. B., & Kelley, D. E. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00317.2009 · Cited by 283

Yacon syrup: Beneficial effects on obesity and insulin resistance in humans

Genta, S. B., Cabrera, W. M., Habib, N. C., Pons, J., Carillo, I. M., Grau, A., & Sánchez, S. (2009) · Clinical Nutrition · doi:10.1016/j.clnu.2009.01.013 · Cited by 278

Environmental pollutants and type 2 diabetes: a review of mechanisms that can disrupt beta cell function

Hectors, T. L. M., Vanparys, C., van der Ven, K., Martens, G. A., Jorens, P. G., Gaal, L. F. V., Covaci, A., Coen, W. D., & Blust, R. (2011) · Diabetologia · doi:10.1007/s00125-011-2109-5 · Cited by 281

The relationship between type 2 diabetes mellitus and related thyroid diseases

Wang, C. (2013) · Journal of Diabetes Research · doi:10.1155/2013/390534 · Cited by 273

Role of fatty acid uptake and fatty acid β-oxidation in mediating insulin resistance in heart and skeletal muscle

Zhang, L., Keung, W., Samokhvalov, V., Wang, W. J., & Lopaschuk, G. D. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2009.09.014 · Cited by 276

Oxidative and endoplasmic reticulum stress in β-cell dysfunction in diabetes

Hasnain, S. Z., Prins, J. B., & McGuckin, M. A. (2015) · Journal of Molecular Endocrinology · doi:10.1530/jme-15-0232 · Cited by 254

BNip3 Regulates Mitochondrial Function and Lipid Metabolism in the Liver

Glick, D., Zhang, W., Beaton, M., Marsboom, G., Gruber, M., Simon, M. C., Hart, J., Dorn, G. W., Brady, M. J., & Macleod, K. F. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00167-12 · Cited by 251

Insulin resistance induced by physical inactivity is associated with multiple transcriptional changes in skeletal muscle in young men

Alibegovic, A. C., Sonne, M. P., Højbjerre, L., Bork-Jensen, J., Jacobsen, S., Nilsson, E., Færch, K., Hiscock, N., Mortensen, B., Friedrichsen, M., et al. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00590.2009 · Cited by 247

Molecular mechanisms of chromium in alleviating insulin resistance

Hua, Y., Clark, S., Ren, J. T., & Sreejayan, N. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2011.11.001 · Cited by 263

Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation

Wei, J., Ferron, M., Clarke, C. J., Hannun, Y. A., Jiang, H., Blaner, W. S., & Karsenty, G. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72323 · Cited by 255

Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis

Sumara, G., Formentini, I., Collins, S. C., Sumara, I., Windak, R., Bodenmiller, B., Ramracheya, R. D., Caille, D., Jiang, H., Platt, K. A., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.018 · Cited by 244

Organophosphorus pesticide chlorpyrifos intake promotes obesity and insulin resistance through impacting gut and gut microbiota

Liang, Y., Zhan, J., Liu, D., Luo, M., Han, J., Liu, X., Liu, C., Cheng, Z. Z., Zhou, Z., & Wang, P. (2019) · Microbiome · doi:10.1186/s40168-019-0635-4 · Cited by 248

Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue

Rosa, S. C. D. S., Nayak, N., Caymo, A. M., & Gordon, J. W. (2020) · Physiological Reports · doi:10.14814/phy2.14607 · Cited by 271

Insulin Resistance in Obesity as the Underlying Cause for the Metabolic Syndrome

Gallagher, E. J., LeRoith, D., & Karnieli, E. (2010) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20212 · Cited by 244

Osteocalcin Promotes β-Cell Proliferation During Development and Adulthood Through Gprc6a

Wei, J., Hanna, T., Suda, N., Karsenty, G., & Ducy, P. F. (2013) · Diabetes · doi:10.2337/db13-0887 · Cited by 237

Protein misfolding and aggregation in Alzheimer’s disease and type 2 diabetes mellitus

Ashraf, G., Greig, N., Khan, T., Hassan, I., Tabrez, S., Shakil, S., Sheikh, I., Zaidi, S., Akram, M., Jabir, N., et al. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140917095514 · Cited by 236

SerpinB1 Promotes Pancreatic β Cell Proliferation

Ouaamari, A. E., Dirice, E., Gedeon, N., Hu, J., Zhou, J.-Y., Shirakawa, J., Hou, L., Goodman, J., Karampelias, C., Qiang, G., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.001 · Cited by 236

Insulin Signal Transduction Perturbations in Insulin Resistance

Khalid, M., Alkaabi, J., Khan, M. A. B., & Adem, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168590 · Cited by 233

High Sugar-Induced Insulin Resistance in Drosophila Relies on the Lipocalin Neural Lazarillo

Pasco, M. Y., & Léopold, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036583 · Cited by 234

Heat Treatment Improves Glucose Tolerance and Prevents Skeletal Muscle Insulin Resistance in Rats Fed a High-Fat Diet

Gupte, A. A., Bomhoff, G. L., Swerdlow, R. H., & Geiger, P. C. (2008) · Diabetes · doi:10.2337/db08-1070 · Cited by 230

Mitochondrial Dysfunction and Lipid Accumulation in the Human Diaphragm during Mechanical Ventilation

Picard, M. A., Jung, B., Liang, F., Azuelos, I., Hussain, S. N. A., Goldberg, P., Godin, R., Danialou, G., Chaturvedi, R. K., Rygiel, K. A., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201206-0982oc · Cited by 225

Inhibition of p53 preserves Parkin-mediated mitophagy and pancreatic β-cell function in diabetes

Hoshino, A., Ariyoshi, M., Okawa, Y., Kaimoto, S., Uchihashi, M., Fukai, K., Iwai‐Kanai, E., Ikeda, K., Ueyama, T., Ogata, T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1318951111 · Cited by 225

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

Birkenfeld, A. L., Lee, H., Guebre‐Egziabher, F., Alves, T. C., Jurczak, M. J., Jornayvaz, F. R., Zhang, D., Hsiao, J. J., Martín‐Montalvo, A., Fischer‐Rosinsky, A., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.009 · Cited by 217

High-fat diet and streptozotocin in the induction of type 2 diabetes mellitus: a new proposal

MAGALHÃES, D. A. D., Kume, W. T., CORREIA, F. S., QUEIROZ, T. S., Neto, E. W. A., dos Santos, M. P., Kawashita, N. H., & de França, S. A. (2019) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201920180314 · Cited by 211

The Role of Vitamin D and Its Molecular Bases in Insulin Resistance, Diabetes, Metabolic Syndrome, and Cardiovascular Disease: State of the Art

Argano, C., Mirarchi, L., Amodeo, S., Orlando, V., Torres, A., & Corrao, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242015485 · Cited by 261

Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis

Bhatnagar, S., Damron, H. A., & Hillgartner, F. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808818200 · Cited by 212

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

Kumar, D. P., Rajagopal, S., Mahavadi, S., Mirshahi, F., Grider, J. R., Murthy, K. S., & Sanyal, A. J. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.09.104 · Cited by 206

Genome sequences of wild and domestic bactrian camels

Jirimutu, Wang, Z., Ding, G., Chen, G., Sun, Y., Sun, Z., Zhang, H., Wang, L., Hasi, S., Zhang, Y., et al. (2012) · Nature Communications · doi:10.1038/ncomms2192 · Cited by 210

Free fatty acids and skeletal muscle insulin resistance

Kraegen, E. W., & Cooney, G. J. (2008) · Current Opinion in Lipidology · doi:10.1097/01.mol.0000319118.44995.9a · Cited by 210

Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci

Stitzel, M. L., Sethupathy, P., Pearson, D. S., Chines, P. S., Song, L., Erdos, M. R., Welch, R., Parker, S. C. J., Boyle, A. P., Scott, L. J., et al. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.09.012 · Cited by 193

Low-Grade Hypothalamic Inflammation Leads to Defective Thermogenesis, Insulin Resistance, and Impaired Insulin Secretion

Arruda, A. P., Milanski, M., Coope, A., Torsoni, A. S., Ropelle, E. R., de Carvalho, D. P., Carvalheira, J. B. C., & Velloso, L. A. (2011) · Endocrinology · doi:10.1210/en.2010-0659 · Cited by 207

Circulating Metabolite Predictors of Glycemia in Middle-Aged Men and Women

Würtz, P., Tiainen, M., Mäkinen, V., Kangas, A. J., Soininen, P., Saltevo, J. T., Keinanen-Kiukaanniemi, S. M., Mäntyselkä, P. T., Lehtimäki, T. J., Laakso, M., et al. (2012) · Diabetes Care · doi:10.2337/dc11-1838 · Cited by 206

Angiotensin II and the development of insulin resistance: Implications for diabetes

Olivares-Reyes, J. A., Arellano-Plancarte, A., & Castillo-Hernández, J. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.12.011 · Cited by 208

Ubiquitin Fold Modifier 1 (UFM1) and Its Target UFBP1 Protect Pancreatic Beta Cells from ER Stress-Induced Apoptosis

Lemaire, K., de Moura, R. F., Granvik, M., Igoillo‐Esteve, M., Hohmeier, H. E., Hendrickx, N., Newgard, C. B., Waelkens, E., Cnop, M., & Schuit, F. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018517 · Cited by 196

Flavonol kaempferol improves chronic hyperglycemia-impaired pancreatic beta-cell viability and insulin secretory function

Zhang, Y., & Liu, D. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.08.011 · Cited by 193

mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells

Ardestani, A. D., Lupše, B., Kido, Y., Leibowitz, G., & Maedler, K. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.004 · Cited by 198

Metabolism, Metabolomics, and Inflammation in Posttraumatic Stress Disorder

Mellon, S. H., Gautam, A., Hammamieh, R., Jett, M., & Wolkowitz, O. M. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.007 · Cited by 184

Effects of type 1 diabetes mellitus on skeletal muscle: clinical observations and physiological mechanisms

Krause, M. P., Riddell, M. C., & Hawke, T. J. (2010) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2010.00699.x · Cited by 190

Effect of extracellular vesicles of human adipose tissue on insulin signaling in liver and muscle cells

Kranendonk, M. E. G., Visseren, F. L. J., van Herwaarden, J. A., Hoen, E. N. M. N., de Jager, W., Wauben, M. H. M., & Kalkhoven, E. (2014) · Obesity · doi:10.1002/oby.20847 · Cited by 195

Mitochondrially derived peptides as novel regulators of metabolism

Kim, S., Xiao, J., Wan, J., Cohen, P., & Yen, K. (2017) · The Journal of Physiology · doi:10.1113/jp274472 · Cited by 185

Targeting fatty acid metabolism to improve glucose metabolism

Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183

Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism

Gut, P., Baeza-Raja, B., Andersson, O., Hasenkamp, L., Hsiao, J., Hesselson, D., Akassoglou, K., Verdin, E. M., Hirschey, M. D., & Stainier, D. Y. R. (2012) · Nature Chemical Biology · doi:10.1038/nchembio.1136 · Cited by 188

Risk of Cancer Following Hospitalization for Type 2 Diabetes

Hemminki, K., Li, X., Sundquist, J., & Sundquist, K. (2010) · The Oncologist · doi:10.1634/theoncologist.2009-0300 · Cited by 180

Lactobacillus plantarum Strain Ln4 Attenuates Diet-Induced Obesity, Insulin Resistance, and Changes in Hepatic mRNA Levels Associated with Glucose and Lipid Metabolism

Lee, E., Jung, S.-R., Lee, S., Lee, N., Paik, H., & Lim, S. (2018) · Nutrients · doi:10.3390/nu10050643 · Cited by 177

Pancreatic β-cell failure in type 2 diabetes mellitus

Kaneto, H. (2015) · Expert Review of Endocrinology & Metabolism · doi:10.1586/17446651.2016.1123090 · Cited by 4

β-cell failure as a complication of diabetes

Chang-Chen, K. J., Mullur, R., & Bernal-Mizrachi, E. (2008) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-008-9101-5 · Cited by 225

An islet in distress: β cell failure in type 2 diabetes

Ogihara, T., & Mirmira, R. G. (2010) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2010.00021.x · Cited by 46

Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?

Cantley, J., & Ashcroft, F. M. (2015) · BMC Biology · doi:10.1186/s12915-015-0140-6 · Cited by 158

Insulin resistance and β‐cell dysfunction as therapeutic targets in type 2 diabetes

Evans, A. J., & Krentz, A. J. (2001) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2001.00101.x · Cited by 13