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Cited by 573

The DOI matches its Crossref record; 117 of the 117 references it cites were found in a registry or an index.

Exploring mechanisms of FGF signalling through the lens of structural biology

Open access
Goetz, Regina, Mohammadi, Moosa·2013·Nature Reviews Molecular Cell Biology

Abstract

Fibroblast growth factors (FGFs) mediate a broad range of functions in both the developing and adult organism. The accumulated wealth of structural information on the FGF signalling pathway has begun to unveil the underlying molecular mechanisms that modulate this system to generate a myriad of distinct biological outputs in development, tissue homeostasis and metabolism. At the ligand and receptor level, these mechanisms include alternative splicing of the ligand (FGF8 subfamily) and the receptor (FGFR1–FGFR3), ligand homodimerization (FGF9 subfamily), site-specific proteolytic cleavage of the ligand (FGF23), and interaction of the ligand and the receptor with heparan sulphate cofactor and Klotho co-receptor.

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Crossref · 10.1038/nrm3528

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Metadata

Authors
Goetz, R., & Mohammadi, M.
Venue
Nature Reviews Molecular Cell Biology
Published
2013-02-13
Volume
14
Issue
3
Pages
166-180
ISSN
  • 1471-0072 (ISSN-L)
  • 1471-0080
OpenAlex
W1965358479
Cited by
573
References
117
FWCI
3.54
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Exploring mechanisms of FGF signalling through the lens of structural biology. https://app.cochat.ai/papers/10.1038/nrm3528
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Goetz, R., & Mohammadi, M. (2013). Exploring mechanisms of FGF signalling through the lens of structural biology. Nature Reviews Molecular Cell Biology. https://doi.org/10.1038/nrm3528

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.