Cited by 5,462MicroRNA in disease regulationRNA regulation and diseasePlant Molecular Biology Research

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Regulation of microRNA biogenesis

Ha, Minju, Kim, V. Narry·2014·Nature Reviews Molecular Cell Biology

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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that function as guide molecules in RNA silencing. Targeting most protein-coding transcripts, miRNAs are involved in nearly all developmental and pathological processes in animals. The biogenesis of miRNAs is under tight temporal and spatial control, and their dysregulation is associated with many human diseases, particularly cancer. In animals, miRNAs are ∼22 nucleotides in length, and they are produced by two RNase III proteins--Drosha and Dicer. miRNA biogenesis is regulated at multiple levels, including at the level of miRNA transcription; its processing by Drosha and Dicer in the nucleus and cytoplasm, respectively; its modification by RNA editing, RNA methylation, uridylation and adenylation; Argonaute loading; and RNA decay. Non-canonical pathways for miRNA biogenesis, including those that are independent of Drosha or Dicer, are also emerging.

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Authors: Ha, M., & Kim, V. N.
Affiliations: Seoul National University (KR)
Corresponding author: Kim, V. Narry
ORCID: Ha, Minju
Kim, V. Narry
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2014-07-16
Volume: 15
Issue: 8
Pages: 509-524
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm3838
OpenAlex: W2006247279
Cited by: 5,462
References: 272
Citations by year: 2026: 226 · 2025: 296 · 2024: 477 · 2023: 489 · 2022: 572 · 2021: 582 · 2020: 525 · 2019: 496 · 2018: 500 · 2017: 514 · 2016: 430 · 2015: 310 · 2014: 38
FWCI: 42.81
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Seoul National University Open Repository (Seoul National University) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: microRNA biogenesis, Drosha, Dicer, RNA processing, RNA editing, RNA methylation, uridylation, adenylylation, RNA degradation, RNA silencing, cancer
MeSH terms: Animals, Cell Nucleus, Gene Expression Regulation, Humans, Plants, RNA Processing, Post-Transcriptional, RNA, Messenger, Transcription, Genetic, Active Transport, Cell Nucleus, RNA Interference, MicroRNAs

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